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1. 发明申请

WO1994002509A1 HLA-DR3 BLOCKING PEPTIDES AND THEIR USE IN THE TREATMENT OF HLA-DR3 ASSOCIATED AUTOIMMUNE DISEASES. 审中-公开
标题翻译： HLA-DR3阻断肽及其在治疗HLA-DR3相关自身免疫性疾病中的应用。
公开(公告)号：WO1994002509A1
公开(公告)日：1994-02-03
申请号：PCT/NL1993000151
申请日：1993-07-14
申请人： RIJKSUNIVERSITEIT LEIDEN , GELUK, Annemieke , OTTENHOFF, Thomas, Henricus, Maria , DE VRIES, Rene, Rudolf, Pieter
发明人： RIJKSUNIVERSITEIT LEIDEN
IPC分类号： C07K07/06
CPC分类号： C07K14/35 , A61K38/00
摘要： A peptide comprising the amino acid sequence: An-1 An An+1 An+2 An+3 An+4 An+5 wherein An-1 is any amino acid; An is I, L or V; An+1 is A, H or Q; An+2 is Y, S, R or P; An+3 is D, E or Q; An+4 is E or D; An+5 is any amino acid; with the proviso that said sequence differs by one amino acid substitution from the sequence T I A Y D E E. Use of the peptide which has an HLA DR3 blocking activity in a treatment of HLA DR3 related autoimmune diseases.
摘要翻译：包含An-1 An An + An + 2 An + 3 An + 4 An + 5的氨基酸序列的肽，其中An-1是任何氨基酸; A是I，L或V; A + 1为A，H或Q; A + 2为Y，S，R或P; A + 3为D，E或Q; A + 4是E或D; An + 5是任何氨基酸; 条件是所述序列不同于序列T I A Y D E E的一个氨基酸取代。具有HLA DR3阻断活性的肽在治疗HLA DR3相关自身免疫疾病中的用途。

2. 发明申请

WO1991017186A1 BETA CELL ANTIGEN 审中-公开
标题翻译： BETA细胞抗原
公开(公告)号：WO1991017186A1
公开(公告)日：1991-11-14
申请号：PCT/NL1991000077
申请日：1991-05-06
申请人： RIJKSUNIVERSITEIT TE LEIDEN , ROEP, Bart, Otto , DE VRIES, Rene, Rudolf, Pieter , HUTTON, John, Charles
发明人： RIJKSUNIVERSITEIT TE LEIDEN
IPC分类号： C07K15/06
CPC分类号： C07K16/28 , A61K38/00 , A61K39/00 , C07K14/705 , C07K14/7051
摘要： Beta cell antigen consisting of an intrinsic transmembrane protein of insulin secretory granules of beta cells located in pancreatic islets of Langerhans, which protein contains an epitope recognised by T-cell clone 1C6. The antigen has a molecular weight of 38 kD. The variable part of the beta -chain of the T-cell receptor of clone 1C6 belongs to the TCR-V beta 19 family. Peptide which mimicks said beta cell antigen epitope and can be recognised by T-cell clone 1C6. T-cell which is capable of recognising the beta-cell antigen, receptor of this T-cell, and peptide mimicking this T-cell receptor. Antibody specific for a T-cell which is capable of recognising the beta cell antigen, and antibody specific for the beta cell antigen. Use of one of these substances for type-1 diabetes mellitus diagnostics, monitoring, therapy or prevention.
摘要翻译：由位于胰岛胰岛的β细胞的胰岛素分泌颗粒的内在跨膜蛋白构成的β细胞抗原，该蛋白含有被T细胞克隆1C6识别的表位。抗原的分子量为38kD。克隆1C6的T细胞受体的β-链的可变部分属于TCR-Vβ19家族。模仿所述β细胞抗原表位并可被T细胞克隆1C6识别的肽。能够识别β细胞抗原的T细胞，该T细胞的受体，以及模仿该T细胞受体的肽。能够识别β细胞抗原的T细胞特异的抗体和对β细胞抗原特异的抗体。使用这些物质之一进行1型糖尿病诊断，监测，治疗或预防。

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