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1. 发明申请

WO2008114223A1 DRUG DELIVERY DEVICE 审中-公开
标题翻译：药物递送装置
公开(公告)号：WO2008114223A1
公开(公告)日：2008-09-25
申请号：PCT/IB2008/051049
申请日：2008-03-19
申请人： INSULINE MEDICAL LTD. , PESACH, Benny , BITTON, Gabriel , NAGAR, Ron
发明人： PESACH, Benny , BITTON, Gabriel , NAGAR, Ron
IPC分类号： A61M5/20 , A61N1/30
CPC分类号： A61M5/31 , A61B18/08 , A61B18/14 , A61B18/1477 , A61B18/18 , A61B18/20 , A61B2018/1425 , A61F7/007 , A61M5/14244 , A61M5/158 , A61M5/16831 , A61M5/1723 , A61M5/19 , A61M5/20 , A61M5/2448 , A61M5/422 , A61M2005/1581 , A61M2005/1726 , A61M2205/05 , A61M2205/051 , A61M2205/052 , A61M2205/054 , A61M2205/057 , A61M2205/058 , A61N1/30 , A61N7/00 , A61N2005/0645
摘要： The present disclosure presents systems, devices and methods for injection of drugs, substances and/or chemicals to a patient and for improving their effectiveness once they are injected are disclosed. Additional treatment can be applied to a tissue region on the patient into which a drug (e.g., insulin) is injected, to expose the tissue region to various forms of energy or a substance to improve the drug's pharmacokinetic and/or pharmacodynamic profile.
摘要翻译：本公开内容公开了向患者注射药物，物质和/或化学物质并且一旦注射后提高其效力的系统，装置和方法。可以对注射药物（例如胰岛素）的患者的组织区域施加额外的治疗，以将组织区域暴露于各种形式的能量或物质以改善药物的药代动力学和/或药效学特征。

2. 发明申请

WO2008114218A2 METHOD AND DEVICE FOR DRUG DELIVERY 审中-公开
标题翻译：用于药物递送的方法和装置
公开(公告)号：WO2008114218A2
公开(公告)日：2008-09-25
申请号：PCT/IB2008/051044
申请日：2008-03-19
申请人： INSULINE MEDICAL LTD. , PESACH, Benny , BITTON, Gabriel , WEISS, Ram , NAGAR, Ron
发明人： PESACH, Benny , BITTON, Gabriel , WEISS, Ram , NAGAR, Ron
IPC分类号： A61M5/158 , A61M5/168 , A61M5/172 , A61M5/142
CPC分类号： A61M5/1723 , A61B18/08 , A61B18/14 , A61B18/1477 , A61B18/1492 , A61B18/18 , A61B18/20 , A61B2018/1425 , A61F7/007 , A61H9/0057 , A61H23/00 , A61M5/1413 , A61M5/14244 , A61M5/158 , A61M5/16831 , A61M5/20 , A61M5/422 , A61M37/0092 , A61M2005/1581 , A61M2005/1726 , A61M2039/1022 , A61M2205/05 , A61M2205/051 , A61M2205/052 , A61M2205/058 , A61M2205/8206 , A61N1/30 , A61N1/406 , A61N2/002 , A61N5/062 , A61N7/00 , A61N2005/0645

3. 发明申请

WO2008114220A2 DEVICE FOR DRUG DELIVERY AND ASSOCIATED CONNECTIONS THERETO 审中-公开
标题翻译：用于药物递送和相关连接的设备
公开(公告)号：WO2008114220A2
公开(公告)日：2008-09-25
申请号：PCT/IB2008/051046
申请日：2008-03-19
申请人： INSULINE MEDICAL LTD. , PESACH, Benny , BITTON, Gabriel , NAGAR, Ron
发明人： PESACH, Benny , BITTON, Gabriel , NAGAR, Ron
IPC分类号： A61M5/158 , A61M5/168
CPC分类号： A61M5/158 , A61M5/16836 , A61M2005/1581 , A61M2005/1587 , G06F19/00

4. 发明申请

WO2009081262A1 DRUG DELIVERY DEVICE WITH SENSOR FOR CLOSED-LOOP OPERATION 审中-公开
标题翻译：具有传感器的药物递送装置用于闭环操作
公开(公告)号：WO2009081262A1
公开(公告)日：2009-07-02
申请号：PCT/IB2008/003547
申请日：2008-12-18
申请人： INSULINE MEDICAL LTD. , PESACH, Benny , BITTON, Gabriel , NAGAR, Ron
发明人： PESACH, Benny , BITTON, Gabriel , NAGAR, Ron
IPC分类号： A61M5/142 , A61M5/172
CPC分类号： A61M5/1723 , A61M5/14248 , A61M2005/14296 , A61M2005/1726 , A61M2205/3368 , A61M2205/50 , A61M2205/60 , A61M2230/201 , A61M2230/50 , A61M2230/63
摘要： An apparatus and a system for controlling and/or managing administration of a drug to a body of a patient. The apparatus includes a drug infusion device configured to deliver drug at a predetermined location in the body of the patient, at least one sensor disposed in the drug infusion device and configured to measure a. corresponding property related to the patient and selected from the group consisting of physiological properties, biochemical properties, environmental properties and drug- related properties, a controller disposed in the drug infusion device and configured to receive from the at least one sensor data representative of the measured corresponding property and based on the received data, determine a drug delivery rate. The drug delivery device is configured to deliver the drug to the body of the patient based on the determined drug delivery rate.
摘要翻译：一种用于控制和/或管理药物对患者体内的药物的装置和系统。该装置包括药物输注装置，其配置成在患者体内的预定位置输送药物，至少一个传感器设置在药物输注装置中并且被配置为测量a。与患者相关的并且选自生理特性，生物化学性质，环境特性和药物相关性质的对应性质，设置在药物输注装置中并被配置为从所述至少一个传感器接收表示所测量的数据的数据相应的财产，并根据收到的数据，确定药物递送率。药物递送装置被配置为基于确定的药物递送速率将药物递送到患者的身体。

5. 发明申请

WO2011039736A3 DEVICE AND METHOD FOR DRUG DELIVERY TO A TARGETED SKIN LAYER 审中-公开
公开(公告)号：WO2011039736A3
公开(公告)日：2011-04-07
申请号：PCT/IB2010/054476
申请日：2010-10-04
申请人： INSULINE MEDICAL LTD. , PESACH, Benny , BITTON, Gabriel , NAGAR, Ron
发明人： PESACH, Benny , BITTON, Gabriel , NAGAR, Ron
IPC分类号： A61M31/00
摘要： The present invention relates to a device and method for the controlled delivery of a drug to a targeted layer of the skin in a human or animal subject. In particular, the present invention relates to such a device, system and method for selective drug delivery to the cutaneous or subcutaneous layer of skin to enhances the effectiveness of the drug delivery.

6. 发明申请

WO2010052579A2 DEVICE AND METHOD FOR DRUG DELIVERY 审中-公开
标题翻译：用于药物递送的装置和方法
公开(公告)号：WO2010052579A2
公开(公告)日：2010-05-14
申请号：PCT/IB2009/007600
申请日：2009-11-06
申请人： INSULINE MEDICAL LTD. , PESACH, Benny , BITTON, Gabriel , NAGAR, Ron , WEISS, Ram
发明人： PESACH, Benny , BITTON, Gabriel , NAGAR, Ron , WEISS, Ram
IPC分类号： A61F7/08 , A61M5/00 , A61M5/44 , A61M5/50
CPC分类号： A61M5/44 , A61B2018/00005 , A61B2090/0803 , A61F7/007 , A61F7/02 , A61F2007/0093 , A61F2007/0096 , A61F2007/0226 , A61M5/003 , A61M5/20 , A61M5/427 , A61M2205/273 , A61M2205/3368 , A61M2205/3653 , A61M2209/00
摘要： A therapeutic treatment device, system and method for improving administration of a temperature sensitive drug into a tissue on the body of a patient at a drug injection site are disclosed. The device includes a treatment element with a controllable heating element in temperature communicative contact with the tissue adjacent to the drug injection site. The controllable heating element is configured to heat the tissue adjacent to the drug injection site to a controllable temperature but does not heat the injected drug above a predetermined limiting temperature, above which degradation of the injected drug may occur.
摘要翻译：本发明公开了一种治疗性治疗装置，系统和方法，用于在药物注射部位改善温度敏感药物向患者身体组织中的施用。该装置包括处理元件，该处理元件具有与邻近药物注射部位的组织处于温度交流接触的可控加热元件。可控制的加热元件被配置成加热邻近药物注射部位的组织到可控制的温度，但不将注射的药物加热到预定的极限温度以上，在该极限温度以上，注射的药物可能发生降解。

7. 发明申请

WO2008114224A2 METHOD AND DEVICE FOR SUBSTANCE MEASUREMENT 审中-公开
标题翻译：用于物质测量的方法和装置
公开(公告)号：WO2008114224A2
公开(公告)日：2008-09-25
申请号：PCT/IB2008/051050
申请日：2008-03-19
申请人： INSULINE MEDICAL LTD. , PESACH, Benny , BITTON, Gabriel , WEISS, Ram , NAGAR, Ron
发明人： PESACH, Benny , BITTON, Gabriel , WEISS, Ram , NAGAR, Ron
IPC分类号： A61B5/00
CPC分类号： A61B5/1495 , A61B5/14532 , A61B5/14865 , A61B5/1491
摘要： Embodiments of the present disclosure present systems, devices and methods for ISF glucose monitoring that more accurately reflects the blood glucose levels by introducing a treatment element allowing stable and accurate prediction of blood glucose levels based measured glucose levels from interstitial fluid.
摘要翻译：本公开的实施例提供了用于ISF葡萄糖监测的系统，装置和方法，其通过引入治疗元件更准确地反映血糖水平，所述治疗元件允许基于间质液测量的葡萄糖水平来稳定和准确地预测血糖水平。

8. 发明申请

WO2006061829A1 PHOTOACOUSTIC INTRAVASCULAR PROBE 审中-公开
标题翻译：光电脑内腔镜检查
公开(公告)号：WO2006061829A1
公开(公告)日：2006-06-15
申请号：PCT/IL2005/001312
申请日：2005-12-06
申请人： GLUCON INC. , PESACH, Benny , NAGAR, Ron , BITTON, Gabriel
发明人： PESACH, Benny , NAGAR, Ron , BITTON, Gabriel
IPC分类号： A61B5/00
CPC分类号： A61B5/0095 , A61B5/0084 , A61B5/02007 , A61B5/0507 , A61B8/12
摘要： Apparatus for imaging a region of a lumen of a conduit comprising: an elongate body having a distal end that can be positioned in the lumen; at least one radiating element located in a neighborhood of the distal end from which radiation is transmitted to illuminate the lumen at at least one wavelength that stimulates thermoacoustic waves in features of the lumen and/or its walls; at least one acoustic transducer that generates signals responsive to the thermoacoustic waves; at least one acoustic transducer controllable to illuminate the lumen with ultrasound; at least one acoustic transducer that generates signals responsive to acoustic energy reflected from the transmitted ultrasound by features of the lumen; and a controller that processes the signals responsive to reflected acoustic energy to generate an ultrasound image of the lumen and the signals responsive to the thermoacoustic waves to assay a component of material in the lumen and/or the lumen walls.
摘要翻译：用于对导管内腔的区域成像的装置，包括：细长体，其具有能够定位在内腔中的远端; 位于所述远端附近的至少一个辐射元件，从所述至少一个辐射元件透射辐射以在所述内腔和/或其壁的特征中刺激热声波的至少一个波长照射所述内腔; 产生响应于所述热声波的信号的至少一个声换能器; 至少一个声学换能器可控制以用超声照射内腔; 至少一个声换能器，其通过所述腔的特征产生响应于从所述传输的超声反射的声能的信号; 以及控制器，其响应于反射的声能处理所述信号以产生所述内腔的超声图像，并且所述信号响应于所述热声波来测量所述内腔和/或所述腔壁中的材料的分量。

9. 发明申请

WO2006097933A2 METHOD AND APPARATUS FOR MONITORING GLUCOSE 审中-公开
标题翻译：用于监测葡萄糖的方法和装置
公开(公告)号：WO2006097933A2
公开(公告)日：2006-09-21
申请号：PCT/IL2006/000344
申请日：2006-03-16
申请人： GLUCON INC. , BITTON, Gabriel , PESACH, Benny , ANTEBI, Amit , NAGAR, Ron , GRINBERG, Leonid , HELLER, Adam
发明人： BITTON, Gabriel , PESACH, Benny , ANTEBI, Amit , NAGAR, Ron , GRINBERG, Leonid , HELLER, Adam
IPC分类号： A61B5/00 , G01N21/17
CPC分类号： A61B5/0095 , A61B5/14532
摘要： A method of monitoring changes in blood glucose level of a patient comprising: illuminating at least one region of the skin with light that stimulates photoacoustic waves in a marker substance in the blood; and using the photoacoustic waves to measure changes in blood glucose.
摘要翻译：一种监测患者血糖水平变化的方法，包括：用刺激血液中标记物质中的光声波的光照射皮肤的至少一个区域; 并使用光声波来测量血糖变化。

10. 发明申请

WO2009107135A3 DEVICE, SYSTEM AND METHOD FOR MODULAR ANALYTE MONITORING 审中-公开
公开(公告)号：WO2009107135A3
公开(公告)日：2009-09-03
申请号：PCT/IL2009/000221
申请日：2009-02-26
申请人： Mon4D Ltd. , PESACH, Benny , BITTON, Gabriel , NAGAR, Ron
发明人： PESACH, Benny , BITTON, Gabriel , NAGAR, Ron
IPC分类号： A61B5/00
摘要： The present invention relates to a device, system and a method for measuring an analyte and in particular, to such a device, system and method in which analyte from a bodily fluid is measured and/or monitored.

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