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101. 发明申请

WO2006012352A2 BLOOD COMPONENT SEPARATION SYSTEM WITH STATIONARY SEPARATION CHAMBER 审中-公开
标题翻译：具有静态隔离室的血液成分分离系统
公开(公告)号：WO2006012352A2
公开(公告)日：2006-02-02
申请号：PCT/US2005/022608
申请日：2005-06-27
申请人： HAEMONETICS CORPORATION
发明人： RAGUSA, Michael , STACEY, Gary, R. , PAGES, Etienne
IPC分类号： A61F2/50
CPC分类号： G02B27/42 , A61M1/30 , A61M1/302 , A61M1/303 , A61M1/308 , A61M1/3693 , A61M1/3696 , G02B21/32 , G02B27/4205
摘要： Provided is a blood processing system having a stationary component separation chamber. Individual blood components as well as other particles and contaminates are separated from blood flowing through the separation chamber by optical traps configured to manipulate specific components are projected into the flow field of the chamber. Cells or particles of the selected components that are manipulated by the optical traps then may be directed from the flow field to individual reservoirs to collect quantities of the selected components.
摘要翻译：提供了一种具有静止部件分离室的血液处理系统。单独的血液成分以及其它颗粒和污染物与通过配置成操纵特定组分的光学捕集器流经分离室的血液分离，投射到腔室的流场中。然后由光学捕集器操纵的所选择的组分的细胞或颗粒可以从流场引导到各个储存器以收集大量的所选择的组分。

102. 发明申请

WO2005092408A1 SINGLE NEEDLE DEVICE FOR EXTRACORPOREAL TREATMENT OF BLOOD. 审中-公开
标题翻译：用于血液净化处理的单针装置。
公开(公告)号：WO2005092408A1
公开(公告)日：2005-10-06
申请号：PCT/IB2005/000468
申请日：2005-03-03
申请人： GAMBRO LUNDIA AB , CHEVALLET, Jacques , ROMARIE, Jean-Louis , FRUGIER, Alain
发明人： CHEVALLET, Jacques , ROMARIE, Jean-Louis , FRUGIER, Alain
IPC分类号： A61M1/30
CPC分类号： A61M1/30 , A61M1/302 , A61M1/303 , A61M2205/50
摘要： Single needle device for extracorporeal treatment of blood 1 comprising a treatment unit 3 having a first compartment 4 and a second compartment 5 separated by a semipermeable membrane 6, a single needle extracorporeal blood circuit with an intake line 7 and a return line 8, and a purge line 9 at the outlet of the second compartment 5. Closure means acts on intake line 7 and return line 8 to alternate blood intake and return. A first chamber 12 is in fluid communication with the extracorporeal blood circuit, defines a first additional blood volume of variable total content and includes a wall capable of being moved by means 19 acting on the chamber 12, making it possible to store blood during the arterial phase and release blood during the venous phase.
摘要翻译：用于体外处理血液的单针装置1包括具有由半透膜6分离的第一隔室4和第二隔室5的处理单元3，具有进气管线7和返回管线8的单针体外血液回路，以及清除管线9在第二隔室5的出口处。封闭装置作用在进气管线7和返回管线8上以交替进行血液回流。第一腔室12与体外血液回路流体连通，限定可变总含量的第一附加血液体积，并且包括能够通过作用在腔室12上的装置19移动的壁，使得可以在动脉中存储血液在静脉期中相和释放血液。

103. 发明申请

WO2004082731A2 CIRCUIT FOR EXTRACORPOREAL BLOOD CIRCULATION 审中-公开
标题翻译：体外循环血液循环
公开(公告)号：WO2004082731A2
公开(公告)日：2004-09-30
申请号：PCT/IB2004/000750
申请日：2004-03-16
申请人： GAMBRO LUNDIA AB , CALEFFI, Luca
发明人： CALEFFI, Luca
IPC分类号： A61M
CPC分类号： A61M1/30 , A61M1/302 , A61M1/303 , A61M1/3627 , A61M2205/123
摘要： A circuit for extracorporeal blood circulation, which is used for a single-needle dialysis, comprises a blood withdrawal line (2) having an arterial pump portion (23), and a blood return line (4) having a venous pump portion (43). Pump portions are designed to be coupled with corresponding peristaltic pumps (6), (7). An arterial expansion chamber (25) is arranged on the withdrawal line downstream from said arterial pump portion. A venous expansion chamber (45) is arranged on the return line upstream from said venous pump portion. The two expansion chambers are firmly joined one to the other into an integrated structure (9), which is equipped inside with two ducts connecting the arterial expansion chamber with two fluid connections attached outside to the integrated structure. The circuit can be assembled and disassembled from a dialysis machine easily and rapidly.
摘要翻译：用于单针透析的用于体外血液循环的回路包括具有动脉泵部分（23）的血液抽取管线（2）和血液回输管线（4）具有静脉泵部分（43）。泵部分设计成与相应的蠕动泵（6），（7）联接。动脉膨胀室（25）布置在所述动脉泵部分下游的抽取线上。静脉扩张室（45）布置在所述静脉泵部分上游的返回管线上。两个膨胀室彼此牢固连接成一个整体结构（9），该整体结构（9）在内部配备有两个管道，该管道将动脉膨胀室与在外部连接到整体结构的两个流体连接件连接。该电路可以轻松快速地从透析机组装和拆卸。

104. 发明申请

WO2003033066A2 BLOOD PROCESSING SYSTEMS AND METHODS THAT EMPLOY AN IN-LINE LEUKOFILTER MOUNTED IN A RESTRAINING FIXTURE 审中-公开
标题翻译：血液处理系统和方法，使用安装在线的白血球填料进入抑制性固定
公开(公告)号：WO2003033066A2
公开(公告)日：2003-04-24
申请号：PCT/US2002/031316
申请日：2002-10-02
申请人： BAXTER INTERNATIONAL INC.
发明人： VANDLIK, Mark, R. , KAST, Michael, J. , SMITH, Kelly, B.
IPC分类号： A61M37/00
CPC分类号： A61M1/3696 , A61M1/0209 , A61M1/0218 , A61M1/1006 , A61M1/1037 , A61M1/1062 , A61M1/30 , A61M1/302 , A61M1/303 , A61M1/308 , A61M1/3633 , A61M1/3636 , A61M1/3693 , A61M2205/12 , A61M2205/128 , A61M2205/331 , A61M2205/3393
摘要： Systems and methods separate blood cells from whole blood and pump the separated blood cells through an in-line leukofilter to a blood cell storage container. The leukofilter comprises a filtration medium enclosed within a flexible housing. The systems and methods include a fixture to restrain expansion of the flexible filter housing during operation of the pump. The fixture includes a bracket to enable its releasable attachment to the blood processing device employed to carry out the separation process.
摘要翻译：系统和方法从全血分离血细胞并通过在线白细胞过滤器将分离的血细胞泵送到血细胞储存容器。白滤器包括封装在柔性外壳内的过滤介质。该系统和方法包括用于在泵的操作期间抑制柔性过滤器壳体的膨胀的固定装置。该夹具包括支架，以使其可释放地附接到用于执行分离过程的血液处理装置。

105. 发明申请

WO02070034A3 AUTOMATED SYSTEM AND METHOD FOR PRE-SURGICAL BLOOD DONATION AND FLUID REPLACEMENT 审中-公开
标题翻译：自动化系统和方法用于预防手术血液和液体替代
公开(公告)号：WO02070034A3
公开(公告)日：2003-01-16
申请号：PCT/US0205242
申请日：2002-02-13
申请人： BAXTER INT
发明人： FARRELL LIAM , THOM SANDRA , VISHNOI ROHIT , BROWN RICHARD I
IPC分类号： A61M1/02 , A61M1/34 , A61M1/36 , A61M37/00 , C02F1/00
CPC分类号： A61M1/3687 , A61M1/30 , A61M1/302 , A61M1/303 , A61M1/308 , A61M1/342 , A61M1/3441 , A61M1/3451 , A61M1/3672 , A61M1/3675 , A61M1/3679 , A61M1/3692 , A61M1/3693 , A61M1/3696 , A61M2202/0429 , A61M2205/12
摘要： Automated systems and methods for withdrawing and replacing fluids in a patient are disclosed. The system withdraws blood from a donor or patient, separates the blood into two or more components and collects the separated component. A replacement fluid capable of at least partially providing the biological function of the separated component is infused into the patient.
摘要翻译：公开了用于抽出和替换患者体内液体的自动化系统和方法。系统从供体或患者抽出血液，将血液分成两个或更多个组分并收集分离的组分。能够至少部分地提供分离的组分的生物学功能的替换流体被输入到患者体内。

106. 发明申请

WO2002094349A1 VERFAHREN UND VORRICHTUNG ZUM BILANZIEREN VON FLÜSSIGKEITEN 审中-公开
标题翻译：方法和设备资产负债表纸液体的
公开(公告)号：WO2002094349A1
公开(公告)日：2002-11-28
申请号：PCT/EP2002/005407
申请日：2002-05-16
申请人： PLASMA SELECT AG , SCHIMMELPFENNIG, Winfried , LANTOW, Holger
发明人： SCHIMMELPFENNIG, Winfried , LANTOW, Holger
IPC分类号： A61M1/30
CPC分类号： F04B43/1253 , A61M1/16 , A61M1/1607 , A61M1/30 , A61M1/302 , A61M1/303 , A61M1/307 , A61M1/308 , A61M1/3444 , A61M1/3448 , A61M2205/123 , A61M2205/3331 , F04B23/04 , F04B49/22 , F04B2205/09
摘要： Es wird ein Verfahren zur Mengenbilanzierung zweier Flüssigkeiten vorgestellt und darauf basierend ein Disposable zur bilanzierten Förderung von Filtrad und Substituat für eine medizinische Behandlungsvorrichtung, bestehend aus zwei Volumenfördereinheiten (Rollenpumpen), die durch geeignete Steuerelemente zeitlich symmetrisch wechselweise mit den zu bilanzierenden Medien durchströmt werden. Durch die zyklische zeitlich Symmetrie heben sich in der Summe alle Flussdifferenzen in beiden Kanälen komplett auf, beide Fördermengen werden gleich. Zur Unterdrückung systematischer Fehler werden die Drücke in den Zu-und Abläufen der Volumenfördereinheiten hierbei konstant gehalten. Durch ein spezielles Umschaltregime (Spiegelverfahren) werden zeitliche Parameteränderungen der Pumpleistungen ebenfalls als Bilanzfehler eliminiert.
摘要翻译：它提出了一种用于两种液体量测量的方法，并基于一次性一个平衡促进Filtrad和置换对于由运输单元两个卷（滚子泵），其通过适当的控制交替地与时间上对称的待平衡介质流动的医疗设备。通过循环时间对称全流程的差异中脱颖而出总在两个通道来完成，这两个流率相等。在饲料中的压力和处理的单位运输量保持不变，以抑制系统误差。通过特殊Umschaltregime（镜像方法）时间参数改变泵浦功率也被消除作为平衡误差。

107. 发明申请

WO0162314A2 HEMODIALYSIS ASSEMBLY AND METHOD 审中-公开
标题翻译：血液透析装置和方法
公开(公告)号：WO0162314A2
公开(公告)日：2001-08-30
申请号：PCT/US0140154
申请日：2001-02-20
申请人： SPENCER DUDLEY
发明人： SPENCER DUDLEY
IPC分类号： A61M1/16 , A61M1/30 , A61M1/34 , A61M1/36 , A61M
CPC分类号： A61M1/3693 , A61M1/16 , A61M1/30 , A61M1/303 , A61M1/34 , A61M1/3403 , A61M1/3406 , A61M1/3479 , A61M1/3696
摘要： A hemodialysis system and method of operation includes supplying whole blood containing blood cells, plasma fluid and foreign substances to a process control preferably having a centrifuge which operates to separate the cells from the plasma fluid and foreign substances. The plasma fluid and foreign substances are then conveyed away from the centrifuge where the foreign substances are removed from the plasma to result in cleaned blood cells and cleaned plasma fluid which may be used in a patient.
摘要翻译：血液透析系统和操作方法包括将含有血细胞，血浆和异物的全血供给到优选具有操作以将细胞与血浆流体和外来物质分离的离心机的过程控制。然后等离子体流体和异物被输送离开离心机，其中外来物质从等离子体中除去，导致清洁的血液细胞和可用于患者的清除的血浆液。

108. 发明申请

WO01017606A1 BLOOD PROCESSING SYSTEMS AND METHODS EMPLOYING FLUID PRESSURE ACTUATED PUMPS AND VALVES 审中-公开
标题翻译：血液加工系统和使用流体压力泵阀和阀门的方法
公开(公告)号：WO01017606A1
公开(公告)日：2001-03-15
申请号：PCT/US2000/023693
申请日：2000-08-29
IPC分类号： A61M1/02 , A61M1/10 , A61M1/30 , A61M1/36 , F04B49/06 , A61M37/00 , B01D37/00 , B01D61/00 , B01D63/00 , C02F1/00 , C02F1/44 , F04B9/08 , F04B17/00 , F04B35/00 , F04B49/00
CPC分类号： F04B49/06 , A61M1/1006 , A61M1/1037 , A61M1/1053 , A61M1/1062 , A61M1/1087 , A61M1/1096 , A61M1/30 , A61M1/302 , A61M1/303 , A61M1/308 , A61M1/3696 , A61M2205/128 , A61M2205/331 , A61M2205/3393 , F04B2205/09 , Y10S128/12
摘要： Systems and methods for processing blood use at least one fluid activated pump (PPN) and at least one fluid activated valve (VN). The systems and methods apply positive and negative fluid pressures to operate the pump and valve. Different pressure conditions are applied to the pump and the valve (VA1-VA25), to insure that a valve used in conjunction with a pump is not overcome by the pressure applied to operate the pump, and that both the valve and pump are not overcome by normal system (10) processing pressures.
摘要翻译：用于处理血液的至少一种流体活化泵（PPN）和至少一种流体活化阀（VN）的系统和方法。系统和方法应用正和负的流体压力来操作泵和阀。对泵和阀（VA1-VA25）施加不同的压力条件，以确保与泵结合使用的阀不能被用于操作泵的压力克服，并且阀和泵都不被克服通过正常系统（10）处理压力。

109. 发明申请

WO99026678A1 SYSTEMS AND METHODS FOR OBTAINING A UNIFORM TARGETED VOLUME OF CONCENTRATED RED BLOOD CELLS 审中-公开
标题翻译：用于获得均匀浓度浓缩的红血细胞的体积和方法
公开(公告)号：WO99026678A1
公开(公告)日：1999-06-03
申请号：PCT/US1998/024010
申请日：1998-11-11
IPC分类号： A61M1/34 , A61K35/14 , A61M1/02 , A61M1/26 , A61M1/30 , B01D17/02 , B01D21/00 , B01D21/24 , B01D21/26 , B01D21/28 , B01D21/30 , B01D61/00 , B01D61/14 , B01D61/18 , B01D63/06 , B01D63/16 , B01D61/08 , B01D61/22
CPC分类号： B01D21/2405 , A61M1/265 , A61M1/30 , A61M1/303 , A61M1/306 , A61M1/308 , A61M1/309 , A61M1/34 , A61M1/3403 , A61M1/341 , A61M1/3496 , A61M2205/3331 , A61M2205/3334 , A61M2205/3393 , A61M2209/082 , B01D17/0217 , B01D17/085 , B01D21/0012 , B01D21/26 , B01D2221/10
摘要： Blood separation systems (200) and methods operate a pump (230) in the inlet line to convey a volume of whole blood from a donor (210) at a commanded flow rate for processing into plasma constituent (228) and concentrated red blood cells (204). The systems (200) and methods set the commanded flow rate to vary the volume of whole blood conveyed over time as a function of known hematocrit value of the selected donor (244), a targeted collection time (246) and a targeted volume of concentrated red blood cells (248). The systems and methods obtain, after processing of whole blood volume, a targeted volume of concentrated red blood cells, which is substantially constant for the population of blood donors despite variances in known hematocrit values among the donors.
摘要翻译：血液分离系统（200）和方法操作入口管线中的泵（230），以指令的流速输送来自供体（210）的一定体积的全血以加工成血浆成分（228）和浓缩红细胞（ 204）。系统（200）和方法设定所命令的流速以随着时间的推移改变输送的全血的体积，作为所选择的供体（244）的已知血细胞比容值的函数，靶向收集时间（246）和目标体积的浓缩红细胞（248）。系统和方法在全血容量处理后获得目标体积的浓缩红细胞，尽管献血者中已知血细胞比容值的差异，血液供体群体基本上是恒定的。

110. 发明申请

WO99001196A1 SYSTEMS AND METHODS FOR COLLECTING MONONUCLEAR CELLS EMPLOYING CONTROL OF PACKED RED BLOOD CELL HEMATOCRIT 审中-公开
标题翻译：收集包装的红血细胞HEMATOCRIT控制的单核细胞的系统和方法
公开(公告)号：WO99001196A1
公开(公告)日：1999-01-14
申请号：PCT/US1998/012165
申请日：1998-06-22
IPC分类号： A61M1/30 , A61M1/36 , B04B5/04 , B04B13/00 , B01D21/26 , B04B11/04
CPC分类号： B04B5/0442 , A61M1/30 , A61M1/303 , A61M1/308 , A61M1/3693 , A61M1/3696 , A61M2205/331 , B04B13/00 , B04B2005/045
摘要： Blood separation systems and methods employ a rotating chamber (12). The rotating chamber (12) includes an inlet region (38) where whole blood enters for centrifugal separation into packed red blood cells, a plasma constituent, and an interface carrying mononuclear cells between the packed red blood cells and the plasma constituent. The packed red blood cells in the rotating chamber (12) have a hematocrit value HPRBC. A controller operates in a first mode to convey whole blood into the inlet region (38) while removing packed red blood cells and the plasma constituent from the rotating chamber (12) and while maintaining the interface within the rotating chamber (12). The controller also operates in the first mode to maintain a set HPRBC by conveying packed red blood cells into the inlet region (38).
摘要翻译：血液分离系统和方法采用旋转室（12）。旋转室（12）包括入血区域（38），其中全血进入离心分离成包装的红细胞，血浆成分和在填充的红细胞与血浆成分之间携带单核细胞的界面。旋转室（12）中的包装的红细胞具有血细胞比容值HPRBC。控制器以第一模式操作，以将全血输送到入口区域（38），同时从旋转室（12）中移除填充的红细胞和等离子体成分，同时将界面保持在旋转室（12）内。控制器还在第一模式下操作以通过将填充的红细胞输送到入口区域（38）来维持一组HPRBC。

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