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1. 发明申请

WO2007005955A2 ANTI-IL-23 ANTIBODIES, COMPOSITIONS, METHODS AND USES 审中-公开
标题翻译：抗IL-23抗体，组合物，方法和用途
公开(公告)号：WO2007005955A2
公开(公告)日：2007-01-11
申请号：PCT/US2006026174
申请日：2006-06-30
申请人： CENTOCOR INC , BENSON JACQUELINE , CUNNINGHAM MARK , DUCHALA CYNTHIA , GILES-KOMAR JILL M , LUO JINQUAN , RYCYZYN MICHAEL A , SWEET RAYMOND
发明人： BENSON JACQUELINE , CUNNINGHAM MARK , DUCHALA CYNTHIA , GILES-KOMAR JILL M , LUO JINQUAN , RYCYZYN MICHAEL A , SWEET RAYMOND
IPC分类号： A61K39/395 , C07H21/04 , C07K16/24 , C12P21/06 , G01N33/567
CPC分类号： A61K39/3955 , A61K39/00 , A61K45/06 , A61K2039/505 , A61K2039/55527 , A61K2039/55544 , C07K16/244 , C07K2317/30 , C07K2317/33 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C07K2319/55 , G01N33/6869 , G01N2333/54
摘要： An anti-IL-23p19 antibody, including isolated nucleic acids that encode at least one anti-IL-23p19 antibody, vectors, host cells, transgenic animals or plants, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.
摘要翻译：抗IL-23p19抗体，包括编码至少一种抗IL-23p19抗体的分离的核酸，载体，宿主细胞，转基因动物或植物及其制备和使用的方法具有在诊断和/或治疗组合物中的应用，方法和设备。

2. 发明申请

WO2007076524A3 HUMAN ANTI-IL-23 ANTIBODIES, COMPOSITIONS, METHODS AND USES 审中-公开
标题翻译：人类抗IL-23抗体，组合物，方法和用途
公开(公告)号：WO2007076524A3
公开(公告)日：2008-03-27
申请号：PCT/US2006062674
申请日：2006-12-28
申请人： CENTOCOR INC , BENSON JACQUELINE , CARTON JILL , CUNNINGHAM MARK , ORLOVSKY YEVGENIYA I , RAUCHENBERGER ROBERT , SWEET RAYMOND
发明人： BENSON JACQUELINE , CARTON JILL , CUNNINGHAM MARK , ORLOVSKY YEVGENIYA I , RAUCHENBERGER ROBERT , SWEET RAYMOND
IPC分类号： A61K39/395 , G01N33/567
CPC分类号： C07K16/244 , A61K9/0019 , A61K9/08 , A61K39/3955 , A61K47/183 , A61K47/26 , A61K2039/505 , C07K2317/21 , C07K2317/34 , C07K2317/52 , C07K2317/55 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2319/00 , C07K2319/30
摘要： A human anti-IL-23pl9 antibody, including isolated nucleic acids that encode at least one anti-IL-23pl9 antibody, vectors, host cells, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.
摘要翻译：人抗IL-23pl9抗体，包括编码至少一种抗IL-23p19抗体的分离的核酸，载体，宿主细胞及其制备和使用的方法具有诊断和/或治疗组合物，方法和装置中的应用。

3. 发明申请

WO2006036745A2 IL-23P40 SPECIFIC IMMUNOGLOBULIN DERIVED PROTEINS, COMPOSITIONS, EPITOPES, METHODS AND USES 审中-公开
标题翻译： IL-23P40特异性免疫抑制蛋白衍生蛋白，组合物，外周血病毒，方法和用途
公开(公告)号：WO2006036745A2
公开(公告)日：2006-04-06
申请号：PCT/US2005034000
申请日：2005-09-23
申请人： CENTOCOR INC , BENSON JACQUELINE , CUNNINGHAM MARK , LUO JEFFREY
发明人： BENSON JACQUELINE , CUNNINGHAM MARK , LUO JEFFREY
IPC分类号： A61K39/395 , C07H21/04 , C07K16/24 , C12N5/06 , C12P21/06
CPC分类号： C07K16/244 , C07K2317/34 , G01N33/6869
摘要： An anti-IL-23 specific human Ig derived protein, isolated nucleic acids that encode at least one anti-IL-23 Ig derived protein, vectors, host cells, transgenic animals or plants, and methods of making and using thereof are useful as therapeutic and diagnostic compositions, methods and devices. The anti-IL-23 Ig derived protein preferably binds to one or more of the Seg 1, Seg 2, and Seg 3 epitopes of the p40 subunit of IL-23.
摘要翻译：编码至少一种抗IL-23Ig衍生蛋白，载体，宿主细胞，转基因动物或植物的抗IL-23特异性人Ig衍生蛋白，分离的核酸及其制备和使用方法可用作治疗和诊断组合物，方法和装置。抗IL-23Ig衍生的蛋白质优选与IL-23的p40亚基的Seg1，Seg2和Seg3表位的一个或多个表位结合。

4. 发明申请

WO2006060513A3 TOLL LIKE RECEPTOR 3 ANTAGONISTS, METHODS AND USES 审中-公开
标题翻译： TOLL LIKE RECEPTOR 3 ANTAGONISTS，METHODS AND USES
公开(公告)号：WO2006060513A3
公开(公告)日：2009-05-14
申请号：PCT/US2005043373
申请日：2005-11-30
申请人： CENTOCOR INC , CARTON JILL , CUNNINGHAM MARK , DAS ANUK , DUFFY KAREN , KNIGHT DAVID M , LAMB ROBERTA , MBOW MOUHAMADOU L , RAGHUNATHAN GOPALAN , SAN MATEO LANI , SARISKY ROBERT T , STOWELL NICOLE , SWEET RAYMOND , ZHAO SHANRONG , CHEN SHIZHONG , GILES-KOMAR JILL , PICHA KRISTEN , STOJANOVIC-SUSULIC VEDRANA , GOLETZ THERESA J
发明人： CARTON JILL , CUNNINGHAM MARK , DAS ANUK , DUFFY KAREN , KNIGHT DAVID M , LAMB ROBERTA , MBOW MOUHAMADOU L , RAGHUNATHAN GOPALAN , SAN MATEO LANI , SARISKY ROBERT T , STOWELL NICOLE , SWEET RAYMOND , ZHAO SHANRONG , CHEN SHIZHONG , GILES-KOMAR JILL , PICHA KRISTEN , STOJANOVIC-SUSULIC VEDRANA , GOLETZ THERESA J
IPC分类号： A61K39/42 , A61K38/16 , A61K39/395 , C07K14/52 , C07K14/705
CPC分类号： C07K16/2896 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92
摘要： Toll Like Receptor 3 (TLR3) antagonists, polynucleotides encoding TLR3 antagonists or fragments thereof, and methods of making and using the foregoing are disclosed.
摘要翻译： Toll样受体3（TLR3）拮抗剂，编码TLR3拮抗剂或其片段的多核苷酸，以及制备和使用前述物质的方法。

5. 发明申请

WO2004101750A3 IL-23p40 SPECIFIC IMMUNOGLOBULIN DERIVED PROTEINS, COMPOSITIONS, METHODS AND USES 审中-公开
标题翻译： IL-23p40特异性免疫抑制蛋白衍生蛋白，组合物，方法和用途
公开(公告)号：WO2004101750A3
公开(公告)日：2006-12-21
申请号：PCT/US2004014372
申请日：2004-05-06
申请人： CENTOCOR INC , BENSON JACQUELINE , CUNNINGHAM MARK
发明人： BENSON JACQUELINE , CUNNINGHAM MARK
IPC分类号： C12P21/08 , C07H21/04 , C07K16/24 , C12N20060101 , C12N5/06 , C12N5/16 , C12P21/06
CPC分类号： C07K16/244 , A61K2039/505 , C07K2317/74 , C07K2317/76
摘要： Novel anti-IL-23p40 specific human Ig derived proteins, including, without limitation, antibodies, fusion proteins, and mimetibodies, isolated nucleic acids that encode the anti-IL-23p40 Ig derived proteins, vectors, host cells, transgenic animals or plants, and methods of making and using thereof, are useful for therapeutic compositions, methods and devices. Preferably, the anti-IL-23p40 specific human Ig derived proteins do not bind the p40 subunit of IL-12 and, thus, do not neutralize IL-12-related activity.
摘要翻译：新型抗IL-23p40特异性人Ig衍生蛋白，包括但不限于抗体，融合蛋白和模拟抗体，编码抗IL-23p40Ig衍生蛋白质的分离的核酸，载体，宿主细胞，转基因动物或植物，及其制备和使用方法可用于治疗组合物，方法和装置。优选地，抗IL-23p40特异性人Ig衍生的蛋白质不结合IL-12的p40亚基，因此不中和IL-12相关活性。

6. 发明申请

WO2005065239A3 NOVEL RECOMBINANT PROTEINS WITH N-TERMINAL FREE THIOL 审中-公开
标题翻译：具有N-末端游离硫醇的新型重组蛋白
公开(公告)号：WO2005065239A3
公开(公告)日：2005-11-24
申请号：PCT/US2004043081
申请日：2004-12-23
申请人： CENTOCOR INC , POOL CHADLER , MILLS JULIANE , CUNNINGHAM MARK
发明人： POOL CHADLER , MILLS JULIANE , CUNNINGHAM MARK
IPC分类号： C07H21/04 , C07K1/00 , C07K1/107 , C07K14/505 , C12N9/96 , C12N15/85 , C12P21/02
CPC分类号： C07K1/1075 , C07K1/1077 , C07K14/505
摘要： The present invention relates to novel modified proteins having N-terminal free thiols that can be produced by recombinant methods and are ready for further chemical derivatization. In particular, the invention relates to erythropoietin conjugate compounds having altered biochemical, physiochemical and pharmacokinetic properties. More particularly, one embodiment of the invention relates to erythropoietin conjugate compounds of the formula: (M)n-X-A-cys-EPO (I) where EPO is an erythropoeitin moiety selected from erythropoietin or an erythropoietin variant having at least one amino acid different from the wild-type human EPO, or any pharmaceutical acceptable derivatives thereof having biological properties of causing bone marrow cells to increase production of red blood cells; cys represents the amino acid cysteine and occurs at position -1 relative to the amino acid sequence of the erythropoietin moiety; A indicates the structure of the residual moiety used to chemically attach X to the thiol group of -1Cys; X is a water soluble polymer such as a polyalkylene glycol or other polymer; M is an organic molecule (including peptides and proteins) that increases the circulating half-life of the construct; and N is an integer from 0 to 15.
摘要翻译：本发明涉及具有N-末端游离硫醇的新型修饰蛋白，其可以通过重组方法产生并准备用于进一步的化学衍生。特别地，本发明涉及具有改变的生物化学，生理化学和药代动力学性质的促红细胞生成素缀合物化合物。更具体地说，本发明的一个实施方案涉及下式的促红细胞生成素缀合物化合物：（M）nXA-cys-EPO（I）其中EPO是选自红细胞生成素或促红细胞生成素变体的促红细胞生成素部分，所述促红细胞生成素变体具有至少一个不同于野生型人EPO或具有引起骨髓细胞增加红细胞产生的生物学特性的任何药学上可接受的衍生物; cys代表氨基酸半胱氨酸，并且发生在相对于促红细胞生成素部分的氨基酸序列的-1位; A表示用于化学连接X至-1Cys的巯基的残余部分的结构; X是水溶性聚合物，例如聚亚烷基二醇或其他聚合物; M是增加构建体循环半衰期的有机分子（包括肽和蛋白质）; 并且N是0至15的整数。

7. 发明申请

WO2005065239A8 NOVEL RECOMBINANT PROTEINS WITH N-TERMINAL FREE THIOL 审中-公开
标题翻译：新型重组蛋白与N-末端免费THIOL
公开(公告)号：WO2005065239A8
公开(公告)日：2006-08-17
申请号：PCT/US2004043081
申请日：2004-12-23
申请人： CENTOCOR INC , POOL CHADLER , MILLS JULIANE , CUNNINGHAM MARK
发明人： POOL CHADLER , MILLS JULIANE , CUNNINGHAM MARK
IPC分类号： C12N9/96 , C07H21/04 , C07K1/00 , C07K1/107 , C07K14/505 , C12N15/85 , C12P21/02
CPC分类号： C07K1/1075 , C07K1/1077 , C07K14/505
摘要： The present invention relates to novel modified proteins having N-terminal free thiols that can be produced by recombinant methods and are ready for further chemical derivatization. In particular, the invention relates to erythropoietin conjugate compounds having altered biochemical, physiochemical and pharmacokinetic properties. More particularly, one embodiment of the invention relates to erythropoietin conjugate compounds of the formula: (M)n-X-A-cys-EPO (I) where EPO is an erythropoeitin moiety selected from erythropoietin or an erythropoietin variant having at least one amino acid different from the wild-type human EPO, or any pharmaceutical acceptable derivatives thereof having biological properties of causing bone marrow cells to increase production of red blood cells; cys represents the amino acid cysteine and occurs at position -1 relative to the amino acid sequence of the erythropoietin moiety; A indicates the structure of the residual moiety used to chemically attach X to the thiol group of -1Cys; X is a water soluble polymer such as a polyalkylene glycol or other polymer; M is an organic molecule (including peptides and proteins) that increases the circulating half-life of the construct; and N is an integer from 0 to 15.
摘要翻译：本发明涉及具有N-末端游离硫醇的新型修饰蛋白，其可通过重组方法制备并准备进一步化学衍生化。特别地，本发明涉及具有改变的生物化学，生理化学和药代动力学性质的红细胞生成素缀合物化合物。更具体地，本发明的一个实施方案涉及下式的促红细胞生成素缀合物化合物：（M）nXA-cys-EPO（I）其中EPO是选自促红细胞生成素或促红细胞生成素变体的红细胞生成素，其具有至少一个不同于野生型人EPO或其具有引起骨髓细胞增加红细胞产生的生物学特性的任何药物可接受的衍生物; cys代表氨基酸半胱氨酸并且发生在相对于促红细胞生成素部分的氨基酸序列的位置-1; A表示用于将X化学连接到-1Cys的硫醇基上的残留部分的结构; X是水溶性聚合物，例如聚亚烷基二醇或其它聚合物; M是增加构建体的循环半衰期的有机分子（包括肽和蛋白质） N为0〜15的整数。

8. 发明申请

WO2007051201A3 TLR3 GLYCOSYLATION SITE MUTEINS AND METHODS OF USE 审中-公开
标题翻译： TLR3糖蛋白基因座及其使用方法
公开(公告)号：WO2007051201A3
公开(公告)日：2008-02-14
申请号：PCT/US2006060357
申请日：2006-10-30
申请人： CENTOCOR INC , DUFFY KAREN E , CUNNINGHAM MARK , MBOW M LAMINE , SARISKY ROBERT T
发明人： DUFFY KAREN E , CUNNINGHAM MARK , MBOW M LAMINE , SARISKY ROBERT T
IPC分类号： C07K14/00
CPC分类号： C07K14/705 , A61K38/00 , A61K48/00
摘要： TLR3 glycosylation site muteins, nucleic acids encoding the muteins, and methods of modulating TLR3 activity in a cell are disclosed.
摘要翻译：公开了TLR3糖基化位点突变蛋白，编码突变蛋白的核酸和调节细胞中TLR3活性的方法。

9. 发明申请

WO2006047535A2 MELANOCORTIN RECEPTOR BINDING MIMETIBODIES, COMPOSITIONS, METHODS AND USES 审中-公开
标题翻译： MELANOCORTIN受体结合物质，组合物，方法和用途
公开(公告)号：WO2006047535A2
公开(公告)日：2006-05-04
申请号：PCT/US2005038431
申请日：2005-10-25
申请人： CENTOCOR INC , CUNNINGHAM MARK , STOJANOVIC-SUSULIC VEDRANA , O'NEIL KARYN , HUANG CHICHI , LUO JEFFREY
发明人： CUNNINGHAM MARK , STOJANOVIC-SUSULIC VEDRANA , O'NEIL KARYN , HUANG CHICHI , LUO JEFFREY
IPC分类号： A61K38/22 , A61K38/27 , C07H21/04 , C07K14/575
CPC分类号： C07K14/68 , A61K38/1796 , C07K14/47 , C07K2319/30
摘要： Melanocortin receptor binding mimetibody polypeptides are disclosed. Polynucleotides encoding these polypeptides, cells comprising these polynucleotides or expressing the mimetibodies, and methods of making and using the forgoing are also disclosed.
摘要翻译：公开了黑皮质素受体结合模拟体多肽。还公开了编码这些多肽的多核苷酸，包含这些多核苷酸的细胞或表达模拟物，以及制备和使用前述方法。

10. 发明申请

WO2007092594A2 APPROACH FOR FABRICATING CANTILEVER PROBES FOR PROBE CARD ASSEMBLIES 审中-公开
标题翻译：用于制作探针卡组件的CANTILEVER探针的方法
公开(公告)号：WO2007092594A2
公开(公告)日：2007-08-16
申请号：PCT/US2007003476
申请日：2007-02-08
申请人： SV PROBE PTE LTD , TUNABOYLU BAHADIR , CLAUBERG HORST , CUNNINGHAM MARK , THEPPAKUTTAI SENTHIL , MCGLORY JOHN
发明人： TUNABOYLU BAHADIR , CLAUBERG HORST , CUNNINGHAM MARK , THEPPAKUTTAI SENTHIL , MCGLORY JOHN
CPC分类号： G01R3/00 , B33Y80/00 , G01R1/06727 , G01R1/07342 , Y10T29/49147 , Y10T29/49151 , Y10T29/49155 , Y10T29/49156 , Y10T29/49204 , Y10T29/49218
摘要： An approach for fabricating cantilever probes for a probe card assembly includes forming posts on conductive traces on a substrate. A beam panel having beam elements formed therein is aligned to the substrate so that the beam elements are in contact with the plurality of posts. Each beam element is in contact with a post at a portion of the beam element so that both a first end portion and a second end portion overhang the post element. Each beam element is also attached to the beam panel by the first end portion. The beam elements are bonded to the plurality of posts. The first end portion of each beam element is cut, for example using an electrode, laser ablation or by dicing, to release the beam element from the beam panel. The beam panel is then removed, leaving the beam elements attached to the posts.
摘要翻译：用于制造用于探针卡组件的悬臂探针的方法包括在基底上的导电迹线上形成柱。其中形成有梁元件的梁板与衬底对准，使得梁元件与多个柱接触。每个梁元件在梁元件的一部分处与柱接触，使得第一端部和第二端部部分都悬置在柱元件上。每个梁元件也通过第一端部附接到梁板。梁元件结合到多个柱。每个光束元件的第一端部例如使用电极，激光烧蚀或通过切割来切割，以将光束元件从光束面板释放。然后将梁板移除，使梁元件附接到柱上。

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