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1. 发明申请

WO2015086428A1 PROCESS OF MAKING ADAMANTANAMIDES 审中-公开
标题翻译：制备酰胺胺的方法
公开(公告)号：WO2015086428A1
公开(公告)日：2015-06-18
申请号：PCT/EP2014/076583
申请日：2014-12-04
申请人： UNILEVER PLC , UNILEVER N.V. , CONOPCO, INC., D/B/A UNILEVER
发明人： HARICHIAN, Bijan , ROSA, Jose, Guillermo
IPC分类号： C07D215/08 , C07D217/06 , C07C231/02 , C07D205/02 , C07D207/06 , C07D211/16 , C07D211/62 , C07D295/185
CPC分类号： C07D211/16 , C07C231/02 , C07C2603/74 , C07D205/02 , C07D207/06 , C07D211/62 , C07D215/08 , C07D217/06 , C07D295/185 , C07C233/58
摘要： An effective process of making adamantanamide, which process is fast, does not the use of organic solvents or labor-intensive isolation or purification of the product, by removal of organic solvent or by-products, and has improved yield and purity.
摘要翻译：制造金刚烷胺的有效方法，该方法快速，不通过去除有机溶剂或副产物而使用有机溶剂或劳动密集型的产物分离或纯化，并且具有提高的产率和纯度。

2. 发明申请

WO98058934A1 NOVEL 2-(IMINOMETHYL)AMINO-PHENYL DERIVATIVES, PREPARATION, APPLICATION AS MEDICINES AND COMPOSITIONS CONTAINING SAME 审中-公开
标题翻译：新型2-（氨基甲酰基）氨基 - 苯基衍生物，制备，作为含有它们的药物和组合物的应用
公开(公告)号：WO98058934A1
公开(公告)日：1998-12-30
申请号：PCT/FR1998/001250
申请日：1998-06-15
IPC分类号： C07D211/90 , A61K20060101 , A61K31/33 , A61K31/38 , A61K31/381 , A61K31/395 , A61K31/397 , A61K31/4025 , A61K31/415 , A61K31/4178 , A61K31/422 , A61K31/425 , A61K31/427 , A61K31/44 , A61K31/4436 , A61K31/445 , A61K31/45 , A61K31/453 , A61K31/4535 , A61K31/454 , A61P3/06 , A61P25/00 , A61P43/00 , C07D20060101 , C07D205/02 , C07D207/14 , C07D207/16 , C07D211/70 , C07D233/78 , C07D235/02 , C07D263/02 , C07D275/02 , C07D277/04 , C07D277/06 , C07D277/14 , C07D307/68 , C07D333/34 , C07D333/70 , C07D401/12 , C07D403/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D417/14 , C07D521/00 , C07F20060101
CPC分类号： C07D417/12 , C07D333/38 , C07D409/12 , C07D409/14 , C07D413/12
摘要： The invention concerns novel 2-(iminomethyl)amino-phenyl derivatives, their preparation, their application as medicines and compositions containing them.
摘要翻译：本发明涉及新型2-（亚氨基甲基）氨基 - 苯基衍生物，其制备方法，它们作为药物的应用和含有它们的组合物。

3. 发明申请

WO98053814A1 HETEROCYCLIC AMIDE COMPOUNDS AS CELL ADHESION INHIBITORS 审中-公开
标题翻译：杂环化合物作为细胞粘附抑制剂
公开(公告)号：WO98053814A1
公开(公告)日：1998-12-03
申请号：PCT/US1998/010940
申请日：1998-05-29
IPC分类号： A61K38/00 , A61K31/401 , A61K31/445 , A61P1/04 , A61P9/10 , A61P11/06 , A61P25/00 , A61P37/08 , A61P43/00 , C07K5/06 , C07K5/078 , A61K31/395 , A61K31/40 , A61K31/41 , A61K31/415 , A61K31/425 , A61K31/435 , A61K31/44 , A61K31/47 , A61K31/495 , A61K31/535 , C07D205/02 , C07D209/04 , C07D209/14 , C07D209/30 , C07D217/12 , C07D233/64 , C07D235/02 , C07D241/02 , C07D257/04 , C07D265/30 , C07D275/02 , C07D277/02 , C07D277/08 , C07D295/08 , C07D295/26 , C07D401/02 , C07D401/12 , C07D401/14 , C07D413/02 , C07D413/12 , C07D413/14 , C07D417/02 , C07D417/12 , C07D417/14 , C07D487/04 , C07D513/04 , C07F9/02
CPC分类号： A61K31/472 , A61K31/401 , A61K31/445 , A61K31/4725 , A61K38/00 , C07K5/06139 , C07K5/06165 , C07K5/06191
摘要： Compounds of formula (I) are antagonists of VLA-4 and/or alpha 4 beta 7, and as such are useful in the inhibition or prevention of cell adhesion and cell-adhesion mediated pathologies. These compounds may be formulated into pharmaceutical compositions and are suitable for use in the treatment of asthma, allergies, inflammation, multiple sclerosis, and other inflammatory and autoimmune disorders.
摘要翻译：式（I）化合物是VLA-4和/或α4β7的拮抗剂，因此可用于抑制或预防细胞粘附和细胞粘附介导的病理。这些化合物可以配制成药物组合物，并且适用于治疗哮喘，过敏，炎症，多发性硬化以及其它炎性和自身免疫性疾病。

4. 发明申请

WO1993000331A1 FLUOROALKOXYBENZYLAMINO DERIVATIVES OF NITROGEN CONTAINING HETEROCYCLES 审中-公开
标题翻译：含氮杂环化合物的氟代烷氧基苯胺衍生物
公开(公告)号：WO1993000331A1
公开(公告)日：1993-01-07
申请号：PCT/US1992003571
申请日：1992-05-05
申请人： PFIZER INC. , LOWE, John, Adams, III , ROSEN, Terry, Jay
发明人： PFIZER INC.
IPC分类号： C07D205/02
CPC分类号： C07D453/02 , C07C45/44 , C07C45/513 , C07C45/673 , C07C45/71 , C07C47/575 , C07D211/56
摘要： The present invention relates to novel fluoroalkoxybenzylamino derivatives of nitrogen containing heterocyclic compounds, and specifically, to compounds of formula (I) wherein Q, X , X and X are as defined below. These novel compounds are useful in the treatment of inflammatory and central nervous system disorders, as well as other disorders.
摘要翻译：本发明涉及含氮杂环化合物的新的氟代烷氧基苄基氨基衍生物，具体地涉及其中Q，X 1，X 2和X 3如下定义的式（I）化合物。这些新型化合物可用于治疗炎性和中枢神经系统疾病以及其它疾病。

5. 发明申请

WO2022271801A1 PROCESS FOR PREPARING EGFR INHIBITORS 审中-公开
公开(公告)号：WO2022271801A1
公开(公告)日：2022-12-29
申请号：PCT/US2022/034487
申请日：2022-06-22
申请人： BLUEPRINT MEDICINES CORPORATION
发明人： BUTLER, Erika , LEE, Christopher , MACEACHERN, Lauren , WAETZIG, Joshua D.
IPC分类号： C07D401/14 , A61P35/00 , C07D205/02 , C07D217/22 , C07D403/02
摘要： The present disclosure provides methods of producing a compound of structural formula (I): (I) or a pharmaceutically acceptable salt thereof.

6. 发明申请

WO2014160783A1 2-HALO-5-ALKYNYL-PYRIDYL NICOTINIC LIGANDS 审中-公开
标题翻译： 2-羟基-5-烷基 - 吡啶基尼古丁配体
公开(公告)号：WO2014160783A1
公开(公告)日：2014-10-02
申请号：PCT/US2014/031873
申请日：2014-03-26
申请人： GEORGETOWN UNIVERSITY
发明人： XIAO, Yingxian , KELLAR, Kenneth, J. , BROWN, Milton, L. , PAIGE, Mikell, A. , LIU, Yong
IPC分类号： A61K31/44 , A61K31/397 , C07D205/02
CPC分类号： C07D401/12
摘要： Disclosed are heterocyclic compounds that are ligands for nicotinic acetylcholine receptors. The compounds are useful for treating a mammal suffering from any one of a range of therapeutic indications, including Alzheimer's disease, Parkinson's disease, dyskinesias, Tourette's syndrome, schizophrenia, attention deficit disorder, anxiety, pain, depression, obsessive compulsive disorder, chemical substance abuse, alcoholism, memory deficit, pseudodementia, Ganser's syndrome, migraine pain, bulimia, obesity, premenstrual syndrome or late luteal phase syndrome, tobacco abuse, post-traumatic syndrome, social phobia, chronic fatigue syndrome, premature ejaculation, erectile difficulty, anorexia nervosa, disorders of sleep, autism, mutism, trichotillomania, and hypothermia.
摘要翻译：公开了作为烟碱乙酰胆碱受体配体的杂环化合物。该化合物可用于治疗患有一系列治疗适应症，包括阿尔茨海默病，帕金森病，运动障碍，图雷特综合征，精神分裂症，注意力缺陷障碍，焦虑症，疼痛，抑郁症，强迫症，化学物质滥用酒精中毒，记忆缺陷，假性痴呆，甘ser综合征，偏头痛，贪食症，肥胖症，经前期综合征或晚期黄体期综合征，烟草滥用，创伤后综合征，社交恐惧症，慢性疲劳综合征，早泄，勃起障碍，神经性厌食症，睡眠障碍，孤独症，多发症，头发性短暂症和低体温。

7. 发明申请

WO00007591A1 INDOLE sPLA2 INHIBITORS 审中-公开
标题翻译： INDOLE sPLA2抑制剂
公开(公告)号：WO00007591A1
公开(公告)日：2000-02-17
申请号：PCT/US1999/017460
申请日：1999-08-02
IPC分类号： A61K31/405 , A61K31/403 , A61K31/404 , A61P1/18 , A61P7/00 , A61P9/10 , A61P11/00 , A61P19/02 , A61P19/06 , A61P27/16 , A61P29/00 , A61P31/04 , A61P35/00 , A61P37/08 , A61P43/00 , C07D209/18 , C07D209/22 , C07D231/12 , C07D233/54 , C07D233/56 , C07D233/58 , C07D249/08 , A61K31/335 , A61K31/38 , A61K31/395 , A61K31/40 , A61K31/41 , A61K31/415 , A61K31/42 , A61K31/425 , A61K31/435 , A61K31/44 , A61K31/445 , A61K31/47 , A61K31/495 , A61K31/505 , A61K31/535 , C07D205/02 , C07D209/04 , C07D209/12 , C07D209/14 , C07D209/82 , C07D211/26 , C07D211/30 , C07D211/86 , C07D213/36 , C07D213/50 , C07D213/56 , C07D215/12 , C07D219/12 , C07D231/54 , C07D231/56 , C07D237/30 , C07D239/26 , C07D241/04 , C07D241/42 , C07D249/04 , C07D251/22 , C07D261/08 , C07D263/32 , C07D275/02 , C07D277/02 , C07D285/04 , C07D285/06 , C07D285/08 , C07D285/10 , C07D285/12 , C07D317/26 , C07D317/28 , C07D319/12 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D403/14 , C07D405/04 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/06 , C07D409/12 , C07D409/14 , C07D413/04 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/06 , C07D417/12 , C07D417/14
CPC分类号： C07D209/18 , C07D209/22
摘要： A class of novel acylsulfonamide substituted indole compounds is disclosed together with the use of such compounds for inhibiting sPLA2 mediated release of fatty acids for treatment of inflammatory diseases such as septic shock.
摘要翻译：公开了一类新的酰基磺酰胺取代的吲哚化合物以及这些化合物用于抑制sPLA2介导的脂肪酸释放以治疗炎症性疾病如败血性休克的用途。

8. 发明申请

WO98044922A1 SOMATOSTATIN AGONISTS 审中-公开
标题翻译：脂肪酸激动剂
公开(公告)号：WO98044922A1
公开(公告)日：1998-10-15
申请号：PCT/US1998/006488
申请日：1998-04-02
IPC分类号： A61P25/04 , A61K31/454 , A61P1/00 , A61P3/10 , A61P9/00 , A61P25/24 , A61P27/02 , A61P35/00 , A61P43/00 , C07D401/14 , C07D413/14 , C07D417/14 , A61K31/395 , A61K31/40 , A61K31/405 , A61K31/41 , A61K31/415 , A61K31/42 , A61K31/44 , A61K31/445 , A61K31/47 , A61K31/55 , C07D205/02 , C07D209/08 , C07D209/18 , C07D403/14 , C07D498/16 , C07D513/16
CPC分类号： C07D401/14 , C07D413/14 , C07D417/14
摘要： This invention relates to somatostatin agonist compounds which are potent with high selectivity toward the receptor subtype 2. Compounds of formula (I) including pharmaceutically acceptable salts and hydrates thereof are disclosed. These compounds are useful in the treatment of diabetes, cancer, acromegaly, restenosis, depression, irritable bowel syndrome, pain and diabetic retinopathy. Many of the compounds are also orally active.
摘要翻译：本发明涉及式（I）的化合物，其对于受体2的亚型非常有效且高度选择性，以及它们的药学上可相容的盐和水合物，所述化合物具有对生长抑素的激动剂。这些化合物可用于治疗糖尿病，癌症，肢端肥大症，再狭窄，抑郁症，肠易激综合征，疼痛和糖尿病性视网膜病，并且大多数口服有效。

9. 发明申请

WO98042663A1 NAPHTHOPYRAN DERIVATIVES, COMPOSITIONS AND (CO)POLYMERS MATRICES CONTAINING SAME 审中-公开
标题翻译：萘普生衍生物，组合物和（CO）聚合物包含它们的基质
公开(公告)号：WO98042663A1
公开(公告)日：1998-10-01
申请号：PCT/US1998/005235
申请日：1998-03-17
IPC分类号： G02C7/10 , C03C1/10 , C03C4/06 , C03C14/00 , C07D311/92 , C08F24/00 , C08K5/1545 , C08L101/00 , C09K9/02 , G02B5/23 , C07D205/02 , C07D207/02 , C07D223/04 , C07D225/02 , C07D313/18 , C07D333/02 , C07D337/04 , C07D337/16 , C07D409/10
CPC分类号： C08F24/00 , C03C1/10 , C03C4/06 , C03C14/008 , C03C2214/17 , C07D311/92 , C09K9/02
摘要： For subject, the present invention has novel naphthopyran derivatives of formula (I) optionally substituted in position(s) 2, 3, 4, 6, 7, 8, 9 or/and 10; the substituent Z in position 5 being of formula -C(R1)(R2)(OR3). The invention also relates to compositions and (co)polymer matrices containing such derivatives. Said derivatives have interesting photochromic properties.
摘要翻译：对于本发明，本发明具有新的式（I）萘并吡喃衍生物，其任选在位置2,3,4,6,7,8,9或10上取代; 位置5的取代基Z为式-C（R 1）（R 2）（OR 3）。本发明还涉及含有这种衍生物的组合物和（共）聚合物基质。所述衍生物具有有趣的光致变色性质。

10. 发明申请

WO2022109043A1 FORMULATIONS AND METHODS FOR TREATING ACUTE CANNABINOID OVERDOSE 审中-公开
公开(公告)号：WO2022109043A1
公开(公告)日：2022-05-27
申请号：PCT/US2021/059747
申请日：2021-11-17
申请人： ANEBULO PHARMACEUTICALS, INC.
发明人： LAWLER, Joseph Fenton , SCHNEEBERGER, Daniel Pawel
IPC分类号： A61K31/397 , A61P25/30 , A61P43/00 , C07D205/00 , C07D205/02 , C07D205/04
摘要： Described herein are uses of the CB1 inhibitors (e.g., antagonists, neutral antagonists, inverse agonists) and various methods of using and administering a CB1 inhibitor to a patient, especially patients showing symptoms of drug overdose or suspected of a drug overdose. Further described herein are uses wherein the CB1 inhibitor is ANEB-001. Further described herein are treatments with a CB1 inhibitor for THC or synthetic cannabinoid overdose.

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