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121. 发明申请

WO00071202A1 SYSTEM PROVIDING VENTRICULAR PACING AND BIVENTRICULAR COORDINATION 审中-公开
标题翻译：提供静脉瓣和双侧协调的系统
公开(公告)号：WO00071202A1
公开(公告)日：2000-11-30
申请号：PCT/US2000/013877
申请日：2000-05-19
IPC分类号： A61N1/362 , A61N1/368 , A61N1/39
CPC分类号： A61N1/3621 , A61N1/3627 , A61N1/3682 , A61N1/395 , A61N1/3962 , A61N1/3987
摘要： A cardiac rhythm management system includes techniques for computing an indicated pacing interval, AV delay, or other timing interval. In one embodiment, a variable indicated pacing interval is computed based at least in part on an underlying intrinsic heart rate. The indicated pacing interval is used to time the delivery of biventricular coordination therapy even when ventricular heart rates are irregular, such as in the presence of atrial fibrillation. In another embodiment, a variable filter indicated AV interval is computed based at least in part on an underlying intrinsic AV interval. The indicated AV interval is used to time the delivery of atrial tracking biventricular coordination therapy when atrial heart rhythms are not arrhythmic. Other indicated timing intervals may be similarly determined. The indicated pacing interval, AV delay, or other timing interval can also be used in combination with a sensor indicated rate indicator.
摘要翻译：心律管理系统包括用于计算指示的起搏间隔，AV延迟或其它定时间隔的技术。在一个实施例中，至少部分地基于潜在的内在心率来计算变量指示的起搏间隔。即使在室性心率不规则的情况下，例如在心房纤维性颤动的存在下，指示的起搏间隔也用于给双心室协调治疗的时间。在另一个实施例中，至少部分地基于潜在的固有AV间隔来计算指示AV间隔的可变滤波器。指示的AV间隔用于在心房心律不是心律不齐的时候交付心房跟踪双心室协调治疗。可以类似地确定其他指示的定时间隔。指示的起搏间隔，AV延迟或其他定时间隔也可以与传感器指示的速率指示器组合使用。

122. 发明申请

WO00057955A1 METHOD AND APPARATUS FOR ELECTRICALLY FORCING CARDIAC OUTPUT IN AN ARRHYTHMIA PATIENT 审中-公开
标题翻译：用于电力强迫心律失常患者的心脏输出的方法和装置
公开(公告)号：WO00057955A1
公开(公告)日：2000-10-05
申请号：PCT/US2000/007957
申请日：2000-03-24
IPC分类号： A61N1/362 , A61N1/39 , A61N1/368
CPC分类号： A61N1/3625 , A61N1/3622 , A61N1/3918 , A61N1/395 , A61N1/3962
摘要： An electrical method and apparatus for stimulating cardiac cells causing contraction to force hemodynamic output during fibrillation, hemodynamically compromising tachycardia, or asystole. Forcing fields are applied to the heart to give cardiac output on an emergency basis until the arrhythmia ceases or other intervention takes place. The device is used as a stand alone external or internal device, or as a backup to an ICD, atrial defibrillator, or an anti-tachycardia pacemaker. The method and apparatus maintain some cardiac output and not necessarily defibrillation.
摘要翻译：用于刺激引起收缩的心脏细胞以促进原纤维化期间的血流动力学输出，血流动力学上抵消心动过速或心搏停止的电气方法和装置。强迫场应用于心脏以在紧急情况下产生心输出量，直到心律失常停止或其他干预发生。该设备用作独立的外部或内部设备，或作为ICD，心房除颤器或抗心动过速起搏器的备用。该方法和装置维持一些心输出量，而不一定除颤。

123. 发明申请

WO0001299A8 SYSTEM AND METHOD FOR DETECTING ATRIAL EVENTS OF A HEART 审中-公开
标题翻译：用于检测心脏事件的系统和方法
公开(公告)号：WO0001299A8
公开(公告)日：2000-04-27
申请号：PCT/US9908108
申请日：1999-04-14
申请人： CARDIAC PACEMAKERS INC
发明人： KIM JAEHO , BOCEK JOSEPH M
IPC分类号： A61B5/0452 , A61B5/0402 , A61B5/046 , A61N1/39
CPC分类号： A61B5/046 , A61B5/7239 , A61N1/395 , A61N1/3956
摘要： A continuous monitoring system monitors atrial activity of a heart, and activates an atrial fibrillation detector when atrial fibrillation is suspected. The system includes an A wave detector (53, 55) for detecting A waves of the heart. The A wave detector has a first threshold, and a selected second threshold higher than the first threshold. An R wave detector (52) for detecting R waves of the heart is coupled to the A wave detector for selecting the second threshold of the A wave detector during each detected R wave of the heart. An atrial cycle length determining stage (64) determines atrial cycle length, and a comparator activates atrial fibrillation detection when an atrial cycle length is shorter than a predetermined cycle length.
摘要翻译：持续的监测系统监测心脏的心房活动，并且在怀疑心房颤动时激活心房颤动检测器。该系统包括用于检测心脏的A波的A波检测器（53,55）。 A波检测器具有高于第一阈值的第一阈值和选定的第二阈值。用于检测心脏R波的R波检测器（52）耦合到A波检测器，用于在心脏的每个检测到的R波期间选择A波检测器的第二阈值。心房周期长度确定阶段（64）确定心房周期长度，并且当心房周期长度短于预定周期长度时，比较器激活心房颤动检测。

124. 发明申请

WO2000013748A1 A METHOD AND APPARATUS FOR PREVENTING CLOTTING DURING ATRIAL FIBRILLATION 审中-公开
标题翻译：一种用于在ATRIAL FIBRILLATION期间防止衣服的方法和装置
公开(公告)号：WO2000013748A1
公开(公告)日：2000-03-16
申请号：PCT/US1999/020589
申请日：1999-09-08
申请人： GALVANI, LTD.
发明人： KROLL, Kai
IPC分类号： A61N1/39
CPC分类号： A61N1/3925 , A61N1/395 , A61N1/3956
摘要： The present invention is a device for preventing clotting during atrial fibrillation. The device of the present invention includes optional electrical cardiac output forcing (ECOF) or ICD/AED back-up. The device includes a power supply (40) for operating the device, and for providing the necessary output forcing signals. The power supply is located in a housing which may be implanted into a human patient. In one embodiment of the invention, the housing acts as an electrode. At least one additional electrode is connected to the housing, and may be inserted into the human heart. A ventricular lead (18) is mounted to the electrode along with an atrial lead (14). The housing also contains an electrical cardiac stimulator (34). When a certain cardiac event, such as atrial fibrillation, is detected, anti-clotting pulses are applied to the heart via the atrial lead. If, and when ventricular fibrillation is detected, further pulses of a different voltage level are applied to the heart via the ventricular lead. In one embodiment of the invention, the anti-clotting pulses are synchronized to the R-wave sensed by the ventricular lead.
摘要翻译：本发明是一种用于在心房颤动期间预防凝血的装置。本发明的装置包括可选的电心脏输出强迫（ECOF）或ICD / AED备用。该装置包括用于操作该装置的电源（40），并提供必要的输出强制信号。电源位于可以植入人类患者的外壳中。在本发明的一个实施例中，壳体充当电极。至少一个附加电极连接到壳体，并且可以插入到人的心脏中。心室引线（18）与心房引线（14）一起安装到电极上。壳体还包含电心脏刺激器（34）。当检测到某种心脏事件（例如心房颤动）时，通过心房引线将抗凝血脉冲施加到心脏。如果并且当检测到心室颤动时，通过心室引线将不同电压水平的另外的脉冲施加到心脏。在本发明的一个实施方案中，抗凝血脉冲与由心室导线感测到的R波同步。

125. 发明申请

WO00001299A1 SYSTEM AND METHOD FOR DETECTING ATRIAL EVENTS OF A HEART 审中-公开
标题翻译：用于检测心脏的耳部意外的系统和方法
公开(公告)号：WO00001299A1
公开(公告)日：2000-01-13
申请号：PCT/US1999/008108
申请日：1999-04-14
IPC分类号： A61B5/0452 , A61B5/0402 , A61B5/046 , A61N1/39
CPC分类号： A61B5/046 , A61B5/7239 , A61N1/395 , A61N1/3956
摘要： A continuous monitoring system monitors atrial activity of a heart, and activates an atrial fibrillation detector when atrial fibrillation is suspected. The system includes an A wave detector (53, 55) for detecting A waves of the heart. The A wave detector has a first threshold, and a selected second threshold higher than the first threshold. An R wave detector (52) for detecting R waves of the heart is coupled to the A wave detector for selecting the second threshold of the A wave detector during each detected R wave of the heart. An atrial cycle length determining stage (64) determines atrial cycle length, and a comparator activates atrial fibrillation detection when an atrial cycle length is shorter than a predetermined cycle length.
摘要翻译：本发明涉及一种连续监测系统，用于在发生事故风险的情况下监测心脏的心房活动和操作心房颤动检测器。该系统包括用于感测核A波并具有大于第一阈值的第一阈值和第二选择阈值的A波检测器（53,55）。用于检测心脏的R波的R波检测器（52）连接到波检测器A，用于为检测到的心脏的每个R波选择波检测器A的第二阈值。确定心房周期长度（64）的步骤确定心房周期的长度，并且当心房周期长度小于预定周期长度时，比较装置启动对心房纤颤的检测。

126. 发明申请

WO99052592A1 ATRIAL DEFIBRILLATION SYSTEM INCLUDING A PORTABLE AUDIBLE SPEECH COMMUNICATION DEVICE 审中-公开
标题翻译：包括便携式可听话音通信设备的ATRIAL定位系统
公开(公告)号：WO99052592A1
公开(公告)日：1999-10-21
申请号：PCT/US1999/003063
申请日：1999-02-12
IPC分类号： A61N1/39
CPC分类号： A61N1/3925 , A61N1/395
摘要： An atrial defibrillation system (10) monitors activity of a heart, detects atrial fibrillation, and cardioverst detected atrial fibrillation. The system includes an implantable atrial defibrillator (30) including a plurality of operating stages for monitoring heart activity, detecting atrial fibrillation, cardioverting atrial fibrillation, a message generator (69) for generating messages indicative of operating stage operation status, and a transmitter (103) to transmit the messages indicative of operating stage operating status. A nonimplantable communication device (110) is dimensioned to be hand-held and includes a receiver for receiving the transmitted messages indicative of operating stage operation status, an addressable memory for storing a plurality of voice signals, a decoder responsive to received messages indicative of operating stage operation status for addressing selected ones of the stored voice signals, and a converter for converting the selected voice signals to audible sounds.
摘要翻译：心房除颤系统（10）监测心脏的活动，检测心房颤动和心脏复律检测的心房颤动。该系统包括可植入心房除颤器（30），其包括用于监测心脏活动的多个操作阶段，检测心房颤动，心律转复心房颤动，用于产生指示操作阶段操作状态的消息的消息发生器（69））来发送指示操作阶段操作状态的消息。不可植入通信设备（110）的尺寸被设计为手持式的，并且包括用于接收指示操作级操作状态的发送消息的接收器，用于存储多个语音信号的可寻址存储器，响应于接收到的表示操作的消息的解码器用于寻址存储的语音信号中所选择的语音信号的阶段操作状态，以及用于将所选择的语音信号转换成可听见的声音的转换器。

127. 发明申请

WO99027994A1 AN IMPLANTABLE ATRIAL DEFIBRILLATOR HAVING THERAPY INHIBITION RESPONSIVE TO ATRIAL CYCLE LENGTH 审中-公开
标题翻译：具有针对ATRIAL循环长度的治疗抑制作用的可植入式ATRIAL DEFRIRILLATOR
公开(公告)号：WO99027994A1
公开(公告)日：1999-06-10
申请号：PCT/US1998/025609
申请日：1998-12-03
IPC分类号： A61N1/39
CPC分类号： A61N1/3956 , A61N1/395
摘要： There is disclosed an atrial defibrillator (30) including a lead system (34, 36) for sensing activity of a heart in or near at least an atrium of the heart, a detector (58) for detecting atrial events from the sensed atrial activity, and a cardioverter (77) for applying cardioverting electrical energy to the atria of the heart when the atria is in need of cardioversion. A timer (76) determines time spans between successive detected atrial events, and an inhibit stage precludes the cardioverter from applying cardioverting energy to the heart when a time span is greater than a predetermined limit.
摘要翻译：公开了一种心房除颤器（30），其包括用于感测心脏至少心房内心脏或其附近的心脏的活动的引导系统（34,36），用于从所感测的心房活动中检测心房事件的检测器（58）和心脏复律器（77），用于当心房需要心脏复律时，将心电转移到心脏的心房。定时器（76）确定连续检测到的心房事件之间的时间跨度，并且当时间跨度大于预定极限时，抑制阶段阻止心律转复器向心脏施加心脏转换能量。

128. 发明申请

WO1997001373A1 DEFIBRILLATION THRESHOLD REDUCTION PACING SYSTEM 审中-公开
标题翻译：减震阈值减速系统
公开(公告)号：WO1997001373A1
公开(公告)日：1997-01-16
申请号：PCT/US1996002670
申请日：1996-02-27
申请人： MEDTRONIC, INC.
发明人： MEDTRONIC, INC. , MIN, Xiaoyi , MONGEON, Luc, R. , HILL, Michael, R., S.
IPC分类号： A61N01/39
CPC分类号： A61N1/3962 , A61N1/395
摘要： A method and apparatus for treating fibrillation, particulary atrial fibrillation. In response to detection of fibrillation, a high frequency, low energy pulse burst is delivered via pacing electrodes, accompanied by a high energy pulse delivered via defibrillation electrodes. The low energy pulse burst is preferably delivered to an area of the heart which exhibits relatively lower current density during delivery of the high energy pulse.
摘要翻译：一种用于治疗纤维性颤动，特别是心房颤动的方法和装置。响应于原纤维的检测，通过起搏电极输送高频，低能脉冲脉冲，伴随着通过除颤电极传送的高能量脉冲。低能量脉冲脉冲优选地被传送到在高能量脉冲传送期间呈现相对较低的电流密度的心脏区域。

129. 发明申请

WO1995028987A1 METHOD AND APPARATUS FOR TREATMENT OF ATRIAL FIBRILLATION 审中-公开
标题翻译：用于治疗椎间孔纤维化的方法和装置
公开(公告)号：WO1995028987A1
公开(公告)日：1995-11-02
申请号：PCT/US1995002624
申请日：1995-03-03
申请人： MEDTRONIC, INC.
发明人： MEDTRONIC, INC. , COMBS, William, J. , DUFFIN, Edwin, G. , RAO, T., V.
IPC分类号： A61N01/39
CPC分类号： A61N1/3956 , A61N1/395 , A61N1/3962
摘要： A pacemaker system adapted to deliver pacing pulses in the presence of fibrillation. The pacing pulses are delivered via large surface area electrodes of the type normally used to accomplish defibrillation or cardioversion using high voltage pulses. An extended pulse train is delivered in order to gradually entrain greater portions of heart tissue, until a sufficient percentage of tissue is entrained to interrupt fibrillation. The invention is believed most applicable to treatment of atrial fibrillation.
摘要翻译：一种起搏器系统，适用于在纤维性颤动的情况下发出起搏脉冲。起搏脉冲通过通常用于完成除颤或心脏电复律的类型的大表面积电极输送，使用高电压脉冲。递送延长的脉冲串以逐渐夹带心脏组织的较大部分，直到夹带足够百分比的组织以中断原纤维颤动。认为本发明最适用于治疗房颤。

130. 发明申请

WO9400183A3 AUTOMATIC FIBRILLATION DETECTOR AND DEFIBRILLATOR APPARATUS AND METHOD 审中-公开
标题翻译：自动纤维检测器和除颤器装置及方法
公开(公告)号：WO9400183A3
公开(公告)日：1994-03-03
申请号：PCT/US9306123
申请日：1993-06-25
申请人： INDIANA UNIVERSITY FOUNDATION
发明人： ZIPES DOUGLAS P , ADAMS DAVID E
IPC分类号： A61N1/39 , A61N
CPC分类号： A61N1/3956 , A61N1/395
摘要： The present invention involves an apparatus (10) and method for detecting and treating fibrillation in the heart. Electrodes sense electrical activity in two distinct locations of the heart (42, 46). The electrocardiac activations are monitored and the interval between activations at the two locations is measured by an internal calculator (28) and checked for variation. Upon detection of significant variation in the length of the intervals, the fibrillation condition is determined and a defibrillator (16) is activated, so that a defibrillating shock may be delivered to the heart. For atrial fibrillation, the first defibrillating shock is relatively low and is increased until the fibrillation is no longer detected.

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