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1. 发明申请

WO2010071597A1 A METHOD AND SYSTEM FOR DETERMINING THE POSITION OF AN OPTIC CUP BOUNDARY 审中-公开
标题翻译：一种用于确定光触点边界位置的方法和系统
公开(公告)号：WO2010071597A1
公开(公告)日：2010-06-24
申请号：PCT/SG2008/000482
申请日：2008-12-15
申请人： SINGAPORE HEALTH SERVICES PTE LTD , AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH , NATIONAL UNIVERSITY OF SINGAPORE , WONG, Wing Kee, Damon , LIU, Jiang , LIM, Joo Hwee , LI, Huiqi , TAN, Ngan Meng , WONG, Tien Yin
发明人： WONG, Wing Kee, Damon , LIU, Jiang , LIM, Joo Hwee , LI, Huiqi , TAN, Ngan Meng , WONG, Tien Yin
IPC分类号： A61B3/12
CPC分类号： A61B3/12 , G06T7/12 , G06T2207/20161 , G06T2207/30041
摘要： A method for determining the position of an optic cup boundary in a 2D retinal image. The method includes detecting kinks in blood vessels at an estimated boundary of the optic cup and the optic disc, and determining the position of the optic cup boundary in the 2D retinal image based on the detected kinks. The determined optic cup boundary may be used for determining a CDR which may in turn be used for determining a risk of contracting glaucomatous.
摘要翻译：一种用于确定2D视网膜图像中视杯边界的位置的方法。该方法包括在光学杯和视盘的估计边界处检测血管中的扭结，以及基于检测到的扭结来确定视网膜边界在2D视网膜图像中的位置。确定的视杯边界可以用于确定CDR，其可以依次用于确定青光眼感染的风险。

2. 发明申请

WO2009139722A8 AUTOMATIC CUP-TO-DISC RATIO MEASUREMENT SYSTEM 审中-公开
公开(公告)号：WO2009139722A8
公开(公告)日：2009-11-19
申请号：PCT/SG2008/000186
申请日：2008-05-14
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH , SINGAPORE HEALTH SERVICES PTE LTD. , NATIONAL UNIVERSITY OF SINGAPORE , LIU, Jiang , LIM, Joo Hwee , WONG, Wing Kee, Damon , LI, Huiqi , WONG, Tien Yin
发明人： LIU, Jiang , LIM, Joo Hwee , WONG, Wing Kee, Damon , LI, Huiqi , WONG, Tien Yin
IPC分类号： A61B3/12
摘要： A two-dimensional retinal fundus image of the retinal fundus of an eye is processed by optic disc segmentation (2) followed by cup segmentation 4. Data derived from the optic disc segmentation (i.e. the output of the disc segmentation (2) and/or data derived from the output of the optic disc segmentation step, e.g. by a smoothing operation 3) and data derived from the output of the optic cup segmentation ( i.e. the output of the cup segmentation (4) and/or data derived from the output of the optic disc segmentation, e.g. by a smoothing operation 5) are fed (6) to an adaptive model which has been trained to generate from such inputs a value indicative of cup-to-disc ratio (CDR) of the eye. The CDR is indicative of glaucoma. Thus, the method can be used to screen patients for glaucoma.

3. 发明申请

WO2014031086A1 METHODS AND SYSTEMS FOR AUTOMATIC LOCATION OF OPTIC STRUCTURES IN AN IMAGE OF AN EYE, AND FOR AUTOMATIC RETINA CUP-TO-DISC RATIO COMPUTATION 审中-公开
标题翻译：用于自动定位眼睛图像中的光学结构的方法和系统，以及用于自动反坦克对比度计算的方法和系统
公开(公告)号：WO2014031086A1
公开(公告)日：2014-02-27
申请号：PCT/SG2013/000370
申请日：2013-08-26
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH , SINGAPORE HEALTH SERVICES PTE LTD
发明人： CHENG, Jun , LIU, Jiang , XU, Yanwu , YIN, Fengshou , TAN, Ngan Meng , WONG, Wing Kee, Damon , LEE, Beng Hai , CHENG, Xiangang , GAO, Xinting , ZHANG, Zhuo , WONG, Tien Yin , CHENG, Ching-Yu , CHEUNG, Yim-lui, Carol , MANI, Baskaran , AUNG, Tin
IPC分类号： G06T7/00 , A61B3/00 , A61B8/10
CPC分类号： G06T7/0012 , G06K9/0061 , G06K9/00617 , G06K9/4633 , G06K9/6269 , G06K2009/4657 , G06T7/11 , G06T7/187 , G06T7/62 , G06T11/203 , G06T2200/28 , G06T2207/10024 , G06T2207/20016 , G06T2207/30041 , G06T2207/30196 , G06T2210/41
摘要： A method is proposed for automatically locating the optic disc or the optic cup in an image of the rear of an eye. A portion of the image containing the optic disc or optic cup is divided into sub-regions using a clustering algorithm. Biologically inspired features, and optionally other features, are obtained for each of the sub- regions. An adaptive model uses the features to generate data indicative of whether each sub-region is within or outside the optic disc or optic cup. The result is then smoothed, to form an estimate of the position of the optic disc or optic cup.
摘要翻译：提出了一种用于将视盘或视杯自动定位在眼后方的图像中的方法。使用聚类算法将包含视盘或视杯的图像的一部分划分成子区域。获得了每个子区域的生物启发特征，以及可选的其他特征。自适应模型使用特征来产生指示每个子区域是否在视盘或视觉杯内或外的数据。然后使结果平滑，以形成对视盘或视觉杯的位置的估计。

4. 发明申请

WO2016108755A1 METHOD AND APPARATUS FOR ALIGNING A TWO-DIMENSIONAL IMAGE WITH A PREDEFINED AXIS 审中-公开
标题翻译：用于对准具有预定轴的二维图像的方法和装置
公开(公告)号：WO2016108755A1
公开(公告)日：2016-07-07
申请号：PCT/SG2015/050505
申请日：2015-12-23
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH , SINGAPORE HEALTH SERVICES PTE LTD
发明人： XU, Yanwu , LIU, Jiang , DUAN, Lixin , WONG, Wing Kee, Damon , AUNG, Tin , MANI, Baskaran , PERERA, Shamira
IPC分类号： G06T3/00 , G06T3/60 , A61B5/00
CPC分类号： G06T7/0012 , A61B3/102 , A61B5/004 , A61B5/0066 , A61B2576/02 , G06T3/0068 , G06T2207/10101 , G06T2207/20182 , G06T2207/20224 , G06T2207/30041
摘要： A method and apparatus for aligning a two-dimensional eye image with a predefined axis by rotation at a rotation angle are disclosed, the method comprising deriving the rotation angle and a de-noised image, which minimises a cost function comprising (i) a complexity measure of the de-noised image and (ii) magnitude of a noise image obtained by rotating the first image by the rotation angle and subtracting the de-noised image. Related methods and apparatus are disclosed for aligning a plurality of images with the predefined axis before alignments in transverse and parallel directions, as well as averaging the aligned images, in further embodiments, a method and apparatus of determining angle closure are disclosed, using a database of reference eye images with and without eye closure, the method comprising obtaining a two dimensional eye image, determining respective weights for each reference images that minimise a cost function comprising the difference between the received image and sum of the weighted reference images; identifying at Ieast one of the first and second reference images having least differences with received image and determining whether the eye exhibits eye closure based on the received image being closer to first or second weighted reference images.
摘要翻译：公开了一种用于通过以旋转角度旋转将二维眼图与预定轴对准的方法和装置，所述方法包括导出旋转角度和去噪图像，其最小化成本函数，其包括（i）复杂度去噪图像的测量和（ii）通过旋转第一图像旋转角度并减去去噪图像获得的噪声图像的大小。公开了相关的方法和装置，用于在横向和平行方向上的对齐之前将多个图像与预定义的轴对准，以及平均对齐的图像。在另外的实施例中，使用数据库公开了确定角度关闭的方法和装置具有和不具有眼睛闭合的参考眼睛图像，所述方法包括获得二维眼睛图像，确定使包含所述接收图像与所述加权参考图像的和之间的差异的成本函数最小化的每个参考图像的相应权重; 在Ieast识别具有与接收图像具有最小差异的第一和第二参考图像之一，并且基于接收到的图像更接近第一或第二加权参考图像来确定眼睛是否显示眼睛闭合。

5. 发明申请

WO2011025451A1 A METHOD AND SYSTEM OF DETERMINING A GRADE OF NUCLEAR CATARACT 审中-公开
标题翻译：一种确定核能级别等级的方法和系统
公开(公告)号：WO2011025451A1
公开(公告)日：2011-03-03
申请号：PCT/SG2009/000297
申请日：2009-08-24
申请人： SINGAPORE HEALTH SERVICES PTE LTD , AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH , NATIONAL UNIVERSITY OF SINGAPORE , LI, Huiqi , LIM, Joo, Hwee , LIU, Jiang, Jimmy , WONG, Wing Kee, Damon , TAN, Ngan, Meng , ZHANG, Zhuo , LU, Shijian , WONG, Tien, Yin
发明人： LI, Huiqi , LIM, Joo, Hwee , LIU, Jiang, Jimmy , WONG, Wing Kee, Damon , TAN, Ngan, Meng , ZHANG, Zhuo , LU, Shijian , WONG, Tien, Yin
IPC分类号： A61B5/00 , A61B3/14 , G06T7/60
CPC分类号： A61B3/1173 , A61B3/1176 , G06T7/0014 , G06T7/12 , G06T2207/20081 , G06T2207/30041
摘要： A method for determining a grade of nuclear cataract in a test image. The method includes: (1a) defining a contour of a lens structure in the test image, the defined contour of the lens structure comprising a segment around a boundary of a nucleus of the lens structure; (1b) extracting features from the test image based on the defined contour of the lens structure in the test image; and (1c) determining the grade of nuclear cataract in the test image based on the extracted features and a grading model.
摘要翻译：用于确定测试图像中核白内障等级的方法。该方法包括：（1a）在测试图像中定义透镜结构的轮廓，所述透镜结构的限定轮廓包括围绕透镜结构的核的边界的段; （1b）基于测试图像中的透镜结构的限定轮廓从测试图像中提取特征; 和（1c）基于提取的特征和分级模型确定测试图像中的核白内障的等级。

6. 发明申请

WO2014021782A1 METHODS AND SYSTEMS FOR CHARACTERIZING ANGLE CLOSURE GLAUCOMA FOR RISK ASSESSMENT OR SCREENING 审中-公开
标题翻译：用于表征风险评估或筛选的角膜闭合玻璃体的方法和系统
公开(公告)号：WO2014021782A1
公开(公告)日：2014-02-06
申请号：PCT/SG2013/000323
申请日：2013-08-01
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH , SINGAPORE HEALTH SERVICES PTE LTD
发明人： XU, Yanwu , LIU, Jiang , WONG, Wing Kee, Damon , LEE, Beng Hai , AUNG, Ting , MANI, Baskaran , PERERA, Shamira
IPC分类号： G06T7/00 , A61B3/00 , A61B8/10
CPC分类号： G06T7/0012 , A61B3/102 , A61B3/117 , G06K9/46 , G06K2009/4666 , G06T7/73 , G06T2207/10072 , G06T2207/10101 , G06T2207/30041
摘要： A method is proposed for analysing an optical coherence tomography (OCT) image of the anterior segment (AS) of a subject's eye. A region of interest is defined which is a region of the image containing the junction of the cornea and iris, and an estimated position the junction within the region of interest is derived. Using this a second region of the image is obtained, which is a part of the image containing the estimated position of the junction. Features of the second region are obtained, and those features are input to an adaptive model to generate data characterizing the junction.
摘要翻译：提出了一种用于分析受试者眼睛前段（AS）的光学相干断层扫描（OCT）图像的方法。定义感兴趣区域，其是包含角膜和虹膜的交界处的图像的区域，以及估计的位置，导出感兴趣区域内的结。使用该图像获得图像的第二区域，其是包含结点的估计位置的图像的一部分。获得第二区域的特征，并且将这些特征输入到自适应模型以生成表征结点的数据。

7. 发明申请

WO2013184070A8 A DRUSEN LESION IMAGE DETECTION SYSTEM 审中-公开
公开(公告)号：WO2013184070A8
公开(公告)日：2013-12-12
申请号：PCT/SG2013/000235
申请日：2013-06-05
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH , SINGAPORE HEALTH SERVICES PTE LTD
发明人： WONG, Wing Kee, Damon , CHENG, Xiangang , LIU, Jiang , TANG, Ngan Meng , LEE, Beng Hai , YIN, Fengshou , BHARGAVA, Mayuri , CHEUNG, Gemmy , WONG, Tien Yin
IPC分类号： A61B3/12
摘要： A method is proposed for automatically analysing a retina image, to identify the presence of drusen which is indicative of age-related macular degeneration. The method proposes dividing a region of interest including the macula centre into patches, obtaining a local descriptor of each of the patches, reducing the dimensionality of the local descriptor by comparing the local descriptor to a tree-like clustering model and obtaining transformed data indicating the identity of the cluster. The transformed data is fed into an adaptive model which generates data indicative of the presence of drusen in the retinal image. Furthermore, the transformed data can be used to obtain the location of the drusen within the image.

8. 发明申请

WO2011025452A1 A METHOD AND SYSTEM FOR DETECTING DISC HAEMORRHAGES 审中-公开
标题翻译：一种用于检测椎间盘突出症的方法和系统
公开(公告)号：WO2011025452A1
公开(公告)日：2011-03-03
申请号：PCT/SG2009/000298
申请日：2009-08-24
申请人： SINGAPORE HEALTH SERVICES PTE LTD , AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH , NATIONAL UNIVERSITY OF SINGAPORE , ZHANG, Zhuo , LIU, Jiang, Jimmy , WONG, Wing Kee, Damon , LIM, Joo, Hwee , TAN, Ngan, Meng , LI, Huiqi , LU, Shijian , WONG, Tien, Yin
发明人： ZHANG, Zhuo , LIU, Jiang, Jimmy , WONG, Wing Kee, Damon , LIM, Joo, Hwee , TAN, Ngan, Meng , LI, Huiqi , LU, Shijian , WONG, Tien, Yin
IPC分类号： A61B3/12
CPC分类号： A61B3/1241 , A61B3/12 , G06T7/0014 , G06T7/12 , G06T2207/10024 , G06T2207/30041 , G06T2207/30101
摘要： A method for detecting disc haemorrhages in a retinal fundus image. The method includes (a) identifying a ring-shaped region of interest in the retinal fundus image encompassing the optic disc boundary; (b) removing blood vessel regions in the identified region of interest; (c) detecting candidate disc haemorrhages from the removed blood vessels regions in the identified region of interest; and (d) screening the candidate disc haemorrhages. The detected disc haemorrhages may be used to aid in the detection of glaucoma.
摘要翻译：一种用于检测视网膜眼底图像中的椎间盘出血的方法。该方法包括（a）识别包围视盘边界的视网膜眼底图像中的环形区域; （b）清除所识别的感兴趣区域中的血管区域; （c）从所识别的感兴趣区域中移除的血管区域检测候选椎间盘出血; 和（d）筛选候选椎间盘出血。检测到的椎间盘出血可用于帮助检测青光眼。

9. 发明申请

WO2016080914A1 SPECKLE REDUCTION IN OPTICAL COHERENCE TOMOGRAPHY IMAGES 审中-公开
标题翻译：光学相干图像中的光谱减少
公开(公告)号：WO2016080914A1
公开(公告)日：2016-05-26
申请号：PCT/SG2015/050460
申请日：2015-11-19
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH , KABUSHIKI KAISHA TOPCON
发明人： CHENG, Jun , LIU, Jiang , WONG, Wing Kee, Damon , AKIBA, Masahiro
IPC分类号： G06T5/00
CPC分类号： A61B3/102 , A61B3/0025 , G01B9/02082 , G01B9/02083 , G01B9/02091 , G06T5/002 , G06T5/50 , G06T2207/10101
摘要： An optical coherence tomography (OCT) image composed of a plurality of A-scans of a structure is analysed by defining, for each A-scan, a set of neighbouring A-scans surrounding the A-scan. Following an optional de-noising step, the neighbouring A-scans are aligned in the imaging direction, then a matrix X is formed from the aligned A-scans, and matrix completion is performed to obtain a reduced speckle noise image.
摘要翻译：通过为每个A扫描定义围绕A扫描的一组相邻A扫描来分析由结构的多个A扫描组成的光学相干断层摄影（OCT）图像。在可选的去噪步骤之后，相邻的A扫描在成像方向上对准，然后从对准的A扫描形成矩阵X，并执行矩阵完成以获得减少的散斑噪声图像。

10. 发明申请

WO2014116181A3 COST-SENSITIVE LINEAR RECONSTRUCTION BASED OPTIC CUP LOCALIZATION 审中-公开
公开(公告)号：WO2014116181A3
公开(公告)日：2014-07-31
申请号：PCT/SG2014/000026
申请日：2014-01-22
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
发明人： XU, Yanwu , LIU, Jiang , CHENG, Jun , YIN, Fengshou , WONG, Wing Kee, Damon
IPC分类号： A61B3/12 , A61B5/107 , G06K9/54 , G06T17/10 , G06F19/24 , G06T7/60
摘要： A method is presented to obtain, from a retinal image, data characterizing the optic cup, such as data indicating the location and/or size of the optic cup in relation to the optic disc. A disc region of the retinal image of an eye, is expressed as a weighted sum of a plurality of pre-existing "reference" retinal images in a library, with the weights being chosen to minimize a cost function. The data characterizing the cup of the eye is obtained from cup data associated with the pre-existing disc images and the corresponding weights. The cost function includes (i) a construction error term indicating a difference between the disc region of the retinal image and a weighted sum of the reference retinal images, and (ii) a cost term, which may be generated using a weighted sum over the reference retinal images of a difference between the reference retinal images and the disc region of the retinal image.

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