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11. 发明申请

WO2006034474A3 NOVEL PYRIDINE COMPOUNDS, PROCESS FOR THEIR PREPARATION AND COMPOSITIONS CONTAINING THEM 审中-公开
标题翻译：新型吡啶化合物及其制备方法及其组合物
公开(公告)号：WO2006034474A3
公开(公告)日：2007-05-18
申请号：PCT/US2005034244
申请日：2005-09-23
申请人： REDDY US THERAPEUTICS INC , ALEXANDER CHRISTOPHER W , KHANNA ISH KUMAR , IQBAL JAVED , PILLARISETTI SIVARAM , MAITRA SANTANU , ROBERTS GAYLA W , SAGI LAVANYA , PAL MANOJIT , KRISHNA CHINTAKUNTA VAMSEE , SREENU JENNEPALLI
发明人： ALEXANDER CHRISTOPHER W , KHANNA ISH KUMAR , IQBAL JAVED , PILLARISETTI SIVARAM , MAITRA SANTANU , ROBERTS GAYLA W , SAGI LAVANYA , PAL MANOJIT , KRISHNA CHINTAKUNTA VAMSEE , SREENU JENNEPALLI
IPC分类号： C07D213/02 , A61K31/44 , A61K31/4427 , A61K31/4433 , C07D401/02 , C07D419/02
CPC分类号： C07D405/14 , C07D239/30 , C07D239/40 , C07D239/42 , C07D239/46 , C07D239/47 , C07D239/48 , C07D239/50 , C07D239/54 , C07D401/04 , C07D403/12 , C07D405/12
摘要： The present invention provides new heterocyclic compounds, particularly substituted pyridines, methods and compositions for making and using these heterocyclic compounds, and methods for treating a variety of diseases and disease states, including atherosclerosis, arthritis, restenosis, diabetic nephropathy, or dyslipidemia, or disease states mediated by the low expression of Perlecan.
摘要翻译：本发明提供新的杂环化合物，特别是取代的吡啶，制备和使用这些杂环化合物的方法和组合物，以及用于治疗各种疾病和疾病状态的方法，包括动脉粥样硬化，关节炎，再狭窄，糖尿病性肾病或血脂异常或疾病由Perlecan低表达介导的状态。

12. 发明申请

WO2006073610A3 NOVEL BICYCLIC HETEROCYCLIC COMPOUNDS, PROCESS FOR THEIR PREPARATION AND COMPOSITIONS CONTAINING THEM 审中-公开
标题翻译：新型双环杂环化合物，其制备方法及其组合物
公开(公告)号：WO2006073610A3
公开(公告)日：2007-01-04
申请号：PCT/US2005042736
申请日：2005-11-23
申请人： REDDY US THERAPEUTICS INC , PAL MANOJIT , RAO YELESWARAPU KOTESWAR , KHANNA ISH KUMAR , SWAMY NALIVELA KUMARA , SUBRAMANIAN VENKATARAMAN , BATCHU VENKATESWARA RAO , IQBAL JAVED , PILLARISETTI SIVARAM
发明人： PAL MANOJIT , RAO YELESWARAPU KOTESWAR , KHANNA ISH KUMAR , SWAMY NALIVELA KUMARA , SUBRAMANIAN VENKATARAMAN , BATCHU VENKATESWARA RAO , IQBAL JAVED , PILLARISETTI SIVARAM
IPC分类号： C07D487/04 , A61K31/221 , A61K31/415 , A61K31/437 , A61K31/519 , A61K31/5365 , C07D205/02 , C07D231/04 , C07D231/10 , C07D471/04
CPC分类号： C07D471/04 , C07D487/04
摘要： The present invention provides, among other things, new bicyclo heterocyclic compounds, compositions comprising these heterocyclic compounds, methods of making the heterocyclic compounds, and methods of using these heterocyclic compounds for treating a variety of conditions and disease states associated with, for example, cellular proliferation, inflammation, glycosidase expression, or the low expression of Perlecan.
摘要翻译：本发明尤其提供了新的双环杂环化合物，包含这些杂环化合物的组合物，制备杂环化合物的方法，以及使用这些杂环化合物治疗与例如细胞相关的多种病症和疾病状态的方法增殖，炎症，糖苷酶表达或Perlecan的低表达。

13. 发明申请

WO0196307A3 CYCLOALKYL ALKANOIC ACIDS AS INTEGRIN RECEPTOR ANTAGONISTS 审中-公开
标题翻译： CYCLOALKYL ALKANOIC ACIDS作为INTEGRIN受体拮抗剂
公开(公告)号：WO0196307A3
公开(公告)日：2002-08-15
申请号：PCT/US0119104
申请日：2001-06-15
申请人： PHARMACIA CORP , KHANNA ISH KUMAR , CLARE MICHAEL , GASIECKI ALAN F , ROGERS THOMAS , CHEN BARBARA , RUSSEL MARK , HWANG-FUN LU
发明人： KHANNA ISH KUMAR , CLARE MICHAEL , GASIECKI ALAN F , ROGERS THOMAS , CHEN BARBARA , RUSSEL MARK , HWANG-FUN LU
IPC分类号： A61K31/4168 , A61K31/4375 , A61K31/44 , A61K31/4402 , A61K31/443 , A61K31/4439 , A61K31/444 , A61K31/5383 , A61P3/14 , A61P9/00 , A61P9/10 , A61P19/02 , A61P19/10 , A61P21/00 , A61P27/02 , A61P35/00 , A61P35/04 , C07D213/74 , C07D231/38 , C07D233/88 , C07D405/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D498/04 , A61K31/415 , A61K31/425 , C07C59/54
CPC分类号： C07D213/74 , C07D231/38 , C07D233/88 , C07D405/12 , C07D413/12 , C07D417/12 , C07D471/04
摘要： The present invention relates to a class of compounds represented by the Formula (I) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of the Formula (I), and methods of selectively inhibiting or antagonizing the 3 and/or 5 integrin.
摘要翻译：本发明涉及一类由式（I）表示的化合物或其药学上可接受的盐，包含式（I）化合物的药物组合物和选择性抑制或拮抗3和/或5整联蛋白的方法。

14. 发明申请

WO2012012410A3 KAPPA OPIOID RECEPTOR AGONISTS 审中-公开
公开(公告)号：WO2012012410A3
公开(公告)日：2012-05-18
申请号：PCT/US2011044513
申请日：2011-07-19
申请人： REDDYS LAB LTD DR , REDDYS LAB INC DR , SASMAL PRADIP KUMAR , CHINTAKUNTA VAMSEE KRISHNA , POTLURI VIJAY , KHANNA ISH KUMAR , TEHIM ASHOK , JALEEL MAHABOOBI , HOGBERG THOMAS , RIST OYSTEIN , ELSTER LISBETH , FRIMURER THOMAS MICHAEL , GERLACH LARS-OLE
发明人： SASMAL PRADIP KUMAR , CHINTAKUNTA VAMSEE KRISHNA , POTLURI VIJAY , KHANNA ISH KUMAR , TEHIM ASHOK , JALEEL MAHABOOBI , HOGBERG THOMAS , RIST OYSTEIN , ELSTER LISBETH , FRIMURER THOMAS MICHAEL , GERLACH LARS-OLE
IPC分类号： C07D207/09 , A61K31/40 , A61K31/4709 , A61P25/04 , C07D207/06 , C07D207/16 , C07D401/12 , C07D413/12
CPC分类号： C07D419/12 , C07D207/09 , C07D207/12 , C07D209/34 , C07D213/76 , C07D215/12 , C07D215/227 , C07D231/56 , C07D249/18 , C07D261/20 , C07D263/56 , C07D263/58 , C07D275/06 , C07D277/30 , C07D279/02 , C07D295/13 , C07D401/12 , C07D403/12 , C07D413/12 , C07D413/14 , C07D417/12
摘要： The present invention relates to a series of substituted compounds having the general formula (I), including their stereoisomers and/or their pharmaceutically acceptable salts. (I) Wherein A, m, Rls R2, R3, R4 are as defined herein. This invention also relates to methods of making these compounds including intermediates. The compounds of this invention are effective at the kappa (?) opioid receptor (KOR) site. Therefore, the compounds of this invention are useful as pharmaceutical agents, especially in the treatment and/or prevention of a variety of central nervous system disorders (CNS), including but not limited to acute and chronic pain, and associated disorders, particularly functioning peripherally at the CNS.
摘要翻译：本发明涉及一系列具有通式（I）的取代的化合物，包括其立体异构体和/或其药学上可接受的盐。（I）其中A，m，R 2，R 2，R 3，R 4如本文所定义。本发明还涉及制备这些化合物包括中间体的方法。本发明的化合物在κ（κ）阿片受体（KOR）位点是有效的。因此，本发明的化合物可用作药物，特别是用于治疗和/或预防各种中枢神经系统疾病（CNS），包括但不限于急性和慢性疼痛以及相关疾病，特别是周边功能在CNS。

15. 发明申请

WO2010028179A1 HETEROCYCLIC COMPOUNDS AS GATA MODULATORS 审中-公开
标题翻译：杂环化合物作为GATA调节剂
公开(公告)号：WO2010028179A1
公开(公告)日：2010-03-11
申请号：PCT/US2009/055933
申请日：2009-09-03
申请人： DR. REDDY'S LABORATORIES LTD. , ALEXANDER, Christopher W. , DE, Dibyendu , KHANNA, Ish Kumar , PILLARISETTI, Sivaram
发明人： ALEXANDER, Christopher W. , DE, Dibyendu , KHANNA, Ish Kumar , PILLARISETTI, Sivaram
IPC分类号： C07D239/48 , C07D401/04 , C07D401/14 , C07D403/12 , C07D403/14 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/04 , A61K31/505 , A61K31/506 , A61P3/10
CPC分类号： C07D239/48 , C07D401/04 , C07D401/14 , C07D403/12 , C07D403/14 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/04
摘要： Novel heterocyclic compounds, stereoisomers thereof and/or pharmaceutically acceptable salts of formula (I) and its stereoisomers are provided. Additionally, methods of forming novel heterocyclic compounds, stereoisomers thereof and/or pharmaceutically acceptable salts of formula (I) and its stereoisomers are provided.
摘要翻译：提供了新颖的杂环化合物，其立体异构体和/或式（I）的药学上可接受的盐及其立体异构体。此外，提供了形成新的杂环化合物，其立体异构体和/或式（I）的药学上可接受的盐及其立体异构体的方法。

16. 发明申请

WO2006034473A2 NOVEL PYRIMIDINE COMPOUNDS, PROCESS FOR THEIR PREPARATION AND COMPOSITIONS CONTAINING THEM 审中-公开
标题翻译：新的嘧啶化合物，它们的制备方法和含有它们的组合物
公开(公告)号：WO2006034473A2
公开(公告)日：2006-03-30
申请号：PCT/US2005/034243
申请日：2005-09-23
申请人： REDDY US THERAPEUTICS, INC. , KALLEDA, Srinivas , PADAKANTI, Srinivas , KUMAR SWAMY, Nalivela , YELESWARAPU, Koteswar, Rao , ALEXANDER, Christopher, W. , KHANNA, Ish, Kumar , IQBAL, Javed , PILLARISETTI, Sivaram , PAL, Manojit , BARANGE, Deepak
发明人： KALLEDA, Srinivas , PADAKANTI, Srinivas , KUMAR SWAMY, Nalivela , YELESWARAPU, Koteswar, Rao , ALEXANDER, Christopher, W. , KHANNA, Ish, Kumar , IQBAL, Javed , PILLARISETTI, Sivaram , PAL, Manojit , BARANGE, Deepak
IPC分类号： A61K31/541 , A61K31/5377 , A61K31/496 , A61K31/4545 , A61K31/4439 , A61K31/44 , C07D417/02 , C07D403/02 , C07D413/02 , C07D401/02
CPC分类号： C07D405/14 , C07D239/30 , C07D239/40 , C07D239/42 , C07D239/46 , C07D239/47 , C07D239/48 , C07D239/50 , C07D239/54 , C07D401/04 , C07D403/12 , C07D405/12
摘要： The present invention provides new heterocyclic compounds, particularly substituted pyrimidines, methods and compositions for making and using these heterocyclic compounds, and methods for treating a variety of diseases and disease states, including atherosclerosis, arthritis, restenosis, diabetic nephropathy, or dyslipidemia, or disease states mediated by the low expression of Perlecan.
摘要翻译：本发明提供了新的杂环化合物，特别是取代的嘧啶，制备和使用这些杂环化合物的方法和组合物，以及治疗多种疾病和疾病状态的方法，包括动脉粥样硬化，关节炎，再狭窄，糖尿病性肾病或血脂异常，或由基底膜蛋白低表达介导的疾病状态。

17. 发明申请

WO2003091247A3 PIPERIDINYL-AND PIPERAZINYL-SULFONYLMETHYL HYDROXAMIC ACIDS AND THEIR USE AS PROTEASE INHIBITORS 审中-公开
公开(公告)号：WO2003091247A3
公开(公告)日：2003-11-06
申请号：PCT/US2003/013123
申请日：2003-04-25
申请人： PHARMACIA CORPORATION , BARTA, Thomas, E. , BECKER, Daniel, P. , BEDELL, Louis, J. , BOEHM, Terri, L. , BROWN, David, L. , CARROLL, Jeffery, N. , CHEN, Yiyuan , FOBIAN, Yvette , FRESKOS, John, N. , GASIECKI, Alan, F. , GRAPPERHAUS, Margaret , HEINTZ, Robert, M. , HOCKERMAN, Susan, L. , KASSAB, Darren, J. , KHANNA, Ish, Kumar , KOLODZIEJ, Stephen, A. , MASSA, Mark , MCDONALD, Joseph , MISCHKE, Brent, V. , MISCHKE, Deborah, A. , MULLINS, Patrick, B. , NAGY, Mark , NORTON, Monica, B. , RICO, Joseph, G. , SCHMIDT, Michelle, A. , STEHLE, Nathan, W. , TALLEY, John, J. , VERNIER, William, F. , VILLAMILL, Clara, I. , WANG, Lijuan, Jane , WYNN, Thomas, A.
发明人： BARTA, Thomas, E. , BECKER, Daniel, P. , BEDELL, Louis, J. , BOEHM, Terri, L. , BROWN, David, L. , CARROLL, Jeffery, N. , CHEN, Yiyuan , FOBIAN, Yvette , FRESKOS, John, N. , GASIECKI, Alan, F. , GRAPPERHAUS, Margaret , HEINTZ, Robert, M. , HOCKERMAN, Susan, L. , KASSAB, Darren, J. , KHANNA, Ish, Kumar , KOLODZIEJ, Stephen, A. , MASSA, Mark , MCDONALD, Joseph , MISCHKE, Brent, V. , MISCHKE, Deborah, A. , MULLINS, Patrick, B. , NAGY, Mark , NORTON, Monica, B. , RICO, Joseph, G. , SCHMIDT, Michelle, A. , STEHLE, Nathan, W. , TALLEY, John, J. , VERNIER, William, F. , VILLAMILL, Clara, I. , WANG, Lijuan, Jane , WYNN, Thomas, A.
IPC分类号： C07D407/12
摘要： This invention is directed generally to proteinase (also known as "protease") inhibitors, and more particularly, to piperidinyl-and piperazinyl-sulfonylmethyl hydroxamic acids that inter alia, inhibit matrix metalloproteinase (also known as "matrix metalloprotease" or "MMP") activity and/or aggrecanase activity. Such hydroxamic acids generally correspond in structure to formula (I), (Wherein A 1 , A 2 , Y, E 1 , E 2 , E 3 , and R x are as defined in this specification), and further include salts of such compounds. This invention also is directed to compositions of such hydroxamic acids, intermediates for the syntheses of such hydroxamic acids, methods for making such hydroxamic acids, and methods for treating conditions (particularly pathological conditions) associated with MMP activity and/or aggrecanase activity.

18. 发明申请

WO1996012703A1 HETEROALKYL AND HETEROARYLTHIOALKYL THIOPHENOLIC COMPOUNDS AS 5-LIPOXYGENASE INHIBITORS 审中-公开
标题翻译：作为5-LIPOXYGENASE抑制剂的异戊醇和异戊醇锂噻二醇化合物
公开(公告)号：WO1996012703A1
公开(公告)日：1996-05-02
申请号：PCT/US1995012263
申请日：1995-10-02
申请人： G.D. SEARLE & CO. , KHANNA, Ish, Kumar , STEALEY, Michael, Allan , WEIER, Richard, Mathias
发明人： G.D. SEARLE & CO.
IPC分类号： C07D215/22
CPC分类号： C07D215/227 , C07D209/08 , C07D235/06 , C07D263/58 , C07D471/04
摘要： The present invention provides compounds of formula (I) and the pharmaceutically acceptable salts thereof, wherein: R and R are each alkyl; n is an integer of from 1 to 5; p is an integer of from 0 to 1; q is an integer of from 0 to 3; r is an integer of from 0 to 1; and R is a bicyclic group, with the proviso that when R and R are each alkyl, and p, q and r are each O, R is not a napthylmethyl group. These compounds are inhibitors of 5-lipoxygenase, and are useful for the treatment of 5-lipoxygenase mediated conditions, including inflammation-associated disorders and allergic and hypersensitivity reactions. The present invention also provides pharmaceutical compositions comprising a therapeutically-effective amount of a compound of formula (I) in combination with a pharmaceutically-acceptable carrier, and methods for treating 5-lipoxygenase mediated conditions, inflammation-associated disorders and allergies in an animal comprising administering a therapeutically-effective amount of a compound of formula (I) to the animal.
摘要翻译：本发明提供式（I）化合物及其药学上可接受的盐，其中：R 1和R 2各自为烷基; n为1〜5的整数， p是0到1的整数; q为0〜3的整数; r为0〜1的整数; 并且R 3是双环基团，条件是当R 1和R 2各自为烷基且p，q和r各自为O时，R 3不是萘基甲基。这些化合物是5-脂氧合酶的抑制剂，并且可用于治疗5-脂氧合酶介导的病症，包括炎症相关疾病和过敏性和超敏反应。本发明还提供药物组合物，其包含治疗有效量的式（I）化合物与药学上可接受的载体的组合，以及用于治疗动物中的5-脂氧合酶介导的病症，炎症相关疾病和过敏症的方法，包括向动物施用治疗有效量的式（I）化合物。

19. 发明申请

WO1994012500A1 SUBSTITUTED-PHENYL(N,N'-CYCLOALKYL/ALKYL CARBOXAMIDE)-1H/3H-IMIDAZO[4,5-b]PYRIDINE COMPOUNDS AS PAF ANTAGONISTS 审中-公开
标题翻译：取代的苯基（N，N'-环烷基/烷基羧酰胺）-1H / 3H-咪唑并[4,5-b]吡啶化合物作为PAF拮抗剂
公开(公告)号：WO1994012500A1
公开(公告)日：1994-06-09
申请号：PCT/US1993010976
申请日：1993-11-17
申请人： G.D. SEARLE & CO. , WEIER, Richard, Mathias , KHANNA, Ish, Kumar , STEALEY, Michael, Allan , JULIEN, Janet, Anne , LENTZ, Kirk, Thomas
发明人： G.D. SEARLE & CO.
IPC分类号： C07D471/04
CPC分类号： C07D471/04 , C07F7/1804
摘要： A class of N,N'-cycloalkyl/alkyl benzamides of certain 1H-imidazo[4,5-b]pyridine and 3H-imidazo[4,5-b]pyridine compounds is described for treating cardiovascular and immuno-inflammatory related disorders mediated by platelet activating factor (PAF). Compounds of particular interest are those of formula (I), wherein each of X and X is independently selected from nitrogen atom and -CH-, with the proviso that when one of X and X is selected as nitrogen atom, then the other of X and X must be -CH-; wherein R is selected from hydrido, alkyl, hydroxyalkyl, alkoxyalkyl, phenyl, halophenyl, alkylsilyloxyalkyl, amino, monoalkylamino, dialkylamino, aminoalkyl, monoalkylaminoalkyl and dialkylaminoalkyl; wherein each of R , R , R and R is independently selected from hydrido, hydroxy, alkyl, alkoxy, fluoro, chloro, bromo, haloalkyl, alkylthio, alkoxyalkyl, hydroxyalkyl, alkylthioalkyl, cyano, amino, monoalkylamino and dialkylamino; wherein each of R and R is independently selected from hydrido, alkyl, cycloalkyl, bicycloalkyl, heteroaryl, aryl, alkenyl and cycloalkenyl, and wherein any of said R and R substituents may be further substituted with one or more groups selected from linear or branched lower alkyl, lower alkoxy, fluoro, chloro and bromo; or a pharmaceutically-acceptable salt thereof.
摘要翻译：描述了某些1H-咪唑并[4,5-b]吡啶和3H-咪唑并[4,5-b]吡啶化合物的一类N，N'-环烷基/烷基苯甲酰胺，用于治疗心血管和免疫炎性相关病症介导通过血小板激活因子（PAF）。特别感兴趣的化合物是式（I）的化合物，其中X a和X b各自独立地选自氮原子和-CH-，条件是当X a和X b中的一个 >选择为氮原子，则X a和X b中的另一个必须为-CH-; 其中R 1选自氢，烷基，羟基烷基，烷氧基烷基，苯基，卤代苯基，烷基甲硅烷氧基烷基，氨基，单烷基氨基，二烷基氨基，氨基烷基，单烷基氨基烷基和二烷基氨基烷基。其中R 5，R 6，R 7和R 8各自独立地选自氢，羟基，烷基，烷氧基，氟，氯，溴，卤代烷基，烷硫基，烷氧基烷基，羟烷基，烷硫基烷基，氰基，氨基，单烷基氨基和二烷基氨基; 其中R 9和R 10各自独立地选自氢，烷基，环烷基，双环烷基，杂芳基，芳基，烯基和环烯基，并且其中所述R 9和R 10取代基中的任一个可以进一步被一个或多个选自直链或支链的低级烷基，低级烷氧基，氟，氯和溴的基团取代; 或其药学上可接受的盐。

20. 发明申请

WO2010134938A1 MODIFIED RELEASE NIACIN PHARMACEUTICAL FORMULATIONS 审中-公开
标题翻译：改良释放NIACIN药物制剂
公开(公告)号：WO2010134938A1
公开(公告)日：2010-11-25
申请号：PCT/US2009/066333
申请日：2009-12-02
申请人： DR. REDDY'S LABORATORIES LTD. , DR. REDDY'S LABORATORIES, INC. , VOOTURI, Rajesh , SINGARE, Dhananjay , DAMLE, Shantanu Yeshwant , KARATGI, Pradeep Jairao , MARELLA, Sesha Sai , BHAGWATWAR, Harshal Prabhakar , KHANNA, Ish Kumar , PILLAI, Raviraj Sukumar , PILLARISETTI, Sivaram
发明人： VOOTURI, Rajesh , SINGARE, Dhananjay , DAMLE, Shantanu Yeshwant , KARATGI, Pradeep Jairao , MARELLA, Sesha Sai , BHAGWATWAR, Harshal Prabhakar , KHANNA, Ish Kumar , PILLAI, Raviraj Sukumar , PILLARISETTI, Sivaram
IPC分类号： A61K9/32 , A61K9/22 , A61K31/44 , A61K9/14 , A61K9/20 , A61K9/26 , A61K9/28 , A61K31/60
CPC分类号： A61K9/2846 , A61K9/1635 , A61K9/2027 , A61K9/209 , A61K9/2886 , A61K31/44 , A61K31/455 , A61K31/60
摘要： Pharmaceutical formulations comprising niacin in a matrix comprising a hydrophobic polymer that modifies release of niacin.
摘要翻译：包含烟酸在包含改性烟酸释放的疏水性聚合物的基质中的药物制剂。

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