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1. 发明申请

WO2017171655A1 VISION ASSESSMENT BASED ON GAZE 审中-公开
标题翻译：基于GAZE的视觉评估
公开(公告)号：WO2017171655A1
公开(公告)日：2017-10-05
申请号：PCT/SG2017/050184
申请日：2017-03-31
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH , TAN TOCK SENG HOSPITAL PTE LTD
发明人： LIU, Huiying , LAUDE, Augustinus , LIM, Tock Han , XU, Yanwu , WONG, Wing Kee Damon , LIU, Jiang
IPC分类号： A61B3/028 , G06F19/00
摘要： The present disclosure generally relates to automated method and system for vision assessment of a subject. The method comprises: determining a set of test patterns for the subject based on a preliminary assessment of an eye of the subject; displaying the set of test patterns sequentially to the subject; collecting data on the subject's gaze in response to each test pattern displayed to the subject; and assessing vision functionality of the subject based on the collected gaze data.
摘要翻译：本公开总体上涉及用于对象的视力评估的自动化方法和系统。该方法包括：基于对象的眼睛的初步评估确定对象的一组测试模式; 将该组测试图案顺序地显示给对象; 响应于显示给对象的每个测试模式收集关于对象凝视的数据; 并根据收集的注视数据评估受试者的视力功能。

2. 发明申请

WO2016108755A1 METHOD AND APPARATUS FOR ALIGNING A TWO-DIMENSIONAL IMAGE WITH A PREDEFINED AXIS 审中-公开
标题翻译：用于对准具有预定轴的二维图像的方法和装置
公开(公告)号：WO2016108755A1
公开(公告)日：2016-07-07
申请号：PCT/SG2015/050505
申请日：2015-12-23
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH , SINGAPORE HEALTH SERVICES PTE LTD
发明人： XU, Yanwu , LIU, Jiang , DUAN, Lixin , WONG, Wing Kee, Damon , AUNG, Tin , MANI, Baskaran , PERERA, Shamira
IPC分类号： G06T3/00 , G06T3/60 , A61B5/00
CPC分类号： G06T7/0012 , A61B3/102 , A61B5/004 , A61B5/0066 , A61B2576/02 , G06T3/0068 , G06T2207/10101 , G06T2207/20182 , G06T2207/20224 , G06T2207/30041
摘要： A method and apparatus for aligning a two-dimensional eye image with a predefined axis by rotation at a rotation angle are disclosed, the method comprising deriving the rotation angle and a de-noised image, which minimises a cost function comprising (i) a complexity measure of the de-noised image and (ii) magnitude of a noise image obtained by rotating the first image by the rotation angle and subtracting the de-noised image. Related methods and apparatus are disclosed for aligning a plurality of images with the predefined axis before alignments in transverse and parallel directions, as well as averaging the aligned images, in further embodiments, a method and apparatus of determining angle closure are disclosed, using a database of reference eye images with and without eye closure, the method comprising obtaining a two dimensional eye image, determining respective weights for each reference images that minimise a cost function comprising the difference between the received image and sum of the weighted reference images; identifying at Ieast one of the first and second reference images having least differences with received image and determining whether the eye exhibits eye closure based on the received image being closer to first or second weighted reference images.
摘要翻译：公开了一种用于通过以旋转角度旋转将二维眼图与预定轴对准的方法和装置，所述方法包括导出旋转角度和去噪图像，其最小化成本函数，其包括（i）复杂度去噪图像的测量和（ii）通过旋转第一图像旋转角度并减去去噪图像获得的噪声图像的大小。公开了相关的方法和装置，用于在横向和平行方向上的对齐之前将多个图像与预定义的轴对准，以及平均对齐的图像。在另外的实施例中，使用数据库公开了确定角度关闭的方法和装置具有和不具有眼睛闭合的参考眼睛图像，所述方法包括获得二维眼睛图像，确定使包含所述接收图像与所述加权参考图像的和之间的差异的成本函数最小化的每个参考图像的相应权重; 在Ieast识别具有与接收图像具有最小差异的第一和第二参考图像之一，并且基于接收到的图像更接近第一或第二加权参考图像来确定眼睛是否显示眼睛闭合。

3. 发明申请

WO2014116181A3 COST-SENSITIVE LINEAR RECONSTRUCTION BASED OPTIC CUP LOCALIZATION 审中-公开
公开(公告)号：WO2014116181A3
公开(公告)日：2014-07-31
申请号：PCT/SG2014/000026
申请日：2014-01-22
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
发明人： XU, Yanwu , LIU, Jiang , CHENG, Jun , YIN, Fengshou , WONG, Wing Kee, Damon
IPC分类号： A61B3/12 , A61B5/107 , G06K9/54 , G06T17/10 , G06F19/24 , G06T7/60
摘要： A method is presented to obtain, from a retinal image, data characterizing the optic cup, such as data indicating the location and/or size of the optic cup in relation to the optic disc. A disc region of the retinal image of an eye, is expressed as a weighted sum of a plurality of pre-existing "reference" retinal images in a library, with the weights being chosen to minimize a cost function. The data characterizing the cup of the eye is obtained from cup data associated with the pre-existing disc images and the corresponding weights. The cost function includes (i) a construction error term indicating a difference between the disc region of the retinal image and a weighted sum of the reference retinal images, and (ii) a cost term, which may be generated using a weighted sum over the reference retinal images of a difference between the reference retinal images and the disc region of the retinal image.

4. 发明申请

WO2014031086A1 METHODS AND SYSTEMS FOR AUTOMATIC LOCATION OF OPTIC STRUCTURES IN AN IMAGE OF AN EYE, AND FOR AUTOMATIC RETINA CUP-TO-DISC RATIO COMPUTATION 审中-公开
标题翻译：用于自动定位眼睛图像中的光学结构的方法和系统，以及用于自动反坦克对比度计算的方法和系统
公开(公告)号：WO2014031086A1
公开(公告)日：2014-02-27
申请号：PCT/SG2013/000370
申请日：2013-08-26
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH , SINGAPORE HEALTH SERVICES PTE LTD
发明人： CHENG, Jun , LIU, Jiang , XU, Yanwu , YIN, Fengshou , TAN, Ngan Meng , WONG, Wing Kee, Damon , LEE, Beng Hai , CHENG, Xiangang , GAO, Xinting , ZHANG, Zhuo , WONG, Tien Yin , CHENG, Ching-Yu , CHEUNG, Yim-lui, Carol , MANI, Baskaran , AUNG, Tin
IPC分类号： G06T7/00 , A61B3/00 , A61B8/10
CPC分类号： G06T7/0012 , G06K9/0061 , G06K9/00617 , G06K9/4633 , G06K9/6269 , G06K2009/4657 , G06T7/11 , G06T7/187 , G06T7/62 , G06T11/203 , G06T2200/28 , G06T2207/10024 , G06T2207/20016 , G06T2207/30041 , G06T2207/30196 , G06T2210/41
摘要： A method is proposed for automatically locating the optic disc or the optic cup in an image of the rear of an eye. A portion of the image containing the optic disc or optic cup is divided into sub-regions using a clustering algorithm. Biologically inspired features, and optionally other features, are obtained for each of the sub- regions. An adaptive model uses the features to generate data indicative of whether each sub-region is within or outside the optic disc or optic cup. The result is then smoothed, to form an estimate of the position of the optic disc or optic cup.
摘要翻译：提出了一种用于将视盘或视杯自动定位在眼后方的图像中的方法。使用聚类算法将包含视盘或视杯的图像的一部分划分成子区域。获得了每个子区域的生物启发特征，以及可选的其他特征。自适应模型使用特征来产生指示每个子区域是否在视盘或视觉杯内或外的数据。然后使结果平滑，以形成对视盘或视觉杯的位置的估计。

5. 发明申请

WO2015195048A1 REDUCING SPECKLE NOISE IN OPTICAL COHERENCE TOMOGRAPHY IMAGES 审中-公开
标题翻译：减少光学相干图像中的斑点噪声
公开(公告)号：WO2015195048A1
公开(公告)日：2015-12-23
申请号：PCT/SG2015/050162
申请日：2015-06-16
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH , KABUSHIKI KAISHA TOPCON
发明人： CHENG, Jun , LIU, Jiang , DUAN, Lixin , XU, Yanwu , WONG, Wing Kee, Damon , AKIBA, Masahiro
IPC分类号： A61B3/10 , G06T5/00
CPC分类号： G01B9/02082 , A61B3/102 , G01B9/02091 , G06T5/002 , G06T5/20 , G06T5/50 , G06T7/0014 , G06T7/32 , G06T7/337 , G06T2207/10016 , G06T2207/10101 , G06T2207/20021 , G06T2207/20024 , G06T2207/20221 , G06T2207/30041
摘要： A method and system are proposed to obtain a reduced speckle noise image of a subject from optical coherence tomography (OCT) image data of the subject. The cross sectional images each comprise a plurality of scan lines obtained by measuring the time delay of light reflected, in a depth direction, from optical interfaces within the subject. The method comprises two aligning steps. First the cross sectional images are aligned, then image patches of the aligned cross sectional images are aligned to form a set of aligned patches. An image matrix is then formed from the aligned patches; and matrix completion is applied to the image matrix to obtain a reduced speckle noise image of the subject.
摘要翻译：提出了一种方法和系统，以从受试者的光学相干断层摄影（OCT）图像数据中获得受试者的减少的斑点噪声图像。横截面图像各自包括通过测量在对象内的光学界面沿着深度方向反射的光的时间延迟而获得的多条扫描线。该方法包括两个对准步骤。首先对横截面图像进行对准，然后排列对准的横截面图像的图像块以形成一组对齐的贴片。然后从对准的贴片形成图像矩阵; 并且矩阵完成被应用于图像矩阵以获得被摄体的减少的散斑噪声图像。

6. 发明申请

WO2014021782A1 METHODS AND SYSTEMS FOR CHARACTERIZING ANGLE CLOSURE GLAUCOMA FOR RISK ASSESSMENT OR SCREENING 审中-公开
标题翻译：用于表征风险评估或筛选的角膜闭合玻璃体的方法和系统
公开(公告)号：WO2014021782A1
公开(公告)日：2014-02-06
申请号：PCT/SG2013/000323
申请日：2013-08-01
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH , SINGAPORE HEALTH SERVICES PTE LTD
发明人： XU, Yanwu , LIU, Jiang , WONG, Wing Kee, Damon , LEE, Beng Hai , AUNG, Ting , MANI, Baskaran , PERERA, Shamira
IPC分类号： G06T7/00 , A61B3/00 , A61B8/10
CPC分类号： G06T7/0012 , A61B3/102 , A61B3/117 , G06K9/46 , G06K2009/4666 , G06T7/73 , G06T2207/10072 , G06T2207/10101 , G06T2207/30041
摘要： A method is proposed for analysing an optical coherence tomography (OCT) image of the anterior segment (AS) of a subject's eye. A region of interest is defined which is a region of the image containing the junction of the cornea and iris, and an estimated position the junction within the region of interest is derived. Using this a second region of the image is obtained, which is a part of the image containing the estimated position of the junction. Features of the second region are obtained, and those features are input to an adaptive model to generate data characterizing the junction.
摘要翻译：提出了一种用于分析受试者眼睛前段（AS）的光学相干断层扫描（OCT）图像的方法。定义感兴趣区域，其是包含角膜和虹膜的交界处的图像的区域，以及估计的位置，导出感兴趣区域内的结。使用该图像获得图像的第二区域，其是包含结点的估计位置的图像的一部分。获得第二区域的特征，并且将这些特征输入到自适应模型以生成表征结点的数据。

7. 发明申请

WO2013180660A1 ROBUST GRAPH REPRESENTATION AND MATCHING OF RETINA IMAGES 审中-公开
标题翻译：可靠的图表代表和匹配的视觉图像
公开(公告)号：WO2013180660A1
公开(公告)日：2013-12-05
申请号：PCT/SG2013/000229
申请日：2013-06-03
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
发明人： XU, Yanwu , LIU, Jiang , WONG, Wing Kee, Damon , TAN, Ngan Meng
IPC分类号： G06K9/62 , G06T7/00 , G06F21/32 , A61B3/00
CPC分类号： G06K9/6215 , G06F21/32 , G06K9/00597 , G06K9/00604 , G06K9/0061 , G06K9/00617 , G06K9/4604 , G06K9/4642 , G06K9/469 , G06K9/6892
摘要： A numerical parameter indicative of the degree of match between two retina images is produced by comparing two graphs obtained from the respective images. Each graph is composed of edges and vertices. Each vertex is associated with a location the corresponding retina image, and with descriptor data describing a part of the corresponding retina image proximate the corresponding location.
摘要翻译：通过比较从各图像获得的两个图来产生表示两个视网膜图像之间的匹配程度的数值参数。每个图形由边和顶点组成。每个顶点与对应的视网膜图像的位置相关联，并且描述符数据描述在对应位置附近的相应视网膜图像的一部分。

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