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11. 发明申请

WO2007019569A3 AN APPARATUS FOR SURFACE ELECTRICAL STIMULATION AND STABILIZATION TO TREAT DISORDERS OF THE JOINTS 审中-公开
标题翻译：用于表面电刺激和稳定治疗接头疾病的装置
公开(公告)号：WO2007019569A3
公开(公告)日：2007-10-25
申请号：PCT/US2006031243
申请日：2006-08-09
申请人： INT REHABILITATIVE SCI INC , CARROLL WILLIAM J
发明人： CARROLL WILLIAM J
IPC分类号： A61N1/00
CPC分类号： A61N1/0456 , A61N1/0408 , A61N1/0452 , A61N1/0472 , A61N1/0476 , A61N1/0492 , A61N1/36003 , A61N1/36021
摘要： The present invention is an apparatus having a stabilizing device, at least two signal applicators, and a signal generator for surface electrical stimulation and stabilization to treat disorders of the joints.
摘要翻译：本发明是具有稳定装置，至少两个信号施加器和用于表面电刺激和稳定以治疗关节疾病的信号发生器的装置。

12. 发明申请

WO2005111003A1 AMINO-TETRAZOLES ANALOGUES AND METHODS OF USE 审中-公开
标题翻译：氨基四唑类似物和使用方法
公开(公告)号：WO2005111003A1
公开(公告)日：2005-11-24
申请号：PCT/US2005/014641
申请日：2005-04-28
申请人： ABBOTT LABORATORIES , LI, Tongmei , CARROLL, William, A. , PEREZ-MEDRANO, Arturo , FLORJANCIC, Alan, S. , NELSON, Derek, W. , PEDDI, Sridhar , BUNNELLE, Eric, M. , HIRST, Gavin, C. , LI, Biqin
发明人： CARROLL, William, A. , PEREZ-MEDRANO, Arturo , FLORJANCIC, Alan, S. , NELSON, Derek, W. , PEDDI, Sridhar , BUNNELLE, Eric, M. , HIRST, Gavin, C. , LI, Biqin
IPC分类号： C07D257/06
CPC分类号： C07D487/04 , C07D257/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D417/14 , C07D487/08 , C07D491/04 , C07D491/048 , C07D491/08
摘要： A compound having Formula (I) or Formula (II) is disclosed as an P2X 7 antagonist, wherein A, B, C, Y, Y, Z, m, v, R 1 , R 2 , R 3 , R 4 , and R 5 , are as defined in the description. Methods and compositions for treating disease or condition modulated by P2X 7 are also disclosed.
摘要翻译：公开了具有式（I）或式（II）的化合物作为P2X7拮抗剂，其中A，B，C，Y，Y，Z，m，v，R 1，R 2，R 3， R 4和R 5如说明书中所定义。还公开了用于治疗由P2X7调节的疾病或病症的方法和组合物。

13. 发明申请

WO2013169771A2 METHODS AND COMPOSITIONS FOR THE PROGNOSIS AND TREATMENT OF RELAPSED LEUKEMIA 审中-公开
标题翻译：预防和治疗相关性白血病的方法和组合
公开(公告)号：WO2013169771A2
公开(公告)日：2013-11-14
申请号：PCT/US2013/039942
申请日：2013-05-07
申请人： NEW YORK UNIVERSITY , CARROLL, William, L. , MEYER, Julia, A.
发明人： CARROLL, William, L. , MEYER, Julia, A.
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , A61K31/52 , A61K31/573 , A61K31/704 , A61K31/7068 , A61K45/06 , C12Q2600/118 , C12Q2600/156
摘要： The present invention is directed to methods of prognosing relapsed leukemia in a subject. These methods are based on the detection of one or more relapse-specific gene mutations in a patient sample. The present invention further relates to methods of preventing and treating relapse leukemia in a subject based on the determined prognosis of the subject.
摘要翻译：本发明涉及在受试者中预后复发性白血病的方法。这些方法基于检测患者样品中一种或多种复发特异性基因突变。本发明还涉及基于所确定的受试者预后来预防和治疗受试者的复发性白血病的方法。

14. 发明申请

WO2012177377A3 APPARATUS AND METHOD FOR STABILIZING, IMPROVING MOBILITY, AND CONTROLLING CARTILAGE MATRIX DEGRADATION OF WEIGHT-BEARING ARTICULAR JOINTS 审中-公开
标题翻译：装置和方法，用于稳定，改善移动性和控制重量承载接头的卡氏矩阵降级
公开(公告)号：WO2012177377A3
公开(公告)日：2013-02-21
申请号：PCT/US2012040518
申请日：2012-06-01
申请人： MEAGAN MEDICAL INC , CARROLL WILLIAM J
发明人： CARROLL WILLIAM J
IPC分类号： A61N1/18 , A61N1/04 , A61N1/36
CPC分类号： A61N1/36003 , A61N1/0452 , A61N1/0456 , A61N1/0472 , A61N1/0476 , A61N1/326 , A61N1/36014
摘要： An apparatus and method for improving mobility and/or the quality of synovial fluid of an affected articular joint are disclosed, wherein the joint is associated with at least a first muscle group and at least a second muscle group each having an antagonistic relationship for effecting mobility of the joint through a range of motion when recruited by natural neural impulses. The apparatus and method include an electro-medical device configured to apply motor-level electrical stimulation in a multiphasic pattern via at least a first channel and at least a second channel, the multiphasic pattern being programmed into the electro-medical device and corresponding to the sequence of an electromyographic output for the joint; at least two first electrodes connected to the at least first channel of said electro-medical device, the at least two first electrodes being positioned proximate to the at least first muscle group; at least two second electrodes connected to the at least second channel of said electro-medical device, the at least two second electrodes being positioned proximate to the at least second muscle group; and an applicator configured to be worn on the articular segment such that the at least two first electrodes and the at least two second electrodes are disposed between the applicator and the articular segment, the applicator being further configured to reduce compressive forces on at least one compartment of the affected joint.
摘要翻译：公开了一种用于改善受影响的关节关节的滑液的移动性和/或质量的装置和方法，其中所述关节与至少第一肌肉组和至少第二肌肉组相关联，每个具有拮抗关系以影响移动性的关节通过自然神经冲动招募的一系列运动。该装置和方法包括：电医疗装置，被配置为经由至少第一通道和至少第二通道以多相模式施加电动机级电刺激，所述多相模式被编程到所述电疗装置中并且对应于关节肌电图输出顺序; 至少两个第一电极，其连接到所述电 - 医疗装置的所述至少第一通道，所述至少两个第一电极位于所述至少第一肌群附近; 至少两个连接到所述电疗装置的至少第二通道的第二电极，所述至少两个第二电极定位成接近所述至少第二肌群; 以及施用器，其构造成佩戴在所述关节段上，使得所述至少两个第一电极和所述至少两个第二电极设置在所述施用器和所述关节段之间，所述施用器进一步构造成减小至少一个隔室受影响的关节。

15. 发明申请

WO2012177377A4 APPARATUS AND METHOD FOR STABILIZING, IMPROVING MOBILITY, AND CONTROLLING CARTILAGE MATRIX DEGRADATION OF WEIGHT-BEARING ARTICULAR JOINTS 审中-公开
公开(公告)号：WO2012177377A4
公开(公告)日：2012-12-27
申请号：PCT/US2012/040518
申请日：2012-06-01
申请人： MEAGAN MEDICAL, INC. , CARROLL, William J.
发明人： CARROLL, William J.
IPC分类号： A61N1/18 , A61N1/36 , A61N1/04
摘要： An apparatus and method for improving mobility and/or the quality of synovial fluid of an affected articular joint are disclosed, wherein the joint is associated with at least a first muscle group and at least a second muscle group each having an antagonistic relationship for effecting mobility of the joint through a range of motion when recruited by natural neural impulses. The apparatus and method include an electro-medical device configured to apply motor-level electrical stimulation in a multiphasic pattern via at least a first channel and at least a second channel, the multiphasic pattern being programmed into the electro-medical device and corresponding to the sequence of an electromyographic output for the joint; at least two first electrodes connected to the at least first channel of said electro-medical device, the at least two first electrodes being positioned proximate to the at least first muscle group; at least two second electrodes connected to the at least second channel of said electro-medical device, the at least two second electrodes being positioned proximate to the at least second muscle group; and an applicator configured to be worn on the articular segment such that the at least two first electrodes and the at least two second electrodes are disposed between the applicator and the articular segment, the applicator being further configured to reduce compressive forces on at least one compartment of the affected joint.

16. 发明申请

WO2012083164A1 ANTI-VIRAL COMPOUNDS 审中-公开
标题翻译：反虚构化合物
公开(公告)号：WO2012083164A1
公开(公告)日：2012-06-21
申请号：PCT/US2011/065486
申请日：2011-12-16
申请人： ABBOTT LABORATORIES , DEGOEY, David A. , KRUEGER, Allan C. , HUTCHINS, Charles W. , KATI, Warren M. , CARROLL, William A.
发明人： DEGOEY, David A. , KRUEGER, Allan C. , HUTCHINS, Charles W. , KATI, Warren M. , CARROLL, William A.
IPC分类号： C07D403/12 , C07D403/14 , A61K31/4025 , A61K31/4178 , A61K31/4184
CPC分类号： A61K31/55 , A61K31/4025 , A61K31/4178 , A61K31/4184 , A61K31/422 , A61K31/506 , A61K38/00 , A61K45/06 , C07D205/04 , C07D207/16 , C07D207/22 , C07D209/52 , C07D211/60 , C07D263/06 , C07D277/06 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D413/12 , C07D413/14 , C07D417/14 , C07D487/04 , C07K5/06034 , C07K5/06043 , C07K5/0606 , C07K5/06069 , C07K5/06078 , C07K5/06139
摘要： Compounds effective in inhibiting replication of Hepatitis C virus ("HCV") are described. This invention also relates to processes of making such compounds, compositions comprising such compounds, and methods of using such compounds to treat HCV infection.
摘要翻译：描述了有效抑制丙型肝炎病毒（“HCV”）复制的化合物。本发明还涉及制备这种化合物的方法，包含这些化合物的组合物，以及使用这些化合物治疗HCV感染的方法。

17. 发明申请

WO2010138828A3 POTASSIUM CHANNEL MODULATORS 审中-公开
标题翻译：钾通道调节器
公开(公告)号：WO2010138828A3
公开(公告)日：2011-02-17
申请号：PCT/US2010036596
申请日：2010-05-28
申请人： ABBOTT LAB , SCANIO MARC J , BUNNELLE WILLIAM H , CARROLL WILLIAM A , PEDDI SRIDHAR , PEREZ-MEDRANO ARTURO , SHI LEI
发明人： SCANIO MARC J , BUNNELLE WILLIAM H , CARROLL WILLIAM A , PEDDI SRIDHAR , PEREZ-MEDRANO ARTURO , SHI LEI
IPC分类号： C07D239/92 , A61K31/517 , A61K31/519 , A61P25/00 , C07D405/12 , C07D495/04
CPC分类号： C07D239/92 , C07D405/12 , C07D495/04
摘要： Disclosed herein are KCNQ potassium channels modulators of formula (I) wherein ring G1, X, R1, and R2 are as defined in the specification. Compositions comprising such compounds; and methods for treating conditions and disorders using such compounds and compositions are also described.
摘要翻译：本文公开了式（I）的KCNQ钾通道调节剂，其中环G1，X，R1和R2如说明书中所定义。包含这些化合物的组合物; 还描述了使用这些化合物和组合物治疗病症和病症的方法。

18. 发明申请

WO2010028338A2 NOVEL COMPOUNDS AS CANNABINOID RECEPTOR LIGANDS 审中-公开
标题翻译：新型化合物作为CANNABINOID受体配体
公开(公告)号：WO2010028338A2
公开(公告)日：2010-03-11
申请号：PCT/US2009/056179
申请日：2009-09-08
申请人： ABBOTT LABORATORIES , CARROLL, William, A. , DART, Michael, J. , FROST, Jennifer, M. , KOLASA, Teodozyj , LI, Tongmei , LIU, Bo , PEREZ-MEDRANO, Arturo , PATEL, Meena , WANG, Xueqing , PEDDI, Sridhar
发明人： CARROLL, William, A. , DART, Michael, J. , FROST, Jennifer, M. , KOLASA, Teodozyj , LI, Tongmei , LIU, Bo , PEREZ-MEDRANO, Arturo , PATEL, Meena , WANG, Xueqing , PEDDI, Sridhar
IPC分类号： C07D277/46 , C07D417/06 , C07D417/14 , A61K31/427 , A61P29/00
CPC分类号： C07D417/06 , C07D277/46 , C07D417/14
摘要： The present application relates to cannabinoid receptor ligands of formula (I), wherein X 1 , A 1 , R x , R 2 , R 3 , R 4 , and z are as defined in the specification. The present application also relates to compositions comprising such compounds, and methods for treating conditions and disorders using such compounds and compositions.
摘要翻译：本申请涉及式（I）的大麻素受体配体，其中X1，A1，Rx，R2，R3，R4和z如说明书中所定义。本申请还涉及包含这些化合物的组合物，以及使用这些化合物和组合物治疗病症和障碍的方法。

19. 发明申请

WO2008130953A3 2-IMIN0IS0THIAZ0LE DERIVATIVES AS CANNABINOID RECEPTOR LIGANDS 审中-公开
标题翻译：作为CANNABINOID受体配体的2-IMIN0IS0THIAZ0LE衍生物
公开(公告)号：WO2008130953A3
公开(公告)日：2008-12-11
申请号：PCT/US2008060400
申请日：2008-04-16
申请人： ABBOTT LAB , CARROLL WILLIAM A , MEYER MICHAEL D
发明人： CARROLL WILLIAM A , MEYER MICHAEL D
IPC分类号： C07D275/02 , A61K31/425 , A61P9/00 , A61P11/00 , A61P25/00 , A61P29/00 , A61P35/00 , A61P37/00 , C07D275/04 , C07D417/04 , C07D417/06 , C07D417/12 , C07D513/04 , C07D513/10
CPC分类号： A61K31/425 , A61K31/427 , A61K31/429 , A61K31/4436 , A61K31/4725 , A61K31/5377 , C07D275/02 , C07D275/04 , C07D417/04 , C07D417/06 , C07D417/12 , C07D513/04 , C07D513/10 , Y02P20/582
摘要： The present application relates to isothiazolylidene containing compounds of Formula (I) wherein R1, R2, R3, R4, and L are as defined in the specification, compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.
摘要翻译：本申请涉及含有异噻唑基的式（I）化合物，其中R 1，R 2，R 3，R 4和L如说明书中所定义，包含这些化合物的组合物，以及使用这些化合物和组合物治疗病症和障碍的方法。

20. 发明申请

WO2008121558A1 1, 3-THIAZOL-2 (3H) -YLIDENE COMPOUNDS AS CANNABINOID RECEPTOR LIGANDS 审中-公开
标题翻译： 1,3-THIAZOL-2（3H）-YLIDENE化合物作为CANNABINOID受体配体
公开(公告)号：WO2008121558A1
公开(公告)日：2008-10-09
申请号：PCT/US2008/057460
申请日：2008-03-19
申请人： ABBOTT LABORATORIES , CARROLL, William A , KOLASA, Teodozyi , FROST, Jennifer M , DART, Michael J , PATEL, Meena V , LATSHAW, Steven P , PEREZ-MEDRANO, Arturo , WANG, Xueqing , PEDDI, Sridhar
发明人： CARROLL, William A , KOLASA, Teodozyi , FROST, Jennifer M , DART, Michael J , PATEL, Meena V , LATSHAW, Steven P , PEREZ-MEDRANO, Arturo , WANG, Xueqing , PEDDI, Sridhar
IPC分类号： C07D277/46 , A61K31/426 , A61K31/427 , A61K31/429 , C07D417/06 , C07D417/12 , C07D513/04
CPC分类号： C07D277/46 , C07D417/06 , C07D417/12 , C07D513/04 , Y02P20/582
摘要： The present application relates to thiazolylidene containing compounds of formula (I) wherein R1, R2, R3, R4, L2 and A are as defined in the specification. Compositions comprising such compounds, and methods for treating conditions and disorders using such compounds and compositions are also disclosed.
摘要翻译：本申请涉及含有噻唑类的式（I）化合物，其中R 1，R 2，R 3，R 4，L 2和A如说明书中所定义。还公开了包含这些化合物的组合物，以及使用这些化合物和组合物治疗病症和障碍的方法。

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