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111. 发明申请

WO2015179701A1 ENGINEERED XYLOSE TRANSPORTERS WITH REDUCED GLUCOSE INHIBITION 审中-公开
标题翻译：具有减少葡萄糖抑制作用的工程XYLOSE运输机
公开(公告)号：WO2015179701A1
公开(公告)日：2015-11-26
申请号：PCT/US2015/032058
申请日：2015-05-21
申请人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
发明人： ALPER, Hal , YOUNG, Eric , LEE, Sunmi
IPC分类号： A61K38/00 , A61K47/00
CPC分类号： C07K14/40 , A61K38/00 , C07K14/33
摘要： Provided herein are compositions and methods useful for reducing glucose inhibition in transporting xylose, arabinose and other monosaccharides, into a yeast cell.
摘要翻译：本文提供了可用于将木糖，阿拉伯糖和其它单糖转运到酵母细胞中的葡萄糖抑制作用的组合物和方法。

112. 发明申请

WO2014167335A1 PEPTIDES AND BINDING PARTNERS THEREFOR 审中-公开
标题翻译：肽和结合合作伙伴
公开(公告)号：WO2014167335A1
公开(公告)日：2014-10-16
申请号：PCT/GB2014/051118
申请日：2014-04-10
申请人： KING'S COLLEGE LONDON , LEIBNIZ INSTITUT FUR NATURSTOFF-FORSCHUNG UND INFEKTIONSBIOLOGIE E.V.
发明人： NAGLIK, Julian , MOYES, David , TANG, Shirley , HUBE, Bernhard , WILSON, Duncan , HOFS, Sarah , RICHARDSON, Jonathan
IPC分类号： C07K14/40
CPC分类号： C07K16/14 , A61K39/0002 , A61K39/39 , A61K39/39575 , A61K2039/52 , C07K14/40 , G01N33/6845 , G01N2500/04 , G01N2500/20
摘要： The invention provides a peptide obtainable from C. albicansas well as variants and fragments thereof, and labelled forms of these. The peptide is immunogenic and specific binding partners for the peptide and labelled forms of these specific binding partners form a further aspect of the invention. The peptide is a fragment of the ECE1 protein and has been found to be both immunogenic and act as a pore-forming toxin. A range of therapeutic and diagnostic applications for the peptide and the specific binding partners for it form further aspects of the invention. In addition, the peptide may be used in screens for identifying compounds having useful anti-fungal activity.
摘要翻译：本发明提供了可从白色念珠菌得到的肽，以及其变体和片段，以及这些的标记形式。肽是针对肽的免疫原性和特异性结合配偶体，并且这些特异性结合伴侣的标记形式形成本发明的另一方面。肽是ECE1蛋白的片段，并且已被发现既是免疫原性的并且起着孔隙形成毒素的作用。用于肽和特异性结合配偶体的一系列治疗和诊断应用形成本发明的其它方面。此外，肽可以用于筛选用于鉴定具有有用的抗真菌活性的化合物。

113. 发明申请

WO2013040478A3 HYR1-DERIVED COMPOSITIONS AND METHODS OF TREATMENT USING SAME 审中-公开
标题翻译： HYR1衍生的组合物和使用它们的治疗方法
公开(公告)号：WO2013040478A3
公开(公告)日：2013-06-27
申请号：PCT/US2012055604
申请日：2012-09-14
申请人： LOS ANGELES BIOMED RES INST , IBRAHIM ASHRAF S , YEAMAN MICHAEL R , EDWARDS JOHN E JR , LUO GUANPINGSHENG , FU YUE
发明人： IBRAHIM ASHRAF S , YEAMAN MICHAEL R , EDWARDS JOHN E JR , LUO GUANPINGSHENG , FU YUE
IPC分类号： A61K36/06 , A61K38/00 , C07K14/00 , C12Q1/68
CPC分类号： C07K14/40 , A61K39/00 , A61K39/0002 , A61K47/646 , A61K2039/6081 , C07K16/14
摘要： The disclosure features isolated polypeptides of Hyr1. The disclosure further features vaccines and antibodies useful in treating or preventing candidiasis or Acinetobacter infections or both. Further disclosed are isolated polypeptides consisting of between 14 and 20 amino acids for vaccine preparation. The specific amino acid sequences of isolated polypeptides of Hyr1 are also disclosed.
摘要翻译：该公开的特征是Hyr1的分离的多肽。本公开进一步具有用于治疗或预防念珠菌病或不动杆菌感染或两者的疫苗和抗体。进一步公开的是用于疫苗制备的由14个和20个氨基酸组成的分离的多肽。还公开了Hyr1的分离的多肽的特定氨基酸序列。

114. 发明申请

WO2012163533A1 T CELL EPITOPE OF CANDIDA ALBICANS 审中-公开
标题翻译： CIDIDA ALBICANS的T细胞抗体
公开(公告)号：WO2012163533A1
公开(公告)日：2012-12-06
申请号：PCT/EP2012/002310
申请日：2012-05-31
申请人： ETH Zurich , LEIBUNDGUT-LANDMANN, Salomé , BÄR, Eva
发明人： LEIBUNDGUT-LANDMANN, Salomé , BÄR, Eva
IPC分类号： A61K39/00 , C07K7/04 , C07K14/40
CPC分类号： C07K14/40 , A61K39/0002
摘要： The invention provides an epitope of T helper cells. The peptide comprises the amino acid sequence of SEQ ID No. 1 or a derivative thereof. Said peptide is useful for the preparations of compositions or vaccines for fungal infections, in particular Candidiasis.
摘要翻译：本发明提供了T辅助细胞的表位。肽包含SEQ ID No.1的氨基酸序列或其衍生物。所述肽可用于真菌感染，特别是念珠菌病的组合物或疫苗的制备。

115. 发明申请

WO2008033451A2 PROTEIN AGGREGATION DOMAINS AND METHODS OF USE THEREOF 审中-公开
标题翻译：蛋白质聚集域及其使用方法
公开(公告)号：WO2008033451A2
公开(公告)日：2008-03-20
申请号：PCT/US2007019910
申请日：2007-09-13
申请人： WHITEHEAD BIOMEDICAL INST , LINDQUIST SUSAN , TESSIER PETER
发明人： LINDQUIST SUSAN , TESSIER PETER
IPC分类号： C07K14/39 , C07K14/40 , C07K14/47 , G01N33/68
CPC分类号： C07K14/39 , C07K14/40 , C07K14/4711 , G01N33/6896 , G01N2333/4709 , G01N2500/04 , G01N2800/28 , G01N2800/2814
摘要： Using the Sup35 prion proteins of two distantly related yeast species, it is established that prion replication is initiated by small elements of primary sequence, which can be identified using arrays of short peptides. Subtle differences in replication elements govern the formation of distinct aggregate conformations (prion strains) and also determine their species-specific seeding activities. A Sup35 chimera that promiscuously forms prions in more than one species does so by virtue of carrying the replication element of each species. Mutations or conditions that cause the chimera to assemble into distinct prion strains favor recognition of distinct replication elements. Therefore, subtle differences in small sequences that constitute prion replication elements encode important determinants of prion propagation and transmission. The protein aggregation domains, methods for identification thereof, and polypeptides and higher order aggregates including the protein interaction domains, as well as arrays including peptides derived from an aggregation-prone polypeptide are provided.
摘要翻译：使用两种相互关联的酵母菌种的Sup35朊病毒蛋白，确定了朊病毒复制由初级序列的小元件引发，可以使用短肽阵列鉴定。复制元件的微妙差异控制着不同的聚集体构象（朊病毒株）的形成，并且还决定了它们的物种特异性种子活动。通过携带每种物种的复制元件，在一种以上物种中混合形成朊病毒的Sup35嵌合体也是如此。导致嵌合体组装成不同朊病毒菌株的突变或条件有利于识别不同的复制元件。因此，构成朊病毒复制元件的小序列的微妙差异编码了朊病毒传播和传播的重要决定因素。提供了蛋白质聚集域，鉴定方法，以及包括蛋白质相互作用区域的多肽和更高级聚集体，以及包含衍生自聚集多肽的肽的阵列。

116. 发明申请

WO2007016614A3 CONTROL OF SORBOSE UTILIZATION GENES AND USES THEREOF 审中-公开
标题翻译： SORBOSE利用基因的控制及其应用
公开(公告)号：WO2007016614A3
公开(公告)日：2007-11-08
申请号：PCT/US2006030057
申请日：2006-08-02
申请人： UNIV ROCHESTER , KABIR M ANAUL , RUSTCHENKO BULGAC ELENA
发明人： KABIR M ANAUL , RUSTCHENKO BULGAC ELENA
IPC分类号： C07H21/04 , C12N9/00 , C12N9/30 , C12P21/06
CPC分类号： C07K14/40 , G01N33/56961
摘要： This invention relates generally to the discovery of a novel control of sorbose utilization (CSU) genes. The invention further relates to the detection of these genes and their use in the diagnosis and treatment of fungal infections.
摘要翻译：本发明一般涉及发现新的山梨糖利用（CSU）基因控制。本发明进一步涉及检测这些基因及其在真菌感染的诊断和治疗中的用途。

117. 发明申请

WO2006109192A2 ANTIFUNGAL BIFUNCTIONAL MOLECULES, METHODS OF CONSTRUCTION AND METHODS OF TREATING FUNGAL INFECTION THEREWITH 审中-公开
标题翻译：抗菌双功能分子，治疗方法和治疗真菌感染的方法
公开(公告)号：WO2006109192A2
公开(公告)日：2006-10-19
申请号：PCT/IB2006001522
申请日：2006-01-23
申请人： WEST CHINA HOSPITAL SICHUAN UNIV , QIU XIA-QING
发明人： QIU XIA-QING
IPC分类号： A61K38/00 , A61K38/16 , A61P31/00 , C07K14/00 , C07K14/245 , C07K14/40 , C12N15/31 , C12N15/63 , C12P21/02
CPC分类号： C07K14/40 , A61K38/00 , C07K14/245 , C07K2319/01
摘要： The present invention is directed to fusion peptides comprising a fungal targeting agent and a channel-forming domain consisting essentially of amino acids 451-626 of colicin Ia, as well as the polynucleotides encoding the peptides of the invention. The fusion peptides of the peptides of the present invention are particularly useful for the treatment of fungal infections in a wide variety of organisms.
摘要翻译：本发明涉及包含真菌靶向剂和基本上由大肠杆菌素Ia的氨基酸451-626组成的通道形成结构域的融合肽，以及编码本发明的肽的多核苷酸。本发明的肽的融合肽特别可用于治疗各种生物体中的真菌感染。

118. 发明申请

WO2004092328A3 NOVEL BETA-TUBULIN PROTEIN OF CANDIDA GLABRATA AND METHODS FOR ITS USE 审中-公开
标题翻译： CANDIDA GLABRATA的新型BETA-TUBULIN蛋白及其使用方法
公开(公告)号：WO2004092328A3
公开(公告)日：2005-10-13
申请号：PCT/US2004010604
申请日：2004-04-08
申请人： CYTOKINETICS INC , MAXON MARY , CLARKE DAVID , BERAUD CHRISTOPHE
发明人： MAXON MARY , CLARKE DAVID , BERAUD CHRISTOPHE
IPC分类号： C07H21/04 , C07K14/40 , C12N3/00 , C12N1/00 , C12N1/12 , G01N33/569
CPC分类号： C07K14/40 , C07H21/04
摘要： The present invention provides isolated nucleic acid and amino acid sequences of Candida glabrata beta-tubulin, antibodies to C. glabrata beta-tubulin, and methods of screening to identify antifungals using biologically active C. glabrata beta-tubulin.
摘要翻译：本发明提供了分离的光滑念珠菌β微管蛋白的核酸和氨基酸序列，对光滑玻璃β-微管蛋白的抗体，以及使用生物活性光滑玻璃β-微管蛋白筛选鉴定抗真菌剂的方法。

119. 发明申请

WO2004056965A3 NUCLEIC ACIDS ENCODING ANTIFUNGAL DRUG TARGETS AND METHODS OF USE 审中-公开
标题翻译：核酸编码抗真菌药物目标和使用方法
公开(公告)号：WO2004056965A3
公开(公告)日：2005-03-31
申请号：PCT/US0340618
申请日：2003-12-19
申请人： ELITRA PHARMACEUTICALS INC , ELITRA CANADA LTD , ROEMER TERRY , JIANG BO , BOONE CHARLES , BUSSEY HOWARD
发明人： ROEMER TERRY , JIANG BO , BOONE CHARLES , BUSSEY HOWARD
IPC分类号： A61K38/00 , C07K14/40 , C12N1/18 , C12N15/74 , C12N15/81 , C12N15/00
CPC分类号： C12N15/81 , A61K38/00 , C07K14/40 , C12N15/815
摘要： The present invention provides Candida albicans genes that are demonstrated to be essential and are potential targets for drug screening. The nucleotide sequence of the target genes can be used for various drug discovery purposes, such as expression of the recombinant protein, hybridization assay and construction of nucleic acid arrays. The uses of proteins encoded by the essential genes, and genetically engineered cells comprising modified alleles of essential genes in various screening methods are also encompassed by the invention.
摘要翻译：本发明提供了证明是必需的白色念珠菌基因，并且是药物筛选的潜在靶标。靶基因的核苷酸序列可以用于各种药物发现目的，例如重组蛋白的表达，杂交测定和核酸阵列的构建。在各种筛选方法中，由必需基因编码的蛋白质的使用以及包含必需基因的修饰的等位基因的遗传工程改造的细胞也包括在本发明中。

120. 发明申请

WO2005014828A2 PROCESS FOR THE PRODUCTION OF FINE CHEMICALS 审中-公开
标题翻译：生产精细化学品的方法
公开(公告)号：WO2005014828A2
公开(公告)日：2005-02-17
申请号：PCT/EP2004/008136
申请日：2004-07-21
申请人： BASF PLANT SCIENCE GMBH , PLESCH, Gunnar , PUZIO, Piotr , BLAU, Astrid , LOOSER, Ralf , WENDEL, Birgit , KAMLAGE, Beate , CHARDONNENS, Agnes , SHIRLEY, Amber , WANG, Xi-Qing , SARRIA-MILLAN, Rodrigo , MCKERSIE, Bryan , CHEN, Ruoying
发明人： PLESCH, Gunnar , PUZIO, Piotr , BLAU, Astrid , LOOSER, Ralf , WENDEL, Birgit , KAMLAGE, Beate , CHARDONNENS, Agnes , SHIRLEY, Amber , WANG, Xi-Qing , SARRIA-MILLAN, Rodrigo , MCKERSIE, Bryan , CHEN, Ruoying
IPC分类号： C12N15/82
CPC分类号： C12N15/8243 , C07K14/37 , C07K14/38 , C07K14/39 , C07K14/395 , C07K14/40 , C07K14/44
摘要： The present invention relates to a process for the production of the fine chemical in a microorganism, a plant cell, a plant, a plant tissue or in one or more parts thereof. The invention furthermore relates to nucleic acid molecules, polypeptides, nucleic acid constructs, vectors, antisense molecules, antibodies, host cells, plant tissue, propagation material, harvested material, plants, microorganisms as well as agricultural compositions and their use.
摘要翻译：本发明涉及在微生物，植物细胞，植物，植物组织或其一个或多个部分中生产精细化学品的方法。本发明还涉及核酸分子，多肽，核酸构建体，载体，反义分子，抗体，宿主细胞，植物组织，繁殖材料，收获的材料，植物，微生物以及农业组合物及其用途。

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