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91. 发明申请

WO98046306A1 DYNAMIC BANDWITH CONTROL IN AN IMPLANTABLE MEDICAL CARDIAC STIMULATOR 审中-公开
标题翻译：可移植医疗心脏刺激仪中的动态带状控制
公开(公告)号：WO98046306A1
公开(公告)日：1998-10-22
申请号：PCT/US1998/007491
申请日：1998-04-13
IPC分类号： A61N1/362 , A61N1/37 , A61N1/38 , A61N1/39 , A61N1/368
CPC分类号： A61N1/3622 , A61N1/3704 , A61N1/385 , A61N1/395 , A61N1/3962
摘要： An implantable medical device (100) for electrically stimulating the heart to beat includes a sense circuit (218) for detecting cardiac electrical activity. The sense circuit (218) includes a band pass filter (215) with an adjustable frequency response. The frequency response can be repeatedly adjusted after implantation of the medical device and preferably is adjusted upon detection of the loss of normal sinus rhythm (NSR) in the heart's atria. The loss of NSR often indicates atrial fibrillation (AF), and the filter's frequency response is adjusted to increase the sensitivity of the sense circuit to the cardiac electrical activity typical during AF. The medical device is calibrated during implantation or at subsequent doctor visits with the aid of a calibration device (400) external to the body. Cardiac electrical activity in the form of an electrogram is transmitted from the medical device to the external calibration device. The transmitted electrogram preferably includes both NSR and AF rhythms. The calibration device computes (440, 490) two sets of filter coefficients; one set (440) for increased filter sensitivity during NSR and another set (490) for increased sensitivity during AF. The coefficients are transmitted to the medical device which uses the appropriate set of coefficients to increase the filter's frequency response during both NSR and AF.
摘要翻译：用于电刺激心脏跳动的可植入医疗装置（100）包括用于检测心脏电活动的感测电路（218）。感测电路（218）包括具有可调频率响应的带通滤波器（215）。可以在植入医疗装置之后重复地调整频率响应，并且优选地在检测到心脏心房中的正常窦性心律（NSR）的损失时进行调整。 NSR的损失经常表明心房颤动（AF），并且调整滤波器的频率响应以增加感觉电路对AF期间典型的心脏电活动的灵敏度。借助于身体外部的校准装置（400），在植入期间或随后的医生访问期间校准医疗装置。以电图形式的心脏电活动从医疗装置传输到外部校准装置。传输的电描记图优选地包括NSR和AF节奏。校准装置计算（440,490）两组滤波器系数; 一组（440）用于在NSR期间增加滤波器灵敏度，另一组（490）用于在AF期间增加灵敏度。这些系数被传送到使用适当的系数集合的医疗设备，以在NSR和AF期间增加滤波器的频率响应。

92. 发明申请

WO1997040886A1 ATRIAL FIBRILLATION PREVENTION PACING SYSTEM 审中-公开
标题翻译： ATRIAL FIBRILLATION预防系统
公开(公告)号：WO1997040886A1
公开(公告)日：1997-11-06
申请号：PCT/US1997002863
申请日：1997-02-26
申请人： MEDTRONIC, INC.
发明人： MEDTRONIC, INC. , MEHRA, Rahul
IPC分类号： A61N01/39
CPC分类号： A61N1/3962 , A61N1/3622 , A61N1/395
摘要： A method and apparatus for preventing fibrillation, particularly atrial fibrillation or flutter. In response to detection of an atrial premature beat at any given site in the atrial chamber, a low energy pulse burst is delivered to multiple sites of at least one chamber of the atrium for a time period sufficient to depolarize the entire atrium. Preferably, multiple pairs of sense electrodes are distributed about an atrial chamber or both atria to define discrete sensing sites and to widely distribute the simultaneously applied pacing energy pulse burst. Bradycardia pacing between the multiple electrode pairs is also preferably provided.
摘要翻译：一种用于预防原纤维颤动的方法和装置，特别是心房颤动或扑动。响应于在房室的任何给定部位检测到心房早搏，将低能脉冲突发传送至心房至少一个室的多个位置一段足以使整个心房去极化的时间段。优选地，多对感测电极围绕心房或两个心房分布以限定离散感测位置并且广泛分布同时施加的起搏能量脉冲串。也优选提供多个电极对之间的心动过缓起搏。

93. 发明申请

WO1996005885A1 ATRIAL DEFIBRILLATOR AND METHOD OF USE 审中-公开
标题翻译： ATRIAL DEFRIRILLATOR及其使用方法
公开(公告)号：WO1996005885A1
公开(公告)日：1996-02-29
申请号：PCT/US1995009108
申请日：1995-07-19
申请人： MEDTRONIC, INC.
发明人： MEDTRONIC, INC. , MIN, Xiaoyi , MONGEON, Luc, K. , MEHRA, Rahul , ANDERSON, Kenneth, M. , DE GROOT, Paul, J. , HILL, Michael, R., S.
IPC分类号： A61N01/39
CPC分类号： A61N1/3918 , A61N1/395 , A61N1/3962
摘要： An apparatus for treating atrial tachyarrhythmias, particularly atrial fibrillation. High energy pulses are delivered between electrodes locatable in the right atrium/SVC, the right ventricle and the coronary sinus/great vein, with the right ventricular and coronary sinus/great vein electrodes connected in common. Optionally a subcutaneous electrode, preferably located in the left pectoral area may also be employed, coupled in common to the right atrial/SVC electrode.
摘要翻译：一种用于治疗房性快速性心律失常的装置，特别是房颤。在右心房/ SVC，右心室和冠状窦/大静脉之间的电极之间传递高能量脉冲，右心室和冠状窦/大静脉电极共同连接。任选地，也可以使用优选位于左胸部区域的皮下电极，共同连接到右心房/ SVC电极。

94. 发明申请

WO1995028988A1 TREATMENT OF ATRIAL FIBRILLATION 审中-公开
标题翻译： ATRIAL FIBRILLATION治疗
公开(公告)号：WO1995028988A1
公开(公告)日：1995-11-02
申请号：PCT/US1995002661
申请日：1995-03-03
申请人： MEDTRONIC, INC.
发明人： MEDTRONIC, INC. , MONGEON, Luc, R. , HILL, Michael, R., S. , MEHRA, Rahul
IPC分类号： A61N01/39
CPC分类号： A61N1/385 , A61N1/395 , A61N1/3962
摘要： A method and apparatus for treating fibrillation, particularly atrial fibrillation. In response to detection of fibrillation, a series of low energy pulse bursts is delivered, separated by defined inter-burst intervals, and including bursts unsynchronized to heart depolarizations. Detection of termination of fibrillation during inter-burst intervals results in cancellation of further pulse bursts to prevent re-induction of fibrillation.
摘要翻译：一种用于治疗原纤维性颤动的方法和装置，特别是心房颤动。响应于原纤维化的检测，一系列低能量脉冲串被传送，通过限定的突发间隔隔开，并且包括与心脏去极化不同步的突发。在突发间隔期间检测纤维性颤动的终止导致进一步的脉冲突发的消除以防止纤维性颤动的再诱导。

95. 发明申请

WO1994003233A1 ATRIAL DEFIBRILLATOR EMPLOYING TRANSVENOUS AND SUBCUTANEOUS ELECTRODES AND METHOD OF USE 审中-公开
标题翻译：使用透明和不饱和电极的ATRIAL DEFRILLATOR及其使用方法
公开(公告)号：WO1994003233A1
公开(公告)日：1994-02-17
申请号：PCT/US1993006384
申请日：1993-07-06
申请人： MEDTRONIC, INC.
发明人： MEDTRONIC, INC. , BARDY, Gust, H.
IPC分类号： A61N01/39
CPC分类号： A61N1/3962 , A61N1/395
摘要： An atrial and ventricular defibrillation pulse generator and lead system particularly adapted to allow for implant via a single incision. The electrode system consists of a right ventricular electrode and a single subcutaneous electrode, which is preferably located on the housing of the implantable defibrillator. The ventricular and subcutaneous electrodes are used for both atrial and ventricular defibrillation, with higher energy pulses being delivered during ventricular defibrillation. The defibrillator is preferably planted in the left pectoral region of the body, and includes a pulse generator for applying biphasic defibrillation pulses between the two electrodes.
摘要翻译：心房和心室除颤脉冲发生器和引导系统特别适用于通过单个切口进行植入。电极系统由右心室电极和单个皮下电极组成，其优选位于可植入除颤器的壳体上。心室和皮下电极用于心房和心室除颤，在心室除颤期间输送较高的能量脉冲。除颤器优选种植在身体的左胸部区域，并且包括用于在两个电极之间施加双相除颤脉冲的脉冲发生器。

96. 发明申请

WO1992014512A1 DEFIBRILLATION LEAD SYSTEM AND METHOD OF USE 审中-公开
标题翻译：断裂导线系统及其使用方法
公开(公告)号：WO1992014512A1
公开(公告)日：1992-09-03
申请号：PCT/US1991008665
申请日：1991-11-19
申请人： MEDTRONIC, INC.
发明人： MEDTRONIC, INC. , MEHRA, Rahul
IPC分类号： A61N01/39
CPC分类号： A61N1/3918 , A61N1/395
摘要： A method of cardioverting the atrium of a human heart, comprising insertion of first and second elongated electrodes transvenously into the heart and associated vessels. One electrode (212) is preferably located in the coronary sinus and great vein of the heart. The other electrode (206) is preferably located in the vicinity of the atrium of the heart, spaced from the electrode located in the coronary sinus. In response to detection of fibrillation or in response to manual triggering, a defibrillation pulse is applied between the first and second electrodes (212, 206) to effect atrial cardioversion.

97. 发明申请

WO2019108581A1 SIGNAL TRANSMISSION OPTIMIZATION FOR TISSUE CONDUCTION COMMUNICATION 审中-公开
公开(公告)号：WO2019108581A1
公开(公告)日：2019-06-06
申请号：PCT/US2018/062730
申请日：2018-11-28
申请人： MEDTRONIC, INC.
发明人： ROBERTS, Jonathan P. , HEMMING, Michael T. , PEICHEL, David J. , REINKE, James D. , TERRY, Michael B.
IPC分类号： A61N1/372 , A61N1/362 , A61N1/39 , A61N1/375 , A61B5/00
CPC分类号： A61N1/37217 , A61B5/0028 , A61B5/053 , A61N1/3621 , A61N1/36507 , A61N1/37205 , A61N1/3727 , A61N1/37288 , A61N1/3756 , A61N1/395 , A61N1/39622 , H04B13/005
摘要： A device includes a tissue conduction communication (TCC) transmitter that generates a TCC signal including a carrier signal having a peak-to-peak amplitude and a carrier frequency cycle length including a first polarity pulse for a first half of the carrier frequency cycle length and a second polarity pulse opposite the first polarity pulse for a second half of the carrier frequency cycle length. Each of the first polarity pulse and the second polarity pulse inject a half cycle charge into a TCC pathway. The TCC transmitter starts transmitting the TCC signal with a starting pulse having a net charge that is half of the half cycle charge and transmits alternating polarity pulses of the carrier signal consecutively following the starting pulse.

98. 发明申请

WO2017019178A1 TRIGGERING ATRIAL FIBRILLATION ELECTROGRAMS IN AN IMPLANTABLE DEVICE 审中-公开
标题翻译：在可移植设备中触发ATRIAL FIBRILLATION电子
公开(公告)号：WO2017019178A1
公开(公告)日：2017-02-02
申请号：PCT/US2016/036146
申请日：2016-06-07
申请人： CARDIAC PACEMAKERS, INC.
发明人： MAHAJAN, Deepa , PERSCHBACHER, David L. , HERRMANN, Keith L.
IPC分类号： A61N1/362 , A61N1/39 , A61B5/046 , A61B5/0464
CPC分类号： A61B5/046 , A61B5/0205 , A61B5/0215 , A61B5/0245 , A61B5/0404 , A61B5/0432 , A61B5/0464 , A61B5/686 , A61B5/7221 , A61B7/023 , A61N1/3624 , A61N1/36514 , A61N1/395 , A61N1/3956 , A61N1/3987
摘要： An apparatus includes a sensing circuit configured to generate a sensed physiological signal representative of cardiac activity of a subject, an arrhythmia detection circuit, a control circuit, and a memory. The arrhythmia detection circuit detects an episode of atrial fibrillation (AF) in the sensed cardiac signal using a first AF detection criterion, and detects the episode of AF using a second AF detection criterion. The first AF detection criterion has greater sensitivity to AF detection than the second AF detection criterion, and the second AF detection criterion has greater specificity to AF detection than the first AF detection criterion. The control circuit initiates storing of sampled values of a segment of the cardiac signal that includes the episode of AF when the episode of AF is detected by both the first AF detection criterion and the second AF detection criterion.
摘要翻译：一种装置包括：感测电路，被配置为产生代表对象的心脏活动的感测生理信号，心律失常检测电路，控制电路和存储器。心律失常检测电路使用第一AF检测标准检测感测心脏信号中心房颤动（AF）的发作，并使用第二AF检测准则检测AF发作。第一AF检测标准对AF检测具有比第二AF检测准则更高的灵敏度，并且第二AF检测标准对AF检测具有比第一AF检测标准更大的特异性。当通过第一AF检测标准和第二AF检测标准检测到AF的发作时，控制电路启动存储包括AF发作的心脏信号的片段的采样值。

99. 发明申请

WO2016134112A1 APPARATUS FOR ATRIAL ARRHYTHMIA EPISODE DETECTION 审中-公开
标题翻译： ATRIAL ARRHYTHMIA EPISODE检测装置
公开(公告)号：WO2016134112A1
公开(公告)日：2016-08-25
申请号：PCT/US2016/018408
申请日：2016-02-18
申请人： MEDTRONIC, INC.
发明人： SARKAR, Shantanu , HANSEN, Daniel L. , NEITZELL, Grant A. , REILAND, Jerry D. , WYSZYNSKI, Ryan
IPC分类号： A61N1/365 , A61B5/04
CPC分类号： A61B5/046 , A61B5/04 , A61B5/04012 , A61B5/04014 , A61B5/04017 , A61B5/0452 , A61B5/0456 , A61B5/0464 , A61B5/686 , A61N1/3624 , A61N1/36507 , A61N1/36592 , A61N1/395 , A61N1/3987
摘要： Techniques and devices for implementing the techniques for adjusting atrial arrhythmia detection based on analysis of one or more P-wave sensing windows associated with one or more R-waves. An implantable medical device may determine signal characteristics of the cardiac signal within the P-wave sensing window, determine whether the cardiac signal within the sensing window corresponds to a P-wave based on the determined signal characteristics, determine a signal to noise ratio of the cardiac signal within the sensing window, update the arrhythmia score when the P wave is identified in the sensing window and the determined signal to noise ratio satisfies a signal to noise threshold.
摘要翻译：基于与一个或多个R波相关联的一个或多个P波感测窗口的分析来实施用于调整心房心律失常检测技术的技术和装置。可植入医疗装置可以确定P波感测窗口内的心脏信号的信号特征，基于确定的信号特性来确定感测窗口内的心脏信号是否对应于P波，确定信噪比感测窗口内的心脏信号，当在感测窗口中识别P波时更新心律失常评分，并且所确定的信噪比满足信噪比阈值。

100. 发明申请

WO2016058002A1 IMPLANTABLE CARDIO DEFIBRILLATOR (ICD), SUBCUTANEOUS IMPLANTABLE CARDIO DEFIBRILLATOR (SICD), AND WAVEFORM ENERGY CONTROL SYSTEMS 审中-公开
标题翻译：可植入式除颤器（ICD），可移植式可拆卸式减震器（SICD）和波形能量控制系统
公开(公告)号：WO2016058002A1
公开(公告)日：2016-04-14
申请号：PCT/US2015/055314
申请日：2015-10-13
申请人： RUSE TECHNOLOGIES, LLC
发明人： IDEKER, Raymond, E. , RUSE, Richard, B. , BOHANAN, Scott
IPC分类号： A61N1/362 , A61N1/368
CPC分类号： A61N1/3962 , A61N1/3906 , A61N1/3937 , A61N1/395 , A61N1/3987
摘要： Cardiac defibrillation or cardioversion waveform energy control systems employ transvenous ICDs or subcutaneous SICDs for treating cardiac arrhythmias. The systems comprise differentially driven amplifier circuit operational modes to control the delivery of defibrillation or cardioversion electrical shocks, wherein the shock waveforms are constant current, constant voltage, or constant energy. Biphasic arbitrary shock waveforms deliver increasing and or level energy with increasing time as represented by phase 1 ascending ramp, ascending exponential, ascending chopped, ascending stepped, ascending curved, square, rectilinear or level and or any combination of geometric shaped ascending or level waveforms.
摘要翻译：心脏除颤或心脏复律波形能量控制系统采用经静脉ICD或皮下SICD治疗心律失常。该系统包括差分驱动的放大器电路操作模式以控制除颤或心脏复律电击的传递，其中冲击波形是恒定电流，恒定电压或恒定能量。双相任意的冲击波形通过增加时间增加和/或增加能量，如第1阶段上升斜坡，上升指数，上升斩波，上升阶梯，上升曲线，平方，直线或水平以及或几何形状上升或电平波形的任何组合所表示的。

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