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1. 发明申请

WO2007075194A1 SELECTIVE BENZYLAMINE DERIVATIVES AND THEIR UTILITY AS CHOLESTEROL ESTER-TRANSFER PROTEIN INHIBITORS 审中-公开
标题翻译：选择性苯甲酰胺衍生物及其作为胆固醇转运蛋白抑制剂的应用
公开(公告)号：WO2007075194A1
公开(公告)日：2007-07-05
申请号：PCT/US2006/025427
申请日：2006-06-29
申请人： REDDY US THERAPEUTICS, INC. , BARUAH, Anima , DE, Dibyendu , KHANNA, Ish, Kumar , PILLARISETTI, Sivaram , ALEXANDER, Christopher, W. , SREENU, Jennepali
发明人： BARUAH, Anima , DE, Dibyendu , KHANNA, Ish, Kumar , PILLARISETTI, Sivaram , ALEXANDER, Christopher, W. , SREENU, Jennepali
IPC分类号： A01N43/66 , A01N43/54 , A01N43/42 , A01N43/40 , A61K31/44 , A61K31/47 , C07D221/06 , C07D471/02 , C07D491/02 , C07D498/02 , C07D513/02 , C07D515/02 , C07D215/00 , C07D215/38 , C07D215/46 , C07D215/04 , C07D417/00 , C07D211/72 , C07D211/84 , C07D213/62 , C07D403/00 , C07D239/02
CPC分类号： C07D215/36 , C07D215/38 , C07D215/48 , C07D221/06 , C07D401/12 , C07D403/12 , C07D471/04
摘要： The present invention provides, among other things, new benzylamine compounds, compositions comprising benzylamine compounds, methods of making benzylamine compounds, and methods of using benzylamine compounds for treating or preventing a variety of conditions or diseases associated with lipoprotein metabolism.
摘要翻译：本发明尤其提供了新的苄胺化合物，包含苄胺化合物的组合物，制备苄胺化合物的方法，以及使用苄胺化合物治疗或预防与脂蛋白代谢相关的各种病症或疾病的方法。

2. 发明申请

WO1994017063A1 N,N'-CYCLOALKYL/ALKYL CARBOXAMIDE 4H-IMIDAZO[4,5-b]PYRIDINE COMPOUNDS AS PAF ANTAGONISTS 审中-公开
标题翻译： N，N'-环烷基/烷基羧酰胺4H-咪唑并[4,5-b]吡啶化合物作为PAF拮抗剂
公开(公告)号：WO1994017063A1
公开(公告)日：1994-08-04
申请号：PCT/US1993010220
申请日：1993-10-29
申请人： G.D. SEARLE & CO. , WEIER, Richard, Mathias , KHANNA, Ish, Kumar , STEALEY, Michael, Allan , JULIEN, Janet, Anne
发明人： G.D. SEARLE & CO.
IPC分类号： C07D471/04
CPC分类号： C07D471/04
摘要： A class of N,N'-cycloalkyl/alkyl benzamides of certain 4H-imidazo[4,5-b]pyridine compounds is described for treating cardiovascular and immuno-inflammatory related disorders mediated by platelet activating factor (PAF). Compounds of particular interest are those of formula (1) wherein R is selected from hydrido, alkyl, hydroxyalkyl, alkoxyalkyl, phenyl, halophenyl, pyridinyl, alkylsilyloxyalkyl, amino, monoalkylamino, dialkylamino, aminoalkyl, monoalkylaminoalkyl and dialkylaminoalkyl; wherein each of R , R , R and R is independently selected from hydrido, hydroxy, alkyl, alkoxy, fluoro, chloro, bromo, haloalkyl, alkylthio, alkoxyalkyl, hydroxyalkyl, alkylthioalkyl, cyano, amino, monoalkylamino and dialkylamino; wherein each of R and R is independently selected from hydrido, alkyl, cycloalkyl, bicycloalkyl, heterocyclic, heterocyclicalkyl, aryl, alkenyl and cycloalkenyl, and wherein any of said R and R substituents may be further substituted with one ore more groups selected from linear or branched lower alkyl, lower alkoxy, fluoro, chloro and bromo; or a pharmaceutically-acceptable salt thereof.
摘要翻译：描述了某些4H-咪唑并[4,5-b]吡啶化合物的一类N，N'-环烷基/烷基苯甲酰胺，用于治疗由血小板活化因子（PAF）介导的心血管和免疫炎性相关病症。烷基，羟基烷基，烷氧基烷基，苯基，卤代苯基，吡啶基，烷基甲硅烷氧基烷基，氨基，单烷基氨基，二烷基氨基，氨基烷基，单烷基氨基烷基和二烷基氨基烷基的式（1）化合物，其中R 1选自氢，其中R 5，R 6，R 7和R 8各自独立地选自氢，羟基，烷基，烷氧基，氟，氯，溴，卤代烷基，烷硫基，烷氧基烷基，羟烷基，烷硫基烷基，氰基，氨基，单烷基氨基和二烷基氨基; 其中R 9和R 10各自独立地选自氢，烷基，环烷基，双环烷基，杂环，杂环烷基，芳基，烯基和环烯基，并且其中所述R 9和R 10取代基中的任何一个可以进一步被一个或多个选自直链或支链的低级烷基，低级烷氧基，氟，氯和溴的基团取代; 或其药学上可接受的盐。

3. 发明申请

WO2012012410A2 KAPPA OPIOID RECEPTOR AGONISTS 审中-公开
标题翻译： KAPPA阿片受体激动剂
公开(公告)号：WO2012012410A2
公开(公告)日：2012-01-26
申请号：PCT/US2011/044513
申请日：2011-07-19
申请人： DR. REDDY'S LABORATORIES LTD. , DR. REDDY'S LABORATORIES, INC. , SASMAL, Pradip Kumar , CHINTAKUNTA, Vamsee Krishna , POTLURI, Vijay , KHANNA, Ish Kumar , TEHIM, Ashok , JALEEL, Mahaboobi , HOGBERG, Thomas , RIST, Oystein , ELSTER, Lisbeth , FRIMURER, Thomas Michael , GERLACH, Lars-Ole
发明人： SASMAL, Pradip Kumar , CHINTAKUNTA, Vamsee Krishna , POTLURI, Vijay , KHANNA, Ish Kumar , TEHIM, Ashok , JALEEL, Mahaboobi , HOGBERG, Thomas , RIST, Oystein , ELSTER, Lisbeth , FRIMURER, Thomas Michael , GERLACH, Lars-Ole
IPC分类号： C07D207/09 , C07D207/16 , C07D207/06 , C07D401/12 , C07D413/12 , A61K31/40 , A61K31/4709 , A61P25/04
CPC分类号： C07D419/12 , C07D207/09 , C07D207/12 , C07D209/34 , C07D213/76 , C07D215/12 , C07D215/227 , C07D231/56 , C07D249/18 , C07D261/20 , C07D263/56 , C07D263/58 , C07D275/06 , C07D277/30 , C07D279/02 , C07D295/13 , C07D401/12 , C07D403/12 , C07D413/12 , C07D413/14 , C07D417/12
摘要： The present invention relates to a series of substituted compounds having the general formula (I), including their stereoisomers and/or their pharmaceutically acceptable salts. (I) Wherein A, m, Rls R2, R3, R4 are as defined herein. This invention also relates to methods of making these compounds including intermediates. The compounds of this invention are effective at the kappa (κ) opioid receptor (KOR) site. Therefore, the compounds of this invention are useful as pharmaceutical agents, especially in the treatment and/or prevention of a variety of central nervous system disorders (CNS), including but not limited to acute and chronic pain, and associated disorders, particularly functioning peripherally at the CNS.
摘要翻译：本发明涉及一系列具有通式（I）的取代的化合物，包括其立体异构体和/或其药学上可接受的盐。（I）其中A，m，R 1，R 2，R 3，R 4如本文所定义。本发明还涉及制备这些包括中间体的化合物的方法。本发明化合物在κ（κ）阿片受体（KOR）位点是有效的。因此，本发明化合物可用作药物，特别是用于治疗和/或预防多种中枢神经系统疾病（CNS），包括但不限于急性和慢性疼痛以及相关疾病，特别是在外周功能在CNS。

4. 发明申请

WO2009149056A3 COMBINATIONS OF NIACIN AND AN OXICAM 审中-公开
公开(公告)号：WO2009149056A3
公开(公告)日：2009-12-10
申请号：PCT/US2009/045923
申请日：2009-06-02
申请人： DR. REDDY'S LABORATORIES LTD. , DR. REDDY'S LABORATORIES, INC. , KARATGI, Pradeep, Jairao , MUNIYAPPAN, Thilek, Kumar , DAMLE, Shantanu, Yeshwant , MARELLA, Sesha, Sai , BHAGWATWAR, Harshal, Prabhakar , PILLAI, Raviraj, Sukumar , KHANNA, Ish, Kumar
发明人： KARATGI, Pradeep, Jairao , MUNIYAPPAN, Thilek, Kumar , DAMLE, Shantanu, Yeshwant , MARELLA, Sesha, Sai , BHAGWATWAR, Harshal, Prabhakar , PILLAI, Raviraj, Sukumar , KHANNA, Ish, Kumar
IPC分类号： A61K31/455 , A61K31/54 , A61K9/22 , A61K9/28 , A61P3/10
摘要： Pharmaceutical formulations comprising a combination of niacin and an oxicam NSAID, for oral administration, and methods of preparing the formulations.

5. 发明申请

WO2009149056A2 COMBINATIONS OF NIACIN AND AN OXICAM 审中-公开
标题翻译： NIACIN和OXICAM的组合
公开(公告)号：WO2009149056A2
公开(公告)日：2009-12-10
申请号：PCT/US2009045923
申请日：2009-06-02
申请人： REDDYS LAB LTD DR , REDDYS LAB INC DR , KARATGI PRADEEP JAIRAO , MUNIYAPPAN THILEK KUMAR , DAMLE SHANTANU YESHWANT , MARELLA SESHA SAI , BHAGWATWAR HARSHAL PRABHAKAR , PILLAI RAVIRAJ SUKUMAR , KHANNA ISH KUMAR
发明人： KARATGI PRADEEP JAIRAO , MUNIYAPPAN THILEK KUMAR , DAMLE SHANTANU YESHWANT , MARELLA SESHA SAI , BHAGWATWAR HARSHAL PRABHAKAR , PILLAI RAVIRAJ SUKUMAR , KHANNA ISH KUMAR
IPC分类号： A61K31/455 , A61K9/22 , A61K9/28 , A61K31/54 , A61P3/10
CPC分类号： A61K31/455 , A61K9/2081 , A61K9/209 , A61K9/2886 , A61K9/5026 , A61K9/5073 , A61K9/5084 , A61K31/54 , A61K45/06 , A61K2300/00
摘要： Pharmaceutical formulations comprising a combination of niacin and an oxicam NSAID, for oral administration, and methods of preparing the formulations.
摘要翻译：包含烟酸和奥昔康NSAID的组合用于口服给药的药物制剂和制备该制剂的方法。

6. 发明申请

WO2006073973A3 NOVEL BENZYLAMINE DERIVATIVES AS CETP INHIBITORS 审中-公开
标题翻译：新型苯甲酰胺衍生物作为CETP抑制剂
公开(公告)号：WO2006073973A3
公开(公告)日：2008-12-04
申请号：PCT/US2005047203
申请日：2005-12-28
申请人： REDDY US THERAPEUTICS INC , BARUAH ANIMA , DE DIBYENDU , KHANNA ISH KUMAR , PILLARISETTI SIVARAM , MAITRA SANTANU , ALEXANDER CHRISTOPHER W , SREENU JENNEPALLI , DAGER INDU
发明人： BARUAH ANIMA , DE DIBYENDU , KHANNA ISH KUMAR , PILLARISETTI SIVARAM , MAITRA SANTANU , ALEXANDER CHRISTOPHER W , SREENU JENNEPALLI , DAGER INDU
IPC分类号： A61K31/44 , A61K31/47 , A61K31/495 , A61K31/4965 , C07D213/72 , C07D215/38 , C07D401/02 , C07D471/02
CPC分类号： A61K31/506 , A61K31/437 , A61K31/438 , A61K31/47 , A61K31/4709 , A61K31/496 , C07D213/73 , C07D213/74 , C07D215/38 , C07D221/04 , C07D239/78 , C07D241/20 , C07D401/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D498/04
摘要： The present invention provides, among other things, new benzylamine compounds, compositions comprising benzylamine compounds, methods of making benzylamine compounds, and methods of using benzylamine compounds for treating or preventing a variety of conditions or diseases associated with lipoprotein metabolism.
摘要翻译：本发明尤其提供了新的苄胺化合物，包含苄胺化合物的组合物，制备苄胺化合物的方法，以及使用苄胺化合物治疗或预防与脂蛋白代谢相关的各种病症或疾病的方法。

7. 发明申请

WO2006073973A2 NOVEL BENZYLAMINE DERIVATIVES AS CETP INHIBITORS 审中-公开
标题翻译：新型苯甲酰胺衍生物作为CETP抑制剂
公开(公告)号：WO2006073973A2
公开(公告)日：2006-07-13
申请号：PCT/US2005/047203
申请日：2005-12-28
申请人： REDDY US THERAPEUTICS, INC. , BARUAH, Anima , DE, Dibyendu , KHANNA, Ish Kumar , PILLARISETTI, Sivaram , MAITRA, Santanu , ALEXANDER, Christopher, W. , SREENU, Jennepalli , DAGER, Indu
发明人： BARUAH, Anima , DE, Dibyendu , KHANNA, Ish Kumar , PILLARISETTI, Sivaram , MAITRA, Santanu , ALEXANDER, Christopher, W. , SREENU, Jennepalli , DAGER, Indu
IPC分类号： A61K31/44 , A61K31/47 , A61K31/495 , A61K31/4965 , C07D213/72 , C07D215/38 , C07D401/02 , C07D471/02
CPC分类号： A61K31/506 , A61K31/437 , A61K31/438 , A61K31/47 , A61K31/4709 , A61K31/496 , C07D213/73 , C07D213/74 , C07D215/38 , C07D221/04 , C07D239/78 , C07D241/20 , C07D401/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D498/04
摘要： The present invention provides, among other things, new benzylamine compounds, compositions comprising benzylamine compounds, methods of making benzylamine compounds, and methods of using benzylamine compounds for treating or preventing a variety of conditions or diseases associated with lipoprotein metabolism.
摘要翻译：本发明尤其提供了新的苄胺化合物，包含苄胺化合物的组合物，制备苄胺化合物的方法，以及使用苄胺化合物治疗或预防与脂蛋白代谢相关的各种病症或疾病的方法。

8. 发明申请

WO2006073610A2 NOVEL BICYCLIC HETEROCYCLIC COMPOUNDS, PROCESS FOR THEIR PREPARATION AND COMPOSITIONS CONTAINING THEM 审中-公开
标题翻译：新型双环杂环化合物，其制备方法和含有它们的组合物
公开(公告)号：WO2006073610A2
公开(公告)日：2006-07-13
申请号：PCT/US2005/042736
申请日：2005-11-23
申请人： REDDY US THERAPEUTICS, INC. , PAL, Manojit , RAO, Yeleswarapu, Koteswar , KHANNA, Ish, Kumar , SWAMY, Nalivela, Kumara , SUBRAMANIAN, Venkataraman , BATCHU, Venkateswara, Rao , IQBAL, Javed , PILLARISETTI, Sivaram
发明人： PAL, Manojit , RAO, Yeleswarapu, Koteswar , KHANNA, Ish, Kumar , SWAMY, Nalivela, Kumara , SUBRAMANIAN, Venkataraman , BATCHU, Venkateswara, Rao , IQBAL, Javed , PILLARISETTI, Sivaram
IPC分类号： A61K31/519 , C07D487/02
CPC分类号： C07D471/04 , C07D487/04
摘要： The present invention provides, among other things, new bicyclo heterocyclic compounds, compositions comprising these heterocyclic compounds, methods of making the heterocyclic compounds, and methods of using these heterocyclic compounds for treating a variety of conditions and disease states associated with, for example, cellular proliferation, inflammation, glycosidase expression, or the low expression of Perlecan.
摘要翻译：除其他之外，本发明提供了新的双环杂环化合物，包含这些杂环化合物的组合物，制备该杂环化合物的方法以及使用这些杂环化合物治疗多种病症和疾病的方法例如与细胞增殖，炎症，糖苷酶表达或者基底膜蛋白聚糖的低表达有关的状态。

9. 发明申请

WO0196334A3 HETEROARYLALKANOIC ACIDS AS INTEGRIN RECEPTOR ANTAGONISTS 审中-公开
标题翻译：作为INTEGRIN受体拮抗剂的异氟烷酸
公开(公告)号：WO0196334A3
公开(公告)日：2002-09-12
申请号：PCT/US0119375
申请日：2001-06-15
申请人： PHARMACIA CORP , NAGARAJAN SCRINIVASAN RAJ , KHANNA ISH KUMAR , TOLLEFSON MICHAEL B , MOHLER SCOTT B , CHEN BARBARA , RUSSELL MARK , DEVADAS BALEKUDRU , PENNING THOMAS D , SCHRETZMAN LORI A , SPANGLER DALE P , BOYS MARK LAURENCE , CHANDRAKUMAR NIZAL SAMUEL , LU HWANG-FUN
发明人： NAGARAJAN SCRINIVASAN RAJ , KHANNA ISH KUMAR , TOLLEFSON MICHAEL B , MOHLER SCOTT B , CHEN BARBARA , RUSSELL MARK , DEVADAS BALEKUDRU , PENNING THOMAS D , SCHRETZMAN LORI A , SPANGLER DALE P , BOYS MARK LAURENCE , CHANDRAKUMAR NIZAL SAMUEL , LU HWANG-FUN
IPC分类号： A61K31/4245 , A61K31/4375 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/4709 , A61K31/496 , A61K31/5383 , A61P3/14 , A61P9/00 , A61P9/08 , A61P9/10 , A61P19/02 , A61P19/10 , A61P21/00 , A61P27/02 , A61P35/00 , A61P43/00 , C07D213/74 , C07D231/38 , C07D233/60 , C07D233/88 , C07D405/12 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04 , C07D498/04 , A61K31/425
CPC分类号： C07D213/74 , C07D231/38 , C07D233/88 , C07D405/12 , C07D413/12 , C07D417/12 , C07D471/04
摘要： The present invention relates to a class of compounds represented by formula (I) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of Formula (I), and methods of selectively antagonizing the 3 and/or the 5 integrin without significantly antagonizing the IIb/IIIa integrin.
摘要翻译：本发明涉及一类由式（I）表示的化合物或其药学上可接受的盐，包含式（I）化合物的药物组合物和选择性拮抗3和/或5整联蛋白而不显着拮抗IIb的方法 / IIIa整合素。

10. 发明申请

WO2010028174A1 NOVEL BICCYCLIC COMPOUNDS AS GATA MODULATORS 审中-公开
标题翻译：新型双环化合物作为GATA调节剂
公开(公告)号：WO2010028174A1
公开(公告)日：2010-03-11
申请号：PCT/US2009/055926
申请日：2009-09-03
申请人： DR. REDDY'S LABORATORIES LTD. , DE, Dibyendu , KHANNA, Ish Kumar , PILLARISETTI, Sivaram
发明人： DE, Dibyendu , KHANNA, Ish Kumar , PILLARISETTI, Sivaram
IPC分类号： C07D239/70 , C07D401/04 , C07D403/04 , C07D413/04 , A61P9/10 , A61P3/10 , A61K31/517
CPC分类号： C07D239/70 , C07D401/04 , C07D403/04 , C07D413/04
摘要： Novel bicyclic compounds, stereoisomers, and/or pharmaceutically acceptable salts of the novel bicyclic compounds, and/or pharmaceutically acceptable salts of the stereoisomers of the novel bicyclic compounds are provided. Additionally, methods of forming novel bicyclic compounds, stereoisomers, and/or pharmaceutically acceptable salts of the novel bicyclic compounds, and/or pharmaceutically acceptable salts of the stereoisomers of the novel bicyclic compounds are provided.
摘要翻译：提供新型双环化合物的新型双环化合物，立体异构体和/或药学上可接受的盐，和/或新型双环化合物的立体异构体的药学上可接受的盐。此外，提供形成新型双环化合物的新型双环化合物，立体异构体和/或药学上可接受的盐的方法，和/或新型双环化合物的立体异构体的药学上可接受的盐。

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