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1. 发明申请

WO2010141475A1 COMPOSITIONS AND METHODS FOR PREVENTING STERNAL WOUND INFECTIONS 审中-公开
标题翻译：防止创伤性感染的组合物和方法
公开(公告)号：WO2010141475A1
公开(公告)日：2010-12-09
申请号：PCT/US2010/036910
申请日：2010-06-01
申请人： TYRX PHARMA, INC. , BAHULEKAR, Raman , MOSES, Arikha , BUEVICH, Fatima , PULAPURA, Satish , MCJAMES, William C.
发明人： BAHULEKAR, Raman , MOSES, Arikha , BUEVICH, Fatima , PULAPURA, Satish , MCJAMES, William C.
IPC分类号： A61K9/06
CPC分类号： A61L26/0066 , A61L26/0019 , A61L26/009 , A61L2300/404 , A61L2300/602 , C08L77/12
摘要： The invention generally relates to compositions and methods for preventing sternal wound infections, such as mediastinitis. In certain embodiments, the invention provides an antimicrobial composition including at least one bioresorbable polymer, such as a tyrosine-derived polyesteramide, and at least one antimicrobial agent, in which the composition is adapted to be topically applied to an esophageal perforation in a subject or a median sternotomy incision site in the subject, and in which the at least one antimicrobial agent is present in an amount effective to inhibit development of mediastinitis in the subject.
摘要翻译：本发明一般涉及用于预防胸骨伤口感染如纵隔炎的组合物和方法。在某些实施方案中，本发明提供了包含至少一种生物可再吸收的聚合物，例如酪氨酸衍生的聚酯酰胺和至少一种抗微生物剂的抗微生物组合物，其中所述组合物适于局部施用于受试者的食道穿孔，或在受试者中的中位胸骨切开术切口部位，其中所述至少一种抗微生物剂以有效抑制受试者纵隔炎发展的量存在。

2. 发明申请

WO2010006046A1 NSAID DELIVERY FROM POLYARYLATES 审中-公开
标题翻译：非甾体抗炎药从各种药物中提取
公开(公告)号：WO2010006046A1
公开(公告)日：2010-01-14
申请号：PCT/US2009/049933
申请日：2009-07-08
申请人： TYRX PHARMA, INC. , MOSES, Arikha , BUEVICH, Fatima , PULAPURA, Satish , VISWANATHAN, Arvind
发明人： MOSES, Arikha , BUEVICH, Fatima , PULAPURA, Satish , VISWANATHAN, Arvind
IPC分类号： A61B19/02 , B65D69/00
CPC分类号： A61K31/195 , A61B17/06166 , A61B2017/00893
摘要： This invention provides biodegradable, sustained-release pharmaceutical compositions of non-steroidal, anti-inflammatory drugs (NSAIDs) formulated with biocompatible, biodegradable tyrosine-derived polyarylates. The compositionsare particularly suitable for localized delivery of NSAIDs for various disease states. For example, implantation of the compositions at the site of surgery leads to relatively high local concentrations of the NSAID to reduce or alleviate post-surgical pain. Long term zero order release of certain NSAIDs can also be provided by with certain polymer formulations.
摘要翻译：本发明提供用生物相容性，可生物降解的酪氨酸衍生的多芳基化合物配制的非甾体抗炎药（NSAID）的可生物降解的持续释放药物组合物。该组合物特别适用于各种疾病状态的NSAID的局部递送。例如，在手术部位植入组合物导致NSAID的局部浓度相对较高以减少或减轻手术后疼痛。某些NSAIDs的长期零级释放也可以通过某些聚合物配方提供。

3. 发明申请

WO2009113972A2 TEMPORARILY STIFFENED MESH PROSTHESES 审中-公开
标题翻译：临时强硬的MESH PROSTHESES
公开(公告)号：WO2009113972A2
公开(公告)日：2009-09-17
申请号：PCT/US2007/061885
申请日：2007-02-08
申请人： TYRX PHARMA, INC. , BUEVICH, Fatima , DO, Frank , McJAMES, William , PULAPURA, Satish , EDELMAN, William , MOSES, Arikha , DIAMOND, Mason , TIMOTHY, Shari
发明人： BUEVICH, Fatima , DO, Frank , McJAMES, William , PULAPURA, Satish , EDELMAN, William , MOSES, Arikha , DIAMOND, Mason , TIMOTHY, Shari
IPC分类号： A61F2/02 , B05D1/02
CPC分类号： A61F2/0063 , A61F2210/0004 , A61F2250/0067 , A61F2310/0097 , A61L27/34 , A61L27/54 , A61L27/56 , A61L27/58 , A61L31/10 , A61L31/146 , A61L31/148 , A61L31/16 , A61L2300/402 , A61L2300/404 , A61L2300/406 , A61L2300/416 , A61L2300/45 , A61L2300/606 , A61L2430/02
摘要： The present invention relates to medical prostheses and methods of manufacturing those devices. In particular, the prostheses are temporarily stiffened meshes with particular coatings to provide initial stiffness and thereby permit easier surgical handling for treatment or reconstruction of soft tissue defects. Preferred embodiments include surgical meshes coated with one or more biodegradable polymers that can act as a stiffening agent by coating the filaments or fibers of the mesh to temporarily immobilize the contact points of those filaments or fibers and/or by increasing the stiffness of the mesh by at least 1.1 times its original stiffness. The devices of the invention can also provide relief from various post-operative complications associated with their implantation, insertion or surgical use. By including biologically active agents and/or drugs in the coating, the devices provide prophylaxis for and can alleviate side effects or complications associated with the surgery or use of prostheses in general.
摘要翻译：本发明涉及医用假体及其制造方法。特别地，假体是具有特定涂层的临时硬化网，以提供初始刚度，从而允许更容易的手术处理以用于治疗或重建软组织缺陷。优选的实施方案包括涂覆有一种或多种可生物降解的聚合物的手术网，所述可生物降解的聚合物可以通过涂覆网状物的细丝或纤维来临时固定那些丝或纤维的接触点和/或通过增加网状物的刚度至少是原始刚度的1.1倍。本发明的装置还可以提供与其植入，插入或手术使用相关的各种术后并发症的缓解。通过将生物活性剂和/或药物包括在涂层中，该装置通常提供与手术或使用假体相关的副作用或并发症的预防和可以减轻。

4. 发明申请

WO2010006249A1 SUSTAINED RELEASE FORMULATIONS OF PSYCHOACTIVE DRUGS 审中-公开
标题翻译：持续药物释放配方
公开(公告)号：WO2010006249A1
公开(公告)日：2010-01-14
申请号：PCT/US2009/050232
申请日：2009-07-10
申请人： TYRX PHARMA, INC. , MOSES, Arikha , BUEVICH, Fatima , PULAPURA, Satish
发明人： MOSES, Arikha , BUEVICH, Fatima , PULAPURA, Satish
IPC分类号： A01N43/62 , A61K31/55
CPC分类号： A61K31/55 , A61K9/5031 , A61K47/34
摘要： This invention provides biodegradable, sustained-release pharmaceutical compositions of a psychoactive drug formulated with biocompatible, biodegradable tyrosine-derived polyarylates.
摘要翻译：本发明提供用生物相容性，可生物降解的酪氨酸衍生的多芳基化合物配制的精神活性药物的可生物降解的持续释放药物组合物。

5. 发明申请

WO2008127411A1 MESH POUCHES FOR IMPLANTABLE MEDICAL DEVICES 审中-公开
公开(公告)号：WO2008127411A1
公开(公告)日：2008-10-23
申请号：PCT/US2007/083843
申请日：2007-11-06
申请人： TYRX PHARMA, INC. , BUEVICH, Fatima , MOSES, Arikha , DO, Frank , MCJAMES, William , EDELMAN, Willam , DIAMOND, Mason , PULAPURA, Satish , TIMOTHY, Shari
发明人： BUEVICH, Fatima , MOSES, Arikha , DO, Frank , MCJAMES, William , EDELMAN, Willam , DIAMOND, Mason , PULAPURA, Satish , TIMOTHY, Shari
IPC分类号： A61B19/00
CPC分类号： A61F2/0063 , A61F2210/0004 , A61L31/048 , A61L31/10 , A61L31/146 , A61L31/16 , A61L2300/00 , A61N1/375 , A61N1/3968 , C08L23/12 , C08L67/04
摘要： Biodegradable polymer-coated surgical meshes formed into pouches are described for use with cardiac rhythm management devices (CRMs) and other implantable medical devices. Such meshes are formed into a receptacle, e.g., a pouch or other covering, capable of encasing, surrounding and/or holding the cardiac rhythm management device or other implantable medical device for the purpose of securing it in position, inhibiting or reducing bacterial growth, providing pain relief and/or inhibiting scarring or fibrosis on or around the CRM or other implantable medical device. Preferred embodiments include surgical mesh pouches coated with one or more biodegradable polymers that can act as a stiffening agent by coating the filaments or fibers of the mesh to temporarily immobilize the contact points of those filaments or fibers and/or by increasing the stiffness of the mesh by at least 1.1 times its original stiffness. The pouches of the invention can also provide relief from various post-operative complications associated with their implantation, insertion or surgical use, and, optionally, include one or more drugs in the polymer matrix of the coating to provide prophylactic effects and/or alleviate side effects or complications associated with the surgery or implantation of the CRM or other implantable medical device.
摘要翻译：描述形成袋的可生物降解的聚合物涂覆的手术网与心律管理装置（CRM）和其他可植入医疗装置一起使用。这样的网状物形成为能够包围，围绕和/或保持心律管理装置或其它可植入医疗装置的容器，例如袋或其它覆盖物，以确保其在适当位置，抑制或减少细菌生长，在CRM或其他可植入医疗设备上或周围提供疼痛缓解和/或抑制瘢痕形成或纤维化。优选的实施方案包括涂覆有一种或多种可生物降解的聚合物的手术网袋，其可以通过涂覆网的细丝或纤维来暂时固定那些丝或纤维的接触点和/或通过增加网的刚度而充当硬化剂至少是其原始刚度的1.1倍。本发明的小袋还可以缓解与其植入，插入或手术使用相关的各种术后并发症，并且任选地在包衣的聚合物基质中包括一种或多种药物以提供预防效果和/或缓解侧与手术或植入CRM或其他可植入医疗器械相关的影响或并发症。

6. 发明申请

WO2008136856A3 RESORBABLE POUCHES FOR IMPLANTABLE MEDICAL DEVICES 审中-公开
公开(公告)号：WO2008136856A3
公开(公告)日：2008-11-13
申请号：PCT/US2007/083841
申请日：2007-11-06
申请人： TYRX PHARMA, INC. , BUEVICH, Fatima , MOSES, Arikha , DO, Frank , MCJAMES, William , EDELMAN, William , DIAMOND, Mason
发明人： BUEVICH, Fatima , MOSES, Arikha , DO, Frank , MCJAMES, William , EDELMAN, William , DIAMOND, Mason
IPC分类号： A61F2/00
摘要： Biodegradable and resorbable polymer pouches are described for use with cardiac rhythm mamagent devices (CRMs) and other implantable medical devices (IMDs), i.e., a pouch, covering, or other receptacle capable of encasing, surrounding and/or holding the CRM or other IMD for the purpose of securing it in position, inhibiting or reducing bacterial growth, providing pain relief and/or inhibiting scarring or fibrosis on or around the CRM or other IMD. Optionally, the biodegradable and resorbable pouches of the invention include one or more drugs in the polymer matrix to provide prophylactic effects and alleviate side effects or complications associated with the surgery or implantation of the CRM or other IMD.

7. 发明申请

WO2008121816A3 BIODEGRADABLE, POLYMER COVERINGS FOR BREAST IMPLANTS 审中-公开
公开(公告)号：WO2008121816A3
公开(公告)日：2008-10-09
申请号：PCT/US2008/058652
申请日：2008-03-28
申请人： TYRX PHARMA, INC. , MOSES, Arikha , PULAPURA, Satish , GE, Qing , NETHULA, Sarita , RAJARAM, Archana
发明人： MOSES, Arikha , PULAPURA, Satish , GE, Qing , NETHULA, Sarita , RAJARAM, Archana
IPC分类号： A61F2/52
摘要： A biodegradable, flexible covering for a breast implant is provided which comprises one or more biodegradable polymer layers dimensioned and shaped to cover at least a portion of the breast implant. The implant can be inserted into an opening of the covering immediately prior to surgery, but alternate configurations and times of insertion are contemplated as well as open or sheet type devices. The coverings can optionally contain one or more drugs for delivery at the surgical site, particularly for treating or preventing infection, pain, inflammation, capsular contracture, scarring or other complications associated with breast augmentation or breast reconstruction.

8. 发明申请

WO2008137807A1 DIHYDROXYBENZOATE POLYMERS AND USES THEREOF 审中-公开
标题翻译：二羟基苯甲酸酯聚合物及其用途
公开(公告)号：WO2008137807A1
公开(公告)日：2008-11-13
申请号：PCT/US2008/062582
申请日：2008-05-02
申请人： TYRX PHARMA, INC. , MOSES, Arikha , PULAPURA, Satish , GE, Qing , NETHULA, Sarita , RAJARAM, Archana
发明人： MOSES, Arikha , PULAPURA, Satish , GE, Qing , NETHULA, Sarita , RAJARAM, Archana
IPC分类号： A23B7/154 , A23L1/27
CPC分类号： A23L3/3481 , A61K31/765 , A61K45/06 , A61K2300/00
摘要： The present invention is directed to polyphenolic polymers formed from dihydroxybenzoic acid (DHB) derivatives or from resorcinol derivatives, monomers which form such polymers, blends of the polymers with drugs and/or additional polymers, as well as medical devices formed from, coated with, impregnated by or coverings made with any of the foregoing polymers (with or without drugs) or blends (with or without drugs).
摘要翻译：本发明涉及由二羟基苯甲酸（DHB）衍生物或间苯二酚衍生物形成的多酚聚合物，形成这种聚合物的单体，聚合物与药物和/或另外的聚合物的共混物，以及由涂覆，用任何前述聚合物（含或不含药物）或共混物（含或不含药物）制成的浸渍或覆盖物。

9. 发明申请

WO2007056134A2 RESORBABLE PHENOLIC POLYMERS 审中-公开
标题翻译：可分离的酚醛聚合物
公开(公告)号：WO2007056134A2
公开(公告)日：2007-05-18
申请号：PCT/US2006/042944
申请日：2006-11-03
申请人： TYRX PHARMA INC. , MOSES, Arikha , PULAPURA, Satish , SCHWARTZ, Arthur , GE, Qing , SHATOVA, Irene
发明人： MOSES, Arikha , PULAPURA, Satish , SCHWARTZ, Arthur , GE, Qing , SHATOVA, Irene
IPC分类号： F24D13/04
CPC分类号： C08G69/48 , C07C235/34 , C07C235/52 , C08G63/6856 , C08G64/12 , C08G73/028
摘要： The invention provides biocompatible resorbable polymers, comprising monomer units having formula (I), formula (II), formula (III) or formula (IV). The polymers degrade over time when implanted in the body, and are useful as components of implantable medical devices.
摘要翻译：本发明提供具有式（I），式（II），式（III）或式（IV））的单体单元的生物相容性可再吸收聚合物。当植入体内时，聚合物随时间降解，并且可用作可植入医疗装置的组件。

10. 发明申请

WO2010033995A1 LINEAR POLYESTERAMIDES FROM AMINOPHENOLIC ESTERS 审中-公开
标题翻译：来自氨基酚的线性聚氨酯
公开(公告)号：WO2010033995A1
公开(公告)日：2010-03-25
申请号：PCT/US2009/057860
申请日：2009-09-22
申请人： TYRX PHARMA, INC. , SCHWARTZ, Arthur , PULAPURA, Satish , NETHULA, Sarita , RAJARAM, Archana , MOSES, Arikha
发明人： SCHWARTZ, Arthur , PULAPURA, Satish , NETHULA, Sarita , RAJARAM, Archana , MOSES, Arikha
IPC分类号： A61L17/00 , A61L27/00
CPC分类号： C08G69/44 , A61K9/0024 , A61K31/09 , A61K31/4465 , A61K31/496 , A61K31/65 , A61K31/7036 , A61K47/34 , A61L29/06 , A61L29/085 , A61L29/148 , A61L29/16 , A61L31/06 , A61L31/10 , A61L31/148 , A61L31/16 , A61L2300/404 , A61L2300/802 , A61L2400/18 , A61L2420/06 , A61M2025/0057 , C08G69/00 , C08L77/12 , C08L101/00 , C08L2666/02 , C08L2666/20
摘要： The present invention is directed to linear, biodegradable polyesteramide (PEA) polymers synthesized with repeating units derived from aminophenol esters and diacids. These PEAs have a monomer repeat represented by the following formula; as well as a variety of uses to coat, form or comprise medical devices, combination medical devices and pharmaceutical compositions, including sustained release formulations.
摘要翻译：本发明涉及由衍生自氨基苯酚酯和二酸的重复单元合成的线性可生物降解聚酯酰胺（PEA）聚合物。这些PEAs具有由下式表示的单体重复; 以及用于涂覆，形成或包括医疗装置，组合医疗装置和药物组合物（包括持续释放制剂）的各种用途。

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