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11. 发明申请

WO2016134360A1 SHEATH FOR MAINTAINING POSITION IN A PERICARDIAL SPACE 审中-公开
标题翻译：用于维持空间中的位置的空气
公开(公告)号：WO2016134360A1
公开(公告)日：2016-08-25
申请号：PCT/US2016/018907
申请日：2016-02-22
申请人： CHILDREN'S HOSPITAL LOS ANGELES , UNIVERSITY OF SOUTHERN CALIFORNIA
发明人： BAR-COHEN, Yaniv , LOEB, Gerald
IPC分类号： A61F2/04 , A61F2/82 , A61F2/848
CPC分类号： A61M25/0662 , A61B17/3421 , A61B17/3478 , A61B2017/3484 , A61B2017/3488 , A61M25/04 , A61M2205/0266 , A61M2210/122 , A61N1/362 , A61N1/37205
摘要： The present invention provides a novel design for sheaths intended for medical procedures. The sheath includes structures that anchor the sheath in a cavity or space when deployed but are at the same time retractable such that the sheath can be removed without tearing the tissue defining the space.
摘要翻译：本发明提供了用于医疗程序的护套的新型设计。护套包括当展开时将护套固定在空腔中的结构，但同时可缩回，使得可以在不撕裂限定空间的组织的情况下移除护套。

12. 发明申请

WO2013188823A3 CANCER PROGNOSTIC ASSAYS 审中-公开
公开(公告)号：WO2013188823A3
公开(公告)日：2013-12-19
申请号：PCT/US2013/045981
申请日：2013-06-14
申请人： CHILDREN'S HOSPITAL LOS ANGELES
发明人： SEEGER, Robert, C. , ASGHARZADEH, Shahab , LIU, Weiyao , SPOSTO, Richard , JI, Lingyun
IPC分类号： C12Q1/68 , C12P19/34
摘要： The present invention provides for molecular analysis of gene expression of tumors at diagnosis as well as molecular analysis of tumor and normal cell gene expression in bone marrow and blood at diagnosis and during and after completion of treatment. These molecular analyses of gene expression provide an assessment of risk of recurrence and response to therapy of tumors, and in particular, neuroblastoma.

13. 发明申请

WO2013152259A1 MINIMALLY INVASIVE EPICARDIAL PACEMAKER 审中-公开
标题翻译：最小的入侵者
公开(公告)号：WO2013152259A1
公开(公告)日：2013-10-10
申请号：PCT/US2013/035377
申请日：2013-04-05
申请人： CHILDREN'S HOSPITAL LOS ANGELES , UNIVERSITY OF SOUTHERN CALIFORNIA
发明人： BAR-COHEN, Yaniv , LOEB, Gerald , SILKA, Michael , CHMAIT, Ramen
IPC分类号： A61N1/362
CPC分类号： A61N1/0587 , A61N1/059 , A61N1/362 , A61N1/37205 , A61N1/375 , A61N1/3756 , A61N1/3787 , Y10T29/49002
摘要： A fully implantable cardiac pacemaker system is provided. The pacemaker system includes a pacemaker having an electrode sub-assembly containing an electrode and a base into which the electrode is embedded. It also includes an implantable package that has electronic components for providing electrical pulses to a patient's heart. The pacemaker also has a power supply and a flexible electrically conductive lead that connects the electronic components to the electrode. In addition to the pacemaker, the pacemaker system includes a removable insertion casing that is physically attached to the base portion of the electrode sub-assembly. Upon insertion of the pacemaker into a patient's heart, the pacemaker is detached from the removable insertion casing and deployed fully in the patient's chest. The pacemaker system has particular use in fetal applications.
摘要翻译：提供完全可植入的心脏起搏器系统。起搏器系统包括具有电极子组件的起搏器，该电极子组件包含电极和嵌入电极的基座。它还包括具有用于向患者心脏提供电脉冲的电子部件的可植入包装。起搏器还具有将电子部件连接到电极的电源和柔性导电引线。除了起搏器之外，起搏器系统包括物理地附接到电极子组件的基部的可移除插入壳体。将起搏器插入患者心脏后，起搏器与可移除的插入套管分离，并充分部署在病人的胸部。起搏器系统在胎儿应用中特别有用。

14. 发明申请

WO2013059471A1 COMPOSITIONS AND METHODS FOR TREATING LEUKEMIA 审中-公开
标题翻译：用于治疗白血病的组合物和方法
公开(公告)号：WO2013059471A1
公开(公告)日：2013-04-25
申请号：PCT/US2012/060827
申请日：2012-10-18
申请人： CHILDREN'S HOSPITAL LOS ANGELES
发明人： WU, Lingtao
IPC分类号： A61P35/02 , A61K38/16
CPC分类号： C07K14/00 , A61K38/00 , C07K14/47
摘要： Described herein are compositions and methods for the treatment of cancer, and particularly leukemia (e.g., AML, CML, ALL and/or CLL) in a mammal. In various embodiments of the invention, MAT1 fragments (peptides) are used in connection with gene therapeutic techniques or direct peptide injection for the aforementioned indications. Pharmaceutical composition and kits useful in practicing the inventive method are also disclosed.
摘要翻译：本文描述了用于治疗哺乳动物的癌症，特别是白血病（例如AML，CML，ALL和/或CLL）的组合物和方法。在本发明的各种实施方案中，MAT1片段（肽）与上述适应症的基因治疗技术或直接肽注射有关。还公开了可用于实施本发明方法的药物组合物和试剂盒。

15. 发明申请

WO2013025817A1 USE OF NEUREGULIN-4 FOR TREATMENT OF INFLAMMATORY BOWEL DISEASE AND NECROTIZING ENTEROCOLITIS 审中-公开
标题翻译：神经细胞-4用于治疗炎症性皮肤病和消化性溃疡的用途
公开(公告)号：WO2013025817A1
公开(公告)日：2013-02-21
申请号：PCT/US2012/050970
申请日：2012-08-15
申请人： CHILDREN'S HOSPITAL LOS ANGELES , FREY, Mark R.
发明人： FREY, Mark R.
IPC分类号： A61K39/00
CPC分类号： A61K38/1883 , G01N33/573 , G01N2333/71 , G01N2440/14 , G01N2500/10 , G01N2800/065
摘要： The invention provides methods, pharmaceutical compositions and kits for treating, inhibiting and/or reducing the severity of inflammatory bowel disease and necrotizing enterocolitis in a subject in need thereof by administering an effective amount of a composition comprising an activator of ErbB4.
摘要翻译：本发明提供了通过施用有效量的包含ErbB4的活化剂的组合物来治疗，抑制和/或降低有需要的受试者的炎症性肠病和坏死性小肠结肠炎的严重性的方法，药物组合物和试剂盒。

16. 发明申请

WO2012178184A2 REMOVABLE PROTECTIVE SHELL FOR IMAGING AGENTS AND BIOACTIVE SUBSTANCES 审中-公开
标题翻译：用于成像剂和生物物质的可拆卸保护壳
公开(公告)号：WO2012178184A2
公开(公告)日：2012-12-27
申请号：PCT/US2012/044052
申请日：2012-06-25
申请人： CHILDREN'S HOSPITAL LOS ANGELES , UNIVERSITY OF SOUTHERN CALIFORNIA , WILLIAMS, Travis, J. , CHANG, Andy, Y.
发明人： WILLIAMS, Travis, J. , CHANG, Andy, Y.
IPC分类号： A61K9/51
CPC分类号： A61K49/1881 , A61K9/0009 , A61K9/5123
摘要： The invention provides nanoparticles for delivery of imaging agents, drugs, and other molecules, such as genetic material. The nanoparticles have a core structure comprising the imaging agent and/or drug, and a shell structure that allows for water solubility. The shell structure further provides a barrier with limited water permeability that protects the core. The nanoparticles can be induced to release their cargo by treatment with ultrasound. Methods of delivering drugs and imaging agents are also provided, whereby the nanoparticles are delivered to tissues of interest in a substantially inert form, then activated using ultrasound to release the drugs or imaging agents.
摘要翻译：本发明提供用于递送成像剂，药物和其它分子（例如遗传物质）的纳米颗粒。纳米颗粒具有包含成像剂和/或药物的核心结构以及允许水溶性的壳结构。壳体结构进一步提供了保护芯的有限水渗透性的屏障。通过用超声波处理可以诱导纳米颗粒释放其货物。还提供递送药物和成像剂的方法，由此将纳米颗粒以基本上惰性的形式递送至感兴趣的组织，然后使用超声波激活以释放药物或成像剂。

17. 发明申请

WO2005049827A3 PPMP AS A CERAMIDE CATABOLISM INHIBITOR FOR CANCER TREATMENT 审中-公开
公开(公告)号：WO2005049827A3
公开(公告)日：2005-06-02
申请号：PCT/US2004/037175
申请日：2004-11-08
申请人： CHILDREN'S HOSPITAL LOS ANGELES , MAURER, Barry, James , REYNOLDS, Charles, Patrick
发明人： MAURER, Barry, James , REYNOLDS, Charles, Patrick
IPC分类号： C12N15/09
摘要： The present invention relates to a method of treating a hyperproliferative disorder comprising administering a ceramide generating retinoid comprising a retinoic acid derivative or a pharmaceutically acceptable salt thereof, and D-threo-PPMP as a ceramide degradation inhibitor or a pharmaceutically acceptable salt thereof, wherein the hyperproliferative disorder is a tumor; and wherein the ceramide generating retinoid is administered in an amount effective to produce necrosis, apoptosis or both in the tumor, and the ceramide degradation inhibitor is administered in an amount effective to increase the necrosis, apoptosis or both in the tumor over that expected to be produced by the sum of that produced by the ceramide generating retinoid and the ceramide degradation inhibitor when administered separately.

18. 发明申请

WO2004041155A2 TREATMENT AND PREVENTION OF ABNORMAL SCAR FORMATION IN KELOIDS AND OTHER CUTANEOUS OR INTERNAL WOUNDS OR LESIONS 审中-公开
标题翻译：治疗和预防瘢痕疙瘩和其他皮肤或内部伤口或损伤中瘢痕形成的异常
公开(公告)号：WO2004041155A2
公开(公告)日：2004-05-21
申请号：PCT/US2003/015548
申请日：2003-05-13
申请人： CHILDREN'S HOSPITAL LOS ANGELES , TUAN, Tai-Lan , BENYA, Paul, D. , WARBURTON, David
发明人： TUAN, Tai-Lan , BENYA, Paul, D. , WARBURTON, David
IPC分类号： A61K
CPC分类号： A61K31/401 , A61K31/355 , A61K31/495 , A61K31/56 , A61K31/58 , A61K38/005 , A61K2039/505 , C07K16/18
摘要： The present invention relates to findings that reducing the activity of Plasrninogen Activator Inhibitor-1 (PAI-1) suppresses an excessive deposition of collagen which is known as a cause for the formation of abnormal scars. These abnormal scars include but are not limited to keloids, adhesions, hypertrophic scars, skin disfiguring conditions, fibrosis, fibrocystic conditions, contractures, and scleroderma, all of which are associated with or caused by an excessive deposit of collagen in a wound healing process. Accordingly, aspects of the present invention are directed to the reduction of PAI-I activity to decrease an excessive accumulation of collagen, prevent the formation of an abnormal scar, and/or treat abnormal scars that result from an excessive accumulation of collagen. The PAI-1 activity can be reduced by PAI-1 inhibitors which include but are not limited to PAI 1 neutralizing antibodies, diketopiperazine based compounds, tetramic acid based compounds, C, Vitamin E, Mifepristone (RU486), and Spironolactone to name a few. Another aspect of the present invention is directed to methods of measuring PAI-I activity in a wound healing process and determining the propensity of the formation of an abnormal scar.
摘要翻译：本发明涉及降低纤维蛋白原激活剂抑制剂-1（PAI-1）活性的抑制剂，其抑制已知作为形成异常瘢痕的原因的胶原过度沉积。这些异常疤痕包括但不限于瘢痕疙瘩，粘连，肥厚性瘢痕，皮肤损伤状况，纤维化，纤维囊性病症，挛缩和硬皮病，所有这些都与伤口愈合过程中胶原过量沉积有关或由其引起。因此，本发明的方面涉及PAI-1活性的降低以减少胶原的过量累积，防止异常瘢痕的形成和/或治疗由胶原蛋白的过度累积引起的异常瘢痕。 PAI-1活性可通过PAI-1抑制剂降低，所述PAI-1抑制剂包括但不限于PAI1中和抗体，基于二酮哌嗪的化合物，基于特仑特酸的化合物，C，维生素E，米非司酮（RU486）和螺内酯，仅举几例。本发明的另一方面涉及在伤口愈合过程中测量PAI-1活性并确定形成异常瘢痕的倾向的方法。

19. 发明申请

WO2022236187A1 METHODS FOR MAKING STEM CELL-DERIVED ENTERIC NEURAL CREST CELLS AND THEIR USE IN ENTERIC NEUROPATHY TREATMENT 审中-公开
公开(公告)号：WO2022236187A1
公开(公告)日：2022-11-10
申请号：PCT/US2022/028385
申请日：2022-05-09
申请人： CHILDREN'S HOSPITAL LOS ANGELES
发明人： GRIKSCHEIT, Tracy , NUCHO, Laura-Marie
IPC分类号： A61K35/545 , A61K35/30 , A61K35/38 , A61P25/02 , C12N5/0797 , C12N5/071
摘要： Provided herein are compositions and methods to treat enteric neuropathies/or slow gut motility comprising intramuscularly administering enteric neural crest cells (ENCCs) to a intestine of a subject in need thereof, wherein the ENCCs are differentiated from stem cells in vitro.

20. 发明申请

WO2021150715A1 KETOGENIC FASTING-MIMICKING DIET TO IMPROVE KIDNEY FUNCTION 审中-公开
公开(公告)号：WO2021150715A1
公开(公告)日：2021-07-29
申请号：PCT/US2021/014362
申请日：2021-01-21
申请人： UNIVERSITY OF SOUTHERN CALIFORNIA , CHILDREN'S HOSPITAL LOS ANGELES
发明人： LONGO, Valter D. , BUONO, Roberta , PERIN, Laura , VILLANI, Valentina
IPC分类号： A23L33/00
摘要： A dietary composition and method for treating kidney damage and/or disease with a fasting-mimicking diet is provided. The method includes a step of identifying a subject having kidney damage. A low sodium fasting-mimicking diet with a specific dietary composition is administered to the subject for a first time period of 1 to 10 days.

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