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    • 112. 发明申请
    • CROSSLINKED POLYMERS
    • 交联聚合物
    • WO1996024074A1
    • 1996-08-08
    • PCT/EP1996000245
    • 1996-01-22
    • CIBA-GEIGY AGMÜLLER, Beat
    • CIBA-GEIGY AG
    • G02B01/04
    • G02B1/043C08F8/00C08F8/28C08F8/30C08F2810/20C08F2810/30C08L29/00C08F16/06C08F226/10C08F218/08C08F8/12C08F118/08
    • The invention relates to a novel process for the production of mouldings, in particular contact lenses, in which a soluble prepolymer comprising units containing a crosslinkable group and at least one unit containing a modifier is crosslinked in solution, and to mouldings, in particular contact lenses, obtainable by this process. The present invention likewise relates to novel prepolymers which can be employed in the novel process, in particular derivatives of a polyvinyl alcohol having a molecular weight of at least about 2000 which comprises from about 0.5 to about 80 %, based on the number of hydroxyl groups in the polyvinyl alcohol, of units of the formulae (I and II, II and III or I, II and III), as disclosed in detail in the description, and to crosslinked polymers, either homopolymers or copolymers, made from these novel prepolymers, a process for the preparation of the novel prepolymers and the homopolymers and copolymers obtainable therefrom, to mouldings made from said homopolymers or copolymers, and to a process for the production of contact lenses using said homopolymers or copolymers.
    • 本发明涉及一种用于生产模制品,特别是隐形眼镜的新方法,其中包含含有可交联基团的单元的可溶性预聚物和至少一种含有改性剂的单元在溶液中交联,并且对于模制品,特别是隐形眼镜 ,可以通过这个过程获得。 本发明同样涉及可用于新方法中的新型预聚物,特别是分子量至少为约2000的聚乙烯醇的衍生物,其包含基于羟基数的约0.5至约80% 在聚乙烯醇中,如在说明书中详细公开的式(I和II,II和III或I,II和III)的单元以及由这些新型预聚物制成的交联聚合物,均聚物或共聚物, 用于制备新型预聚物及由其获得的均聚物和共聚物的方法,由所述均聚物或共聚物制成的成型体以及使用所述均聚物或共聚物制备隐形眼镜的方法。
    • 114. 发明申请
    • FUNCTIONALISED PHOTOINITIATORS, DERIVATIVES AND MACROMERS THEREFROM AND THEIR USE
    • 功能化光敏剂,衍生物及其使用的麦克糖
    • WO1996020919A1
    • 1996-07-11
    • PCT/EP1995005012
    • 1995-12-18
    • CIBA-GEIGY AGCHABRECEK, PeterDIETLIKER, KurtLOHMANN, Dieter
    • CIBA-GEIGY AG
    • C07C271/20
    • G03F7/0757C07C271/20C07C271/24C07C271/28C07C2601/14C08F2/50C08F283/124C08F290/02C08F290/042C08G18/5015C08G18/5024C08G18/61C08G18/6446C08G18/70C08G18/80C08G18/807C08G18/8166C08G18/8175C08G77/442G02B1/043G03F7/027G03F7/031G03F7/033C08L51/085
    • The present invention relates to alpha -aminoacetophenones functionalised with organic diisocyanates, having general structure (I) which can be used as reactive photoinitiators; to oligomers and polymers to which such functionalised alpha -aminoacetophenones are bonded; to alpha -aminoacetophenones having an unsaturated polymerisable side-chain; to dimeric and trimeric photoinitiators; to the use of such photoinitiators; to materials coated with such photoinitiators; and to the use of functionalised alpha -aminoacetophenones for modifying surfaces. In said structure (I), X is bivalent -O-, -NH-, -S-, lower alkylene or (a); Y is a direct bond or -O-(CH2)n- wherein n is an integer from 1 to 6 and the terminal CH2 group of which is linked to the adjacent X in formula (I); R is H, C1-C12alkyl, C1-C12alkoxy, C1-C12alkylNH- or -NR1AR1B wherein R1A is lower alkyl and R1B is H or lower alkyl; R1 is linear or branched lower alkyl, lower alkenyl or aryl-lower alkyl; R2 independently of R1 has the same definitions as R1 or is aryl, or R1 and R2 together are -(CH2)m- wherein m is an integer from 2 to 6; R3 and R4 are each independently of the other linear or branched lower alkyl that may be substituted by C1-C4alkoxy, or aryl-lower alkyl or lower alkenyl; or R3 and R4 together are -(CH2)z-Y1-(CH2)z- wherein Y1 is a direct bond, -O-, -S- or -NR1B-, and R1B is H or lower alkyl and z is independently of the other an integer from 2 to 4; R5 is linear or branched C3-C18alkylene, unsubstituted or C1-C4alkyl- or C1-C4alkoxy- substituted C6-C10arylene, or unsubstituted or C1-C4alkyl- or C1-C4alkoxy-substituted C7-C18aralkylene, unsubstituted or C1-C4alkyl- or C1-C4alkoxy-substituted C13-C24- arylenealkylenearylene, unsubstituted or C1-C4alkyl- or C1-C4alkoxy-substituted C3-C8-cycloalkylene, unsubstituted or C1-C4alkyl- or C1-C4alkoxy-substituted C3-C8cycloalkylene-CyH2y- or unsubstituted or C1-C4alkyl- or C1-C4alkoxy-substituted -CyH2y-(C3-C8-cycloalkylene)-CyH2y-, wherein y is an integer from 1 to 6; and D is an isocyanato group.
    • 本发明涉及用有机二异氰酸酯官能化的α-氨基苯乙酮,其具有可用作反应性光引发剂的通式结构(I); 涉及这种官能化的α-氨基苯乙酮键合的低聚物和聚合物; 具有不饱和可聚合侧链的α-氨基苯乙酮; 二聚和三聚光引发剂; 使用这种光引发剂; 涂覆有这种光引发剂的材料; 以及使用官能化的α-氨基苯乙酮来改性表面。 在所述结构(I)中,X是二价-O - , - NH - , - S-,低级亚烷基或(a)。 Y是直接键或-O-(CH 2)n - ,其中n是1至6的整数,并且其末端基团与式(I)中相邻的X连接; R是H,C1-C12烷基,C1-C12烷氧基,C1-C12烷基NH-或-NR1AR1B,其中R1A是低级烷基,R1B是H或低级烷基; R1是直链或支链的低级烷基,低级烯基或芳基 - 低级烷基; R1独立地为R1具有与R 1相同的定义或芳基,或者R 1和R 2一起是 - (CH 2)m - ,其中m是2至6的整数; R 3和R 4各自独立地为可被C 1 -C 4烷氧基或芳基 - 低级烷基或低级烯基取代的其它直链或支链低级烷基; 或者R 3和R 4一起是 - (CH 2)z -Y 1 - (CH 2)z - ,其中Y 1是直接键,-O - , - S-或-NR 1 B-,并且R 1B是H或低级烷基,z独立地是 另一个从2到4的整数; R5是直链或支链C 3 -C 18亚烷基,未取代的或C 1 -C 4烷基 - 或C 1 -C 4烷氧基取代的C 6 -C 10亚芳基,或未取代的或C 1 -C 4烷基 - 或C 1 -C 4烷氧基取代的C 7 -C 18亚烷基,未被取代的或C 1 -C 4烷基 - 或C 1 -C 1-4烷氧基取代的C 13 -C 24亚芳基亚烷基亚芳基,未取代的或C 1 -C 4烷基 - 或C 1 -C 4烷氧基取代的C 3 -C 8 - 亚环烷基,未取代的或C 1 -C 4烷基 - 或C 1 -C 4烷氧基取代的C 3 -C 8亚环烷基-CYH 2 - 或未取代的或C 1 -C4烷基 - 或C1-C4烷氧基取代的-CyH2y-(C3-C8-亚环烷基)-CyH2y-,其中y是1至6的整数; D为异氰酸酯基。
    • 118. 发明申请
    • O-BENZYL OXIME ETHER DERIVATIVES AND THEIR USE AS PESTICIDES
    • O-BENZYL OXIME醚衍生物及其作为杀虫剂的用途
    • WO1996016026A1
    • 1996-05-30
    • PCT/EP1995004357
    • 1995-11-06
    • CIBA-GEIGY AGZURFLÜH, RenéZIEGLER, HugoTRAH, Stephan
    • CIBA-GEIGY AG
    • C07C255/62
    • C07D295/185A01N37/50A01N37/52C07C251/38C07C251/48C07C255/64C07C257/06C07C257/14C07C257/22C07C2601/02C07D295/30
    • Compounds of formula (I), wherein Y is hydrogen, C1-C4alkyl, C1-C4alkoxy, OH, CN, NO2, Si(CH3)3, CF3 or halogen, and T is a group (a) or (b), and wherein the remaining substituents have the following definitions: X is O, S or NR13; A is O or NR4; R1 is hydrogen, C1-C4alkyl, halo-C1-C4alkyl, cyclopropyl, C1-C4alkoxymethyl, C1-C4alkoxy, C1-C4alkylthio or cyano; R2 is hydrogen, C1-C6alkyl, C3-C6cycloalkyl, cyano unsubstituted or substituted C1-C6alkoxycarbonyl, unsubstituted or substituted di(C1-C6alkyl)aminocarbonyl, unsubstituted or substituted C1-C6alkyl-S(O)q, unsubstituted or substituted aryl-S(O)q, unsubstituted or substituted heteroaryl, unsubstituted or substituted heterocyclyl, unsubstituted or substituted heterocyclylcarbonyl or unsubstituted or substituted phenyl; and R3 is hydrogen, unsubstituted or substituted alkyl, unsubstituted or substituted C3-C6cycloalkyl, unsubstituted or substituted phenyl or unsubstituted or substituted pyridyl; and wherein the remaining substituents are as defined herein, are pesticidal active ingredients. They can be used in pest control, especially as microbicides, insecticides and acaricides in agriculture, in horticulture and in the hygiene sector.
    • 式(I)化合物,其中Y为氢,C 1 -C 4烷基,C 1 -C 4烷氧基,OH,CN,NO 2,Si(CH 3)3,CF 3或卤素,T为(a)或(b) 其中剩余取代基具有以下定义:X为O,S或NR 13; A为O或NR4; R 1是氢,C 1 -C 4烷基,卤代C 1 -C 4烷基,环丙基,C 1 -C 4烷氧基甲基,C 1 -C 4烷氧基,C 1 -C 4烷硫基或氰基; 未取代或取代的二(C 1 -C 6烷基)氨基羰基,未取代或取代的C 1 -C 6烷基-S(O)q,未取代或取代的芳基-S(O)q,C 1 -C 6烷基,C 3 -C 6环烷基,氰基未取代或取代的C 1 -C 6烷氧基羰基, (O)q,未取代或取代的杂芳基,未取代或取代的杂环基,未取代或取代的杂环基羰基或未取代或取代的苯基; 未取代或取代的烷基,未取代或取代的C 3 -C 6环烷基,未取代或取代的苯基或未取代或取代的吡啶基; 并且其中剩余的取代基如本文所定义,是杀虫活性成分。 它们可用于病虫害防治,特别是作为农业,园艺和卫生领域的杀菌剂,杀虫剂和杀螨剂。
    • 119. 发明申请
    • 1-ACYL-4-ALIPHATYLAMINOPIPERIDINE COMPOUNDS
    • 1-ACYL-4-ALIPHATYLAMINOPIPERIDINE化合物
    • WO1996010562A1
    • 1996-04-11
    • PCT/EP1995003681
    • 1995-09-19
    • CIBA-GEIGY AGOFNER, SilvioVEENSTRA, Siem, Jacob
    • CIBA-GEIGY AG
    • C07D211/58
    • C07D211/58
    • The invention relates to novel 1-acyl-4-aliphatylaminopiperidine compounds of formula (I), in which R1 is a benzoyl, naphthoyl or cycloalkanoyl radical which is unsubstituted or substituted by lower alkyl, lower alkoxy, halogen and/or trifluoromethyl; R2 is cycloalkyl or a phenyl or naphthyl radical which is unsubstituted or substituted by lower alkyl, lower alkoxy, halogen, nitro, cyano and/or trifluoromethyl; R3 and R4 together are lower alkylene or aza-, oxa- or thia-lower alkylene; or R3 is lower alkyl, lower alkoxy-lower alkyl, di-lower alkylamino-lower alkyl or a radical of the formula -(CH2)n-C(=O)-R5 (Ia); and R4 is hydrogen, lower alkyl or a radical of the formula -(CH2)n-C(=O)-R5 (Ia); R5 is (i) hydrogen, alkyl or alkyl which is substituted by halogen, lower alkoxy, amino or amino substituted by lower alkyl, amino-lower alkyl, mono- or di-lower alkylaminoalkyl, lower alkanoyl, lower alkoxycarbonyl or lower alkylene or aza-, oxa- or thia-lower alkylene, (ii) hydroxyl, cycloalkoxy, lower alkoxy or lower alkoxy which is substituted by lower alkoxy, amino or amino substituted by lower alkyl, amino-lower alkyl, mono- or di-lower alkylamino-alkyl, lower alkanoyl, lower alkoxycarbonyl or lower alkylene or aza-, oxa- or thia-lower alkylene, or (iii) amino or amino substituted by lower alkyl, cycloalkyl, amino-lower alkyl, mono- or di-lower alkylaminoalkyl, lower alkanoyl, lower alkoxycarbonyl or lower alkylene or aza-, oxa- or thia-lower alkylene; X1 is methyelene, ethylene, a direct bond, a free or ketalized carbonyl group or a free or etherified hydroxymethylene group and n is 0 or 1, and their salts, processes for the preparation of the compounds according to the invention, pharmaceutical compositions containing these and their use as pharmaceutical active ingredients.
    • 本发明涉及式(I)的新颖的1-酰基-4-脂肪族氨基哌啶化合物,其中R1是未被取代或被低级烷基,低级烷氧基,卤素和/或三氟甲基取代的苯甲酰基,萘甲酰基或环烷酰基; R2是环烷基或未被取代或被低级烷基,低级烷氧基,卤素,硝基,氰基和/或三氟甲基取代的苯基或萘基; R3和R4一起是低级亚烷基或氮杂 - ,硫杂或硫代 - 低级亚烷基; 或R 3是低级烷基,低级烷氧基 - 低级烷基,二低级烷基氨基 - 低级烷基或式 - (CH 2)n -C(= O)-R 5(Ia)的基团; 并且R 4是氢,低级烷基或式 - (CH 2)n -C(= O)-R 5(Ia)的基团; R5是(i)被卤素,低级烷氧基,氨基或被低级烷基,氨基 - 低级烷基,一或二 - 低级烷基氨基烷基,低级烷酰基,低级烷氧基羰基或低级亚烷基或氮杂 - , - 硫代 - 低级亚烷基,(ii)被低级烷氧基取代的羟基,环烷氧基,低级烷氧基或低级烷氧基,被低级烷基,氨基 - 低级烷基,一或二 - 低级烷基氨基 - 烷基,低级烷酰基,低级烷氧基羰基或低级亚烷基或氮杂 - ,硫杂 - 或硫代 - 低级亚烷基,或(iii)被低级烷基,环烷基,氨基 - 低级烷基,一或二 - 低级烷基氨基烷基取代的氨基或氨基 烷酰基,低级烷氧基羰基或低级亚烷基或氮杂,氧杂或硫代低级亚烷基; X1是甲烯,乙烯,直接键,游离或缩酮化的羰基或游离的或醚化的羟基亚甲基,n是0或1,它们的盐,根据本发明的化合物的制备方法,含有这些 并将其用作药物活性成分。