专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2015200180A1 COMPOSITIONS RELATING TO VITAMIN D 审中-公开
标题翻译：与维生素D有关的组合物
公开(公告)号：WO2015200180A1
公开(公告)日：2015-12-30
申请号：PCT/US2015/036904
申请日：2015-06-22
申请人： SIEMENS HEALTHCARE DIAGNOSTICS INC.
发明人： TENG, Zhu , LIAO, Qimu , SHARMA, Manoj , DRINAN, Martin, A. , WEI, Tie, Quan
IPC分类号： A61K31/59
CPC分类号： C07C401/00 , C07C2601/14 , C07C2602/24 , G01N33/82
摘要： This invention relates to compositions, methods and kits for determining the presence and/or amount of vitamin D analytes, including vitamin D isomers, and metabolites thereof in a sample suspected of containing the same. Compounds include compounds of the Formula I, namely, (R 1 ) p -(L) q -Z wherein R 1 , L, p and q are as defined herein. These compounds are capable of binding specifically to corresponding antibodies. Compounds and antibodies in accordance with the principles described herein can have therapeutic activity. These compounds may be administered in therapeutically effective amount, which is an amount to provide treatment of a particular disease state associated with vitamin D. Administration of the examples of compounds in accordance with the principles described herein can be by means of any of the accepted modes of administration for agents that serve similar utilities.
摘要翻译：本发明涉及用于确定怀疑含有该维生素D分析物的维生素D分析物（包括维生素D异构体）及其代谢物的存在和/或量的组合物，方法和试剂盒。化合物包括式I的化合物，即（R1）对 - （L）q -Z其中R1，L，p和q如本文所定义。这些化合物能够特异性结合相应的抗体。根据本文所述原理的化合物和抗体可具有治疗活性。这些化合物可以以治疗有效量施用，其量是提供与维生素D相关的特定疾病状态的治疗量。根据本文所述原理施用化合物的实例可以通过任何接受的方式为类似用途的代理商提供管理。

2. 发明申请

WO2012162165A2 ANTIBODIES TO 25-HYDROXYVITAMIN D2 AND D3 AND USES THEREOF 审中-公开
标题翻译： 25羟基维生素D2和D3的抗体及其用途
公开(公告)号：WO2012162165A2
公开(公告)日：2012-11-29
申请号：PCT/US2012/038637
申请日：2012-05-18
申请人： SIEMENS HEALTHCARE DIAGNOSTICS, INC. , SAHAKIAN, Niver, Panosian , CAMPBELL, Bruce, A. , LIN, Spencer, Hsiang-Hsi , FREEMAN, James, Vincent , LIAO, Qimu , EVANGELISTA, Ramon, A.
发明人： SAHAKIAN, Niver, Panosian , CAMPBELL, Bruce, A. , LIN, Spencer, Hsiang-Hsi , FREEMAN, James, Vincent , LIAO, Qimu , EVANGELISTA, Ramon, A.
IPC分类号： G01N33/53
CPC分类号： G01N33/82 , C07K16/44 , G01N2800/02
摘要： Provided herein are antigenic molecules that can be used to generate antibodies capable of binding to a vitamin D derivative, such as 25-hydroxyvitamin D2 and/or 25-hydroxyvitamin D3, or a 25-hydroxyvitamin D analog, such as a vitamin D-C22 immunogenic molecule or compound. Antibodies produced using these antigenic molecules, and related antigenic compounds, are also described. In addition, disclosed herein are methods for detecting vitamin D deficiency in a subject, methods for treating a subject suspected of having a vitamin D deficiency, methods for monitoring progression of vitamin D deficiency in a subject, and methods for monitoring treatment of vitamin D deficiency in a subject in need thereof. Also provided are methods and reagents for the detection or quantification of 25-hydroxyvitamin D2 and D3, methods for stabilizing vitamin D analogs, and methods for separating 25- hydroxyvitamin D2 and D3 from vitamin D binding protein in a biological sample.
摘要翻译：本文提供了可用于产生能够结合维生素D衍生物的抗体的抗原性分子，例如25-羟基维生素D2和/或25-羟基维生素D 3或25-羟基维生素D类似物，例如维生素D-C22 免疫原性分子或化合物。还描述了使用这些抗原分子产生的抗体及相关抗原性化合物。此外，本文公开了检测受试者中维生素D缺乏症的方法，用于治疗疑似维生素D缺乏的受试者的方法，用于监测受试者中维生素D缺乏症的进展的方法，以及用于监测维生素D缺乏症的治疗方法在有需要的受试者中。还提供了用于检测或定量25-羟基维生素D2和D3的方法和试剂，用于稳定维生素D类似物的方法，以及在生物样品中从维生素D结合蛋白分离25-羟基维生素D2和D3的方法。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式