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91. 发明申请

WO2006069984A2 PROCESS FOR THE SYNTHESIS OF CEFACLOR 审中-公开
标题翻译： CEFACLOR合成方法
公开(公告)号：WO2006069984A2
公开(公告)日：2006-07-06
申请号：PCT/EP2005057155
申请日：2005-12-23
申请人： DSM IP ASSETS BV , MOODY HAROLD MONRO , DOOREN VAN THEODORUS JOHANNES
发明人： MOODY HAROLD MONRO , DOOREN VAN THEODORUS JOHANNES
CPC分类号： C12P35/04 , C07D501/58 , C12P35/00
摘要： The present invention relates to a process for the synthesis of cefaclor, which process comprises reacting 7-amino-3-chloro cephalosporanic acid (7-ACCA) with D- phenylglycine in activated form (PGa) in the presence of an enzyme in a reaction mixture to form cefaclor, wherein at least part of 7-ACCA and / or PGa are added to the reaction mixture during the course of the reaction. The invention also relates to an aqueous mixture comprising an amount of cefaclor of > 10 (w/w) %, an amount of 7- amino-3-chloro cephalosporanic acid of 400 ) of less than 0.250.
摘要翻译：本发明涉及头孢克洛的合成方法，该方法包括使7-氨基-3-氯头孢菌酸（7-ACCA）与活性形式（PGa）的D-苯基甘氨酸在酶的存在下反应混合物以形成头孢克洛，其中在反应过程中将7-ACCA和/或PGa的至少一部分加入到反应混合物中。本发明还涉及包含一定量的头孢克洛> 10（w / w）％，7-氨基-3-氯头孢菌酸的量<2（w / w）％和D量的含水混合物（w / w）％的苯基甘氨酸和从该水性混合物中回收头孢克洛的方法。本发明还涉及具有小于0.250的在400nm（A≤400）的吸光度的晶体形式的头孢克洛。

92. 发明申请

WO2006067163A2 BLOOD PRESSURE LOWERING PEPTIDES IN A SINGLE ENZYMATIC STEP 审中-公开
标题翻译：血压降低在一个单一的步骤
公开(公告)号：WO2006067163A2
公开(公告)日：2006-06-29
申请号：PCT/EP2005057000
申请日：2005-12-21
申请人： DSM IP ASSETS BV , EDENS LUPPO , ROOS DE ANDRE LEONARDUS , SCHOUTEN OLAF LEONARDUS , DEEN PHILIPPUS ANTONIUS
发明人： EDENS LUPPO , ROOS DE ANDRE LEONARDUS , SCHOUTEN OLAF LEONARDUS , DEEN PHILIPPUS ANTONIUS
CPC分类号： C12P21/06 , A23J3/344 , A23L33/11 , A23L33/18 , A23L33/19 , A23V2002/00 , A61K38/00 , A23V2200/3262 , A23V2200/332 , A23V2200/326 , A23V2250/54246 , A23V2250/2136 , A23V2250/7052 , A23V2250/706 , A23V2250/7056
摘要： A process to produce IPP and VPP from a protein source that comprises the -I- P-P- and -V-P-P- sequence in its protein sequence and whereby at least 40% of -I-P-P- sequence present in the protein source is converted into the peptide IPP and at least 40% of the -V-P-P- sequence present in the protein source is converted into the peptide VPP, which comprises the use of a proline specific endoprotease and an amino- peptidase preferably in a single enzymatic step.
摘要翻译：从其蛋白质序列中包含-I-PP-和-VPP-序列的蛋白质源产生IPP和VPP的过程，并且其中存在于蛋白质源中的-IPP-序列的至少40％被转化为肽IPP 并且存在于蛋白质源中的至少40％的-VPP-序列被转化为肽VPP，其包括优选在单个酶促步骤中使用脯氨酸特异性内切蛋白酶和氨基肽酶。

93. 发明申请

WO2006029818A3 COSMETIC COMPOSITIONS CONTAINING AN HYDROXAMIC ACID COMPOUND OPTIONALLY IN COMBINATION WITH A RETINOID 审中-公开
标题翻译：含有抗氧化剂的化妆品组合物选择性地与抗菌剂组合
公开(公告)号：WO2006029818A3
公开(公告)日：2006-05-11
申请号：PCT/EP2005009832
申请日：2005-09-13
申请人： DSM IP ASSETS BV , BEUMER RAPHAEL , KLOCK JOCHEN
发明人： BEUMER RAPHAEL , KLOCK JOCHEN
IPC分类号： A61K8/67 , A61K8/42 , A61Q19/00
CPC分类号： A61K8/40 , A61K8/671 , A61Q7/00 , A61Q19/00 , A61Q19/004 , A61Q19/005 , A61Q19/007 , A61Q19/08
摘要： The present invention is directed to cosmetic compositions comprising a compound of the general formula (I) wherein L is hydrogen, branched alkyl, aryl, heteroaryl, cycloalkyl, heterocycloalkyl, hydroxyl, OR, HO-(CH 2 -CH 2 -O) n, HO-(CH 2 -O) n , HO-(CH 2 -CH 2 -CH 2 -O) n , HO(CH 2 -CH(CH 3 )-O) n , HO-(CH(CH 3 )-CH 2 -O) n , NR 4 R 5 , C(O)NR 6 R 7 , with R being C 1-4 -alkyl or C 2-18 -alkanoyl; n being an integer from 1 to 8; R 4 , R 5 , R 6 and R 7 being independently from each other hydrogen or C 1-18 -alkyl; R 1 is alkylene, alkenylene or alkinylene, optionally substituted with one or more methyl or ethyl groups; R 2 is hydrogen or alkyl; and R 3 is hydrogen, alkyl, or a cosmetically acceptable cation; and a carrier conventionally used in cosmetic compositions. The compositions preferably comprise additionally a retinoid. The present invention concerns further inter alia the use of such compositions for the treatment or prevention of any symptoms caused by negative developments of the physiological homeostasis of healthy skin, as wel as for the promotion of hair growth and protection from hair loss.
摘要翻译：本发明涉及包含通式（I）的化合物的化妆品组合物，其中L是氢，支链烷基，芳基，杂芳基，环烷基，杂环烷基，羟基，OR，HO-（CH 2） -CH 2 - （O）n，HO - （CH 2 -O）n，HO-（CH H（CH 2）2 CH 2 CH 2 CH 2 CH 2 CH 3（CH 3 CH 3）-O（CH 2 CH 2 CH 3）-O） > - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - 其中R为C 1-4 - 烷基或C 2-18烷基; n为1至8的整数; R 4，R 5，R 6和R 7彼此独立地为氢或C 1 -C 6烷基， 1-18 - 烷基; R 1是亚烷基，亚烯基或亚炔基，任选被一个或多个甲基或乙基取代; R 2是氢或烷基; R 3是氢，烷基或化妆品可接受的阳离子; 和通常用于化妆品组合物中的载体。组合物优选另外包含类视色素。本发明进一步涉及这样的组合物用于治疗或预防由健康皮肤的生理平衡的负面发展引起的任何症状，如促进头发生长和防止脱发。

94. 发明申请

WO2004101662A8 PROCESS FOR PREPARING A COMPOSITE MATERIAL 审中-公开
标题翻译：制备复合材料的方法
公开(公告)号：WO2004101662A8
公开(公告)日：2005-12-29
申请号：PCT/NL2004000313
申请日：2004-05-10
申请人： DSM IP ASSETS BV , JAHROMI SHAHAB
发明人： JAHROMI SHAHAB
IPC分类号： B05D3/06 , B05D3/14 , B05D7/24 , C08J7/06 , C23C14/12 , C08J7/00 , C23C14/00
CPC分类号： C08J7/065 , B05D1/60 , B05D3/044 , B05D3/0446 , B05D3/046 , B05D3/062 , B05D3/063 , B05D3/067 , B05D3/068 , B05D3/142 , B05D3/144 , B05D3/145 , B05D2201/02 , C23C14/022 , C23C14/12 , Y10T428/31504 , Y10T428/31605 , Y10T428/31667 , Y10T428/31678 , Y10T428/31938
摘要： The invention relates to a process for the preparation of a composite material, said composite material comprising a substrate and a layer on the substrate, comprising a vapour-depositing step in which a compound comprising a triazine compound is deposited on the substrate at a pressure below 1000 Pa, whereby the layer is formed, wherein during the vapour-depositing step the temperature of the substrate lies between -15 °C and +125 °C. The invention further relates to a composite material, obtainable by the process as disclosed.
摘要翻译：本发明涉及一种制备复合材料的方法，所述复合材料包括基底和基底上的层，包括气相沉积步骤，其中包含三嗪化合物的化合物以低于 1000Pa，由此形成层，其中在气相沉积步骤期间，基板的温度在-15℃和+ 125℃之间。本发明还涉及通过所公开的方法获得的复合材料。

95. 发明申请

WO2005058993A3 A POLYURETHANE AND VINYL POLYMER BASED RECYCLABLE AQUEOUS COATING COMPOSITION 审中-公开
标题翻译：聚氨酯和乙烯基聚合物基可回收水性涂料组合物
公开(公告)号：WO2005058993A3
公开(公告)日：2005-11-24
申请号：PCT/GB2004005194
申请日：2004-12-08
申请人： DSM IP ASSETS BV , SATGURUNATHAN RAJASINGHAM , ROELANDS MARC , VAN GINKEL MARTIN
发明人： SATGURUNATHAN RAJASINGHAM , ROELANDS MARC , VAN GINKEL MARTIN
IPC分类号： C08G18/08 , C08L33/12 , C08L75/04 , C09D175/04 , C08J11/04
CPC分类号： C08L75/04 , C08G18/0823 , C08L33/12 , C09D175/04 , C08L2666/04
摘要： A recyclable aqueous coating composition comprising a combination of a polyurethane polymer (A), a vinyl polymer (B) having a Tg >= 20°C, a Mw > 50,000 and an acid value = 70°C, a Mw from 15,000 to 50,000 and an acid value >= 40 mgKOH/g where the ration of (A)+(B):(C) is in the range of from 95:5 to 65:35.
摘要翻译：一种可再循环的水性涂料组合物，其包含聚氨酯聚合物（A），Tg≥20℃，Mw> 50,000且酸值<40mgKOH / g的乙烯基聚合物（B）和乙烯基聚合物（C）的组合，当（A）+（B）：（C）的比例在95:5至95:5的范围内时，具有Tg≥70℃，Mw为15,000至50,000和酸值≥40mgKOH/ 65:35。

96. 发明申请

WO2005059565A3 METHOD FOR THE DETERMINATION OF 25-HYDROXYCHOLECALCIFEROL IN FEED 审中-公开
标题翻译：测定饲料中25-羟基胆固醇的方法
公开(公告)号：WO2005059565A3
公开(公告)日：2005-10-27
申请号：PCT/EP2004013427
申请日：2004-11-26
申请人： DSM IP ASSETS BV , DENU LAURENT , GOESSL RICHARD , HOFMANN PETER
发明人： DENU LAURENT , GOESSL RICHARD , HOFMANN PETER
IPC分类号： G01N33/82
CPC分类号： G01N33/82 , Y10T436/24 , Y10T436/25 , Y10T436/25375 , Y10T436/255
摘要： A method for quantitative determination of 25-hydroxycholecalciferol in feed is described. The method comprises the steps of adding a defined amount of an internal standard which has a mass different from 25-hydroxycholecalciferol and a polarity similar to that compound, e.g., 26,27-hexadeutero-25-hydroxycholecalciferol, to an aqueous dispersion of the feed, extracting the aqueous dispersion with tert.butyl methyl ether and further processing the extract by HPLC and mass spectrometry as described in the specification.
摘要翻译：描述了定量测定饲料中25-羟基胆钙化甾醇的方法。该方法包括以下步骤：将具有不同于25-羟基胆钙化甾醇质量的确定量的内标和极性与该化合物例如26,27-十六氢-25-羟基胆钙化甾醇类似的极性添加至饲料的水分散体用叔丁基甲基醚萃取水分散体，并如说明书中所述通过HPLC和质谱法进一步处理萃取物。

97. 发明申请

WO2004046088A8 PROCESS FOR THE RACEMISATION OF ENANTIOMERICALLY ENRICHED ALPHA-AMINO NITRILES 审中-公开
标题翻译：高效液相色谱法制备高效液相色谱法
公开(公告)号：WO2004046088A8
公开(公告)日：2005-09-29
申请号：PCT/EP0312412
申请日：2003-11-03
申请人： DSM IP ASSETS BV , VERZIJL GERARDUS KAREL MARIA , BROXTERMAN QUIRINUS BERNARDUS
发明人： VERZIJL GERARDUS KAREL MARIA , KAPTEIN BERNARDUS , BROXTERMAN QUIRINUS BERNARDUS
IPC分类号： C07C253/30 , C07C255/24 , C07C255/42 , C07C255/44
CPC分类号： C07C253/30 , C07C255/24 , C07C255/42 , C07C255/44
摘要： Process for the racemisation of an enantiomerically enriched alpha-amino nitrile characterized in that the enantiomerically enriched alpha-amino nitrile is contacted with a lewis acid catalyst. Preferably an aprotic solvent is used. The lewis acid catalyst preferably comprises a metal chosen from main group elements IA-IVA of the Periodic Table (CAS version), the transition metals and the lanthanides, in particular Al, Ti, Zr, or lanthanides. The catalsyt for example has the general structure MnXpSqLr, and preferably is chosen from the group of aluminum alkoxides, aluminum alkyls, lanthanide alkoxydes and lanthanocenes. The racemisation may be performed in combination with a resolution process, for instance in combination with an enzymatic or a crystallization induced resolution process, preferably in situ, for instance in situ in a crystallization induced asymmetric transformation process.
摘要翻译：对映异构体富集的α-氨基腈的外消旋化方法，其特征在于对映异构体富集的α-氨基腈与路易斯酸催化剂接触。优选使用非质子溶剂。路易斯酸催化剂优选包含选自元素周期表主要元素IA-IVA（CAS版）的金属，过渡金属和镧系元素，特别是Al，Ti，Zr或镧系元素。例如，催化剂具有MnXpSqLr的一般结构，优选选自烷氧基铝，烷基铝，镧系烷氧基化物和镧系元素。外消旋化可以与分辨方法结合进行，例如与酶或结晶诱导的分辨方法组合进行，优选原位，例如在结晶诱导的非对称转化过程中原位。

98. 发明申请

WO2005050324A2 A METHOD AND APPARATUS FOR PRODUCING MICROCHIPS 审中-公开
标题翻译：一种用于生产微生物的方法和装置
公开(公告)号：WO2005050324A2
公开(公告)日：2005-06-02
申请号：PCT/EP2004012248
申请日：2004-10-28
申请人： DSM IP ASSETS BV , JAHROMI SHAHAB , WIENKE DIETRICH , BREMER LEONARDUS GERARDUS BERN
发明人： JAHROMI SHAHAB , WIENKE DIETRICH , BREMER LEONARDUS GERARDUS BERN
IPC分类号： G03F7/20 , H01L21/47
CPC分类号： G03F7/2041
摘要： Method for producing microchips by using immersion lithography, wherein the immersion fluid comprises an additive so that the refractive index of the immersion fluid is increased relative to the fluid not comprising the additive. The exposure light in the method has improved resolution, so that microchips having an increased integration density are obtained. The invention also relates to the immersion fluid and an apparatus for immersion lithography, comprising the immersion fluid.
摘要翻译：通过浸渍光刻制造微芯片的方法，其中浸没流体包括添加剂，使得浸没流体的折射率相对于不包含添加剂的流体增加。该方法中的曝光光分辨率提高，从而获得具有增加的积分密度的微芯片。本发明还涉及浸没流体和用于浸没式光刻的装置，其包括浸没流体。

99. 发明申请

WO2005023740A2 PROCESS FOR THE PREPARATION OF STILBENE DERIVATIVES 审中-公开
标题翻译： Stilbene衍生物的制备方法
公开(公告)号：WO2005023740A2
公开(公告)日：2005-03-17
申请号：PCT/EP2004009669
申请日：2004-08-31
申请人： DSM IP ASSETS BV , HAERTER RALPH , LEMKE ULRIKE , RADSPIELER ALEXANDER
发明人： HAERTER RALPH , LEMKE ULRIKE , RADSPIELER ALEXANDER
IPC分类号： C07C37/055 , C07C37/18 , C07C39/21 , C07C39/215 , C07C69/017 , C07C39/00
CPC分类号： C07C37/0555 , C07C69/017 , C07C39/215
摘要： A novel process for the preparation of resveratrol and piceatannol and esters thereof involving a Heck type reaction is disclosed. Also disclosed are novel intermediates in that process.
摘要翻译：公开了涉及Heck型反应的制备白藜芦醇和白藜芦醇及其酯的新方法。在该过程中还公开了新颖的中间体。

100. 发明申请

WO2004067132A3 PROCESS FOR SEPARATING NH3 AND OPTIONALLY CO2 AND H2O FROM A MIXTURE CONTAINING NH3, CO2 AND H2O 审中-公开
标题翻译：从含有NH3，CO2和H2O的混合物分离NH3和可选择的二氧化碳和水的方法
公开(公告)号：WO2004067132A3
公开(公告)日：2004-10-07
申请号：PCT/NL2004000014
申请日：2004-01-09
申请人： DSM IP ASSETS BV , BIERMANS ANDREAS JOHANNES , MENNEN JOHANNES HENRICUS , JONCKERS KEES , DE WIT NORA ANNA , HOOIJKAAS HERBERT WILLEM GERRI , VAN DE KERKHOVE BASTIAAN RENE
发明人： BIERMANS ANDREAS JOHANNES , MENNEN JOHANNES HENRICUS , JONCKERS KEES , DE WIT NORA ANNA , HOOIJKAAS HERBERT WILLEM GERRI , VAN DE KERKHOVE BASTIAAN RENE
IPC分类号： C01C1/12
CPC分类号： C01C1/12
摘要： The invention relates to a process for separating NH3 from a mixture containing NH3, CO2 and H2O which comprises an NH3 rectification step carried out in a NH3 separation device to which one or more streams containing NH3, CO2 and H2O, including the mixture, are supplied, with a stream consisting substantially of gaseous NH3 being formed in the NH3 separation device, separated from the mixture and discharged. In the process according to the invention a condensation step is carried out on at least one of the stream consisting substantially of gaseous NH3 or the one or more streams containing NH3, CO2 and H2O supplied to the NH3 separation device, in which at least a part of the existing CO2 is converted to a liquid phase.
摘要翻译：本发明涉及从包含NH 3，CO 2和H 2 O的混合物中分离NH 3的方法，其包括在NH 3分离装置中进行的NH 3精馏步骤，向其中提供包含混合物的包含NH 3，CO 2和H 2 O的一个或多个流，其中基本上由在NH 3分离装置中形成的气态NH 3组成的物流与混合物分离并排出。在根据本发明的方法中，对基本上由气态NH 3组成的流中的至少一个流或者包含NH 3，CO 2和H 2 O的一个或多个流进行NH 3分离装置的冷凝步骤，其中至少一部分的现有CO2转化为液相。

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