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91. 发明申请

WO02002501A1 ALPHA-ARYLATED CINNAMIC ESTERS AND 1,4-BIS(ALPHA-CARBOXYL-BETA-STYRYL)BENZENE ESTERS AS UV-BLOCKING AGENTS 审中-公开
标题翻译： ALPHA-ARYLATED CINNAMIC ESTERS和1,4-BIS（ALPHA-CARBOXY-BETA-STYRYL）苯乙烯酯作为UV阻隔剂
公开(公告)号：WO02002501A1
公开(公告)日：2002-01-10
申请号：PCT/US2001/020013
申请日：2001-06-22
IPC分类号： A61K8/37 , A61Q17/04 , C07C51/367 , C07C59/64 , C07C69/732 , C07C69/734 , C07C69/76 , A61K7/42
CPC分类号： C07C69/734 , A61K8/37 , A61Q17/04 , C07C51/367 , C07C59/64 , C07C69/732
摘要： Compounds of the structure wherein R and R' are H, alkyl or aryl and each Z, X, Y and X' is H, acylamino, acyloxy, alkanoyl, alkoxycarbonyl, amino, alkyl, alkoxy, hydroxy, alkylamino, dialkylamino, arylamino, alkylaryl, diarylamino, halo, carboxyl or cyano; and Z can also be effective UV blockers.
摘要翻译：其中R和R'为H，烷基或芳基并且各Z，X，Y和X'为H，酰氨基，酰氧基，烷酰基，烷氧基羰基，氨基，烷基，烷氧基，羟基，烷基氨基，二烷基氨基，芳基氨基，烷基芳基，二芳基氨基，卤素，羧基或氰基; Z也可以是有效的UV阻断剂。

92. 发明申请

WO01051451A2 METHODS FOR MANUFACTURING BETULINIC ACID 审中-公开
标题翻译：制备白杨酸的方法
公开(公告)号：WO01051451A2
公开(公告)日：2001-07-19
申请号：PCT/US2001/000991
申请日：2001-01-11
IPC分类号： C07C67/29 , C07C45/64 , C07C47/46 , C07C51/16 , C07C51/235 , C07C51/367 , C07C62/06 , C07C62/32 , C07C69/00 , C07C69/16 , C07C69/013 , C07C67/03 , C07C67/08 , C07C67/39 , C07C69/732
CPC分类号： C07C51/367 , C07C51/16 , C07C62/32 , C07C67/08 , C07C67/14 , C07C67/29 , C07C2603/52 , C07C69/013 , C07C69/16 , C07C69/78 , C07C69/14
摘要： The present invention provides a method for preparing betulin-3-acetate including alcoholyzing betulin 3,28-dibenzoate; a process for preparing betulin-3-acetate including: (1) acylating betulin to provide betulin 3,28-dibenzoate and (2) alcoholyzing betulin 3,28-dibenzoate to provide betulin-3-acetate; and a process for preparing betulinic acid including: (1) acylating betulin to provide betulin 3,28-dibenzoate; (2) alcoholyzing betulin 3,28-dibenzoate to provide betulin-3-acetate; (3) oxidizing betulin-3-acetate to provide betulinic aldehyde-3-acetate; (4) oxidizing betulinic aldehyde-3-acetate to provide betulinic acid-3-acetate; and (5) deprotecting betulinic acid-3-acetate to provide betulinic acid.
摘要翻译：本发明提供了一种制备桦木酸-3-乙酸酯的方法，包括：乙酸bet ulin 3,28-二苯甲酸酯; 制备桦木酸-3-乙酸酯的方法，包括：（1）酰化桦木醇以提供桦木328-二苯甲酸酯和（2）醇zing ulin ulin ulin 3,28-二苯甲酸酯以提供桦木醇-3-乙酸酯; 和一种制备桦木酸的方法，包括：（1）酰化桦木醇以提供桦木328-二苯甲酸酯; （2）将桦木醇3,28-二苯甲酸乙醇溶解，得到桦木醇-3-乙酸酯; （3）氧化桦木醇-3-乙酸酯以提供桦木醛-3-乙酸酯; （4）氧化桦木醛-3-乙酸酯，得到桦木酸-3-乙酸酯; 和（5）将桦木酸-3-乙酸酯脱保护得到桦木酸。

93. 发明申请

WO1993014060A1 PROCESS FOR PRODUCING OLIGOMERIC FATTY ACIDS 审中-公开
标题翻译：生产低聚脂肪酸的方法
公开(公告)号：WO1993014060A1
公开(公告)日：1993-07-22
申请号：PCT/EP1993000041
申请日：1993-01-11
申请人： HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN , GRUBER, Bert
发明人： HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN
IPC分类号： C07C69/708
CPC分类号： C07C51/367 , C07C51/09 , C07C67/31 , C07C59/305 , C07C69/708
摘要： Oligomeric fatty acids can be produced selectively and with a good yield by causing epoxidisation products of unsaturated fatty acid esters of the formula (I): R1CO-OR2, in which: R1CO is an aliphatic acyl residue with 16 to 22 carbon atoms and 1 to 5 double bonds; and R2 is a linear or branched alkyl residue with 1 to 4 carbon atoms, to react with hydroxy compounds in the molar ratio 1:1 to 10:1 in the presence of acid catalysts and the resultant bridged ring opening products are saponified in a manner known per se.

94. 发明申请

WO1993013215A1 SYNTHESIS OF HOMOCHIRAL 2-HYDROXY ACIDS 审中-公开
标题翻译：合成2-羟基丙酸的合成
公开(公告)号：WO1993013215A1
公开(公告)日：1993-07-08
申请号：PCT/GB1992002396
申请日：1992-12-23
申请人： LEE, Dennis +hm , GENZYME LIMITED , CASY, Guy
发明人： LEE, Dennis +hm , GENZYME LIMITED , LEE, Thomas, Victor +di
IPC分类号： C12P07/42
CPC分类号： C07D307/33 , C07C51/367 , C12P7/42 , C07C59/215 , C07C59/90 , C07C59/01
摘要： A process for the production of a homochiral 2-hydroxy carboxylic acid or salt thereof corresponding to general formula (I), wherein R represents one of formulae (II), (III), (IV), (V), wherein R' represents straight- or branched-chain alkyl or phenyl optionally para-substituted with methyl, methoxy, nitro or amino; and R'' represents hydrogen, halogen or phenyl optionally para-substituted with methyl, methoxy, nitro or amino; and M represents hydrogen or a salt-forming moiety; characterised in that it comprises reducing a corresponding 2-keto carboxylic acid or salt thereof using a (R)- or (S)-2-oxo carboxylic acid dehydrogenase, inter alia, is disclosed.
摘要翻译：一种制备与通式（I）相应的同基因2-羟基羧酸或其盐的方法，其中R表示式（II），（III），（IV），（V）中的一种，其中R'表示任选被甲基，甲氧基，硝基或氨基取代的直链或支链烷基或苯基; R“表示氢，卤素或任选被甲基，甲氧基，硝基或氨基取代的苯基; M代表氢或成盐部分; 其特征在于其包括使用（R） - 或（S）-2-氧代羧酸脱氢酶还原相应的2-酮羧酸或其盐，特别是公开。

95. 发明申请

WO1993012062A1 PROCESS FOR PREPARING KETONE ENANTIOMER 审中-公开
标题翻译：制备酮酮的方法
公开(公告)号：WO1993012062A1
公开(公告)日：1993-06-24
申请号：PCT/US1992007654
申请日：1992-09-15
申请人： PFIZER INC. , QUALLICH, George, J.
发明人： PFIZER INC.
IPC分类号： C07C49/697
CPC分类号： C07D307/58 , C07B57/00 , C07C45/46 , C07C49/697 , C07C51/09 , C07C51/367 , C07C67/31 , C07C303/28 , C07F7/1804 , C07C57/58 , C07C59/56 , C07C309/66
摘要： A novel multi-step process for preparing the (4S &cir& _-enantiomer of 4-(3,4-dichlorophenyl)-3,4-dihydro-1(2H)-naphthalenone in a highly-optically pure form is disclosed. The process involves (1) first esterifying 4-(3,4-dichlorophenyl)-4-ketobutanoic acid with isopropylene or isobutylene to form the corresponding isopropyl or t &cir& _e &cir& _r &cir& _t &cir& _.-butyl 4-(3,4-dichlorophenyl)-4-ketobutanoate; (2) then reducing the ketobutanoic acid ester obtained in the first step with an asymmetric carbonyl reducing agent to form the corresponding chiral isopropyl or t &cir& _e &cir& _r &cir& _t &cir& _.-butyl 4-(3,4-dichlorophenyl)-(4R &cir& _)-hydroxybutanoate; (3) then sulfonylating the (4R &cir& _)-hydroxybutanoic acid ester with methanesulfonyl, benzenesulfonyl or p &cir& _-toluenesulfonyl chloride or bromide in the presence of a standard base to yield the corresponding isopropyl or t &cir& _e &cir& _r &cir& _t &cir& _.-butyl 4-(3,4-dichlorophenyl)-(4R &cir& _)-sulfonyloxybutanoate; (4) next subjecting the 4-sulfonyloxybutanoic acid ester obtained in the third step to a copper-coupling reaction with dilithium diphenyl(cyano)cuprate of the formula PHI 2Cu(CN)Li2 to effect a stereochemical displacement of the organic (4R &cir& _)-sulfonyloxy group of the (4R &cir& _)-sulfonyloxybutanoic acid ester by the phenyl group of the dilithium diphenylcuprate reagent and so selectively form the corresponding isopropyl or t &cir& _e &cir& _r &cir& _t &cir& _.-butyl 4-(3,4-dichlorophenyl)-(4R &cir& _)-phenylbutanoate, and (5) thereafter cyclizing the stereospecific (4R &cir& _)-phenylated n-butanoic acid ester in the presence of a protic or Lewis acid catalyst to finally yield the desired (4S &cir& _)-4-(3,4-dichlorophenyl)-3,4-dihydro-1(2H)-naphthalenone compound in a highly-optically pure form. The latter compound, which is a novel (4S &cir& _)-enantiomer per se, has utility as an intermediate that ultimately leads to pure c &cir& _i &cir& _s &cir& _-(1S &cir& _)(4S &cir& _)N-methyl-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthaleneamine (sertraline), which is a known antidepressant agent. The aforementioned isopropyl and t &cir& _e &cir& _r &cir& _t &cir& _.-butyl esters of 4-(3,4-dichlorophenyl)-(4R &cir& _)-hydroxybutanoic acid, as well as their corresponding (4R &cir& _)-methanesulfonyl, (4R &cir& _)-benzenesulfonyl and (4R &cir& _)-p &cir& _-toluenesulfonyl derivatives, are also novel compounds, as are the aforementioned isopropyl and t &cir& _e &cir& _r &cir& _t &cir& _.-butyl esters of 4-(3,4-dichlorophenyl)-(4R &cir& _)-phenylbutanoic acid as well as the aforesaid acid per se. These novel chiral compounds are all useful as key intermediates in the overall process of the present invention.
摘要翻译：公开了一种用于以高光学纯度形式制备4-（3,4-二氯苯基）-3,4-二氢-1（2H） - 萘酮的（4S +） - 对映异构体的新型多步法。包括（1）首先用异丙烯或异丁烯酯化4-（3,4-二氯苯基）-4-酮丁酸，形成相应的异丙基或叔丁基4-（3,4-二氯苯基））-4-酮丁酸酯;（2）然后用不对称羰基还原剂还原第一步得到的酮丁酸酯形成相应的手性异丙基或叔丁基4-（3，（4R）和（R） - 羟基丁酸酯;（3）然后在标准碱的存在下，用甲磺酰基，苯磺酰基或对甲苯磺酰氯或溴化物磺酰化（4R和C） - 羟基丁酸酯，得到相应的异丙基或叔丁基4-（3,4-二氯苯基） - （4R和C） - 磺酰氧基丁基吃了; （4）接着将第三步骤中得到的4-磺酰氧基丁酸酯与式PHI 2Cu（CN）Li 2的二苯基二苯基（氰基）铜盐进行铜偶联反应，以进行有机（4R＆（4R和C 1 -C 6） - 磺酰氧基丁酸酯的苯基磺酰氧基），并选择性地形成相应的异丙基或叔丁基4-（3,4 （4R）和苯基丁酸酯，和（5）然后在质子或路易斯酸催化剂的存在下环化立体定向（4R和C 1 -C 6） - 苯基的正丁酸酯，最终得到所需的（4S＆ _）-4-（3,4-二氯苯基）-3,4-二氢-1（2H） - 萘酮化合物，为高光学纯的形式。后一种化合物，它是一种新型的（4S和Cir） - 对映异构体本身，具有作为中间体的作用，最终导致纯化合物（1S＆cir）和（4S）和（c） 4-（3,4-二氯苯基）-1,2,3,4-四氢-1-萘胺（舍曲林），其是已知的抗抑郁剂。上述异丙基和叔丁基-4-（3,4-二氯苯基） - （4R和C 1-6烯基） - 羟基丁酸的叔丁酯以及它们相应的（4R和C 1-6烷基） - 甲磺酰基，（4R和C 1-6）苯磺酰基和（4R和C 1-4 - 苯基） - 甲苯磺酰基衍生物也是新化合物，如上述异丙基和叔丁基酯的4-（3 ，4-二氯苯基） - （4R和C 1-6）苯基丁酸，以及上述酸本身。这些新型手性化合物在本发明的整个方法中都可用作关键中间体。

96. 发明申请

WO9011997A3 INHIBITORS OF MONO-AMINE OXIDASE, PROCESS FOR THEIR PREPARATION, AND THEIR USE IN THERAPEUTICS. 审中-公开
标题翻译：单胺氧化酶抑制剂，其制备方法及其在治疗中的用途。
公开(公告)号：WO9011997A3
公开(公告)日：1990-11-15
申请号：PCT/FR9000209
申请日：1990-03-28
申请人： FOURNIER INNOVATION SYNERGIE
发明人： RENAUT PATRICE , BELLAMY FRANCOIS , BOUCHER THIERRY
IPC分类号： C07C43/225 , C07C43/23 , C07C45/71 , C07C49/255 , C07C49/84 , C07C51/367 , C07C59/68 , C07C69/007 , C07C69/92 , C07C205/32 , C07C205/35 , C07C217/20 , C07C217/58 , C07C217/60 , C07C217/62 , C07C235/16 , C07C235/48 , C07C235/50 , C07C237/04 , C07C255/54 , C07D295/096 , A61K31/085 , A61K31/165
CPC分类号： C07D295/096 , C07C43/225 , C07C43/23 , C07C45/71 , C07C49/255 , C07C49/84 , C07C51/367 , C07C59/68 , C07C69/007 , C07C69/92 , C07C205/32 , C07C205/35 , C07C217/20 , C07C217/58 , C07C217/60 , C07C217/62 , C07C235/16 , C07C235/48 , C07C235/50 , C07C237/04 , C07C255/54
摘要： The present invention relates to those compounds which, as new industrial products, are chosen from amongst the compounds of formula (I), in which R represents a halogen atom, an alkoxy group at C1-C4, a cyano group, a nitro group or trifluoromethyl group; X represents a -(CH2)2O- group or a -CH2O- group; Z represents (i) a NR1R2 group (where R1 and R2, identical or different, each represent the hydrogen atom, an alkyl group at C1-C4, a -(CH2)v-CH2OH group where v equals 1, 2 or 3, R1 and R2, considered together, being able to form with the nitrogen atom to which they are attached an N-heterocyclic group of 5 to 7 apexes capable of containing a second heteroatom chosen from amongst N, O and S) and Y represents a simple bond, in which case n = 0, 1, 2, or 3 and p= 0 or 1; the oxygen atom, in which case n = 1 and p = 1; the CONH group or the NHCO group, in which case n = 2 and p = 0; and the addition salts formed with the NR1R2 group; ii) an OR3 group (where R3 represents the hydrogen atom, an alkyl group at C1-C4 or a -COalk- group where alk representsan alkyl group at C1-C4) and y represents a simple bond, in which case n = 1, 2, or 3 and p = 0 or 1; the CONH group or the NHCO group, in which case n = 2 and p = 0.
摘要翻译：本发明涉及作为新型工业产品的那些化合物，其选自式（I）的化合物，其中R表示卤素原子，C 1 -C 4的烷氧基，氰基，硝基或三氟甲基; X表示 - （CH 2）2 O-基团或-CH 2 O-基团; Z代表（i）NR 1 R 2基团（其中R 1和R 2相同或不同，各自代表氢原子，C 1 -C 4的烷基， - （CH 2）v -CH 2 OH基团，其中v等于1,2或3， R 1和R 2一起考虑能够与它们所连接的氮原子形成5-7个能够含有选自N，O和S的第二杂原子的顶端的N-杂环基团，并且Y表示简单的键，在这种情况下，n = 0,1,2或3，p = 0或1; 氧原子，在这种情况下n = 1和p = 1; CONH组或NHCO组，在这种情况下n = 2和p = 0; 和与NR1R2基团形成的加成盐; ii）OR 3基团（其中R 3代表氢原子，C 1 -C 4的烷基或-CO-基团，其中C 1 -C 4处的烷基代表烷基）且y代表单键，在这种情况下n = 1， 2或3并且p = 0或1; CONH组或NHCO组，在这种情况下n = 2和p = 0。

97. 发明申请

WO1990011997A2 INHIBITORS OF MONO-AMINE OXIDASE, PROCESS FOR THEIR PREPARATION, AND THEIR USE IN THERAPEUTICS. 审中-公开
标题翻译：单胺氧化酶的抑制剂，其制备方法及其在治疗中的应用。
公开(公告)号：WO1990011997A2
公开(公告)日：1990-10-18
申请号：PCT/FR1990000209
申请日：1990-03-28
申请人： FOURNIER INNOVATION ET SYNERGIE , RENAUT, Patrice , BELLAMY, François , BOUCHER, Thierry
发明人： FOURNIER INNOVATION ET SYNERGIE
IPC分类号： C07C217/58
CPC分类号： C07D295/096 , C07C43/225 , C07C43/23 , C07C45/71 , C07C49/255 , C07C49/84 , C07C51/367 , C07C59/68 , C07C69/007 , C07C69/92 , C07C205/32 , C07C205/35 , C07C217/20 , C07C217/58 , C07C217/60 , C07C217/62 , C07C235/16 , C07C235/48 , C07C235/50 , C07C237/04 , C07C255/54
摘要： The present invention relates to those compounds which, as new industrial products, are chosen from amongst the compounds of formula (I), in which R represents a halogen atom, an alkoxy group at C1-C4, a cyano group, a nitro group or trifluoromethyl group; X represents a -(CH2)2O- group or a -CH2O- group; Z represents (i) a NR1R2 group (where R1 and R2, identical or different, each represent the hydrogen atom, an alkyl group at C1-C4, a -(CH2)v-CH2OH group where v equals 1, 2 or 3, R1 and R2, considered together, being able to form with the nitrogen atom to which they are attached an N-heterocyclic group of 5 to 7 apexes capable of containing a second heteroatom chosen from amongst N, O and S) and Y represents a simple bond, in which case n = 0, 1, 2, or 3 and p= 0 or 1; the oxygen atom, in which case n = 1 and p = 1; the CONH group or the NHCO group, in which case n = 2 and p = 0; and the addition salts formed with the NR1R2 group; ii) an OR3 group (where R3 represents the hydrogen atom, an alkyl group at C1-C4 or a -COalk- group where alk representsan alkyl group at C1-C4) and y represents a simple bond, in which case n = 1, 2, or 3 and p = 0 or 1; the CONH group or the NHCO group, in which case n = 2 and p = 0.

98. 发明申请

WO1990009976A1 METHOD OF SYNTHESIS OF HYDROXY-SUBSTITUTED-4-ALKOXYPHENYLACETIC ACIDS 审中-公开
标题翻译：羟基取代的4-烷氧基苯甲酸合成方法
公开(公告)号：WO1990009976A1
公开(公告)日：1990-09-07
申请号：PCT/US1990001081
申请日：1990-03-05
申请人： THE UNITED STATES OF AMERICA, represented by THE ...
发明人： THE UNITED STATES OF AMERICA, represented by THE ... , RICE, Kenner, C.
IPC分类号： C07C51/38
CPC分类号： C07C51/363 , C07C51/367 , C07C59/64
摘要： A process for preparing hydroxy-substituted-4-alkoxyphenylacetic acids by reacting a 4-alkoxyphenyl-acetic acid with bromine and then treating the brominated acid with a strong base and a copper salt to form the desired hydroxy-substituted-4-alkoxyphenylacetic acid.

99. 发明申请

WO2017102087A8 METHOD FOR PRODUCING A POLYOL 审中-公开
标题翻译：制备多元醇的方法
公开(公告)号：WO2017102087A8
公开(公告)日：2017-08-17
申请号：PCT/EP2016002122
申请日：2016-12-16
申请人： KARLSRUHER INST FÜR TECH (KIT)
发明人： UNVERFERTH MAIKE , MEIER MICHAEL
IPC分类号： C07C67/31 , C07C51/367 , C07C59/105 , C07C69/67 , C07C407/00 , C07D301/19 , C07D303/14
CPC分类号： C07C51/367 , C07C67/31 , C07C407/00 , C07D301/19 , C07D303/14 , C07C59/105 , C07C409/04 , C07C69/675
摘要： The present invention relates to a method for producing a polyol from an unsaturated fatty acid with one or more double bonds, or a polyol from a fatty acid derivative having at least one unsaturated fatty acid group with one or more double bonds.
摘要翻译：本发明涉及由具有一个或多个双键的不饱和脂肪酸或多元醇由具有至少一个具有一个或多个双键的不饱和脂肪酸残基的脂肪酸衍生物生产多元醇的方法。

100. 发明申请

WO2017134139A1 A METHOD OF PREPARING GLYCOLIC ACID (HOCH2COOH) 审中-公开
标题翻译：一种制备甘油酸（HOCH2COOH）的方法
公开(公告)号：WO2017134139A1
公开(公告)日：2017-08-10
申请号：PCT/EP2017/052210
申请日：2017-02-02
申请人： SHELL INTERNATIONALE RESEARCH MAATSCHAPPIJ B.V. , SHELL OIL COMPANY
发明人： LANGE, Jean Paul, Andre, Marie, Joseph, Ghislain , MEURS, Jan, Hermen, Hendrik , RIGUTTO, Marcello, Stefano , STIL, Hans, Arie
IPC分类号： C07C29/149 , C07C51/367 , C07C59/06 , C07C31/20
CPC分类号： C07C51/367 , C07C29/149 , C07C59/06 , C07C31/202
摘要： The present invention provides a method of preparing glycolic acid ( HOCH 2 COOH ), the method at least comprising the steps of: (a) providing an aqueous oxalic acid (HOOCCOOH) containing stream having a molar ratio of water/oxalic acid of above 5.0; (b) subjecting the aqueous oxalic acid (HOOCCOOH) containing stream provided in step (a) to hydrogenation in the presence of a hydrogenation metal catalyst and hydrogen, thereby obtaining a glycolic acid (HOCH 2 COOH ) containing stream; and (c) optionally subjecting the glycolic acid containing stream obtained in step (b) to hydrogenation in the presence of a hydrogenation metal catalyst and hydrogen, thereby obtaining an ethylene glycol ( HOCH 2 CH 2 OH ) containing stream.
摘要翻译：本发明提供了制备乙醇酸（HOCH 2 COOH）的方法，所述方法至少包括以下步骤：（a）提供草酸水溶液（HOOCCOOH ）含水流，其中水/草酸的摩尔比大于5.0; （b）使步骤（a）中提供的含草酸（HOOCCOOH）的含水物流在氢化金属催化剂和氢存在下进行氢化，从而获得含有乙醇酸（HOCHCOOH）的乙醇酸（HOCH 2 COOH）流; 和（c）任选地使在步骤（b）中获得的含乙醇酸的料流在氢化金属催化剂和氢存在下进行氢化，从而获得乙二醇（HOCH 2 CH 2 OH）的流。

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