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1. 发明申请

WO2007127193A2 SYSTEM AND METHOD FOR ELECTROSTATIC-ASSISTED SPRAY COATING OF A MEDICAL DEVICE 审中-公开
标题翻译：用于医疗装置静电辅助喷雾涂层的系统和方法
公开(公告)号：WO2007127193A2
公开(公告)日：2007-11-08
申请号：PCT/US2007/009920
申请日：2007-04-24
申请人： BOSTON SCIENTIFIC SCIMED, INC. , FREDRICKSON, Gerald , PHAM, Lan , WORSHAM, Robert , FENG, James , ANDERSON, Narin , EIDENSCHINK, Thomas , O'CONNOR, Timothy
发明人： FREDRICKSON, Gerald , PHAM, Lan , WORSHAM, Robert , FENG, James , ANDERSON, Narin , EIDENSCHINK, Thomas , O'CONNOR, Timothy
IPC分类号： C23C24/00 , A61L27/00 , B05D1/00
CPC分类号： B05B5/035 , A61L27/34 , A61L27/54 , A61L29/085 , A61L29/16 , A61L31/10 , A61L31/16 , A61L2300/606 , A61L2420/02 , B05B1/3415 , B05B5/0407 , B05B5/08 , B05B7/0433 , B05D1/04
摘要： A system and method for the electrostatic spray application of a coating material onto a medical device. The coating material is electrically charged and an atomizer is used to atomize the coating material, creating electrically charged droplets which coat the medical device. In alternate embodiments, a swirl atomizer, a pressure atomizer, an ultrasound atomizer, a rotary atomizer, and an effervescent atomizer are used to atomize the coating material.
摘要翻译：一种用于将涂层材料静电喷涂到医疗装置上的系统和方法。涂覆材料带电，并且使用雾化器来雾化涂层材料，产生涂覆医疗装置的带电液滴。在替代实施例中，使用旋流雾化器，压力雾化器，超声雾化器，旋转雾化器和泡腾雾化器来雾化涂层材料。

2. 发明申请

WO2005077542A1 APPARATUS AND METHOD FOR ELECTROSTATIC SPRAY COATING OF MEDICAL DEVICES 审中-公开
标题翻译：医疗器械静电喷涂的装置和方法
公开(公告)号：WO2005077542A1
公开(公告)日：2005-08-25
申请号：PCT/US2005/004077
申请日：2005-02-10
申请人： BOSTON SCIENTIFIC SCIMED, INC. , WORSHAM, Robert , HANSEN, James, G.
发明人： WORSHAM, Robert , HANSEN, James, G.
IPC分类号： B05B5/10
CPC分类号： B05B5/10 , B05B5/03 , Y10S118/11
摘要： An apparatus and method for electrostatic spray deposition of small targets, such as medical devices like stents. The apparatus includes a target holder (2) which applies a first electrical potential to the target (1), and an electrostatic dispensing nozzle (4) which applies a second potential sufficient to attract the coating fluid from the nozzle (4) toward the target (1) . Because the entire dispensing nozzle (4)is conductive, the coating fluid may receive a greater charge than may be obtained with internal electrode-type nozzles. Electrostatic attraction of the coating fluid to the target (1) is enhanced by the combination of higher charge density imparted to the coating fluid by the conductive nozzle, and application of a momentary voltage spike to the target (1) to provide consistent conductivity between the target (1) and its holder (2), thereby ensuring the target (1) is presents the full first potential applied to the holder(2) . The voltage spike may also be used independently of the conductive nozzle (4).
摘要翻译：静电喷雾沉积小靶的装置和方法，例如支架等医疗装置。该设备包括向目标（1）施加第一电势的目标保持器（2）和施加足以将涂覆流体从喷嘴（4）吸引到目标的第二电位的静电分配喷嘴（4）（1）。因为整个分配喷嘴（4）是导电的，所以涂覆流体可以接受比用内部电极型喷嘴获得的更大的电荷。通过由导电喷嘴施加到涂覆液体的较高电荷密度和向目标（1）施加瞬时电压尖峰来提高涂层流体对目标（1）的静电吸引，以提供一致的导电性目标（1）及其支架（2），从而确保目标（1）呈现施加到支架（2）的全部第一电位。电压尖峰也可独立于导电喷嘴（4）使用。

3. 发明申请

WO2019213398A1 METHODS FOR THE MANUFACTURE OF LIPOSOMAL DRUG FORMULATIONS 审中-公开
公开(公告)号：WO2019213398A1
公开(公告)日：2019-11-07
申请号：PCT/US2019/030404
申请日：2019-05-02
申请人： INSMED INCORPORATED , WORSHAM, Robert
发明人： WORSHAM, Robert
IPC分类号： A61K9/127 , A61K31/7036 , A61K47/24
摘要： Provided herein is a method for the large-scale manufacture of liposomal drug formulations containing an aminoglycoside such as amikacin having advantageous lipid/drag characteristics. The method utilizes a particular relative flow rate ratio of lipid to drug streams to obtain liposomes with a high aminoglycoside encapsulation efficiency. The resulting liposomal drug formulations advantageously comprise an overall lipid-to-drug weight ratio of less than 1:1.

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