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11. 发明申请

WO2014028787A3 BLOOD PUMP SYSTEMS AND METHODS 审中-公开
公开(公告)号：WO2014028787A3
公开(公告)日：2014-02-20
申请号：PCT/US2013/055221
申请日：2013-08-15
申请人： NOVITA THERAPEUTICS , FRANANO, F. Nicholas , LOREE II, Howard M. , TANSLEY, Geoff , WOODARD, Steve , HUTTO, Barrett
发明人： FRANANO, F. Nicholas , LOREE II, Howard M. , TANSLEY, Geoff , WOODARD, Steve , HUTTO, Barrett
IPC分类号： A61M1/10 , A61M1/12 , A61M5/14 , A61M5/142
摘要： The present invention relates to a rotary blood pump with a double pivot contact bearing system with an operating range between about 50 mL/min and about 1500 mL/min. The rotary blood pump is part of a blood pump system that includes blood conduit(s), a control system with optional sensors, and a power source. Embodiments of the present invention may include elements such as wear resistant bearing materials, a rotor back plate for magnetic attraction of the rotor to reduce bearing pivot bearing forces and wear, a rotor size and shape and a bearing gap that combine to create a hydrodynamic bearing effect and reduce bearing pivot bearing forces and wear, improved intravascular conduits with increased resistance to thrombosis, conduit insertion site cuffs to resist infection, and conduit side ports amenable to the easy insertion of guidewire and catheter-based medical devices.

12. 发明申请

WO2014028787A2 BLOOD PUMP SYSTEMS AND METHODS 审中-公开
标题翻译：血液泵系统和方法
公开(公告)号：WO2014028787A2
公开(公告)日：2014-02-20
申请号：PCT/US2013055221
申请日：2013-08-15
申请人： NOVITA THERAPEUTICS , FRANANO F NICHOLAS , LOREE II HOWARD M , TANSLEY GEOFF , WOODARD STEVE , HUTTO BARRETT
发明人： FRANANO F NICHOLAS , LOREE II HOWARD M , TANSLEY GEOFF , WOODARD STEVE , HUTTO BARRETT
IPC分类号： A61M1/10
CPC分类号： A61M1/3653 , A61M1/1008 , A61M1/101 , A61M1/1012 , A61M1/1013 , A61M1/1015 , A61M1/1017 , A61M1/1031 , A61M1/1086 , A61M1/12 , A61M1/122 , A61M1/3655 , A61M1/3659 , A61M2205/32 , A61M2205/3334 , A61M2205/3344
摘要： The present invention relates to a rotary blood pump with a double pivot contact bearing system with an operating range between about 50 mL/min and about 1500 mL/min, wherein the force on the upper bearing is less than 3N during operating speeds up to 6000 rpm. The rotary blood pump is part of a blood pump system that includes blood conduit(s), a control system with optional sensors, and a power source. Embodiments of the present invention may include elements designed to increase the length of time the rotary blood system can operate effectively in vivo, including wear resistant bearing materials, a rotor back plate for magnetic attraction of the rotor to reduce bearing pivot bearing forces and wear, a rotor size and shape and a bearing gap that combine to create a hydrodynamic bearing effect and reduce bearing pivot bearing forces and wear, improved intravascular conduits with increased resistance to thrombosis, conduit insertion site cuffs to resist infection, and conduit side ports amenable to the easy insertion of guidewire and catheter-based medical devices to treat conduits and related blood vessels to maintain blood pump system function over time. The pump system is configured to connect to the vascular system in a patient and pump blood at a desired rate. The invention also relates to a method of using a blood pump system for persistently increasing the overall diameter and lumen diameter of peripheral veins and arteries by persistently increasing the velocity of blood and the wall shear stress in a peripheral vein or artery for period of time sufficient to result in a persistent increase in the overall diameter and lumen diameter of the vessel is provided. For blood pump systems intended for use to increase the overall diameter and lumen diameter of a blood vessel, the pumping of blood is monitored and adjusted, as necessary, to maintain the desired elevated blood velocity and wall shear stress, and the desired pulsatility in the target blood vessel in order to optimize the rate and extent of the persistent increase in the overall diameter and lumen diameter of the target blood vessel. The blood pump system may also be used to reduce venous hypertension in a lower extremity and increasing the rate of healing of lower extremity venous ulcers in patients is provided. For blood pump systems intended for use to treat venous hypertension of an extremity, the pumping of blood is monitored and adjusted, as necessary, to maintain the desired venous blood pressure in the treated extremity.
摘要翻译：本发明涉及具有约50mL / min至约1500mL / min的操作范围的双重枢轴接触轴承系统的旋转式血液泵，其中在高达6000的操作速度下，上轴承上的力小于3N 转。旋转式血液泵是血液泵系统的一部分，其包括血液导管，具有可选传感器的控制系统和电源。本发明的实施例可以包括设计用于增加旋转血液系统在体内有效操作的时间长度的元件，包括耐磨轴承材料，用于转子磁吸引以减少轴承枢转轴承力和磨损的转子后板，转子尺寸和形状以及轴承间隙，其组合以产生流体动力轴承效应并减少轴承枢转轴承力和磨损，改善的血管内管道具有增加的抗血栓形成，导管插入部位袖带以抵抗感染，以及导管侧端口适于容易地插入导丝和基于导管的医疗装置来治疗导管和相关的血管以维持血液泵系统随时间的功能。泵系统被配置为连接到患者中的血管系统并以期望的速率泵血。本发明还涉及一种使用血液泵系统持续增加外周静脉和动脉的总直径和内腔直径的方法，其通过持续增加外周静脉或动脉中的血液速度和壁剪切应力足够长的时间导致容器的总直径和管腔直径的持续增加。对于旨在用于增加血管的总直径和管腔直径的血泵系统，根据需要监测和调节血液的泵送，以保持所需的升高的血液速度和壁剪切应力，以及所需的搏动目标血管，以优化目标血管总直径和内腔直径持续增加的速度和程度。血泵系统也可用于减少下肢静脉高血压，提高患者下肢静脉溃疡愈合率。对于旨在用于治疗肢体静脉高血压的血液泵系统，根据需要监测和调整血液的抽吸，以在治疗的末端保持所需的静脉血压。

13. 发明申请

WO2013109309A1 EXPANDABLE BODY DEVICE AND METHOD OF USE 审中-公开
标题翻译：可扩展身体装置及其使用方法
公开(公告)号：WO2013109309A1
公开(公告)日：2013-07-25
申请号：PCT/US2012/047072
申请日：2012-07-17
申请人： NOVITA THERAPEUTICS, LLC , FRANANO, Nicholas , STEPHENSON, Katherine
发明人： FRANANO, Nicholas , STEPHENSON, Katherine
IPC分类号： A61F2/06
CPC分类号： A61B17/12113 , A61B17/12136 , A61B17/1214 , A61B17/12172 , A61B17/12186 , A61B17/3415 , A61B2017/00004 , A61B2017/00349 , A61B2017/00526 , A61B2017/00849 , A61B2017/00884 , A61B2017/00929 , A61B2017/00995 , A61B2017/12063 , A61B2017/12068 , A61B2017/22038 , A61B2090/3966 , A61B2217/007
摘要： Disclosed herein are medical devices comprising a single-lobed, thin-walled, expandable body ("ballstent" or "blockstent") and a flexible, elongated delivery device ("delivery catheter") and systems and methods of use for treating saccular vascular aneurysms and methods of use for occluding segments of blood vessels and other biological conduits. Expandable bodies comprising gold, platinum, or silver that can be compressed, positioned in the lumen of an aneurysm or blood vessel, and expanded to conform to the shape of the aneurysm or segment of blood vessel or biological conduit are disclosed.
摘要翻译：本文公开了包括单裂片，薄壁，可扩张体（“球状体”或“块状物”）和柔性细长递送装置（“递送导管”）以及用于治疗囊状血管动脉瘤的系统和方法的医疗装置以及用于阻塞血管和其他生物管道段的使用方法。公开了包括金，铂或银的可膨胀体，其可被压缩，定位在动脉瘤或血管的内腔中，并且扩张以符合动脉瘤或血管或生物管道的形状。

14. 发明申请

WO2012099909A3 DETACHABLE METAL BALLOON DELIVERY DEVICE AND METHOD 审中-公开
标题翻译：可拆卸的金属气囊输送装置和方法
公开(公告)号：WO2012099909A3
公开(公告)日：2012-09-27
申请号：PCT/US2012021620
申请日：2012-01-17
申请人： NOVITA THERAPEUTICS LLC , FRANANO F NICHOLAS
发明人： FRANANO F NICHOLAS
IPC分类号： A61M29/00
CPC分类号： A61F2/958 , A61B17/12031 , A61B17/12109 , A61B17/12131 , A61B17/12136 , A61B2017/00526 , A61B2017/00893 , A61B2017/12054 , A61B2017/12059 , A61B2017/12063 , A61B2017/12068 , A61B2090/037 , A61F2/06 , A61M25/1029 , Y10T29/49826
摘要： A medical device comprising a compressed, inflatable, detachable single-lobed metal balloon attached to a catheter and methods of use for occluding blood vessels or treating vascular aneurysms are disclosed. The balloon can be made with ductile metals such as gold, platinum, or silver so that the balloon will conform to the shape of the void space during inflation and so that the balloon can be subsequently shaped by the application of an external force. The balloon can be configured such that it can be detached from the catheter by physical means or by electrolysis. The surface of the balloon can be configured to promote the growth of tissue into the wall of the balloon and to release drugs or pharmacologically active molecules, so that vessel occlusion or the sealing of an aneurysm will be maintained over time.
摘要翻译：公开了一种医疗装置，其包括附接到导管的压缩，可充气，可拆卸的单裂片金属球囊以及用于闭塞血管或治疗血管动脉瘤的方法。气球可以用诸如金，铂或银的延性金属制成，使得球囊在充气期间将符合空隙空间的形状，并且可以随后通过施加外力来使气球成形。气囊可以被配置成使得其可以通过物理手段或通过电解从导管分离。球囊的表面可以被配置为促进组织生长到球囊的壁中并释放药物或药理活性分子，使得血管闭塞或动脉瘤的密封将随时间而保持。

15. 发明申请

WO2012099909A2 DETACHABLE METAL BALLOON DELIVERY DEVICE AND METHOD 审中-公开
标题翻译：可拆卸的金属球囊输送装置和方法
公开(公告)号：WO2012099909A2
公开(公告)日：2012-07-26
申请号：PCT/US2012/021620
申请日：2012-01-17
申请人： NOVITA THERAPEUTICS, LLC , FRANANO, F. Nicholas
发明人： FRANANO, F. Nicholas
IPC分类号： A61M25/10
CPC分类号： A61F2/958 , A61B17/12031 , A61B17/12109 , A61B17/12131 , A61B17/12136 , A61B2017/00526 , A61B2017/00893 , A61B2017/12054 , A61B2017/12059 , A61B2017/12063 , A61B2017/12068 , A61B2090/037 , A61F2/06 , A61M25/1029 , Y10T29/49826
摘要： A medical device comprising a compressed, inflatable, detachable single-lobed metal balloon attached to a catheter and methods of use for occluding blood vessels or treating vascular aneurysms are disclosed. The balloon can be made with ductile metals such as gold, platinum, or silver so that the balloon will conform to the shape of the void space during inflation and so that the balloon can be subsequently shaped by the application of an external force. The balloon can be configured such that it can be detached from the catheter by physical means or by electrolysis. The surface of the balloon can be configured to promote the growth of tissue into the wall of the balloon and to release drugs or pharmacologically active molecules, so that vessel occlusion or the sealing of an aneurysm will be maintained over time.
摘要翻译：公开了一种医疗装置，其包括附接到导管的压缩的，可膨胀的，可拆卸的单瓣金属球囊以及用于闭塞血管或治疗血管动脉瘤的方法。气球可以由延展性金属如金，铂或银制成，使得气球在充气过程中将符合空隙空间的形状，并且随后可以通过施加外力来使气球成形。球囊可以被配置为使得它可以通过物理手段或通过电解从导管分离。球囊的表面可以被配置为促进组织生长进入球囊壁并释放药物或药理学活性分子，从而随着时间的推移，血管闭塞或动脉瘤的密封将被维持。

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