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91. 发明申请

WO99037798A1 METHODS FOR DETECTING FALSE NEGATIVE RESULTS IN BLOOD SCREENING ASSAYS USING A SINGLE ALIQUOT ELEVATED BASELINE AS AN INTERNAL ASSAY CONTROL 审中-公开
标题翻译：使用单一ALIQUOT ELEVATED BASELINE作为内部测定控制来检测血液筛选测定中的阴性结果的方法
公开(公告)号：WO99037798A1
公开(公告)日：1999-07-29
申请号：PCT/US1999/001536
申请日：1999-01-26
IPC分类号： G01N33/569 , G01N33/58 , G01N33/96 , C12Q1/00 , C12Q1/70 , G01N33/53 , G01N33/567 , G01N1/00 , G01N33/536 , G01N33/531
CPC分类号： G01N33/56911 , G01N33/56983 , G01N33/58 , G01N33/96 , G01N2496/05 , Y02A50/54
摘要： The present invention relates to novel methods for detecting false negative results that can occur with conventional specific binding assays used for screening blood or blood derived products. These erroneous results can occur from either non-sample sources (such as operator error, electromechanical error, and assay component production error), or from sample assay interference (such as endogenous proteins or exogenous interfering chemicals). A single aliquot elevated baseline is used as an internal assay control to detect false negatives without requiring the use of separate assays.
摘要翻译：本发明涉及用于检测用于筛选血液或血液衍生产品的常规特异性结合测定法可能发生的假阴性结果的新方法。这些错误的结果可能发生在非样本来源（如操作员错误，机电误差和测定成分产生误差），或来自样品测定干扰（如内源性蛋白质或外源性干扰化学物质）。单一等分试样升高的基线用作内部测定对照以检测假阴性，而不需要使用单独的测定。

92. 发明申请

WO1997044657A1 BLOOD GAS/ELECTROLYTE CALIBRATOR AND METHOD FOR USE 审中-公开
标题翻译：血液/电解质校准器和使用方法
公开(公告)号：WO1997044657A1
公开(公告)日：1997-11-27
申请号：PCT/US1997008581
申请日：1997-05-19
申请人： SENDX MEDICAL, INC.
发明人： SENDX MEDICAL, INC. , BETTS, Ronald, E.
IPC分类号： G01N31/00
CPC分类号： G01N33/96 , G01N33/492 , G01N33/84 , G01N2496/70
摘要： Free calcium ion is maintained in an aqueous calibration solution for maintaining quality control in a blood gas/electrolyte analyzer, which solution contains calcium and sodium bicarbonate, by addition of sufficient of a protecting species, preferably acetate ion, to prevent formation of calcium carbonate in the solution.
摘要翻译：游离钙离子保持在水性校准溶液中，以通过加入足够的保护物质，优选乙酸根离子来保持血液/电解质分析仪中的质量控制，该溶液含有碳酸氢钙和碳酸氢钠，以防止碳酸钙形成解决方案。

93. 发明申请

WO1996040986A1 CALIBRATOR FOR USE IN A SOLUBLE FIBRIN ASSAY 审中-公开
标题翻译：用于可溶纤维蛋白测定的校准仪
公开(公告)号：WO1996040986A1
公开(公告)日：1996-12-19
申请号：PCT/US1996007891
申请日：1996-04-29
申请人： AMERICAN BIOGENETIC SCIENCES, INC.
发明人： AMERICAN BIOGENETIC SCIENCES, INC. , DIMITRIJEVIC, Nikola , DIMITRIJEVIC, Nada
IPC分类号： C12Q01/56
CPC分类号： C07K16/18 , G01N33/86 , G01N33/96 , G01N2333/75
摘要： The invention provides a calibrator for use in an in vitro soluble fibrin assay wherein the calibrator composition is lyophilized and comprises a known amount of soluble crosslinked and soluble non-crosslinked DesAABB fibrin polymers, a stabilizing agent and an aqueous buffer.
摘要翻译：本发明提供了一种用于体外可溶性纤维蛋白测定的校准器，其中校准组合物被冻干并包含已知量的可溶性交联和可溶性非交联DesAABB纤维蛋白聚合物，稳定剂和水性缓冲液。

94. 发明申请

WO1996025175A1 ADMINISTRATION OF A CYCLOSPORINE-SPECIFIC MONOCLONAL ANTIBODY THAT CROSS-REACTS WITH HIV-1 p24 GAG TO TREAT HIV INFECTION 审中-公开
标题翻译：与HIV-1 p24 GAG交叉反应以治疗HIV感染的环孢菌素特异性单克隆抗体的施用
公开(公告)号：WO1996025175A1
公开(公告)日：1996-08-22
申请号：PCT/US1996002129
申请日：1996-02-16
申请人： THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
发明人： THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK , ERLANGER, Bernard, F. , CHEN, Bi-Xing
IPC分类号： A61K39/42
CPC分类号： G01N33/96 , A61K38/00 , A61K47/643 , C07K7/645 , C07K16/1054 , C07K16/14 , C07K16/4208 , C07K16/44 , G01N33/68 , G01N2410/08
摘要： The generation of a monoclonal antibody that specifically recognizes N-methyl leucine residues (9 and 10) of cyclosporine is disclosed. This antibody also displays cross-reactivity towards the HIV-1 p24 Gag protein. Methods for the treatment of HIV infection and acquired immune deficiency syndrome employing this antibody are contemplated.
摘要翻译：公开了特异性识别环孢菌素的N-甲基亮氨酸残基（9和10）的单克隆抗体的产生。该抗体还显示对HIV-1 p24 Gag蛋白的交叉反应性。考虑使用该抗体治疗HIV感染和获得性免疫缺陷综合征的方法。

95. 发明申请

WO1995030154A1 CALIBRATOR FOR PROTHROMBIN TIME (PT) ASSAYS 审中-公开
标题翻译：校准器用于PROTHROMBIN时间（PT）测定
公开(公告)号：WO1995030154A1
公开(公告)日：1995-11-09
申请号：PCT/US1995005195
申请日：1995-04-28
申请人： DADE INTERNATIONAL INC.
发明人： DADE INTERNATIONAL INC. , WOODHAMS, Barry, J. , BURGESS-WILSON, Michael, E.
IPC分类号： G01N33/86
CPC分类号： G01N33/96 , G01N33/86 , G01N2333/96447 , G01N2496/05 , Y10S436/811 , Y10T436/10 , Y10T436/105831 , Y10T436/106664
摘要： This invention pertains to a PT Assay Calibrator and a method of preparing a PT Assay Calibrator including a coagulation factor such as recombinant FVII or recombinant FVIIa that will allow preparation of PT calibration curves with values about 100 % and which will give results analogous to those obtained using fresh normal plasma.
摘要翻译：本发明涉及PT测定校准物和制备包括凝血因子如重组FVII或重组FVIIa的PT测定校准物的方法，其将允许制备具有约100％的值的PT校准曲线，并且将得到类似于获得的结果的结果使用新鲜正常血浆。

96. 发明申请

WO1994029385A1 SYNTHETIC FECAL MATERIAL 审中-公开
标题翻译：合成材料
公开(公告)号：WO1994029385A1
公开(公告)日：1994-12-22
申请号：PCT/US1994005816
申请日：1994-05-24
申请人： THE PROCTER & GAMBLE COMPANY
发明人： THE PROCTER & GAMBLE COMPANY , JACKSON, Charles, Andrew , GITHUKU, David, Ngibuini , ROE, Donald, Carroll
IPC分类号： C08L33/02
CPC分类号： G01N33/96
摘要： The synthetic fecal material is a viscoelastic analog which simulates natural fecal material, particularly that excreted by young infants. The synthetic fecal material satisfies a particular yield value and zero shear viscosity equation. The equation may be approximated by a linear regression on a log-log scale.
摘要翻译：合成粪便材料是一种模拟天然粪便材料的粘弹性类似物，特别是年轻婴儿排泄的粪便。合成粪便材料满足特定屈服值和零剪切粘度方程。该方程可以通过对数对数标度的线性回归近似。

97. 发明申请

WO1994014058A1 CONTROL REAGENT CONTAINING A HYDROXYLAMINE OR AN ANTIOXIDANT 审中-公开
标题翻译：含有羟基胺或抗氧化剂的对照试剂
公开(公告)号：WO1994014058A1
公开(公告)日：1994-06-23
申请号：PCT/US1993011823
申请日：1993-12-06
申请人： BOEHRINGER MANNHEIM CORPORATION
发明人： BOEHRINGER MANNHEIM CORPORATION , RAPKIN, Myron , TABB, David , DIEBOLD, Eric
IPC分类号： G01N31/00
CPC分类号： G01N33/96 , C12Q1/54 , C12Q1/60 , G01N33/66 , G01N33/92 , G01N2496/80 , Y10T436/104165 , Y10T436/104998 , Y10T436/106664 , Y10T436/108331 , Y10T436/144444 , Y10T436/17
摘要： The invention relates to improved control reagents. These materials contain an antioxidant or a hydroxylamine compound together with other ingredients, the most important of which is a known amount of the analyte for which the reagent acts as a control.
摘要翻译：本发明涉及改进的对照试剂。这些材料与其他成分一起含有抗氧化剂或羟胺化合物，其中最重要的是试剂作为对照物的已知量的分析物。

98. 发明申请

WO1993018397A1 REFERENCE CONTROL FOR USE WITH MANUAL AND FLOW CYTOMETRIC RETICULOCYTE COUNTING DEVICES 审中-公开
标题翻译：使用手动和流动细胞计数器计数器件的参考控制
公开(公告)号：WO1993018397A1
公开(公告)日：1993-09-16
申请号：PCT/US1993001839
申请日：1993-03-01
申请人： STRECK LABORATORIES, INC. , RYAN, Wayne, L. , EBRAHIM, Alireza
发明人： STRECK LABORATORIES, INC.
IPC分类号： G01N31/00
CPC分类号： G01N15/1012 , G01N33/96 , G01N2496/05 , Y10T436/10 , Y10T436/101666 , Y10T436/106664 , Y10T436/25
摘要： A stable reticulocyte reference control which is usable with both manual and flow cytometric reticulocyte counting devices and methods such as those used to access bone marrow activity is provided. The reference control includes a suspension of erythrocytes that are loaded with either nucleic acid or a polyanion capable of binding with a cationic dye, in an aqueous preserving medium. The reference control is preferably prepared using a reversible osmotic lysis procedure whereby the nucleic acid or polyanion is encapsulated inside the erythrocytes by first introducing the cells into a hypotonic solution in the presence of the compound to be encapsulated, followed by replacing the hypotonic solution with a hypertonic solution. The reference control of the invention is advantageous in that it has long-term stability and it can be used to give highly accurate readings of reticulocyte counts using either manual or flow cytometric procedures.
摘要翻译：提供了可用于手动和流式细胞计数网织红细胞计数装置的稳定的网织红细胞参考对照和用于进行骨髓活性的方法。参考对照包括在水性保存培养基中装载有能够与阳离子染料结合的核酸或聚阴离子的红细胞的悬浮液。参考对照优选使用可逆渗透裂解方法制备，其中核酸或聚阴离子被包封在红细胞内，首先在待包被化合物存在下将细胞引入低渗溶液中，然后用高渗溶液。本发明的参考对照是有利的，因为它具有长期的稳定性，并且可用于使用手动或流式细胞术程序提供高度精确的网织红细胞计数读数。

99. 发明申请

WO1993017329A1 SUSPENSION MEDIA FOR HEMATOLOGICAL COMPOSITION AND METHOD FOR ITS USE 审中-公开
标题翻译：用于血液学组合物的悬浮介质及其使用方法
公开(公告)号：WO1993017329A1
公开(公告)日：1993-09-02
申请号：PCT/US1993001427
申请日：1993-02-17
申请人： COULTER CORPORATION
发明人： COULTER CORPORATION , YOUNG, Carole , ELLIOTT, Michael, N. , NAYLOR, Nancy, R. , FISCHER, Timothy, J.
IPC分类号： G01N31/00
CPC分类号： G01N33/96 , G01N2496/05 , Y10T436/101666
摘要： A hematology control product comprising leukocyte analogs and an aqueous solution of a plasma substance for use in a blood counting instrument is described. The instrument employs a lytic reagent system for the lysable red blood cells in the control product. The plasma substance is in an amount effective to enable the differentiation of each of said leukocyte analogs relative to the physical attributes of the analogs, said physical attributes of the analog are similar to human leukocytes. Preferably, the plasma substance comprises cholesterol or its derivatives. A method for using the cell suspension media comprising an aqueous solution of a plasma substance is also described. The method provides a quality control to determine whether an instrument is operating within manufacturer's specifications.
摘要翻译：描述了包含白细胞类似物和用于血液计数仪器的血浆物质的水溶液的血液控制产品。该仪器在对照产品中使用溶解性红细胞的溶解试剂系统。等离子体物质的量相对于类似物的物理属性有效地使每种所述白细胞类似物分化，所述类似物的所述物理属性类似于人白细胞。优选地，血浆物质包含胆固醇或其衍生物。还描述了使用包含等离子体物质的水溶液的细胞悬浮介质的方法。该方法提供质量控制以确定仪器是否在制造商的规格范围内运行。

100. 发明申请

WO1991012525A1 GLUCOSE MEASUREMENT CONTROL REAGENT 审中-公开
标题翻译：葡萄糖测量控制试剂
公开(公告)号：WO1991012525A1
公开(公告)日：1991-08-22
申请号：PCT/US1991000741
申请日：1991-02-01
申请人： BOEHRINGER MANNHEIM CORPORATION
发明人： BOEHRINGER MANNHEIM CORPORATION , KENNAMER, James, E. , STORHOFF, Diana, F. , BONTRAGER, Roger, L. , TABB, David, Lee , USMANI, Arthur, M.
IPC分类号： G01N31/00
CPC分类号： C12Q1/54 , G01N33/66 , G01N33/96 , G01N2496/25 , Y10T436/10 , Y10T436/104998 , Y10T436/108331 , Y10T436/144444
摘要： The invention relates to a serum-free control reagent for glucose determination. Rather than using modified serum, the control reagent contains water, glucose, and the viscosity agent polystyrene sulphonate. The control reagent may also contain a buffer, preservatives, and surfactants or surface active agents.

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