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91. 发明申请

WO2017031581A1 SYSTEM AND METHOD FOR DETECTING SPIKES IN NOISY SIGNALS 审中-公开
标题翻译：用于检测噪声信号中的SPIKES的系统和方法
公开(公告)号：WO2017031581A1
公开(公告)日：2017-03-02
申请号：PCT/CA2016/050991
申请日：2016-08-23
申请人： UNIVERSITÉ LAVAL
发明人： GAGNON-TURCOTTE, Gabriel , GOSSELIN, Benoit
IPC分类号： G06F17/10 , A61B5/04 , G05B1/02 , G06F17/18 , G06F3/01
CPC分类号： G06K9/0053 , A61N1/362 , G06F3/01 , G06F17/10
摘要： A method for determining a threshold for spike detection in a noisy signal in real- time is provided. The method includes estimating a current variability of noise in the noisy signal according to a measured instantaneous value and a window of previous instantaneous values using a sigma-delta control loop, determining the threshold based on the estimated variability of the noise; and repeating the steps to update the estimate of the variability of the noise and adjust the threshold in real-time as the noisy signal changes. A non-transitory computer-readable storage medium for executing the method on a processing unit, and a low-power digital system implementing the method are also provided.
摘要翻译：提供了一种用于在实时噪声信号中确定峰值检测阈值的方法。该方法包括根据所测量的瞬时值和使用Σ-Δ控制回路的先前瞬时值的窗口来估计噪声信号中的噪声的当前可变性，基于噪声的估计可变性确定阈值; 并且重复上述步骤来更新噪声的可变性的估计，并随着噪声信号改变而实时地调整阈值。还提供了一种用于在处理单元上执行该方法的非暂时计算机可读存储介质，以及实现该方法的低功率数字系统。

92. 发明申请

WO2015051466A1 EXTRACELLULAR MITOCHONDRIAL COMPONENTS FOR DETECTING INFLAMMATORY REACTIONS AND CONDITIONS 审中-公开
标题翻译：用于检测炎症反应和条件的细胞培养基组分
公开(公告)号：WO2015051466A1
公开(公告)日：2015-04-16
申请号：PCT/CA2014/050984
申请日：2014-10-10
申请人： UNIVERSITÉ LAVAL , HÉMA-QUÉBEC , UNIVERSITY OF WASHINGTON
发明人： BOILARD, Éric , BOUDREAU, Luc , THIBAULT, Louis , GELB, Michael Herman
IPC分类号： G01N33/48 , C12N5/078 , C12Q1/02 , G01N1/28
CPC分类号： G01N33/56966 , G01N15/14 , G01N33/502 , G01N33/5079 , G01N33/564 , G01N2015/0084 , G01N2015/1486 , G01N2500/10 , G01N2800/104 , G01N2800/222 , G01N2800/7095
摘要： The present disclosure highlights the relationship between extracellular mitochondrial components, optionally in combination with the secreted phospholipase A 2 -IIA and/or an auto-antibody, and in vivo as well as in vitro and inflammatory reactions/conditions, especially those released as a result of the degradation of a platelet. The present disclosure provides methods for determining the presence of inflammatory mediators, for limiting inflammatory reactions/conditions, for the diagnosis inflammatory reactions/conditions, for screening therapeutics for the treatment and/or the alleviation of symptoms of inflammatory reactions/conditions based on the detection or modulation of the level of these extracellular mitochondrial components.
摘要翻译：本公开突出了细胞外线粒体成分之间的关系，任选地与分泌的磷脂酶A2-IIA和/或自身抗体组合，以及体内以及体外和炎症反应/病症，特别是作为血小板降解。本公开提供了用于确定炎症介质的存在，用于限制炎症反应/病症，用于诊断炎症反应/病症，用于筛选用于治疗和/或缓解基于检测的炎症反应/病症症状的治疗剂的方法或调节这些细胞外线粒体成分的水平。

93. 发明申请

WO2014078964A1 ELECTROCHEMICAL SENSOR 审中-公开
标题翻译：电化学传感器
公开(公告)号：WO2014078964A1
公开(公告)日：2014-05-30
申请号：PCT/CA2013/050893
申请日：2013-11-22
申请人： UNIVERSITÉ LAVAL
发明人： VIENS, Jean-François , NORMANDEAU, Charles-Olivier , MESSADDEQ, Younes
IPC分类号： G01N27/417 , G01N27/406
CPC分类号： G01N27/3335 , G01N27/36 , G01N27/406 , G01N27/4112 , G01N27/4146 , G01N27/4148
摘要： An electrochemical ion sensor and a method for sensing a presence of at least one ion species in a solution are provided. The electrochemical sensor includes a solid- state electrolyte medium doped with an organometallic material, having an electrochemical affinity with the ion species, and a pair of electrodes electrically contacting the solid-state electrolyte. The electrochemical sensor also includes an electrical circuit configured to drive the pair of electrodes with an AC electrical excitation and to measure at least one parameter related to a complex electrical impedance of the doped solid-state electrolyte medium in response to the AC electrical excitation. The parameter may be an electrical resistance, an inductance or a combination of both, and represents the presence of the ion species in the solution when the solid-state electrolyte medium is exposed to the solution.
摘要翻译：提供了电化学离子传感器和用于感测溶液中至少一种离子物质的存在的方法。电化学传感器包括掺杂有有机金属材料的固态电解质介质，其具有与离子种类的电化学亲和力，以及一对与固态电解质电接触的电极。电化学传感器还包括电路，其被配置为用AC电激励来驱动该对电极，并且响应于AC电激发而测量与掺杂固态电解质介质的复电阻抗相关的至少一个参数。该参数可以是电阻，电感或两者的组合，并且表示当固态电解质介质暴露于溶液时溶液中存在离子种类。

94. 发明申请

WO2014029014A1 THIENO, FURO AND SELENOPHENO-[3,4-C]PYRROLE-4,6-DIONE COPOLYMERS 审中-公开
标题翻译：噻吩，FURO和SELENOPHENO- [3,4-C]吡咯-4,6-二酮共聚物
公开(公告)号：WO2014029014A1
公开(公告)日：2014-02-27
申请号：PCT/CA2013/000736
申请日：2013-08-20
申请人： UNIVERSITÉ LAVAL
发明人： LECLERC, Mario , BEAUPRÉ, Serge
IPC分类号： C07D517/04 , C07D491/048 , C08G61/12 , H01L51/46
CPC分类号： C07D491/048 , C07D517/04 , C08G61/123 , C08G61/125 , C08G61/126 , C08G2261/124 , C08G2261/1412 , C08G2261/1424 , C08G2261/3222 , C08G2261/3223 , C08G2261/3225 , C08G2261/3243 , C08G2261/344 , C08G2261/41 , C08G2261/414 , C08G2261/90 , C08G2261/91 , C08G2261/92 , C08G2261/94 , C08G2261/95 , H01L51/0036 , H01L51/0043 , H01L51/4253 , H01L51/5012 , Y02E10/549
摘要： Novel photoactive copolymers based on thieno, furo or selenopheno-[3,4- c]pyrrole-4,6-dione-derivative are described herein. More specifically, the photoactive copolymers comprise repeating units of Formula I -[A 1 -A 2 ]- I wherein A1 is an electron donating unit such as a mono or polycyclic heteroaryl that is unsubstitued or substituted with one or more C 1-20 -alkyl or C 1-20 -alkoxy; and A 2 is an alkylfuro or alkylselenopheno-[3,4-c]pyrrole-4,6-dione-derivative. The photoactive copolymers are suitable for use in BHJ solar cells.
摘要翻译：基于噻吩并，呋喃或硒吩并[3,4-c]吡咯-4,6-二酮衍生物的新型光活性共聚物在本文中描述。更具体地，光敏共聚物包含式I - [A1-A2] -I的重复单元，其中A1是未被取代或被一个或多个C 1-20 - 烷基或C 1 -C 18取代的给电子单元，例如单或多环杂芳基 -20 - 烷氧基; 并且A2是烷基呋喃基或烷基硒代苯并[3,4-c]吡咯-4,6-二酮衍生物。光敏共聚物适用于BHJ太阳能电池。

95. 发明申请

WO2013049926A1 PROGNOSTIC MARKERS OF INHERITED VARIATIONS IN THE 17β-HYDROXYSTEROID DEHYDROGENASE (HSD17B) GENES FOR PROSTATE CANCER 审中-公开
标题翻译： 17β-羟基脱氢酶脱氢酶（HSD17B）前列腺癌基因的预测标记
公开(公告)号：WO2013049926A1
公开(公告)日：2013-04-11
申请号：PCT/CA2012/000928
申请日：2012-10-05
申请人： UNIVERSITÉ LAVAL
发明人： LÉVESQUE, Éric , GUILLEMETTE, Chantal , FRADET, Yves , LACOMBE, Louis
IPC分类号： C12Q1/68 , C40B30/04
CPC分类号： C12Q1/6886 , C12Q2600/118 , C12Q2600/156
摘要： The relationship between polymorphisms in the 17β -hydroxysteroid dehydrogenase (HSD17B ) family of enzymes, involved in active steroid hormones biotransformation, and the risk of prostate cancer (PCa) progression remains unexplored. Objective. To determine if inherited variations in HSD17B genes are associated with PCa progression. Design. We studied two independent Caucasian cohorts composed of 526 men with organ-confined PCa and 213 with advanced disease who had a median follow-up of 7.4 and 7.8 years after surgery, respectively. Measurements. Patients with localized PCa were genotyped for 88 htSNPs in HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B5 and HSD17B12 genes and their prognostic significance on disease progression was assessed using Kaplan-Meier survival curves and Cox regression models. Positive findings were then investigated in advanced disease. Results. After adjusting for known risk factors, 12 SNPs distributed across the HSD17B2, HSD17B3 and HSD17B12 genes were significantly associated with risk of biochemical relapse (BCR) in localized PCa. In addition, four variants of the HSD17B2 (rs1364287, rs2955162, rs1119933, rs9934209) were significantly associated with progression in advanced disease. HSD17B2 polymorphisms, which occurred in 26% and 15% of patients with localized and advanced PCa respectively, were thus associated with high risk of BCR (HR: 2.63, 95%CI: 1.81-3.80, P =0.0000003), progression free survival (HR: 2.81, 95%CI: 1.43-5.52, P=0.008) and overall survival (HR: 3.07, 95%CI: 1.29-7.30, P =0.011). Conclusion. This study suggests a predominant role for common genetic variants in the HSD17B2 pathway and PCa progression.
摘要翻译：参与活性类固醇激素生物转化的17β-羟基类固醇脱氢酶（HSD17B）家族的多态性与前列腺癌（PCa）发展的风险之间的关系尚未被探索。目的。确定HSD17B基因的遗传变异是否与PCa进展相关。设计。我们研究了两名独立的白种人队列，其中包括526名患有器官限制性PCa的男性和213名患有晚期疾病的男性，分别在手术后中位随访7.4和7.8年。测量。在HSD17B1，HSD17B2，HSD17B3，HSD17B4，HSD17B5和HSD17B12基因中，对局部PCa患者进行88 htSNPs的基因分型，并使用Kaplan-Meier生存曲线和Cox回归模型评估其对疾病进展的预后意义。然后在晚期疾病中调查阳性结果。结果。调整已知风险因子后，分布在HSD17B2，HSD17B3和HSD17B12基因上的12个SNP与局部PCa中生化复发（BCR）的风险显着相关。此外，HSD17B2（rs1364287，rs2955162，rs1119933，rs9934209）的四种变体与晚期疾病的进展显着相关。发生在26％和15％的局部和晚期PCa患者的HSD17B2多态性因此与BCR的高风险相关（HR：2.63,95％CI：1.81-3.80，P = 0.0000003），无进展生存期 HR：2.81,95％CI：1.43-5.52，P = 0.008）和总生存期（HR：3.07,95％CI：1.29-7.30，P = 0.011）。结论。这项研究表明HSD17B2途径和PCa进展中常见遗传变异体的主要作用。

96. 发明申请

WO2012151701A1 METHODS FOR THE TREATMENT AND DIAGNOSTIC OF PULMONARY ARTERIAL HYPERTENSION 审中-公开
标题翻译：用于治疗和诊断肺动脉高压的方法
公开(公告)号：WO2012151701A1
公开(公告)日：2012-11-15
申请号：PCT/CA2012/050306
申请日：2012-05-10
申请人： UNIVERSITÉ LAVAL / VICE-RECTORAT À LA RECHERCHE ET À LA CRÉATION , BONNET, Sébastien , MASSON, Jean-Yves , POIRIER, Guy
发明人： BONNET, Sébastien , MASSON, Jean-Yves , POIRIER, Guy
IPC分类号： A61K31/4184 , A61K31/166 , A61K31/454 , A61K31/502 , A61K31/517 , A61P9/12
CPC分类号： G01N33/53 , A61K31/166 , A61K31/4184 , A61K31/454 , A61K31/502 , A61K31/517 , A61K45/06 , C12Q1/6876 , Y02A50/423 , A61K2300/00
摘要： The present application relates to the use at least one PARP inhibitor or a pharmaceutically acceptable salt thereof for the treatment of Group 1 pulmonary arterial hypertension (PAH) in a subject, including a human, in need of such treatment. There is also provided methods of treating and diagnosing Group 1 pulmonary arterial hypertension (PAH).
摘要翻译：本申请涉及在需要这种治疗的受试者（包括人）中使用至少一种PARP抑制剂或其药学上可接受的盐用于治疗组1肺动脉高压（PAH）。还提供了治疗和诊断第1组肺动脉高压（PAH）的方法。

97. 发明申请

WO2012113079A1 CYSTAMINE ANALOGUES FOR THE TREATMENT OF PARKINSON'S DISEASE 审中-公开
标题翻译：用于治疗帕金森病的CYSTAMINE ANALOGUES
公开(公告)号：WO2012113079A1
公开(公告)日：2012-08-30
申请号：PCT/CA2012/050106
申请日：2012-02-23
申请人： UNIVERSITÉ LAVAL , CICCHETTI, Francesca , ROUILLARD, Claude , CALON, Frédéric
发明人： CICCHETTI, Francesca , ROUILLARD, Claude , CALON, Frédéric
IPC分类号： A61K31/145 , A61K31/185 , A61K31/198 , A61P25/28
CPC分类号： A61K31/145 , A61K31/185 , A61K31/198 , A61K2300/00
摘要： The present invention relates to the use of cystamine analogues for the treatment of Parkinson's disease. The present invention also relates to the use of composition comprising cystamine analogues and cysteine. The present invention relates to a method for modifying the progression of Parkinson's disease comprising administering a therapeutically effective amount of at least one cystamine analogue or a pharmaceutically acceptable salt of a cystamine analogue to a patient in need thereof.
摘要翻译：本发明涉及胱胺类似物用于治疗帕金森病的用途。本发明还涉及包含胱胺类似物和半胱氨酸的组合物的用途。本发明涉及一种用于改变帕金森病进展的方法，包括向有需要的患者施用治疗有效量的至少一种胱氨酸类似物或其可药用的胱氨酸类似物的盐。

98. 发明申请

WO2012100340A1 ANODE AND CONNECTOR FOR A HALL-HEROULT INDUSTRIAL CELL 审中-公开
标题翻译：一个HALL-HEROULT工业细胞的阳极和连接器
公开(公告)号：WO2012100340A1
公开(公告)日：2012-08-02
申请号：PCT/CA2012/000084
申请日：2012-01-27
申请人： UNIVERSITÉ LAVAL , FAFARD, Mario , TREMPE, Olivier , GOULET, Patrice , MARTIN, Dave
发明人： FAFARD, Mario , TREMPE, Olivier , GOULET, Patrice , MARTIN, Dave
IPC分类号： C25C3/12 , C25C3/08
CPC分类号： C25C3/125 , C25C3/16
摘要： The present invention provides a combination of an anode and its connector for use in an electrolysis industrial cell in a Hall-Heroult process. The combination of the connector and the anode comprises a yokeless connector made of a conductive material for transmitting electrical current to the anode, the connector having an inverted T-shape, and an anode comprising a groove extending longitudinally along the a top surface of the anode and being sized and shaped to receive a longitudinal bar of the connector. The combination also comprises a pourable conductive material for filling the groove and bonding the longitudinal bar of the connector to the anode. The present invention also relates to a method of connecting the connector to the anode.
摘要翻译：本发明提供了一种用于Hall-Heroult电解工业电池中的阳极及其连接器的组合。连接器和阳极的组合包括由用于将电流传输到阳极的导电材料制成的无轭连接器，连接器具有倒置的T形形状，以及阳极，该阳极包括沿阳极顶表面纵向延伸的槽并且其尺寸和形状适于容纳连接器的纵向条。该组合还包括用于填充凹槽并将连接器的纵向条连接到阳极的可倾倒的导电材料。本发明还涉及将连接器连接到阳极的方法。

99. 发明申请

WO2011032294A1 Q-SWITCHED DFB FIBER LASER WITH SWITCHABLE POLARIZATION OUTPUT 审中-公开
标题翻译： Q开关DFB光纤激光器，具有可切换的极化输出
公开(公告)号：WO2011032294A1
公开(公告)日：2011-03-24
申请号：PCT/CA2010/001492
申请日：2010-09-21
申请人： PHASOPTX INC. , WEYNANT, Eric , FRASER, Alex , BERNIER, Martin , VALLÉE, Réal , UNIVERSITÉ LAVAL
发明人： WEYNANT, Eric , FRASER, Alex , BERNIER, Martin , VALLÉE, Réal
IPC分类号： G02B26/06 , G02B5/18 , G02B5/20 , H01S3/067 , H01S3/105 , H04J14/02
CPC分类号： H01S3/06754 , G02F1/0134 , G02F2201/02 , G02F2201/307 , H01S3/06704 , H01S3/0675 , H01S3/121
摘要： An optical fiber phase modulator has a body made of a shape memory alloy. The body includes a conduit for receiving an optical fiber. An actuator such as, for example, a piezoelectric transducer varies the constrictive (radially compressive force) applied by the conduit on the optical fiber to modulate the phase of the optical signal carried by the optical fiber. A fiber Bragg grating (FBG) incorporating this novel tunable phase modulator may be used in distributed feedback (DFB) fiber lasers and narrow band pass filters. This invention also provides a tunable birefringent phase modulator, which may be used in fiber polarization switches. The shape memory alloy phase modulator does not require glue to connect the fiber to the actuator and, consequently, this novel modulator does not suffer the optical losses that typical arise with prior-art devices nor is it prone to breakage as are the more fragile bonded devices.
摘要翻译：光纤相位调制器具有由形状记忆合金制成的主体。主体包括用于接收光纤的导管。诸如压电换能器的致动器改变由光纤上的导管施加的约束（径向压缩力），以调制由光纤承载的光信号的相位。结合这种新型可调相位调制器的光纤布拉格光栅（FBG）可用于分布式反馈（DFB）光纤激光器和窄带通滤波器。本发明还提供可调谐双折射相位调制器，其可用于光纤偏振开关中。形状记忆合金相位调制器不需要胶来将光纤连接到致动器，因此，这种新颖的调制器不会遭受现有技术设备典型出现的光学损耗，也不会容易断裂，更脆弱的键合设备。

100. 发明申请

WO2010034103A1 METHOD FOR POLYCLONAL IMMUNOGLOBULIN G PRODUCTION BY HUMAN B CELLS 审中-公开
标题翻译：人B细胞产生多克隆免疫球蛋白G的方法
公开(公告)号：WO2010034103A1
公开(公告)日：2010-04-01
申请号：PCT/CA2009/001150
申请日：2009-08-17
申请人： HÉMA-QUÉBEC , UNIVERSITÉ LAVAL , NÉRON, Sonia , ROY, Annie , FECTEAU, Jessie Farah
发明人： NÉRON, Sonia , ROY, Annie , FECTEAU, Jessie Farah
IPC分类号： C12P21/00 , C07K16/00 , C12N5/071
CPC分类号： C12N5/0635 , C07K16/00 , C07K2317/14 , C07K2317/21 , C12N2500/25 , C12N2501/2302 , C12N2501/231 , C12N2511/00
摘要： This application relates to an in vitro method of producing a polyclonal IgG preparation. The method comprises (i) placing a polyclonal B-cell population enriched in IgG-secreting B cells in a culture medium; and (ii) culturing the polyclonal B-cell population under conditions enabling the production of the polyclonal IgG preparation from the polyclonal B-cell population. This improved method enables the production of antibodies (preferably IgG) and facilitates long-term culture of polyclonal B-cell populations.
摘要翻译：本申请涉及制备多克隆IgG制剂的体外方法。该方法包括（i）将富含IgG分泌B细胞的多克隆B-细胞群放入培养基中; 和（ii）在能够从多克隆B细胞群产生多克隆IgG制备物的条件下培养多克隆B-细胞群体。该改进的方法能够产生抗体（优选IgG）并促进多克隆B-细胞群体的长期培养。

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