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121. 发明申请

WO2004019032A1 BIOEQUIVALENCE TEST FOR IRON-CONTAINING FORMULATIONS 审中-公开
标题翻译：含铁制剂的生物等效试验
公开(公告)号：WO2004019032A1
公开(公告)日：2004-03-04
申请号：PCT/US2002/026989
申请日：2002-08-26
申请人： LUITPOLD PHARMACEUTICALS, INC. , HELENEK, Mary, Jane , LANGE, Ralph, A. , LAWRENCE, Richard, P.
发明人： HELENEK, Mary, Jane , LANGE, Ralph, A. , LAWRENCE, Richard, P.
IPC分类号： G01N33/20
CPC分类号： A61K31/295 , G01N31/22 , G01N33/84 , Y10T436/142222 , Y10T436/143333
摘要： A rapid method for assessing the bioequivalence of iron in iron-supplement formulations, particularly iron-sucrose formulations is described, which is based upon the kinetics of reduction of iron (III) to iron (II) in a sample of the formulation. Quality control methods and associated kits also are described.
摘要翻译：描述了一种用于评估铁补充制剂，特别是铁 - 蔗糖制剂中铁的生物等效性的快速方法，其基于在制剂样品中还原铁（III）至铁（II）的动力学。还描述了质量控制方法和相关工具包。

122. 发明申请

WO2004018447A1 キラルセンサー审中-公开
标题翻译： CHIRAL SENSOR
公开(公告)号：WO2004018447A1
公开(公告)日：2004-03-04
申请号：PCT/JP2003/007313
申请日：2003-06-10
申请人：科学技術振興事業団 , 戸部義人 , 廣瀬敬治
发明人：戸部義人 , 廣瀬敬治
IPC分类号： C07D323/00
CPC分类号： G01N21/6428 , C07D323/00 , G01N31/22 , Y10T436/142222
摘要：不飽和結合を有する光学活性結合部位の該不飽和結合と蛍光性置換基または蛍光性を付与する置換基とが共役するように結合してなる光学活性化合物、および前記光学活性化合物からなるキラルセンサー。該キラルセンサーは、特定のキラル化合物を高感度かつ高選択的に認識することができる。
摘要翻译：在光学活性组合位置具有不饱和键的光学活性化合物，其中不饱和键和荧光取代基或能够赋予荧光的取代基结合在共轭状态; 和由该化合物组成的手性传感器。手性传感器可以高灵敏度和高选择性地识别特异性手性化合物。

123. 发明申请

WO2003085422A2 SINGLE PASS ATTENUATED TOTAL REFLECTION FOURIER TRANSFORM INFRARED MICROSCOPY APPARATUS AND METHOD FOR IDENTIFYING PROTEIN SECONDARY STRUCTURE, SURFACE CHARGE AND BINDING AFFINITY 审中-公开
标题翻译：单通道衰减的全反射傅立叶变换红外显微镜装置和识别蛋白质二级结构，表面电荷和结合亲和力的方法
公开(公告)号：WO2003085422A2
公开(公告)日：2003-10-16
申请号：PCT/US2002/028039
申请日：2002-09-04
申请人： NORTH CAROLINA STATE UNIVERSITY , FRANZEN, Stefan , LAPPI, Simon, E.
发明人： FRANZEN, Stefan , LAPPI, Simon, E.
IPC分类号： G02B
CPC分类号： G01N21/552 , G01N2021/3595 , Y10T436/14 , Y10T436/141111 , Y10T436/142222 , Y10T436/143333 , Y10T436/144444 , Y10T436/145555 , Y10T436/146666 , Y10T436/147777 , Y10T436/148888
摘要： Apparatus and method for acquiring an infrared spectrum of a sample having or suspected to have an amide I band, an amide II band, an amide III band, an amide A band, an OH stretching region or a combination thereof. A representative method includes providing a sample; providing an internal reflecting element (IRE) with a functionalized tip; contacting the sample with the IRE to form a sample-IRE interface; directing a beam of infrared (IR) radiation through the IRE under conditions such that the IR radiation interacts with the sample-IRE interface once; recording a reflectance profile over a range of preselected frequencies, whereby an infrared spectrum of the of a sample having or suspected of having an amide I band, an amide II band, an amide III band, an amide A band, an OH stretching region or a combination thereof, disposed in an aqueous solution is acquired. Representative apparatus includes an internal reflecting element (IRE) comprising a reflection face located on the IRE at a region of intended contact between the IRE and a solublized sample; an infrared radiation source for supplying an evanescent wave of infrared radiation and directing the same from the outside of the IRE to the inside thereof so as to cause the infrared radiation to be incident on the reflection face, wherein the infrared radiation is reflected from the reflection face once; a sample cell; a functionalized tip comprising a surface-immobilized probe that partially or completely fills the volume exposed to the evanescent wave; and a detector for detecting the once-reflected infrared radiation.
摘要翻译：用于获取具有或怀疑具有酰胺I带，酰胺II带，酰胺III带，酰胺A带，OH拉伸区域或其组合的样品的红外光谱的装置和方法。代表性的方法包括提供样品; 提供具有功能化尖端的内部反射元件（IRE）将样品与IRE接触以形成样品IRE界面; 在IRIR辐射与样品IRE界面相互作用的条件下，将红外线（IR）光束引导通过IRE; 在预选频率的范围内记录反射率分布，由此具有或怀疑具有酰胺I带，酰胺II带，酰胺III带，酰胺A带，OH拉伸区域的样品的红外光谱或获得其配置在水溶液中的组合。代表性装置包括内部反射元件（IRE），其包括反射面，所述反射面位于所述IRE上的所述IRE与所述被溶解的样品之间预期接触的区域上; 红外辐射源，用于提供红外线的ev逝波，并将其从IRE的外部引导到其内部，以使红外辐射入射到反射面上，其中红外辐射从反射反射面对一次; 样品池; 功能化尖端，其包括部分或完全填充暴露于ev逝波的体积的表面固定的探针; 以及用于检测一次反射的红外辐射的检测器。

124. 发明申请

WO2003081236A2 METHOD AND DEVICE FOR PREDICTING CARDIOVASCULAR EVENTS 审中-公开
标题翻译：用于预测心血管事件的方法和装置
公开(公告)号：WO2003081236A2
公开(公告)日：2003-10-02
申请号：PCT/CA2003/000422
申请日：2003-03-24
申请人： MCMASTER UNIVERSITY , YUSUF, Salim , HIRSH, Jack , EIKELBOOM, John
发明人： YUSUF, Salim , HIRSH, Jack , EIKELBOOM, John
IPC分类号： G01N33/50
CPC分类号： G01N33/54386 , G01N33/54366 , G01N33/6893 , G01N33/70 , G01N33/86 , G01N33/88 , G01N2800/32 , Y10S435/803 , Y10S435/967 , Y10S435/97 , Y10S436/804 , Y10S436/807 , Y10S436/808 , Y10S436/81 , Y10S436/811 , Y10S436/815 , Y10T436/10 , Y10T436/142222 , Y10T436/147777 , Y10T436/201666 , Y10T436/203332
摘要： A novel method for assessing the risk of cardiovascular event is provided. The concentration of 11-dehydro thromboxane in a urine sample is measured and compared to a set of standardized quartile concentrations. A concentration of urinary 11-dehydro thromboxane that falls within the fourth quartile is indicative of a greatly increased risk of a recurrent cardiovascular event.
摘要翻译：提供了一种评估心血管事件风险的新方法。测量尿液样品中11-脱氢血栓素的浓度并与一组标准化四分位数浓度进行比较。排在第四四分位数内的尿11-脱氢血栓素的浓度表明复发性心血管事件的风险大大增加。

125. 发明申请

WO03061563A2 METHOD OF PREPARING DELTA-9 TETRAHYDROCANNABINOL 审中-公开
标题翻译：制备DELTA-9四氢胞嘧啶的方法
公开(公告)号：WO03061563A2
公开(公告)日：2003-07-31
申请号：PCT/US0237488
申请日：2002-11-22
申请人： UNIV MISSISSIPPI MEDICAL CT
发明人： ELSOHLY MAHMOUD A , ROSS SAMIR A
IPC分类号： G01N1/22 , A61K36/18 , A61P1/08 , A61P1/14 , A61P25/04 , A61P25/06 , A61P25/08 , A61P25/22 , A61P27/06 , C07D311/78 , C07D311/80 , C07D311/94 , G01N20060101 , G01N1/18 , G01N1/28 , G01N1/40 , G01N30/00 , G01N30/02 , G01N30/12 , G01N30/34 , G01N30/88 , G01N33/15 , A61K
CPC分类号： B01D15/265 , B01D15/426 , B01J20/284 , C07D311/80 , G01N30/02 , G01N2001/4027 , G01N2001/4033 , G01N2030/009 , G01N2030/126 , Y10S436/901 , Y10T436/142222 , Y10T436/25375 , Y10T436/255 , B01D15/325
摘要： A method for the isolation of delta-9-tetrahydrocannibinol (THC) from Cannabis plant material, wherein delta-9-THC Acid and THC are separately obtained comprising the steps of extracting the Cannabis plant material, chelating delta-9-THC acid on alumina solid support from cannabis extracts rich in the acid washing of non-acid washing of non-acid components of the extract with organic solvents and eluting of the delta-9-THC acid with strong polar solvents. MThe method also includes a process by which to increase the THC content and decrease the weight of Cannabis extracts or residue from distillation of Cannabis extracts containing a low concentration of THC, comprising treatment of such materials with watermissible organic solvents followed by filtration and evaporation of the solvent to obtain the concentrated residue.
摘要翻译：从大麻植物材料中分离δ-9-四氢甘氨酸酚（THC）的方法，其中分别获得δ-9-THC酸和THC，其包括以下步骤：提取大麻植物材料，在氧化铝上螯合δ-9-THC酸大麻提取物的固体支持物，用有机溶剂非酸洗涤非酸组分的酸洗涤酸洗，并用强极性溶剂洗脱δ-9-THC酸。 MThe方法还包括一个方法，通过该方法增加THC含量并降低大麻提取物或残留物从含有低浓度THC的大麻提取物的蒸馏中的重量，包括用可用的有机溶剂处理这些物质，然后过滤和蒸发溶剂，得到浓缩残留物。

126. 发明申请

WO02081076A3 A COMBINATORIAL CHEMISTRY REACTOR SYSTEM 审中-公开
标题翻译：组合化学反应器系统
公开(公告)号：WO02081076A3
公开(公告)日：2003-04-24
申请号：PCT/US0210935
申请日：2002-04-04
申请人： SYMYX TECHNOLOGIES INC
发明人： WHEELER TONY H , VAN ERDEN LYNN , CHANDLER WILLIAM H JR , TIEDE RICHARD , SAXTON ROBERT J , GURAM ANIL
IPC分类号： B01J19/00 , C40B60/14 , F28F27/00
CPC分类号： F28F27/00 , B01J19/0046 , B01J2219/00155 , B01J2219/00283 , B01J2219/00308 , B01J2219/00351 , B01J2219/00477 , B01J2219/00481 , B01J2219/00495 , B01J2219/00585 , B01J2219/0059 , B01J2219/00698 , B01J2219/00718 , C40B60/14 , Y10T436/11 , Y10T436/142222
摘要： A combinatorial chemistry reactor system for the parallel processing of reaction mixtures. The system comprises a frame, a head mounted in fixed position on the frame, and a reactor block having a plurality of wells therein for containing reaction mixtures. The reactor block is movable with respect to the head between a first position in which the reactor block and head are assembled for conducting reactions in the wells and a second position in which the reactor block is removed from the head for providing access to the vessels. Gaps in the reactor block between the wells serve to thermally isolate the wells from one another. Other features relating to pressure relief, reactor block temperature control, and sensor mounting are also disclosed.
摘要翻译：用于并行处理反应混合物的组合化学反应器系统。该系统包括框架，安装在框架上的固定位置的头部和反应器块，其中具有用于容纳反应混合物的多个孔。反应器模块可相对于头部在第一位置和第二位置之间相对于第一位置移动，在第一位置，反应器块和头组装在其中以在井中进行反应，而在第二位置，反应器块从头部移除以提供对容器的通路。两个井之间的反应器块中的间隙用于将孔彼此热隔离。还公开了与减压，反应堆块温度控制和传感器安装相关的其它特征。

127. 发明申请

WO2002088674A2 ADSORPTIVE METHOD FOR DETERMINING A SURFACE PROPERTY OF A SOLID 审中-公开
标题翻译：用于确定固体表面性质的吸附方法
公开(公告)号：WO2002088674A2
公开(公告)日：2002-11-07
申请号：PCT/US2002/013054
申请日：2002-04-23
申请人： UOP LLC , SWENSON, Lasalle, R. , BRANDVOLD, Timothy, A. , MCCALL, Michael, J. , WILLIS, Richard, R.
发明人： SWENSON, Lasalle, R. , BRANDVOLD, Timothy, A. , MCCALL, Michael, J. , WILLIS, Richard, R.
IPC分类号： G01N15/08
CPC分类号： G01N15/088 , G01N15/0806 , G01N2015/0813 , G01N2015/0833 , Y10T436/142222
摘要： A method of determining a surface property of solids in a plurality by contacting the solids with a fluid, measuring the radiation emitted, absorbed, or altered during adsorption of the fluid using a detector, and then determining at least one surface property of the solids from the radiation measurements has been invented. The invention is particularly useful in combinatorial applications in order to evaluate a plurality of solids or mixtures of solids to determine at least one surface property of each of the solids.
摘要翻译：通过使固体与流体接触来测定多个固体的表面性质，例如孔隙率，孔径，孔密度，孔体积，孔形状，吸附，解吸，吸附，吸附，吸附，吸附，吸附，吸附，吸附，吸收，或者在使用检测器吸附流体时改变，然后确定来自辐射测量的固体的至少一个表面性质已被发明。本发明在组合应用中特别有用，以评估多种固体或固体混合物，以确定每种固体的至少一种表面性质，并将每种固体依次暴露于不同的吸附物。

128. 发明申请

WO00031531A1 MONITORING PATIENT COMPLIANCE AND BIOAVAILABILITY OF DRUGS BY DEPROTEINIZING BODY FLUIDS 审中-公开
标题翻译：通过清洗体液监测患者的药物合格性和生物利用度
公开(公告)号：WO00031531A1
公开(公告)日：2000-06-02
申请号：PCT/BR1999/000096
申请日：1999-11-23
IPC分类号： G01N33/94 , G01N33/487 , G01N33/50 , G01N33/539 , G01N33/573
CPC分类号： G01N33/9446 , G01N33/94 , Y10T436/141111 , Y10T436/142222 , Y10T436/145555 , Y10T436/147777 , Y10T436/25125 , Y10T436/25375
摘要： The present invention is a method for drug level detection by using a simplified and effective deproteinizing step from body fluids, such as plasma, blood, urine, saliva, tear fluid, followed by drug extraction and measurement using an accurate technique, such as a colorimetric assay or a High-Performance Liquid Chromatography method. In a particular embodiment, the invention is directed to a method to quantify rifampicin in order to monitor its levels in body fluids and also to a Kit for rifampicin concentration measurement.
摘要翻译：本发明是通过使用诸如血浆，血液，尿液，唾液，泪液等体液的简单有效的脱蛋白步骤进行药物水平检测的方法，然后使用精确的技术进行药物提取和测量，例如比色测定或高效液相色谱法。在一个具体实施方案中，本发明涉及量化利福平以便监测其体液中的水平以及用于利福平浓度测定的试剂盒的方法。

129. 发明申请

WO98031829A1 METHODS AND REAGENTS FOR QUANTITATIVELY DETERMINING ASCORBIC ACID 审中-公开
标题翻译：定量测定抗坏血酸的方法和试剂
公开(公告)号：WO98031829A1
公开(公告)日：1998-07-23
申请号：PCT/JP1998/000196
申请日：1998-01-20
IPC分类号： C12Q1/26 , C12Q1/28 , G01N33/82
CPC分类号： C12Q1/28 , C12Q1/26 , C12Q2326/00 , G01N33/82 , Y10T436/142222
摘要： A method for determining ascorbic acid by quantitatively determining ascorbic acid in a sample by using an ascorbate oxidase (hereinafter referred to as "ASOD") capable of catalyzing a reaction of ascorbic acid of reduced form with oxygen to produce ascorbic acid of oxidized form and hydrogen peroxide, characterized by simultaneously conducting a reaction of ascorbic acid of reduced form with oxygen to produce ascorbic acid of oxidized form and hydrogen peroxide and a reaction of the resultant hydrogen peroxide with a chromogen in the presence of a peroxidase to produce a dye in the same reaction system in an aqueous medium in the presence of ASOD and the formed dye quantitatively determining. A method for quantitatively determining total ascorbic acid by adding a reducing agent capable of reducing ascorbic acid of oxidized form to ascorbic acid of reduced form to the above aqueous medium to conduct an enzymatic reaction, whereby total ascorbic acid present in a low concentration can be quantitatively determined. Another method for quantitatively determining total ascorbic acid by reducing ascorbic acid of oxidized form in the sample with a reducing agent capable of reducing ascorbic acid of oxidized form to ascorbic acid of reduced form and conducting an enzymatic reaction in the presence of a compound capable of depriving the reducing agent of the reducing power. A reagent for quantitatively determining ascorbic acid and a kit for quantitatively determining ascorbic acid used for the above quantitative determination methods. The above methods can be applied also to the screening for a clinical test, can simultaneously determine a plurality of analytes, and are simple.
摘要翻译：通过使用能够用还原形式的抗坏血酸与氧反应产生氧化形式和氢的抗坏血酸的抗坏血酸氧化酶（以下称为“ASOD”）定量测定样品中的抗坏血酸来测定抗坏血酸的方法过氧化物，其特征在于同时进行还原形式的抗坏血酸与氧的反应以产生氧化形式的抗坏血酸和过氧化氢，并且在过氧化物酶的存在下使所得过氧化氢与色原反应产生相同的染料反应体系在水性介质中存在的ASOD和形成的染料定量测定。通过将能够将还原形式的抗坏血酸还原形式的还原剂还原成还原剂的还原剂添加到上述水性介质中以进行酶反应来定量测定总抗坏血酸的方法，从而可以定量地存在低浓度的总抗坏血酸决心。另一种通过用能够将还原形式的抗坏血酸还原形式的抗坏血酸还原形式的还原性还原剂进行酶反应的方法，通过将样品中的氧化形式的抗坏血酸还原为氧化形式的抗坏血酸来定量测定总的抗坏血酸的方法，还原剂的还原剂。用于定量测定抗坏血酸的试剂和用于定量测定用于上述定量测定方法的抗坏血酸的试剂盒。上述方法也可以应用于筛选临床试验，可以同时测定多种分析物，而且简单。

130. 发明申请

WO1995033993A1 THE USE OF SIALIC ACID DETERMINATION FOR DETERMINING ALCOHOL CONSUMPTION 审中-公开
标题翻译：用于确定酒精消费的酸度测定法的使用
公开(公告)号：WO1995033993A1
公开(公告)日：1995-12-14
申请号：PCT/SE1995000672
申请日：1995-06-07
申请人： PHARMACIA AB , SILLANAUKEE, Pekka , SEPPÄ, Kaija , MÅRTENSSON, Ola
发明人： PHARMACIA AB
IPC分类号： G01N33/50
CPC分类号： C12Q1/34 , G01N33/98 , G01N2800/307 , Y10T436/142222 , Y10T436/143333 , Y10T436/145555 , Y10T436/201666 , Y10T436/203332 , Y10T436/204165
摘要： A method for the determination of an individual's alcohol consumption, characterized in comprising the steps: i) determining the level of sialic acid in a body fluid sample from the individual; ii) comparing the level found in step (i) with the level for the normal population, an increased level being an indication of an increased alcohol consumption relative to the consumption (per individual) of the normal population.
摘要翻译：一种用于测定个体饮酒量的方法，其特征在于包括以下步骤：i）确定来自个体的体液样品中唾液酸的含量; ii）将步骤（i）中发现的水平与正常人口的水平进行比较，增加的水平是相对于正常人群的消费（每个人）增加的饮酒量的指示。

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