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91. 发明申请

WO1986007057A1 METHYL DERIVATIVES OF METHYLATED BIS 7H PYRIDOCARBAZOLES AND FARMACEUTICAL COMPOSITIONS CONTAINING THEM 审中-公开
标题翻译：甲基化二硫化7H IS BA BA M M M M M M M M M M M M M M M M M M M M M
公开(公告)号：WO1986007057A1
公开(公告)日：1986-12-04
申请号：PCT/FR1986000183
申请日：1986-05-29
申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , ROQUES, Bernard , LE PECQ, Jean-Bernard
发明人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
IPC分类号： C07D471/04
CPC分类号： C07D471/04
摘要： Quaternary ammonium salt of a derivative of bis 7H pyridocarbazole having formula (IV); wherein R1 which is in position 11 on the corresponding aromatic ring is particularly hydrogen; R2 which is in position 10 on the ring represents particularly a group OH; R3 is particularly hydrogen; R4 is CH3; R5 is H; the chain Z has the following structure: -(CH2)n - W - (CH2)n'- wherein: n and n' vary from 2 to 6; W is as represented by formula (a), with X representing (CH2)m, O or S; m varying from 0 to 4. These compounds have an antitumoral activity.

92. 发明申请

WO1986000620A1 MOLECULE COMPRISING AT LEAST ONE PEPTIDIC SEQUENCE CARRYING AN EPITOPE 审中-公开
标题翻译：包含至少一个携带EPITOPE的肽序列的分子
公开(公告)号：WO1986000620A1
公开(公告)日：1986-01-30
申请号：PCT/FR1985000183
申请日：1985-07-02
申请人： INSTITUT PASTEUR , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , KOENEN, Michaël , SCHERF, Arthur , MÜLLER-HILL, Benno , MERCEREAU-PUIJALON, Odile , PEREIRA DA SILVA, Luiz
发明人： INSTITUT PASTEUR , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
IPC分类号： C07K07/00
CPC分类号： C07K14/445 , A61K39/00 , C12Q1/6893 , G01N33/56905 , Y02A50/412
摘要： Molecule having at least one peptidic sequence carrying an epitope characteristic of a proteine produced by cells infected by the parasites of paludism. It is characterized in that it contains a peptidic sequence having the formula: X-glu-Y-Val-A-Glu-Val-Z-Pro wherein: X is Glu or Val, Y is Val, Leu or Ileu, Z is Val or Ile and A is Glu or Asp.

93. 发明申请

WO1985002104A1 QUICK OCCLUSION CONTROLLED DEVICE 审中-公开
标题翻译：快速监控控制设备
公开(公告)号：WO1985002104A1
公开(公告)日：1985-05-23
申请号：PCT/FR1984000258
申请日：1984-11-12
申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , UNIVERSITE LOUIS PASTEUR (STRASBOURG I) , SPEICH, Jean-Pierre , ZOULOUMIAN, Pierre, Joseph
发明人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , UNIVERSITE LOUIS PASTEUR (STRASBOURG I)
IPC分类号： A61B05/08
CPC分类号： A61M16/20 , A61B5/08 , A61B5/085 , A61M16/0858 , A61M2209/02
摘要： A quick occlusion controlled device particularly intended to evaluate the sensitivity of respiratory centres comprises a body (1) connected to the respiratory apparatus of the patient through a buccal connector (2), provided with a pressure tap (3). According to the invention, the device is characterized in that the body (1) comprises an inspiration connector (4) which opens into the inner volume of the body (1) through a valve (5), as well as a respiration connector (6) which opens into the inner volume of the body (1) through a second valve (7), said device being further provided with an occlusion means of both/either of the valves (5) and (7).
摘要翻译：特别旨在评估呼吸中枢的敏感性的快速阻塞控制装置包括通过设置有压力分接头（3）的颊部连接器（2）连接到患者的呼吸装置的主体（1）。根据本发明，该装置的特征在于，主体（1）包括通过阀（5）向主体（1）的内部容积以及呼吸连接器（6）打开的吸气连接器（4）），其通过第二阀（7）进入主体（1）的内部容积，所述装置还设置有两个/任一阀（5）和（7）的闭塞装置。

94. 发明申请

WO1984004858A1 ECHO SUPPRESSOR WITH ADAPTIVE DIGITAL FILTER FOR TRANSMISSION SYSTEM 审中-公开
标题翻译：具有自适应数字滤波器的ECHO抑制器用于传输系统
公开(公告)号：WO1984004858A1
公开(公告)日：1984-12-06
申请号：PCT/FR1984000140
申请日：1984-05-25
申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , BONNET, Madeleine , MACCHI, Odile
发明人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
IPC分类号： H04B03/23
CPC分类号： H04B3/232
摘要： The echo suppressor which may be used in a system for the simultaneous bidirectional transmission by MAQ modulation or phase modulation between two remote sources on a same transmission medium or circuit (10) comprises an adaptive digital filter (13) which provides the estimation sigma k of the effective echo. The adaptation algorithm of the vector C of the coefficients in: wherein mu is a predetermined incrementing pitch, ak is the conjugated value of the local data signals, ek is the signal deprived of the echo and f is a predetermined function. The output signal of the filter is subtracted from the signal arriving by the transmission medium. A corrector circuit is arranged between the transmission medium (10) and the subtractor (14) of the adapted filter to transform the complex remote data into a substantially real or imaginary data, the function f being able to use the sign only of ek.
摘要翻译：可用于通过同一传输介质或电路（10）上的两个远程源之间的MAQ调制或相位调制的同时双向传输的系统中的回波抑制器包括：自适应数字滤波器（13），其提供有效回声。系数的矢量C的适应算法：其中mu是预定的增加音调，ak是局部数据信号的共轭值，ek是被消除回波的信号，f是预定函数。从传输介质到达的信号中减去滤波器的输出信号。校正器电路布置在适配滤波器的传输介质（10）和减法器（14）之间，以将复杂的远程数据转换为基本上实际或虚数据，函数f仅能够使用ek的符号。

95. 发明申请

WO1984000419A1 METHOD FOR DETERMINING THE BIO- AND/OR TECHNO-SYNTHETIC ORIGINS OF ORGANIC SUBSTANCES AND MEANS FOR THE IMPLEMENTATION THEREOF 审中-公开
标题翻译：用于确定有机物质的生物和/或技术合成原料的方法及其实施方法
公开(公告)号：WO1984000419A1
公开(公告)日：1984-02-02
申请号：PCT/FR1983000140
申请日：1983-07-08
申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , BENGSCH, Eberhard, Richard , GRIVET, Jean-Philippe , SCHULTEN, Hans-Rolf
发明人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
IPC分类号： G01N24/08
CPC分类号： G01R33/46 , G01R33/465
摘要： Method for identifying and optionally carrying out a quantitative determination of the bio- and/or techno-synthetic origins of organic substances as a function of their global ratio and mainly of their characteristic matrix of intramolecular distribution of light, stable and magnetically active isotopes, particularly of carbon 13, characterized in that it comprises the determination of the positional isotopic distribution of at least one light, stable and magnetically active isotope other than the deuterium by quantitative nuclear magnetic resonance by Fourier transform. Application, determination of the bio- and/or techno-synthetic origin of organic substances and means for the implementation thereof.

96. 发明申请

WO1998029358A2 SURFACE MODIFIED CARBONATE MATERIALS 审中-公开
标题翻译：表面改性碳酸盐材料
公开(公告)号：WO1998029358A2
公开(公告)日：1998-07-09
申请号：PCT/CA1997001008
申请日：1997-12-30
申请人： HYDRO-QUEBEC , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , MICHOT, Christophe , ARMAND, Michel , GAUTHIER, Michel , CHOQUETTE, Yves
发明人： HYDRO-QUEBEC , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
IPC分类号： C04B41/00
CPC分类号： B01J31/0224 , B01J31/0215 , B01J31/0222 , B01J31/0225 , B01J31/0227 , B01J31/0235 , B01J31/0239 , B01J31/0247 , B01J31/0251 , B01J31/0252 , B01J31/0267 , B01J31/0271 , B01J31/0281 , B01J31/0288 , B01J31/0289 , B01J31/04 , B01J31/06 , B01J31/068 , B01J31/124 , B01J31/1815 , B01J31/2208 , B01J2231/122 , B01J2231/14 , B01J2231/326 , B01J2231/341 , B01J2231/348 , B01J2231/4205 , B01J2231/543 , B01J2531/35 , B01J2531/824 , C07B37/02 , C07B37/12 , C07C45/46 , C07C45/69 , C07C67/00 , C07C255/10 , C07C255/17 , C07C255/27 , C07C255/46 , C07C255/65 , C07C257/14 , C07C311/03 , C07C311/04 , C07C311/09 , C07C311/48 , C07C317/04 , C07C317/08 , C07C317/14 , C07C317/22 , C07C317/24 , C07C317/34 , C07C317/44 , C07C2601/10 , C07C2602/42 , C07D207/452 , C07D213/76 , C07D219/10 , C07D231/18 , C07D233/90 , C07D239/60 , C07D241/42 , C07D249/04 , C07D249/10 , C07D249/12 , C07D251/70 , C07D277/64 , C07D277/82 , C07D285/125 , C07D285/135 , C07D285/15 , C07D285/16 , C07D303/34 , C07D307/54 , C07D307/64 , C07D311/52 , C07D311/58 , C07D311/82 , C07D319/06 , C07D333/16 , C07D333/24 , C07D405/06 , C07D409/12 , C07D417/10 , C07D417/14 , C07F17/02 , C08F4/04 , C08G65/3344 , C09B69/00 , C09B69/02 , C09B69/10 , G02F1/1525 , G02F2001/151 , H01B1/122 , H01B1/128 , H01G9/022 , H01G9/038 , H01G11/02 , H01G11/62 , H01M4/00 , H01M4/02 , H01M4/131 , H01M4/133 , H01M4/134 , H01M4/382 , H01M4/405 , H01M4/48 , H01M4/485 , H01M4/505 , H01M4/525 , H01M4/5815 , H01M4/5825 , H01M4/60 , H01M4/625 , H01M4/661 , H01M6/00 , H01M6/04 , H01M6/164 , H01M6/166 , H01M6/168 , H01M6/181 , H01M6/183 , H01M10/052 , H01M10/0525 , H01M10/0565 , H01M10/0567 , H01M10/0568 , Y02E60/13 , Y10S430/127 , Y10T29/49108 , Y10T428/2918 , C07C49/84 , C07C49/553
摘要： Disclosed is a method for grafting a polymer onto the surface of a carbonate material with carboxyl, amine, and/or hydroxyl functions on its surface. Said material is placed in suspension in a solution including the polymer to be grafted, which has a carboxyl, amine, and/or hydroxyl function, said solution also being comprised of a polymer solvent. A process which stimulates the dehydration into a carboxyl function of an amine and/or hydroxyl function is then performed, and the polymer is grafted onto the carbonate material using ester or amide links. The invention can be used in the cathode or naode of an electrochemical generator, in polymer materials with low polar properties, in ink, and also as a conductive coating on flexible plastic used as an electrical contact, as electromagnetic shielding, or as static protection.
摘要翻译：公开了一种在其表面上将聚合物接枝到具有羧基，胺和/或羟基官能团的碳酸酯材料的表面上的方法。将所述材料悬浮在含有羧基，胺和/或羟基官能团的待接枝聚合物的溶液中，所述溶液也由聚合物溶剂组成。然后进行刺激脱水成胺和/或羟基官能团的羧基官能团的方法，并使用酯或酰胺连接将聚合物接枝到碳酸酯材料上。本发明可用于电化学发生器的阴极或天线，具有低极性的聚合物材料，油墨中，以及用作电接触的柔性塑料上的导电涂层，电磁屏蔽或静电保护。

97. 发明申请

WO1998020123A2 STABLE CELL LINES EXPRESSING THE CFTR PROTEIN OR A MUTANT OF THIS PROTEIN, TOOL FOR SELECTING MOLECULES HAVING AN EFFECT ON THE INTRACELLULAR TRANSPORT OF THESE PROTEINS 审中-公开
标题翻译：稳定的细胞系表达CFTR蛋白或该蛋白质的突变体，用于选择对这些蛋白质的细胞内运输有影响的分子的工具
公开(公告)号：WO1998020123A2
公开(公告)日：1998-05-14
申请号：PCT/EP1997006095
申请日：1997-11-04
申请人： INSTITUT CURIE , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
发明人： INSTITUT CURIE , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , COSTA DE BEAUREGARD, Marie-Alyette , LOUVARD, Daniel , ROBINE, Sylvie , EDELMAN, Alexandre , CHESNOY-MARCHAIS, Dominique , CHEN, Ming , BUCHWALD, Manuel
IPC分类号： C12N15/12
CPC分类号： C07K14/4712 , C07K2319/00 , G01N2800/382
摘要： The invention relates to a recombinant nucleic acid, characterized in that it comprises: a nucleotide sequence encoding (coding sequence) the normal CFTR protein, an epitope sequence located at the 3' end of the abovementioned coding sequence, a strong promoter sequence capable of controlling the expression of the abovementioned coding sequence and epitope sequence, when they are integrated into a determined cell.
摘要翻译：本发明涉及重组核酸，其特征在于其包含：编码（编码序列）正常CFTR蛋白的核苷酸序列，位于上述编码序列3'端的表位序列，能够控制的强启动子序列当将它们整合到确定的细胞中时，上述编码序列和表位序列的表达。

98. 发明申请

WO1998013489A1 NUCLEIC ACID MOLECULES CODING FOR TUMOR SUPPRESSOR PROTEINS AND METHODS FOR THEIR ISOLATION 审中-公开
标题翻译：肿瘤抑制蛋白的核酸分子编码及其分离方法
公开(公告)号：WO1998013489A1
公开(公告)日：1998-04-02
申请号：PCT/EP1997005198
申请日：1997-09-22
申请人： MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V. , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , SPENGLER, Dietmar , JOURNOT, Laurent
发明人： MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V. , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
IPC分类号： C12N15/12
CPC分类号： C07K14/4703 , A61K38/00 , C07K14/4705
摘要： Described are novel proteins having the biological activity of a tumor suppressor protein and nucleic molecules coding for such proteins. Methods for the isolation of nucleic acid molecules encoding tumor suppressor proteins as well as nucleic acid molecules obtainable by said method are also provided. Further, vectors comprising said nucleic molecules wherein the nucleic acid molecules are operatively linked to regulatory elements allowing expression in prokaryotic or eukaryotic host cells can be used for the production of polypeptides encoded by said nucleic acid molecules which have tumor suppressor activity. Pharmaceutical and diagnostic compositions are provided comprising the nucleic acid molecules of the invention and/or comprising a nucleic acid molecule which is complementary to such a nucleic acid molecule. Described are also compositions which comprise polypeptides encoded by the described nucleic acid molecules which have tumor suppressor activity and/or an antibody specifically recognizing such polypeptides.
摘要翻译：描述了具有肿瘤抑制蛋白的生物活性和编码这种蛋白质的核酸分子的新型蛋白质。还提供了分离编码肿瘤抑制蛋白的核酸分子的方法以及通过所述方法可获得的核酸分子。此外，包含所述核酸分子的载体，其中所述核酸分子可操作地连接到允许在原核或真核宿主细胞中表达的调节元件，可用于产生由具有肿瘤抑制活性的所述核酸分子编码的多肽。提供了包含本发明的核酸分子和/或包含与这种核酸分子互补的核酸分子的药物和诊断组合物。还描述了包含由具有肿瘤抑制活性的所述核酸分子编码的多肽的组合物和/或特异性识别这些多肽的抗体。

99. 发明申请

WO1998002455A2 TRANSCRIPTIONAL INTERMEDIARY FACTOR-2 审中-公开
标题翻译：转录中间因子-2
公开(公告)号：WO1998002455A2
公开(公告)日：1998-01-22
申请号：PCT/US1997012100
申请日：1997-07-11
申请人： INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , UNIVERSITE LOUIS PASTEUR , BRISTOL-MYERS SQUIBB COMPANY
发明人： INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , UNIVERSITE LOUIS PASTEUR , BRISTOL-MYERS SQUIBB COMPANY , CHAMBON, Pierre , GRONEMEYER, Hinrich , VOEGEL, Johannes , LUTZ, Yves
IPC分类号： C07K14/00
CPC分类号： C07K14/4702
摘要： The present invention concerns a nuclear receptor (NR) transcriptional mediator. More specifically, isolated nucleic acid molecules are provided encoding transcriptional intermediary factor-2 (TIF2). Recombinant methods for making TIF2 polypeptides are also provided as are TIF2 antibodies. Screening methods are also provided for identifying agonists and antagonists of the activation function AF-2 of nuclear receptors, for identifying agonists and antagonists of the AD1 activation domain activity of TIF2, and for identifying agonists and antagonists of the AD2 activation domain activity of TIF2.
摘要翻译：本发明涉及核受体（NR）转录介体。更具体地，提供编码转录中介因子-2（TIF2）的分离的核酸分子。还提供了用于制备TIF2多肽的重组方法，如TIF2抗体。还提供筛选方法用于鉴定核受体的激活功能AF-2的激动剂和拮抗剂，用于鉴定TIF2的AD1活化域活性的激动剂和拮抗剂，以及用于鉴定TIF2的AD2活化域活性的激动剂和拮抗剂。

100. 发明申请

WO1997043660A1 METHOD AND DEVICE FOR LOCATING A SOURCE PROVIDED WITH A MICROWAVE TRANSMITTER 审中-公开
标题翻译：用于定位由微波发射器提供的源的方法和装置
公开(公告)号：WO1997043660A1
公开(公告)日：1997-11-20
申请号：PCT/EP1997002425
申请日：1997-05-12
申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , LEROY, Yves , BERLARBI-DELAI, Aziz , COVILLERS, Jean-Pierre
发明人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
IPC分类号： G01S05/06
CPC分类号： G01S5/06
摘要： A device and a method for locating a source (1) provided with a microwave transmitter, particularly over short distances in a portion of a plane or space, are disclosed. The location method comprises using at least two antenna pairs (2, 3) positioned outside the area in which the source (1) is moving, positioning the source transmitter in such a way that the antenna pairs (2, 3) pick up the signal therefrom, measuring, for each antenna pair (2, 3), the phase shift between the signals received by each of the antennas (5, 6, 8, 9) of said pair (2, 3), determining the equation of the hyperboloid of revolution representing the locus of points where wave transmission identical to that of the source (1) would correspond to the phase shift ( phi 1, phi 2) measured by each antenna pair (2, 3), and determining the intersection of the hyperboloids of revolution in order to locate the source accurately and with a single solution. Said device and said method are useful for location and detection over short distances.
摘要翻译：公开了一种用于定位设置有微波发射器的源（1）的装置和方法，特别是在平面或空间的一部分中的短距离处。定位方法包括使用位于源（1）移动的区域外的至少两个天线对（2,3），以使得天线对（2,3）拾取信号的方式定位源发射机对于每个天线对（2,3），测量由所述对（2,3）中的每个天线（5,6,8,9）接收的信号之间的相移，确定双曲面的方程表示与源（1）的波传播相同的波传播的点的轨迹的旋转对应于由每个天线对（2,3）测量的相移（phi 1，phi 2），并且确定双曲面的交点的革命，以便准确地定位源，并使用单一解决方案。所述装置和所述方法对于在短距离上的定位和检测是有用的。

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