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11. 发明申请

WO2007081769A2 SYSTEM AND METHOD FOR COATING A MEDICAL APPLIANCE UTILIZING A VIBRATING MESH NEBULIZER 审中-公开
标题翻译：用振动网状弹性体涂覆医疗器械的系统和方法
公开(公告)号：WO2007081769A2
公开(公告)日：2007-07-19
申请号：PCT/US2007000218
申请日：2007-01-05
申请人： BOSTON SCIENT SCIMED INC , O'CONNOR TIMOTHY , GRENHAM NIALL , MCMORROW DAVID , SHANNON JAMES , SCHAUER TRAVIS , HOLLY THOMAS
发明人： O'CONNOR TIMOTHY , GRENHAM NIALL , MCMORROW DAVID , SHANNON JAMES , SCHAUER TRAVIS , HOLLY THOMAS
IPC分类号： B05B7/00 , B05B7/16 , B05B17/06
CPC分类号： B05B17/0646 , A61L27/34 , A61L29/085 , A61L31/10 , B05B5/08 , B05B7/0012 , B05B7/16 , B05B17/0676
摘要： A method and device for coating a medical device, such as a stent (100), including forming coating droplets using a mesh nebulizer (110) and transporting the coating droplets to the medical device, for example through a converging chamber (310). The coating droplets may be accelerated to a speed sufficient to break the coating droplets into smaller droplets upon impact with the medical device. The mesh nebulizer (110) may have a convex inlet side and may form a converging plume (300) of coating droplets. The mesh nebulizer (110) may have one or more groups of pores (724), the pores (724) within each group maybe subject to similar amplitudes of vibration. The coating material may be heated or cooled prior to nebulizing. The chamber may include baffles (700, 701) configured to allow only a predetermined size range of coating particles to pass.
摘要翻译：一种用于涂覆诸如支架（100）的医疗装置的方法和装置，包括使用网状雾化器（110）形成涂层液滴并且例如通过会聚室（310）将涂层液滴输送到医疗装置。在与医疗装置碰撞时，涂层液滴可被加速到足以使涂层液滴破裂成较小液滴的速度。网孔式喷雾器（110）可以具有凸入口侧并且可以形成涂布液滴的会聚羽流（300）。网状雾化器（110）可以具有一组或多组孔隙（724），每组内的孔隙（724）可以经受相似的振动幅度。在喷雾之前涂层材料可以被加热或冷却。腔室可以包括构造成仅允许预定尺寸范围的涂层颗粒通过的挡板（700,701）。

12. 发明申请

WO2006091615A3 METHOD AND APPARATUS FOR TRACING COMMINGLED MATERIALS 审中-公开
标题翻译：跟踪材料的方法和装置
公开(公告)号：WO2006091615A3
公开(公告)日：2007-06-07
申请号：PCT/US2006006156
申请日：2006-02-23
申请人： O'CONNOR TIMOTHY C , FROMME GUY A
发明人： O'CONNOR TIMOTHY C , FROMME GUY A
IPC分类号： G06F15/00 , G01C9/00 , G01C17/00 , G01F19/00
CPC分类号： B01F5/241 , B01F15/00253 , G06Q99/00
摘要： A method and system collects and manipulates information from various sources for the purpose of determining the location of loads of material in a bulk material storage container and tracing the number and identity of bulk material sources, such as farms or processing plants, for loads located within a bulk material storage container. Such production source information is thus uniquely associated with a particular non-liquid bulk material load. Surface mapping of a surface of bulk material stored in a storage container is performed before and after material is added to the container, and are used to determine position of loads within the storage container. Embodiments of the present invention, using knowledge of the position of loads within the container, may be used for the purposes of preplanning and enhancing blended load-out batches.
摘要翻译：方法和系统收集和操作来自各种来源的信息，以确定散装材料储存容器中材料的载荷位置，并追踪散装材料源（如农场或加工厂）的数量和身份，位于散装材料储存容器。因此，这样的生产源信息与特定的非液体散装物料负荷唯一相关。在将物料添加到容器中之前和之后进行存储在存储容器中的散装材料的表面的表面映射，并且用于确定存储容器内的负载位置。使用对容器内的负载位置的了解的本发明的实施例可以用于预先规划和增强混合装载批次的目的。

13. 发明申请

WO1998010392A1 BURGLAR ALARM APPARATUS FOR NEIGHBORHOODS 审中-公开
标题翻译：用于邻里的BURGLAR ALARM装置
公开(公告)号：WO1998010392A1
公开(公告)日：1998-03-12
申请号：PCT/CA1997000627
申请日：1997-09-05
申请人： O'CONNOR, Timothy
IPC分类号： G08B27/00
CPC分类号： G08B27/003
摘要： A burglar alarm apparatus comprises a plurality of separate alarm elements each of which is located in a separate premises to be watched. Each alarm element has an input for receiving a detector signal from an infrared sensor for detecting presence of an intruder, a panic button for actuation by an infirm person and an input for a smoke detector. A programmable control responds to the signals and actuates a transmitter of a coded alarm signal identifying the element concerned to each of the other alarm elements. Each control includes a receiver programmed to be responsive to an alarm signal from each of the other alarm elements and an audible or visual alarm signal for warning persons in the premises at which the respective alarm element is located. There are more than two alarm elements for generating a cell of such alarm elements for use in a neighborhood.
摘要翻译：防盗报警装置包括多个单独的报警元件，每个报警元件位于要被监视的单独房屋内。每个报警元件具有用于接收来自用于检测入侵者的存在的红外传感器的检测器信号的输入，用于由弱智人员致动的紧急按钮和用于烟雾探测器的输入。可编程控制器对信号进行响应并致动编码的报警信号的发射器，其将相关元件标识到每个其它报警元件。每个控制器包括被编程为响应来自每个其它报警元件的报警信号的接收器和用于在相应的报警元件所位于的处所内的警告人员的声音或视觉报警信号。有两个以上的报警元件用于产生用于附近的这种报警元件的单元。

14. 发明申请

WO2009018340A3 MEDICAL DEVICE COATING BY LASER CLADDING 审中-公开
标题翻译：激光切割的医疗器械涂层
公开(公告)号：WO2009018340A3
公开(公告)日：2009-06-25
申请号：PCT/US2008071592
申请日：2008-07-30
申请人： BOSTON SCIENT SCIMED INC , FLANAGAN AIDEN , O'CONNOR TIMOTHY
发明人： FLANAGAN AIDEN , O'CONNOR TIMOTHY
IPC分类号： A61L27/16 , A61L27/54 , A61L27/56 , A61L31/14
CPC分类号： A61L31/146 , A61L27/16 , A61L27/54 , A61L27/56 , A61L31/16 , A61L2300/608 , B05D1/12 , B05D3/0466 , B05D3/06 , B05D7/52 , B05D2202/00 , B23K26/32 , B23K26/324 , B23K26/34 , B23K35/0244 , B23K35/365 , B23K2201/34 , B23K2203/30 , B23K2203/50 , B23K2203/52 , B33Y80/00 , Y10T428/12 , Y10T428/1352 , Y10T428/1355
摘要： Methods for making medical devices having porous coatings. Methods may comprise providing a tubing section having inner and outer surfaces and positioning a nozzle proximate to a target surface of the parent tubing section. A powder form of the porous coating may be delivered toward the tubing section, and a laser may be directed at the powder to melt the powder to form a melt pool. The melt pool can solidify to form the porous coating on the target surface. Portions of the parent tubing section may then be cut away to form the support structure of the medical device, such as a stent.
摘要翻译：制造具有多孔涂层的医疗装置的方法。方法可以包括提供具有内表面和外表面并且将喷嘴定位在母管部分的目标表面附近的管段。多孔涂层的粉末形式可以朝向管道部分递送，并且激光可以被引导到粉末以熔化粉末以形成熔池。熔池可以固化以在目标表面上形成多孔涂层。然后可以将母管部分的部分切除以形成医疗装置（例如支架）的支撑结构。

15. 发明申请

WO2006096287A1 COATING A MEDICAL APPLIANCE UTILIZING A VIBRATING MESH NEBULIZER 审中-公开
标题翻译：涂覆一个医疗器具使用振动网格NEBULIZER
公开(公告)号：WO2006096287A1
公开(公告)日：2006-09-14
申请号：PCT/US2006/004994
申请日：2006-02-14
申请人： BOSTON SCIENTIFIC SCIMED, INC. , BEHAN, Niall , MCMORROW, David , O'CONNOR, Timothy
发明人： BEHAN, Niall , MCMORROW, David , O'CONNOR, Timothy
IPC分类号： B05B17/06
CPC分类号： B05B17/0646 , A61L2420/02 , B05D1/02
摘要： A method of coating a medical appliance is provided that includes contacting a coating material (131) with a first side of a mesh nebulizer (110) . The mesh nebulizer (110) includes at least one aperture. The method also includes vibrating the mesh nebulizer (110) and arranging the medical appliance (100) in a region of a second side of the mesh nebulizer (110) . The second side is opposite the first side. A system is provided for coating a medical appliance (100) that includes a coating source (130) , a mesh nebulizer (110) an arrangement (120,121) for vibrating the mesh nebulizer (110) , and an arrangement for holding the medical appliance (100) .
摘要翻译：提供了一种涂覆医疗器具的方法，包括使涂层材料（131）与网状喷雾器（110）的第一侧接触。网状雾化器（110）包括至少一个孔。该方法还包括使网状雾化器（110）振动并将医疗器具（100）布置在网状喷雾器（110）的第二侧的区域中。第二面与第一面相对。提供一种用于涂覆医疗器具（100）的系统，其包括涂料源（130），网眼雾化器（110），用于振动网眼雾化器（110）的装置（120,121），以及用于保持医疗器具 100）。

16. 发明申请

WO2009012108A1 METHODS FOR MAKING DRUG-ELUTING MEDICAL DEVICES 审中-公开
标题翻译：制造药物治疗设备的方法
公开(公告)号：WO2009012108A1
公开(公告)日：2009-01-22
申请号：PCT/US2008/069626
申请日：2008-07-10
申请人： BOSTON SCIENTIFIC SCIMED, INC. , CLARKE, John T. , O'CONNOR, Timothy
发明人： CLARKE, John T. , O'CONNOR, Timothy
IPC分类号： A61F2/90
CPC分类号： B05D5/00 , A61F2/91 , A61F2210/0076 , A61F2240/001 , A61F2250/0023 , A61F2250/0067
摘要： The present invention is directed to medical implants that are configured to controllably release therapeutic agent to a target site of a patient and methods of making these implants. Embodiments of the present invention may include a method comprising the steps of providing a tube having a wall (323) with inner and outer surfaces and defining a passageway, forming an opening (320) through the wall of the tube, applying a porous coating layer (322) to at least one of the inner and outer surfaces of the tube, and loading a therapeutic agent solution (325) into the passageway so that therapeutic agent passes through the opening and into the porous coating layer. The method may also include removing portions of the tube to form the implantable medical device, which may be a stent.
摘要翻译：本发明涉及被配置为将治疗剂可控地释放到患者的靶位点的医疗植入物和制造这些植入物的方法。本发明的实施例可以包括一种方法，包括以下步骤：提供具有内表面和外表面的壁（323）的管，并限定通道，通过管的壁形成开口（320），施加多孔涂层（322）连接到管的内表面和外表面中的至少一个，并将治疗剂溶液（325）装载到通道中，使得治疗剂通过开口并进入多孔涂层。该方法还可以包括移除管的部分以形成可植入医疗装置，其可以是支架。

17. 发明申请

WO2008121933A1 USING MAGNETISM TO PREPARE A MEDICAL DEVICE 审中-公开
标题翻译：使用MAGNETISM制定医疗器械
公开(公告)号：WO2008121933A1
公开(公告)日：2008-10-09
申请号：PCT/US2008/058848
申请日：2008-03-31
申请人： BOSTON SCIENTIFIC SCIMED, INC. , ATANASOSKA, Liliana , FLANAGAN, Aiden , O'CONNOR, Timothy , MCMORROW, David , NOLAN, Robert , MALONE, Anthony , WEBER, Jan
发明人： ATANASOSKA, Liliana , FLANAGAN, Aiden , O'CONNOR, Timothy , MCMORROW, David , NOLAN, Robert , MALONE, Anthony , WEBER, Jan
IPC分类号： A61F2/82 , B05D1/00 , B05B5/00 , B05C3/09 , A61L31/10
CPC分类号： B05B5/00 , A61F2/91 , A61F2210/009 , A61L31/14 , A61L31/146 , A61L31/16 , A61L2300/60 , A61L2300/62 , B05C3/09 , B05D1/18 , B05D1/32 , B05D3/207 , B05D2401/32
摘要： The present invention is directed to methods, processes, and systems for delivering therapeutic agent to a medical device (114). Under some methods, processes, and systems of the invention, particles including a magnetic material (122) and a therapeutic agent may be directed towards a medical device via magnetic attraction (132). In another embodiment particles including a magnetic material may force a therapeutic agent/solvent solution into porous matrix by using a magnetic attraction. In still another embodiment, a medical device having at least a portion thereof including a magnetic material is used to attract and adhere particles comprising magnetic material and therapeutic agent to a target surface of the medical device, wherein the particles are fused to the target surface.
摘要翻译：本发明涉及将治疗剂递送到医疗装置（114）的方法，过程和系统。在一些方法下，本发明的方法和系统可以通过磁吸引（132）将包括磁性材料（122）和治疗剂的颗粒引向医疗装置。在另一个实施方案中，包括磁性材料的颗粒可以通过使用磁吸引剂将治疗剂/溶剂溶液强制成多孔基质。在另一个实施例中，使用包括磁性材料的至少其一部分的医疗装置将包含磁性材料和治疗剂的颗粒吸附并附着到医疗装置的靶表面上，其中所述颗粒与目标表面融合。

18. 发明申请

WO2008109773A2 CHRONIC OBSTRUCTIVE PULMONARY DISEASE SUSCEPTIBILITY AND RELATED COMPOSITIONS AND METHODS 审中-公开
标题翻译：慢性阻塞性肺疾病易感性及相关成分及方法
公开(公告)号：WO2008109773A2
公开(公告)日：2008-09-12
申请号：PCT/US2008/056091
申请日：2008-03-06
申请人： CORNELL RESEARCH FOUNDATION, INC. , CRYSTAL, Ronald, G. , HACKETT, Neil, R. , HEGUY, Adriana , HARVEY, Ben-gary , LEOPOLD, Philip, L. , TILLEY, Ann, E. , O'CONNOR, Timothy
发明人： CRYSTAL, Ronald, G. , HACKETT, Neil, R. , HEGUY, Adriana , HARVEY, Ben-gary , LEOPOLD, Philip, L. , TILLEY, Ann, E. , O'CONNOR, Timothy
CPC分类号： C12Q1/6883 , C12Q2600/156 , C12Q2600/158
摘要： The invention provides a method of determining the likelihood that a smoker will or will not develop chronic obstructive pulmonary disease (COPD) by obtaining a sample from the smoker, analyzing the sample for the expression of a set of biomarkers associated with COPD, and comparing the expression pattern determined in the sample with a standard expression pattern to determine the likelihood that the smoker will or will not develop COPD. The invention further provides a composition, a method of treatment, and methods of determining the efficacy of treatment for COPD.
摘要翻译：本发明提供了一种通过从吸烟者获得样品来分析吸烟者将会或不会发展成慢性阻塞性肺病（COPD）的可能性的方法，分析样品与COPD相关的一组生物标志物的表达，并比较用标准表达模式在样本中确定表达模式，以确定吸烟者将或不会发展COPD的可能性。本发明还提供了一种组合物，治疗方法和确定COPD治疗功效的方法。

19. 发明申请

WO2007127193A2 SYSTEM AND METHOD FOR ELECTROSTATIC-ASSISTED SPRAY COATING OF A MEDICAL DEVICE 审中-公开
标题翻译：用于医疗装置静电辅助喷雾涂层的系统和方法
公开(公告)号：WO2007127193A2
公开(公告)日：2007-11-08
申请号：PCT/US2007/009920
申请日：2007-04-24
申请人： BOSTON SCIENTIFIC SCIMED, INC. , FREDRICKSON, Gerald , PHAM, Lan , WORSHAM, Robert , FENG, James , ANDERSON, Narin , EIDENSCHINK, Thomas , O'CONNOR, Timothy
发明人： FREDRICKSON, Gerald , PHAM, Lan , WORSHAM, Robert , FENG, James , ANDERSON, Narin , EIDENSCHINK, Thomas , O'CONNOR, Timothy
IPC分类号： C23C24/00 , A61L27/00 , B05D1/00
CPC分类号： B05B5/035 , A61L27/34 , A61L27/54 , A61L29/085 , A61L29/16 , A61L31/10 , A61L31/16 , A61L2300/606 , A61L2420/02 , B05B1/3415 , B05B5/0407 , B05B5/08 , B05B7/0433 , B05D1/04
摘要： A system and method for the electrostatic spray application of a coating material onto a medical device. The coating material is electrically charged and an atomizer is used to atomize the coating material, creating electrically charged droplets which coat the medical device. In alternate embodiments, a swirl atomizer, a pressure atomizer, an ultrasound atomizer, a rotary atomizer, and an effervescent atomizer are used to atomize the coating material.
摘要翻译：一种用于将涂层材料静电喷涂到医疗装置上的系统和方法。涂覆材料带电，并且使用雾化器来雾化涂层材料，产生涂覆医疗装置的带电液滴。在替代实施例中，使用旋流雾化器，压力雾化器，超声雾化器，旋转雾化器和泡腾雾化器来雾化涂层材料。

20. 发明申请

WO2014160872A3 THROAT GARGLE TABLET AND METHOD OF USE THEREOF 审中-公开
标题翻译： THROAT GARGLE TABLET及其使用方法
公开(公告)号：WO2014160872A3
公开(公告)日：2015-10-22
申请号：PCT/US2014032029
申请日：2014-03-27
申请人： O'CONNOR TIMOTHY P , LOCKARD-O'CONNOR JANET JANUARY
发明人： O'CONNOR TIMOTHY P , LOCKARD-O'CONNOR JANET JANUARY
IPC分类号： A61K31/355 , A23L21/25 , A61K31/375
CPC分类号： A61K33/14 , A61K9/0007 , A61K9/2009 , A61K31/05 , A61K31/355 , A61K31/375 , A61K33/10 , A61K33/30 , A61K35/644 , A61K36/28 , A61K36/82 , A61K36/886 , A61K45/06 , A61K2300/00
摘要： An anhydrous composition is provided. The anhydrous composition may be a tablet configured to dissolve in water, the tablet including Vitamin C (as ascorbic acid), Vitamin E (as dl-alpha-tocopheryl acetate), Magnesium (as magnesium sulfate and magnesium oxide), Zinc (as zinc sulfate), Chloride (as sodium chloride), Sodium (as sodium chloride, sodium bicarbonate and Sodium carbonate), Potassium (as potassium bicarbonate), Salt (as sodium chloride), Aloe Vera, Chamomile (as matricaria recutita), Honey, and/or Stevia Leaf extract. The anhydrous composition may further comprise Citric Acid, Sorbitol, Natural flavor, Wheat Germ Oil, and/or Magnesium Oxide.
摘要翻译：提供无水组合物。无水组合物可以是配置成溶解在水中的片剂，片剂包括维生素C（作为抗坏血酸），维生素E（作为dl-α-生育酚乙酸酯），镁（硫酸镁和氧化镁），锌（如锌硫酸盐），氯化钠（氯化钠），钠（作为氯化钠，碳酸氢钠和碳酸钠），钾（作为碳酸氢钾），盐（作为氯化钠），芦荟，洋甘菊（作为香料），蜂蜜和 /或甜菊叶提取物。无水组合物还可以包含柠檬酸，山梨糖醇，天然香料，小麦胚芽油和/或氧化镁。

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