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    • 95. 发明申请
    • METALLIC GLASS ALLOYS OF Zr, Ti, Cu AND Ni
    • Zr,Ti,Cu和Ni的金属玻璃合金
    • WO1996024702A1
    • 1996-08-15
    • PCT/US1996001664
    • 1996-02-08
    • CALIFORNIA INSTITUTE OF TECHNOLOGY
    • CALIFORNIA INSTITUTE OF TECHNOLOGYLIN, XianghongPEKER, AtakanJOHNSON, William, L.
    • C22C45/10
    • C22C45/10
    • At least quaternary alloys form metallic glass upon cooling below the glass transition temperature at a rate less than 10 K/s. One group of such alloys comprise titanium from 19 to 41 atomic percent, an early transition metal (ETM) from 4 to 21 atomic percent and copper plus a late transition metal (LTM) from 49 to 64 atomic percent. The ETM comprises zirconium and/or hafnium. The LTM comprises cobalt and/or nickel. The composition is further constrained such that the product of the copper plus LTM times the atomic proportion of LTM relative to the copper is from 2 to 14. The atomic percentage of ETM is less than 10 when the atomic percentage of titanium is as high as 41, and may be as large as 21 when the atomic percentage of titanium is as low as 24. Furthermore, when the total of copper and LTM are low, the amount of LTM present must be further limited. Another group of glass forming alloys has the formula: (ETM1-xTix)aCub(Ni1-yCoy)c, wherein x is from 0.1 to 0.3, y c is from 0 to 18, a is from 47 to 67, b is from 8 to 42, and c is from 4 to 37. This definition of the alloys has additional constraints on the range of copper content.
    • 在玻璃化转变温度以低于10 3 K / s的速率冷却时,至少四价合金形成金属玻璃。 一组这样的合金包括19至41原子%的钛,4至21原子%的早期过渡金属(ETM)和铜加上从49至64原子百分比的后过渡金属(LTM)。 ETM包括锆和/或铪。 LTM包括钴和/或镍。 该组合物被进一步约束,使得铜加LTM的乘积与LTM相对于铜的原子比例为2至14.当钛的原子百分比高达41时,ETM的原子百分比小于10 ,当钛的原子百分比低至24时,可能高达21。此外,当铜和LTM的总量低时,必须进一步限制存在的LTM的量。 另一组玻璃形成合金具有下式:(ETM1-xTix)aCub(Ni1-yCoy)c,其中x为0.1至0.3,y c为0至18,a为47至67,b 为8〜42,c为4〜37。合金的定义对铜含量范围有附加限制。
    • 97. 发明申请
    • METHOD AND APPARATUS FOR SYNTHESIZING REALISTIC ANIMATIONS OF A HUMAN SPEAKING USING A COMPUTER
    • 用于使用计算机合成人声演示的现实动画的方法和装置
    • WO1996017323A1
    • 1996-06-06
    • PCT/US1995015507
    • 1995-11-30
    • CALIFORNIA INSTITUTE OF TECHNOLOGYSCOTT, Kenneth, C.YEATES, Matthew, C.KAGELS, David, S.WATSON, Stephen, Hilary
    • CALIFORNIA INSTITUTE OF TECHNOLOGY
    • G06T13/00
    • G06T13/205G06T13/40G10L13/00G10L2021/105
    • A method and apparatus for synthesizing speech or facial movements to match selected speech sequences. A videotape of an arbitrary text sequence is obtained including a plurality of images of a user speaking various sequences. Video images corresponding to specific spoken phonemes are obtained (300). A video frame is digitized from that sequence which represents the extreme of mouth motion and shape (302). This is used to create a data base of images of different facial positions relative to spoken phonemes and diphthongs (306). An audio speech sequence is then used as the element to which a video sequence will be matched (308). The audio sequence is analyzed to determine spoken phoneme sequences and relative timings (310). The database is used to obtain images for each of these phonemes and these times, and morphing techniques are used to create transitions between the images (204). Different parts of the images can be processed in different ways to make a more realistic speech pattern.
    • 一种用于合成语音或面部动作以匹配所选语音序列的方法和装置。 获得任意文本序列的录像带,其包括说出各种序列的用户的多个图像。 获得与特定语音对应的视频图像(300)。 从该序列数字化视频帧,其代表口部运动和形状的极端(302)。 这用于创建相对于语音和双声道的不同面部位置的图像的数据库(306)。 然后,音频语音序列被用作视频序列将被匹配的元素(308)。 分析音频序列以确定口头音素序列和相对定时(310)。 数据库用于获得这些音素和这些时间中的每一个的图像,并且使用变形技术来创建图像之间的转换(204)。 图像的不同部分可以以不同的方式进行处理,以形成更逼真的语音模式。
    • 98. 发明申请
    • UBIQUITIN-BASED SPLIT PROTEIN SENSOR
    • 基于UBIQUITIN的分离蛋白传感器
    • WO1995029195A1
    • 1995-11-02
    • PCT/US1995004536
    • 1995-04-07
    • CALIFORNIA INSTITUTE OF TECHNOLOGY
    • CALIFORNIA INSTITUTE OF TECHNOLOGYVARSHAVSKY, AlexanderJOHNSSON, Nils
    • C07K19/00
    • G01N33/542C07K14/00C07K2319/00C12Q1/37G01N33/532G01N33/54306
    • Disclosed are novel compositions and methods useful for studying interactions between proteins. An N-terminal subdomain and a C-terminal subdomain of ubiquitin are linked to a pair of proteins or peptides to be examined for their ability to interact. When contacted with one another, a quasi-native ubiquitin moiety is reconstituted provided that the protein or peptide pair do, in fact, interact (bind) with one another. The quasi-native ubiquitin moiety is recognized and cleaved by ubiquitin-specific proteases after the last residue of ubiquitin. The cleavage at the quasi-native ubiquitin moiety within a linear protein fusion is the indication of interaction between the protein or peptide pair. Also disclosed are novel compositions and methods, based on ubiquitin subdomain fusion proteins, which are useful for studying the interactions of two members of a specific binding pair, both of which are predetermined. A preferred embodiment relates to the determination of a predetermined ligand in a sample.
    • 公开了用于研究蛋白质之间的相互作用的新型组合物和方法。 泛素的N-末端亚结构域和C末端亚结构域与一对待检查的蛋白质或肽的相互作用能力相关联。 当彼此接触时,重新构建准天然泛素部分,条件是蛋白质或肽对实际上彼此相互作用(结合)。 在泛蛋白的最后残基之后,准天然泛素部分被泛素特异性蛋白酶识别和切割。 线性蛋白融合中准天然泛素部分的切割是蛋白质或肽对之间相互作用的指示。 还公开了基于泛素亚结构域融合蛋白的新型组合物和方法,其可用于研究两种预定的特异性结合对的两个成员的相互作用。 优选实施方案涉及样品中预定配体的测定。