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1. 发明申请

WO2004091610A1 IMIDAZOLE DERIVATIVES FOR TREATMENT OF ALLERGIC AND HYPERPROLIFERATIVE DISORDERS 审中-公开
标题翻译：用于治疗过敏和高血压疾病的咪唑衍生物
公开(公告)号：WO2004091610A1
公开(公告)日：2004-10-28
申请号：PCT/US2004/011010
申请日：2004-04-09
申请人： AVANIR PHARMACEUTICALS , SIRCAR, Jagadish, C. , THOMAS, Richard, J. , RICHARDS, Mark, L. , KHATUYA, Haripada
发明人： SIRCAR, Jagadish, C. , THOMAS, Richard, J. , RICHARDS, Mark, L. , KHATUYA, Haripada
IPC分类号： A61K31/4164
CPC分类号： C07D233/64 , A61K31/4164 , C07D401/12 , C07D401/14
摘要： The preferred embodiments are directed to small molecule inhibitors of the IgE response to allergens, which are useful in the treatment of allergy and/or asthma or any diseases where IgE is pathogenic. The preferred embodiments also relate to imidazole molecules that are cellular proliferation inhibitors and thus are useful as anticancer agents. The preferred embodiments further relate to small molecules which suppress cytokines and leukocytes.
摘要翻译：优选的实施方案涉及对变应原的IgE应答的小分子抑制剂，其可用于治疗过敏和/或哮喘或IgE是致病性的任何疾病。优选的实施方案还涉及作为细胞增殖抑制剂的咪唑分子，因此可用作抗癌剂。优选实施方案还涉及抑制细胞因子和白细胞的小分子。

2. 发明申请

WO2004024897A2 PHENYL-AZA-BENZIMIDAZOLE COMPOUNDS FOR MODULATING IgE AND INHIBITING CELLULAR PROLIFERATION 审中-公开
标题翻译：用于调节IgE和抑制细胞增殖的苯基 - AZA-苯并咪唑化合物
公开(公告)号：WO2004024897A2
公开(公告)日：2004-03-25
申请号：PCT/US2003/030962
申请日：2003-09-12
申请人： AVANIR PHARMACEUTICALS , SIRCAR, Jagadish, c. , THOMAS, Richard, J. , RICHARDS, Mark, L. , SINHA, Anjana
发明人： SIRCAR, Jagadish, c. , THOMAS, Richard, J. , RICHARDS, Mark, L. , SINHA, Anjana
IPC分类号： C12N
CPC分类号： C07D471/04 , A61K31/437
摘要： The present invention is directed to small molecule inhibitors of the IgE response to allergens, which are useful in the treatment of allergy and/or asthma or any diseases where IgE is pathogenic. This invention also relates to phenyl-aza-benzimidazole molecules that are cellular proliferation inhibitors and thus are useful as anticancer agents. This invention further relates to small molecules which suppress cytokines and leukocytes.
摘要翻译：本发明涉及对变应原的IgE应答的小分子抑制剂，其可用于治疗过敏和/或哮喘或IgE致病的任何疾病。本发明还涉及作为细胞增殖抑制剂的苯基 - 氮杂 - 苯并咪唑分子，因此可用作抗癌剂。本发明还涉及抑制细胞因子和白细胞的小分子。

3. 发明申请

WO2004024896A2 PHENYL-INDOLE COMPOUNDS FOR MODULATING IgE AND INHIBITING CELLULAR PROLIFERATION 审中-公开
标题翻译：用于调节IgE和抑制细胞增殖的苯基吲哚化合物
公开(公告)号：WO2004024896A2
公开(公告)日：2004-03-25
申请号：PCT/US2003/030959
申请日：2003-09-12
申请人： AVANIR PHARMACEUTICALS , SIRCAR, Jagadish, C. , RAMNAUTH, Jailall , RICHARDS, Mark, L.
发明人： SIRCAR, Jagadish, C. , RAMNAUTH, Jailall , RICHARDS, Mark, L.
IPC分类号： C12N
CPC分类号： C07D209/18 , A61K31/404 , A61K45/06 , C07D209/10 , C07D209/14 , A61K2300/00
摘要： The present invention is directed to small molecule inhibitors of the IgE response to allergens, which are useful in the treatment of allergy and/or asthma or any diseases where IgE is pathogenic. This invention also relates to phenyl-indole molecules that are cellular proliferation inhibitors and thus are useful as anticancer agents. This invention further relates to small molecules which suppress cytokines and leukocytes.
摘要翻译：本发明涉及对变应原的IgE应答的小分子抑制剂，其可用于治疗过敏和/或哮喘或IgE致病的任何疾病。本发明还涉及作为细胞增殖抑制剂的苯基 - 吲哚分子，因此可用作抗癌剂。本发明还涉及抑制细胞因子和白细胞的小分子。

4. 发明申请

WO2003082186A2 USE OF BENZIMIDAZOLE ANALOGS IN THE TREATMENT OF CELL PROLIFERATION 审中-公开
标题翻译：苯并咪唑类似物在细胞增殖治疗中的应用
公开(公告)号：WO2003082186A2
公开(公告)日：2003-10-09
申请号：PCT/US2003/006981
申请日：2003-03-06
申请人： AVANIR PHARMACEUTICALS , SIRCAR, Jagadish, C. , RICHARDS, Mark, L.
发明人： SIRCAR, Jagadish, C. , RICHARDS, Mark, L.
IPC分类号： A61K
CPC分类号： A61K31/4184
摘要： The preferred embodiments are directed to small molecule inhibitors that are cellular proliferation inhibitors and thus are useful as anticancer agents. The small molecules have the general formulas that include a phenylbenzimidazole core ring.
摘要翻译：优选的实施方案涉及作为细胞增殖抑制剂的小分子抑制剂，因此可用作抗癌剂。小分子具有包括苯基苯并咪唑核心环的通式。

5. 发明申请

WO2003082186A3 USE OF BENZIMIDAZOLE ANALOGS IN THE TREATMENT OF CELL PROLIFERATION 审中-公开
公开(公告)号：WO2003082186A3
公开(公告)日：2003-10-09
申请号：PCT/US2003/006981
申请日：2003-03-06
申请人： AVANIR PHARMACEUTICALS , SIRCAR, Jagadish, C. , RICHARDS, Mark, L.
发明人： SIRCAR, Jagadish, C. , RICHARDS, Mark, L.
IPC分类号： A61K31/4184
摘要： The preferred embodiments are directed to small molecule inhibitors that are cellular proliferation inhibitors and thus are useful as anticancer agents. The small molecules have the general formulas that include a phenylbenzimidazole core ring.

6. 发明申请

WO2008008841A2 USE OF BENZIMIDAZOLE DERIVATIVES FOR THE TREATMENT AND/OR PREVENTION OF AUTOIMMUNE DISORDERS 审中-公开
标题翻译：苯并咪唑衍生物用于治疗和/或预防自身免疫疾病的用途
公开(公告)号：WO2008008841A2
公开(公告)日：2008-01-17
申请号：PCT/US2007/073266
申请日：2007-07-11
申请人： AVANIR PHARMACEUTICALS , SIRCAR, Jagadish, C. , RICHARDS, Mark, L.
发明人： SIRCAR, Jagadish, C. , RICHARDS, Mark, L.
IPC分类号： H04J1/02
CPC分类号： C07D471/04 , C07D209/14 , C07D401/12
摘要： Preferred aspects of the present invention relate to treating and/or preventing autoimmune disorders, such as systemic lupus erythematosus and multiple sclerosis, using a family of benzimidazole derivatives.
摘要翻译：本发明的优选方面涉及使用苯并咪唑衍生物家族治疗和/或预防自身免疫病症，例如系统性红斑狼疮和多发性硬化症。

7. 发明申请

WO2004024655A2 PHENYL-INDOLE COMPOUNDS FOR MODULATING IgE AND INHIBITING CELLULAR PROLIFERATION 审中-公开
标题翻译：用于调节粒子和抑制细胞增殖的苯基吲哚化合物
公开(公告)号：WO2004024655A2
公开(公告)日：2004-03-25
申请号：PCT/US2003/028145
申请日：2003-09-09
申请人： AVANIR PHARMACEUTICALS , SIRCAR, Jagadish, C. , RAMNAUTH, Jailall , RICHARDS, Mark, L.
发明人： SIRCAR, Jagadish, C. , RAMNAUTH, Jailall , RICHARDS, Mark, L.
IPC分类号： C07C
CPC分类号： C07D209/18 , A61K31/404 , A61K45/06 , C07D209/10 , C07D209/14 , A61K2300/00
摘要： The present invention is directed to small molecule inhibitors of the IgE response to allergens, which are useful in the treatment of allergy and/or asthma or any diseases where IgE is pathogenic. This invention also relates to phenyl-indole molecules that are cellular proliferation inhibitors and thus are useful as anticancer agents. This invention further relates to small molecules which suppress cytokines and leukocytes.
摘要翻译：本发明涉及对变应原的IgE应答的小分子抑制剂，其可用于治疗过敏和/或哮喘或IgE致病的任何疾病。本发明还涉及作为细胞增殖抑制剂的苯基 - 吲哚分子，因此可用作抗癌剂。本发明还涉及抑制细胞因子和白细胞的小分子。

8. 发明申请

WO2005013950A2 SELECTIVE PHARMACOLOGIC INHIBITION OF PROTEIN TRAFFICKING AND RELATED METHODS OF TREATING HUMAN DISEASES 审中-公开
标题翻译：蛋白质转运的选择性药理学抑制及相关治疗人类疾病的方法
公开(公告)号：WO2005013950A2
公开(公告)日：2005-02-17
申请号：PCT/US2004/026435
申请日：2004-08-09
申请人： AVANIR PHARMACEUTICALS , SIRCAR, Jagadish , RICHARDS, Mark, L.
发明人： SIRCAR, Jagadish , RICHARDS, Mark, L.
IPC分类号： A61K31/00
CPC分类号： G01N33/5035 , A61K31/00 , A61K31/404 , A61K31/4164 , A61K31/4184 , A61K31/4188 , A61K31/423 , A61K31/428 , G01N33/5008 , G01N33/5011 , G01N33/5023 , G01N33/6872
摘要： Preferred aspects of the present invention relate to the inhibition of intracellular protein trafficking pathways through selective pharmacologic down-regulation of specific resident ER and golgi proteins, and more particularly, to methods of treating a variety of disease conditions, which depend on these intracellular protein trafficking pathways.
摘要翻译：本发明的优选方面涉及通过特异性驻留的ER和高尔基体蛋白质的选择性药理学下调抑制细胞内蛋白质运输途径，更具体地，涉及治疗依赖于这些细胞内蛋白质运输的各种疾病状况的方法途径。

9. 发明申请

WO2002072090A1 BENZIMIDAZOLE COMPOUNDS FOR MODULATING IGE AND INHIBITING CELLULAR PROLIFERATION 审中-公开
标题翻译：用于调节皮肤和抑制细胞增殖的苯扎咪唑化合物
公开(公告)号：WO2002072090A1
公开(公告)日：2002-09-19
申请号：PCT/US2002/006801
申请日：2002-02-28
申请人： AVANIR PHARMACEUTICALS
发明人： SIRCAR, Jagadish, C. , RICHARDS, Mark, L. , MAJOR, Michael, W.
IPC分类号： A61K31/4184
CPC分类号： A61K31/4184 , A61K31/422 , A61K31/4439 , A61K45/06 , C07D235/18 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D413/12 , A61K2300/00
摘要： The present invention is directed to small molecule inhibitors of the IgE response to allergens, which are useful in the treatment of allergy and/or asthma or any diseases where IgE is pathogenic. This invention also relates to benzimidazole molecules that are cellular proliferation inhibitors and thus are useful as anticancer agents.
摘要翻译：本发明涉及对变应原的IgE应答的小分子抑制剂，其可用于治疗过敏和/或哮喘或IgE致病的任何疾病。本发明还涉及作为细胞增殖抑制剂的苯并咪唑分子，因此可用作抗癌剂。

10. 发明申请

WO2007109220A2 METHOD AND APPARATUS FOR PERFORMING A POWER EFFICIENT CELL SEARCH IN A MULTI-CELL WIRELESS COMMUNICATION SYSTEM 审中-公开
标题翻译：用于在多小区无线通信系统中执行功率有效的小区搜索的方法和设备
公开(公告)号：WO2007109220A2
公开(公告)日：2007-09-27
申请号：PCT/US2007/006784
申请日：2007-03-19
申请人： INTERDIGITAL TECHNOLOGY CORPORATION , MONFET, Frederic , DEMIR, Alpaslan , RICHARDS, Mark, L.
发明人： MONFET, Frederic , DEMIR, Alpaslan , RICHARDS, Mark, L.
IPC分类号： H04B1/707
CPC分类号： H04B1/7083 , H04B1/70735 , H04B2201/70707
摘要： A method and apparatus for performing a power efficient cell search in a multi-cell wireless communication system are disclosed. A wireless transmit/receive unit (WTRU) having a memory that stores a cell identification list of prioritized previously top-ranked cell identities (IDs) is used to perform the cell search. A primary synchronization code (PSC) correlation peak location on a received signal is selected. A common pilot channel (CPICH) correlation value is determined by non-coherent integration of a local signal created based on a first cell ID on the cell identification list to the received signal. If the CPICH correlation value is greater than a noise threshold, thus indicating that the first cell ID is a newly found cell ID, or if a last cell ID in the cell identification list is reached, an additional determination is made as to whether there is more than one cell ID on the list having the same timing.
摘要翻译：公开了一种用于在多小区无线通信系统中执行功率效率小区搜索的方法和设备。具有存储优先化先前排名最高的小区标识（ID）的小区标识列表的存储器的无线发射/接收单元（WTRU）被用于执行小区搜索。选择接收信号上的主同步码（PSC）相关峰值位置。公共导频信道（CPICH）相关值通过基于小区标识列表上的第一小区ID创建的本地信号与接收信号的非相干积分来确定。如果CPICH相关值大于噪声阈值，从而指示第一小区ID是新发现的小区ID，或者如果达到小区标识列表中的最后一个小区ID，则做出关于是否存在的附加确定列表中的多个单元ID具有相同的时间。

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