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12. 发明申请

WO1992001440A1 TRANS-MUCOSAL DRUG PREPARATIONS AND TRANS-MUCOSAL ADMINISTRATION 审中-公开
标题翻译：转移药物制剂和转移管理
公开(公告)号：WO1992001440A1
公开(公告)日：1992-02-06
申请号：PCT/NL1991000134
申请日：1991-07-23
申请人： RIJKSUNIVERSITEIT TE LEIDEN , MERKUS, Franciscus, Wilhelmus, Henricus, Maria , VERHOEF, Jacobus , ROMEIJN, Stefanus, Gerardus , SCHIPPER, Nicolaas, Gerardus, Maria
发明人： RIJKSUNIVERSITEIT TE LEIDEN
IPC分类号： A61K09/08
CPC分类号： A61K47/40 , A61K9/0043
摘要： Pharmaceutical preparation of a form and composition suitable for trans-mucosal, particularly nasal, administration, which preparation comprises at least one (poly)peptide or protein drug, or a fragment or analogue thereof, as an active agent, as well as dimethyl- beta -cyclodextrin as an absoption enhancing agent. Method of trans-mucosally administering a (poly)peptide or protein drug, or a fragment or analogue thereof, comprising administering a pharmaceutical preparation of a form and composition suitable for transmucosal, particularly nasal, administration, which contains dimethyl- beta -cyclodextrin as an absoption enhancing agent. Preferably, the polypeptide is insulin or calcitonin.
摘要翻译：适用于反粘膜，特别是鼻腔给药的形式和组合物的药物制剂，该制剂包含至少一种（多）肽或蛋白质药物，或其片段或类似物作为活性剂，以及二甲基-β 环糊精作为吸收增强剂。反式粘膜施用（多）肽或蛋白质药物或其片段或类似物的方法，其包括施用适于经粘膜，特别是鼻给药的形式和组合物的药物制剂，其含有二甲基-β-环糊精作为吸收增强剂。优选地，多肽是胰岛素或降钙素。

13. 发明申请

WO1991017186A1 BETA CELL ANTIGEN 审中-公开
标题翻译： BETA细胞抗原
公开(公告)号：WO1991017186A1
公开(公告)日：1991-11-14
申请号：PCT/NL1991000077
申请日：1991-05-06
申请人： RIJKSUNIVERSITEIT TE LEIDEN , ROEP, Bart, Otto , DE VRIES, Rene, Rudolf, Pieter , HUTTON, John, Charles
发明人： RIJKSUNIVERSITEIT TE LEIDEN
IPC分类号： C07K15/06
CPC分类号： C07K16/28 , A61K38/00 , A61K39/00 , C07K14/705 , C07K14/7051
摘要： Beta cell antigen consisting of an intrinsic transmembrane protein of insulin secretory granules of beta cells located in pancreatic islets of Langerhans, which protein contains an epitope recognised by T-cell clone 1C6. The antigen has a molecular weight of 38 kD. The variable part of the beta -chain of the T-cell receptor of clone 1C6 belongs to the TCR-V beta 19 family. Peptide which mimicks said beta cell antigen epitope and can be recognised by T-cell clone 1C6. T-cell which is capable of recognising the beta-cell antigen, receptor of this T-cell, and peptide mimicking this T-cell receptor. Antibody specific for a T-cell which is capable of recognising the beta cell antigen, and antibody specific for the beta cell antigen. Use of one of these substances for type-1 diabetes mellitus diagnostics, monitoring, therapy or prevention.
摘要翻译：由位于胰岛胰岛的β细胞的胰岛素分泌颗粒的内在跨膜蛋白构成的β细胞抗原，该蛋白含有被T细胞克隆1C6识别的表位。抗原的分子量为38kD。克隆1C6的T细胞受体的β-链的可变部分属于TCR-Vβ19家族。模仿所述β细胞抗原表位并可被T细胞克隆1C6识别的肽。能够识别β细胞抗原的T细胞，该T细胞的受体，以及模仿该T细胞受体的肽。能够识别β细胞抗原的T细胞特异的抗体和对β细胞抗原特异的抗体。使用这些物质之一进行1型糖尿病诊断，监测，治疗或预防。

14. 发明申请

WO1990000621A1 DNA SEQUENCING METHOD AND PRIMER SUITABLE THEREFOR 审中-公开
标题翻译： DNA顺序方法和适用于其的引物
公开(公告)号：WO1990000621A1
公开(公告)日：1990-01-25
申请号：PCT/NL1989000057
申请日：1989-07-13
申请人： RIJKSUNIVERSITEIT TE LEIDEN , VAN DE KLUNDERT, Joseph, Alfons, Maria
发明人： RIJKSUNIVERSITEIT TE LEIDEN
IPC分类号： C12Q01/68
CPC分类号： C12Q1/6876 , C12Q1/6869 , C12Q2535/101
摘要： Dideoxy DNA sequencing method using the substantially random insertion of the gamma-delta element of an F-plasmid into a starting plasmid containing the DNA to be sequenced. Fragments comprising a portion of the DNA to be sequenced and, adjacent thereto, either the gamma end or the delta end of the gamma-delta insert are isolated and subjected to dideoxy sequencing using an oligonucleotide having a length of at least 10 nucleotides, which is complementary to both 5' ends of the gamma-delta element, as a primer. The above also covers suitable primer oligonucleotides.

15. 发明申请

WO1998013490A2 A GENE RELATED TO MIGRAINE IN MAN 审中-公开
标题翻译：与人类相关的基因
公开(公告)号：WO1998013490A2
公开(公告)日：1998-04-02
申请号：PCT/NL1997000538
申请日：1997-09-26
申请人： RIJKSUNIVERSITEIT TE LEIDEN , FRANTS, Rune, Robert, Isak, Erik , FERRARI, Michel, Dominique , TERWINDT, Gisela, Marie , OPHOFF, Roel, André
发明人： RIJKSUNIVERSITEIT TE LEIDEN
IPC分类号： C12N15/12
CPC分类号： C07K14/705 , A01K2217/05
摘要： Genes for familial hemeplegic migraine (FHM), episodic ataxia type-2 (EA-2), common forms of migraine, and other episodic neurological disorders, such as epilepsy, have been mapped to chromosome 19p13 and chromosome 10p12. A brain-specific P/Q-type calcium channel subunit gene, covering 300 kb with 47 exons is provided. The exons and their surroundings reveal polymorphic variations and deleterious mutations that are linked to various types of calcium channel dysfunctions causing episodic neurological disorders in man or animals.
摘要翻译：家族性偏头痛（FHM），2型发作性共济失调（EA-2），常见形式的偏头痛和其他发作性神经障碍如癫痫的基因已被绘制到19p13染色体和10p12染色体上。提供了一种脑特异性P / Q型钙通道亚基基因，覆盖300 kb，其中包含47个外显子。外显子及其周围环境显示与各种类型的钙通道功能障碍有关的多态性变异和有害突变，导致人或动物发生神经障碍。

16. 发明申请

WO1997005168A1 THE H-Y ANTIGEN 审中-公开
标题翻译： H-Y抗原
公开(公告)号：WO1997005168A1
公开(公告)日：1997-02-13
申请号：PCT/NL1996000307
申请日：1996-07-29
申请人： RIJKSUNIVERSITEIT TE LEIDEN , GOULMY, Els., A., J., M. , HUNT, Donald, F. , ENGELHARD, Victor, H.
发明人： RIJKSUNIVERSITEIT TE LEIDEN
IPC分类号： C07K14/705
CPC分类号： C07K14/705 , A61K38/00 , A61K39/00
摘要： H-Y is a transplantation antigen that can lead to rejection of HLA-matched male organ and bone marrow grafts by female recipients, and may play a role in pregnancy and spermatogenesis. However, the origin and function of H-Y antigens has eluded researchers for 40 years. We show that one human H-Y peptide antigen presented by HLA-B7 is an 11 residue peptide derived from SMCY, an evolutionarily conserved Y chromosomal protein. A homologous gene on the X chromosome, SMCX, differs by two residues in the same region. We also show a peptide antigen recognized by two HLA-A2.1 restricted T cell clones, which is also encoded by SMCY. The identification of H-Y offers prospects for improvements in transplantation outcome, prenatal diagnosis and fertilization strategies.
摘要翻译： H-Y是一种移植抗原，可以导致女性接受者与HLA匹配的男性器官和骨髓移植物排斥，并可能在怀孕和精子发生中发挥作用。然而，H-Y抗原的起源和功能已经使研究人员已经40年了。我们显示HLA-B7提供的一种人H-Y肽抗原是衍生自SMCY（一种进化上保守的Y染色体蛋白）的11残基肽。 X染色体SMCX上的同源基因在同一区域有两个残基差异。我们还显示由SMCY编码的两个HLA-A2.1受限T细胞克隆识别的肽抗原。 H-Y的鉴定提供了改善移植结果，产前诊断和受精策略的前景。

17. 发明申请

WO1991002741A1 SUGAR ALCOHOL DERIVATIVES, A PROCESS FOR PREPARING 3-DEOXY-2-OCTULOSONIC ACID AND 3-DEOXY-2-HEPTULOSONIC ACID COMPOUNDS AND DERIVATIVES 审中-公开
标题翻译：糖醇衍生物，制备3-脱氧-2-十二烷酸和3-脱氧-2-羟基苯甲酸的化合物和衍生物的方法
公开(公告)号：WO1991002741A1
公开(公告)日：1991-03-07
申请号：PCT/NL1990000124
申请日：1990-08-23
申请人： RIJKSUNIVERSITEIT TE LEIDEN , VAN BOOM, Jacobus, Hubertus , VAN DER KLEIN, Petrus, Antonius, Maria , VEENEMAN, Gerrit, Herman
发明人： RIJKSUNIVERSITEIT TE LEIDEN
IPC分类号： C07H07/027
CPC分类号： C07D493/04 , C07D309/30 , C07D317/30 , C07D327/10 , C07D497/04 , C07H7/027 , C07H15/14
摘要： The invention provides a novel class of versatile intermediates, i.e. 1,4 cyclic sulfates of sugar alcohols having protected hydroxy groups, such as 1,4 cyclic sulfates of D-mannitol having protected 2-, 3-, 5- and 6-hydroxy groups and D-arabinitol having protected 2-, 3- and 5-hydroxy groups. The invention also provides methods for preparing 3-deoxy-2-octulosonic acid and 3-deoxy-2-heptulosonic acid compounds and derivatives, in which these novel 1,4 cyclic sulfates are used as intermediates.
摘要翻译：本发明提供了一类新颖的多功能中间体，即具有保护的羟基的糖醇的1,4-环状硫酸盐，例如具有受保护的2-，3-，5-和6-羟基的D-甘露糖醇的1,4-环状硫酸盐和具有受保护的2-，3-和5-羟基的D-阿拉伯糖醇。本发明还提供了使用这些新型的1,4-环状硫酸盐作为中间体的3-脱氧-2-辛酮酸和3-脱氧-2-庚酮酸化合物及其衍生物的制备方法。

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