专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

11. 发明申请

WO2006049597A1 AMINO ACID-DERIVED COMPOUNDS AS MODULATORS OF THE REVERSE CHOLESTEROL TRANSPORT 审中-公开
标题翻译：氨基酸衍生化合物作为反向胆固醇运输的调节剂
公开(公告)号：WO2006049597A1
公开(公告)日：2006-05-11
申请号：PCT/US2004/035749
申请日：2004-10-27
申请人： AVANIR PHARMACEUTICALS , SIRCAR, Jagadish, C. , ALISALA, Kashinatham , NIKOULIN, Igor
发明人： SIRCAR, Jagadish, C. , ALISALA, Kashinatham , NIKOULIN, Igor
IPC分类号： C07K14/775
CPC分类号： C07K5/0817 , A61K38/06 , A61K38/07 , A61K38/08 , C07K5/06139 , C07K5/0812 , C07K5/0819 , C07K5/1016 , C07K5/1019 , C07K5/1021 , C07K14/775 , Y02P20/55
摘要： The present invention provides compositions adapted to enhance reverse cholesterol transport in mammals. The compositions are suitable for oral ,delivery and useful in the treatment and/or prevention of disease conditions associated with hypercholesterolemia. For example, the compositions contain one of the following active agents: i) a compound comprising between 3 and 10 L or D amino acid residues or anal thereof, said compound having an amino and a carboxy terminal, and comprising the sequence: Xl-X2-X3, wherein X1 is an acidic amino acid, X2 a lipophilic or aromatic amino acid, and X3 is a basic amino acid, and wherein X1, X2 and X3 may be arranged in any sequential order; wherein at least one of X1, X2 or X3 further comprises a peptidomimetic modification and wherein at least one of the amino or carboxy terminals further compri a protecting group; or ii)A substantially pure amino acid-derived compound having an amino and a carboxy terminal and comprising an L or D enantiomer of an acidic amino a residue or peptidomimetic modification thereof, an L or D enantiomer of a lipophilic or aromatic amino acid residue or peptidomimetic modification thereof, and an L or D enantiomer of a basic amino acid residue or peptid mimetic modification thereof; wherein the amino and the carboxy terminal comprise a first and a second protecting group; and wherein said compound has at least one of the following properties: (1) it mimicks ApoA-I bindi to LDL and HDL, (2) it binds preferentially to liver, (3) it enhances LDL uptake by liver LDL-receptors, (4) it lower the levels of LDL, IDL, and V cholesterol, (5) it enhances cholesterol efflux from macrophages and ther inhibits foam cell formation, (6) it reduces plaque formation, (7) it increases the levels of HDL cholesterol, and (8) it improves plasma lipoprotein profiles.
摘要翻译：本发明提供适于增强哺乳动物逆转胆固醇转运的组合物。所述组合物适合于口服，递送并且可用于治疗和/或预防与高胆固醇血症相关的疾病状况。例如，组合物含有以下活性剂之一：i）包含3至10L或D氨基酸残基或其分析物的所述化合物，所述化合物具有氨基和羧基末端，并且包含以下序列：X1-X2 -X3，其中X1是酸性氨基酸，X2是亲脂性或芳香族氨基酸，X3是碱性氨基酸，并且其中X1，X2和X3可以以任何顺序排列; 其中X 1，X 2或X 3中的至少一个还包含拟肽修饰，并且其中所述氨基或羧基末端中的至少一个还包含保护基; 或ii）具有氨基和羧基末端并且包含酸性氨基酸残基或其拟肽修饰的L或D对映异构体的基本上纯的氨基酸衍生化合物，亲脂性或芳族氨基酸残基的L或D对映体，或其拟肽修饰，以及碱性氨基酸残基或其肽模拟修饰的L或D对映异构体; 其中所述氨基和所述羧基末端包含第一和第二保护基团; 并且其中所述化合物具有以下性质中的至少一种：（1）它模拟与LDL和HDL结合的ApoA-I，（2）其优先结合肝脏，（3）其增强肝脏LDL受体的LDL摄取， 4）降低LDL，IDL和V胆固醇水平;（5）增强巨噬细胞胆固醇流出，抑制泡沫细胞形成，（6）减少斑块形成，（7）提高HDL胆固醇水平，和（8）它改善了血浆脂蛋白谱。

12. 发明申请

WO2005123770A1 MEDIATORS OF REVERSE CHOLESTEROL TRANSPORT FOR THE TREATMENT OF HYPERCHOLESTEROLEMIA 审中-公开
标题翻译：逆转胆固醇输送介质治疗高胆固醇血症
公开(公告)号：WO2005123770A1
公开(公告)日：2005-12-29
申请号：PCT/US2005/020662
申请日：2005-06-09
申请人： AVANIR PHARMACEUTICALS , SIRCAR, Jagadish, C. , VASSAR, Victor, Charles , NIKOULIN, Igor , ALISALA, Kashinatham
发明人： SIRCAR, Jagadish, C. , VASSAR, Victor, Charles , NIKOULIN, Igor , ALISALA, Kashinatham
IPC分类号： C07K14/775
CPC分类号： A61K38/04 , A61K31/198 , A61K31/415 , A61K31/4172 , A61K31/505 , A61K38/06 , C07K5/06078 , C07K5/06095 , C07K5/06104 , C07K5/06139
摘要： The present invention provides compositions adapted to enhance reverse cholesterol transport in mammals. The compositions are suitable for oral delivery and useful in the treatment and/or prevention of hypercholesterolemia, atherosclerosis and associated cardiovascular diseases.
摘要翻译：本发明提供了适用于增强哺乳动物中胆固醇逆向转运的组合物。该组合物适用于口服递送并可用于治疗和/或预防高胆固醇血症，动脉粥样硬化和相关的心血管疾病。

13. 发明申请

WO2004094471A2 MEDIATORS OF REVERSE CHOLESTEROL TRANSPORT FOR THE TREATMENT OF HYPERCHOLESTEROLEMIA 审中-公开
标题翻译：用于治疗高脂血症的反向胆固醇运输的介质
公开(公告)号：WO2004094471A2
公开(公告)日：2004-11-04
申请号：PCT/US2004/012445
申请日：2004-04-22
申请人： AVANIR PHARMACEUTICALS , SIRCAR, Jagadish, C. , ALISALA, Kashinatham , NIKOULIN, Igor
发明人： SIRCAR, Jagadish, C. , ALISALA, Kashinatham , NIKOULIN, Igor
IPC分类号： C07K14/775
CPC分类号： C07K5/06139 , A61K38/00 , C07K5/0812 , C07K5/0817 , C07K5/0819 , C07K5/1016 , C07K5/1019 , C07K5/1021 , C07K14/775
摘要： The present invention provides compositions adapted to enhance reverse cholesterol transport in mammals. The compositions are suitable for oral delivery and useful in the treatment and/or prevention of hypercholesterolemia, atherosclerosis and associated cardiovascular diseases.
摘要翻译：本发明提供适于增强哺乳动物逆向胆固醇转运的组合物。所述组合物适用于口服递送，并且可用于治疗和/或预防高胆固醇血症，动脉粥样硬化和相关的心血管疾病。

14. 发明申请

WO2004091610A1 IMIDAZOLE DERIVATIVES FOR TREATMENT OF ALLERGIC AND HYPERPROLIFERATIVE DISORDERS 审中-公开
标题翻译：用于治疗过敏和高血压疾病的咪唑衍生物
公开(公告)号：WO2004091610A1
公开(公告)日：2004-10-28
申请号：PCT/US2004/011010
申请日：2004-04-09
申请人： AVANIR PHARMACEUTICALS , SIRCAR, Jagadish, C. , THOMAS, Richard, J. , RICHARDS, Mark, L. , KHATUYA, Haripada
发明人： SIRCAR, Jagadish, C. , THOMAS, Richard, J. , RICHARDS, Mark, L. , KHATUYA, Haripada
IPC分类号： A61K31/4164
CPC分类号： C07D233/64 , A61K31/4164 , C07D401/12 , C07D401/14
摘要： The preferred embodiments are directed to small molecule inhibitors of the IgE response to allergens, which are useful in the treatment of allergy and/or asthma or any diseases where IgE is pathogenic. The preferred embodiments also relate to imidazole molecules that are cellular proliferation inhibitors and thus are useful as anticancer agents. The preferred embodiments further relate to small molecules which suppress cytokines and leukocytes.
摘要翻译：优选的实施方案涉及对变应原的IgE应答的小分子抑制剂，其可用于治疗过敏和/或哮喘或IgE是致病性的任何疾病。优选的实施方案还涉及作为细胞增殖抑制剂的咪唑分子，因此可用作抗癌剂。优选实施方案还涉及抑制细胞因子和白细胞的小分子。

15. 发明申请

WO2004074218A3 INHIBITORS OF MACROPHAGE MIGRATION INHIBITORY FACTOR AND METHODS FOR IDENTIFYING THE SAME 审中-公开
公开(公告)号：WO2004074218A3
公开(公告)日：2004-09-02
申请号：PCT/US2004/004433
申请日：2004-02-13
申请人： AVANIR PHARMACEUTICALS , SIRCAR, Jagadish, C. , KUMAR, Sunil, K., C. , YING, Wenbin
发明人： SIRCAR, Jagadish, C. , KUMAR, Sunil, K., C. , YING, Wenbin
IPC分类号： A61K31/496
摘要： Inhibitors of MIF are provided which have utility in the treatment of a variety of disorders, including the treatment of pathological conditions associated with MIF activity. The inhibitors of MIF have the following structures (Ia), (Ib) including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein n, R 1 , R 2 , R 3 , R 4 , X, and Z are as defined herein. Compositions containing an inhibitor of MIF in combination with a pharmaceutically acceptable carrier are also provided, as well as methods for use of the same.

16. 发明申请

WO2004024896A3 PHENYL-INDOLE COMPOUNDS 审中-公开
标题翻译：苯酚化合物
公开(公告)号：WO2004024896A3
公开(公告)日：2004-06-24
申请号：PCT/US0330959
申请日：2003-09-12
申请人： AVANIR PHARMACEUTICALS , SIRCAR JAGADISH C , RAMNAUTH JAILALL , RICHARDS MARK L
发明人： SIRCAR JAGADISH C , RAMNAUTH JAILALL , RICHARDS MARK L
IPC分类号： A61K31/404 , A61K45/06 , C07D209/10 , C07D209/14 , C07D209/18
CPC分类号： C07D209/18 , A61K31/404 , A61K45/06 , C07D209/10 , C07D209/14 , A61K2300/00
摘要： The present invention is directed to small molecule inhibitors of the IgE response to allergens, which are useful in the treatment of allergy and/or asthma or any diseases where IgE is pathogenic. This invention also relates to phenyl-indole molecules that are cellular proliferation inhibitors and thus are useful as anticancer agents. This invention further relates to small molecules which suppress cytokines and leukocytes.
摘要翻译：本发明涉及对变应原的IgE应答的小分子抑制剂，其可用于治疗过敏和/或哮喘或IgE致病的任何疾病。本发明还涉及作为细胞增殖抑制剂的苯基 - 吲哚分子，因此可用作抗癌剂。本发明还涉及抑制细胞因子和白细胞的小分子。

17. 发明申请

WO2003082186A3 USE OF BENZIMIDAZOLE ANALOGS IN THE TREATMENT OF CELL PROLIFERATION 审中-公开
公开(公告)号：WO2003082186A3
公开(公告)日：2003-10-09
申请号：PCT/US2003/006981
申请日：2003-03-06
申请人： AVANIR PHARMACEUTICALS , SIRCAR, Jagadish, C. , RICHARDS, Mark, L.
发明人： SIRCAR, Jagadish, C. , RICHARDS, Mark, L.
IPC分类号： A61K31/4184
摘要： The preferred embodiments are directed to small molecule inhibitors that are cellular proliferation inhibitors and thus are useful as anticancer agents. The small molecules have the general formulas that include a phenylbenzimidazole core ring.

18. 发明申请

WO2011140520A2 BIOREACTORS COMPRISING FUNGAL STRAINS 审中-公开
标题翻译：包含真菌菌株的生物反应器
公开(公告)号：WO2011140520A2
公开(公告)日：2011-11-10
申请号：PCT/US2011035644
申请日：2011-05-06
申请人： MENON & ASSOCIATES , MENON SURESH M , ORCHARD SAMANTHA S , BADGER JESSICA , LIPSON DAVID , GUIDI SARA , NEWMAN DAVID , SURESH ARUL VICTOR , SIRCAR JAGADISH C , ALISALA KASHINATHAM
发明人： MENON SURESH M , ORCHARD SAMANTHA S , BADGER JESSICA , LIPSON DAVID , GUIDI SARA , NEWMAN DAVID , SURESH ARUL VICTOR , SIRCAR JAGADISH C , ALISALA KASHINATHAM
IPC分类号： C12M3/02 , A23K1/12 , C12M1/06 , C12M1/12 , C12M1/24 , C12N1/14 , C12P7/64 , C12R1/645
CPC分类号： C12M21/12 , A01N63/04 , A23K10/12 , A23K20/142 , A23K20/147 , A23K20/158 , A23K40/20 , A23K50/10 , A23K50/42 , A23K50/75 , A23K50/80 , A23L33/12 , A23V2002/00 , C11B1/10 , C11C3/003 , C12M25/02 , C12M27/02 , C12M27/20 , C12N1/14 , C12P5/005 , C12P5/02 , C12P7/6463 , C12P7/6481 , C12P2203/00 , C12R1/645 , C12R1/80 , Y02A40/818 , Y10S426/805 , Y10S426/807
摘要： Disclosed herein are compositions comprising an isolated cellulose degrading fungus. Also disclosed are culture compositions and bioreactor compositions comprising the cellulose degrading fungus. Further described herein are filtration and extraction devices comprising the cellulose degrading fungus. Still further disclosed are bioprocessing facilities for and methods for producing co-products resulting from one or more bioprocesses of the cellulose degrading fungus.
摘要翻译：本文公开了包含分离的降解纤维素的真菌的组合物。还公开了包含纤维素降解菌的培养组合物和生物反应器组合物。本文进一步描述的是包含纤维素降解菌的过滤和提取装置。还公开了生物处理设备和用于生产由一种或多种纤维素降解真菌生物处理产生的副产物的方法。

19. 发明申请

WO2008008841A3 USE OF BENZIMIDAZOLE DERIVATIVES FOR THE TREATMENT AND/OR PREVENTION OF AUTOIMMUNE DISORDERS 审中-公开
标题翻译：苯并咪唑衍生物用于治疗和/或预防自身免疫疾病的用途
公开(公告)号：WO2008008841A3
公开(公告)日：2008-05-29
申请号：PCT/US2007073266
申请日：2007-07-11
申请人： AVANIR PHARMACEUTICALS , SIRCAR JAGADISH C , RICHARDS MARK L
发明人： SIRCAR JAGADISH C , RICHARDS MARK L
IPC分类号： C07D235/04 , A61K31/4184 , A61P31/00
CPC分类号： C07D471/04 , C07D209/14 , C07D401/12
摘要： Preferred aspects of the present invention relate to treating and/or preventing autoimmune disorders, such as systemic lupus erythematosus and multiple sclerosis, using a family of benzimidazole derivatives.
摘要翻译：本发明的优选方面涉及使用苯并咪唑衍生物族来治疗和/或预防自身免疫性疾病，例如系统性红斑狼疮和多发性硬化症。

20. 发明申请

WO2008008841A2 USE OF BENZIMIDAZOLE DERIVATIVES FOR THE TREATMENT AND/OR PREVENTION OF AUTOIMMUNE DISORDERS 审中-公开
标题翻译：苯并咪唑衍生物用于治疗和/或预防自身免疫疾病的用途
公开(公告)号：WO2008008841A2
公开(公告)日：2008-01-17
申请号：PCT/US2007/073266
申请日：2007-07-11
申请人： AVANIR PHARMACEUTICALS , SIRCAR, Jagadish, C. , RICHARDS, Mark, L.
发明人： SIRCAR, Jagadish, C. , RICHARDS, Mark, L.
IPC分类号： H04J1/02
CPC分类号： C07D471/04 , C07D209/14 , C07D401/12
摘要： Preferred aspects of the present invention relate to treating and/or preventing autoimmune disorders, such as systemic lupus erythematosus and multiple sclerosis, using a family of benzimidazole derivatives.
摘要翻译：本发明的优选方面涉及使用苯并咪唑衍生物家族治疗和/或预防自身免疫病症，例如系统性红斑狼疮和多发性硬化症。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式