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1. 发明申请

WO2022197683A1 ON-DEVICE FUNCTIONALITY USING REMOTE SYSTEM UPDATES 审中-公开
公开(公告)号：WO2022197683A1
公开(公告)日：2022-09-22
申请号：PCT/US2022/020353
申请日：2022-03-15
申请人： BRANCH METRICS, INC.
发明人： GLOVER J., Eric , KHAITAN, Rishi , GARCIA-MARTINEZ, Antonio , BEHR, Colin, Nathan , AUSTIN, Alexander
IPC分类号： G06F8/65 , G06F8/61 , G06Q30/02 , G06Q30/06 , G06F16/903 , G06F16/955 , G06F16/23
摘要： A user device includes a local service module application and an advertising application. The user device receives, at the advertising application, advertisement data from an application-specific server associated with the advertising application. The advertisement data includes advertisement content data configured to render an advertisement. The user device is further configured to send the advertisement data from the advertising application to the local service module application. The user device is further configured to receive, at the local service module application, an advertisement request from an advertisement requesting application installed on the user device. The user device is further configured to send, from the local service module application, the advertisement data to the advertisement requesting application in response to the advertisement request.

2. 发明申请

WO2021080940A1 SEARCH QUERY ADVERTISEMENTS 审中-公开
公开(公告)号：WO2021080940A1
公开(公告)日：2021-04-29
申请号：PCT/US2020/056417
申请日：2020-10-20
申请人： BRANCH METRICS, INC.
发明人： GLOVER, Eric J. , BEHR, Colin Nathan , GARCIA-MARTINEZ, Antonio
IPC分类号： G06Q30/02 , G06F16/33
摘要： A method includes receiving a first request from a user device. The first request includes a partial search query sent from the user device while a user is typing a search query. The method includes generating one or more suggested search queries based on the partial search query and selecting a query advertisement record based on the partial search query. The query advertisement record includes an advertised search query and a bid price associated with the advertised search query. The method further includes sending a first response to the user device that includes the advertised search query and the one or more suggested search queries. The method further includes receiving a second request that includes the advertised search query, generating search results based on the advertised search query included in the second request, and sending the search results to the user device.

3. 发明申请

WO2018119248A1 A SYSTEM AND METHOD FOR SELECTING A PATIENT POPULATION FOR SPINAL REPAIR USING A MEASURABLE OUTCOME PREDICTIVE METRIC OF THE SPINE 审中-公开
公开(公告)号：WO2018119248A1
公开(公告)日：2018-06-28
申请号：PCT/US2017/067920
申请日：2017-12-21
申请人： MEDICAL METRICS, INC.
发明人： HIPP, John A.
IPC分类号： G16H50/70 , G16H20/00 , G16H10/60
摘要： The present disclosure describes systems and methods for determining whether a particular treatment would provide an extended benefit or a detriment to a subpopulation of patients. The system and methods provide a simple pictorial representation of patient benefits using an outcome predictive metric to see if any subpopulation produces significantly better results than the average or significantly worse results than the average.

4. 发明申请

WO2005044080A2 BLADDER-BASED CUFF FOR MEASURING PHYSIOLOGICAL PARAMETERS AND METHOD OF MEASURING PHYSIOLOGICAL PARAMETERS USING SAME 审中-公开
标题翻译：用于测量生理参数的基于叶片的模块和使用相同方法测量生理参数的方法
公开(公告)号：WO2005044080A2
公开(公告)日：2005-05-19
申请号：PCT/US2004/035144
申请日：2004-10-22
申请人： HEMA METRICS, INC. , LAW, Perry , COX, Douglas , MILLER, David , BELL, David
发明人： LAW, Perry , COX, Douglas , MILLER, David , BELL, David
IPC分类号： A61B
CPC分类号： A61B5/02233 , A61B5/02241 , A61B5/02422
摘要： A cuff for measuring volume and change in volume of a body appendage includes a hollow, rigid tube and a bladder, the ends of which are sealed to each other to create an enclosed internal volume between the inner surfaces of the bladder and the tube and an external volume defined by the outer surface of the bladder and surrounded by the internal volume. The bladder has a normal, relaxed state, in which the internal volume is filled with a fluid and a retracted state in which the fluid is evacuated from the internal volume. A plurality of emitters and detectors arranged in a linear array are embedded in one of two stiffener ribs placed on the inner surface of the bladder. A fluid port extends through the tube and communicates with the internal volume, through which the internal volume can be filled with or emptied of the fluid.
摘要翻译：用于测量身体附件的体积和体积变化的袖带包括中空的刚性管和囊，其端部彼此密封以在囊和管的内表面之间产生封闭的内部容积，并且外部体积由膀胱的外表面限定并被内部体积包围。气囊具有正常的松弛状态，其中内部容积充满流体和从内部空间排出流体的缩回状态。布置成线性阵列的多个发射器和检测器嵌入放置在膀胱内表面上的两个加强肋之一中。流体端口延伸穿过管并与内部容积连通，通过该内部容积可以填充或排空流体。

5. 发明申请

WO2004043356A2 COATED DIBASIC CALCIUM PHOSPHATE 审中-公开
标题翻译：涂层碳酸钙
公开(公告)号：WO2004043356A2
公开(公告)日：2004-05-27
申请号：PCT/US2003/035075
申请日：2003-11-04
申请人： METRICS, INC. , RUFF, Michael, D. , COBB, Joseph, E., Jr.
发明人： RUFF, Michael, D. , COBB, Joseph, E., Jr.
IPC分类号： A61K
CPC分类号： A61K9/1676 , A61K9/5026 , A61K9/5042 , A61K9/5078 , A61K38/28
摘要： An oral formulation containing an active pharmaceutical ingredient, for instance a peptide pharmaceutical, such as insulin, coated onto a suitable particulate substrate, such as dibasic calcium phosphate. The oral formulation may be a modified release formulation, for instance a controlled release formulation or a sustained release formulation, or may be an immediate release formulation. Also, the formulation may be encapsulated in gelatin capsules or may be compressed into tablets.
摘要翻译：含有活性药物成分，例如肽药物如胰岛素的口服制剂，其涂覆在合适的颗粒基质上，例如磷酸氢钙。口服制剂可以是调制释放制剂，例如控释制剂或持续释放制剂，或可以是立即释放制剂。此外，制剂可以包封在明胶胶囊中，或者可以压制成片剂。

6. 发明申请

WO02053212B1 METHOD OF MEASURING TRANSCUTANEOUS ACCESS BLOOD FLOW 审中-公开
标题翻译：测量经皮进入血液流量的方法
公开(公告)号：WO02053212B1
公开(公告)日：2002-08-22
申请号：PCT/US0148566
申请日：2001-12-20
申请人： HEMA METRICS INC
发明人： STEUER ROBERT R , BELL DAVID A , MILLER DAVID R
IPC分类号： G01F1/00 , A61B5/026 , A61B5/0275 , A61M1/14 , A61M1/36
CPC分类号： A61B5/0275 , A61M1/3609 , A61M1/3653 , A61M1/3655 , A61M1/3656
摘要： Indicator dilution techniques are used to measure vascular access flow rates during routine hemodialysis. A bolus injection port is used to infuse a specific volume (Vi) of an indicator diluent, such as saline or dye, into the patient cardiovascular circuit by one of the following: 1. Needle injection of a known volume (bolus) of indicator diluent directly into the access site in the presence or absence of the hemodialysis circuit. 2. Infusion of an indicator diluent into the arterial, venous line upstream of the venous needle. 3. Turning the ultrafiltration of the dialysis delivery system from OFF to ON and OFF again over a predetermined time period. 4. In a hemodialysis circuit, turning on the hemodialysis pump and using the priming saline volume as a single saline bolus. A transdermal sensor (10) is used to measure the percent change in a blood parameter. The sensor (10) is positioned directly over the vascular access site (12) a prescribed distance downstream of the injection site (12) and upstream of the access-vein connection (20C). The sensor (109) employs emitter (10A) and detector (106) elements at multiple spacings (d1, d2) for the purpose of measuring the bulk absorptivity (a) of the area immediately surrounding and including the access site (12), and the absorptivity (a) of the tissue itself.
摘要翻译：指标稀释技术用于测量常规血液透析过程中的血管通路流量。通过以下方式之一，使用快速浓注入口将指示剂稀释剂（例如盐水或染料）的特定体积（Vi）注入患者心血管回路中：1.将已知体积（快速浓注）指示剂稀释剂在存在或不存在血液透析回路的情况下直接进入存取部位。 2.将指示剂稀释液输注到静脉针上游的动脉，静脉管线中。 3.在预定的时间内将透析输送系统的超滤从OFF切换到ON和OFF。 4.在血液透析回路中，打开血液透析泵并使用启动盐水体积作为单次生理盐水灌注。透皮传感器（10）用于测量血液参数的百分比变化。传感器（10）直接位于血管进入部位（12）上方注射部位（12）下游和进入血管连接部位（20C）上游的预定距离处。为了测量直接围绕和包括进入部位（12）的区域的总体吸收率（a），传感器（109）在多个间隔（d1，d2）处采用发射器（10A）和检测器（106）组织本身的吸收率（a）。

7. 发明申请

WO0042907A9 SYSTEM AND METHOD FOR NONINVASIVE BLOOD ANALYTE MEASUREMENTS 审中-公开
标题翻译：非血液分析仪测量的系统和方法
公开(公告)号：WO0042907A9
公开(公告)日：2001-10-25
申请号：PCT/US0001378
申请日：2000-01-19
申请人： INSTRUMENTATION METRICS INC
发明人： MALIN STEPHEN F , RUCHTI TIMOTHY L
IPC分类号： G01N21/35 , A61B5/00 , A61B5/107 , A61B5/145 , A61B5/1455 , A61B5/1495 , C12M1/34 , C12Q1/54 , G01N21/47 , G06Q50/00
CPC分类号： A61B5/14546 , A61B5/0075 , A61B5/1075 , A61B5/14532 , A61B5/1455 , A61B5/7264 , A61B5/7267 , A61B2560/0223 , G01N21/4785
摘要： An intelligent system for measuring blood analytes noninvasively operates on a near infrared absorbance spectrum of in vivo skin tissue. A hierarchical architecture employs a pattern classification engine to adapt the calibration to the structural properties and physiological state of the subject as manifested in the absorbance spectrum. A priori information about the primary sources of sample variability are used to establish general categories of subjects. By applying calibration schemes specific to the various categories, the spectral interference is reduced resulting in improved prediction accuracy and parsimounious calibrations. Two classification rules are disclosed. The first rule assumes the classes are mutually exclusive and applies specific calibration models to the various subject categories. The second rule uses fuzzy set theory to develop calibration models and blood analyte predictions. Therefore, each calibration sample has the opportunity to influence more than one calibration model according to its class membership. Similarly, the predictions from more than one calibration are combined through defuzzification to produce the final blood analyte prediction.
摘要翻译：用于测量血液分析物的智能系统非侵入性地在体内皮肤组织的近红外吸收光谱上操作。层次结构采用模式分类引擎来使校准适应于吸收光谱中显示的受试者的结构性质和生理状态。关于样本变异性的主要来源的先验信息用于建立主体的一般类别。通过应用专门针对各种类别的校准方案，减小了频谱干扰，从而提高了预测精度和简单的校准。公开了两个分类规则。第一条规则假设这些类是相互排斥的，并将特定的校准模型应用于各种主题类别。第二条规则使用模糊集理论来开发校准模型和血液分析物预测。因此，每个校准样本都有机会根据其类别成员影响多个校准模型。类似地，来自多于一个校准的预测通过去模糊化来组合以产生最终的血液分析物预测。

8. 发明申请

WO1997028438A1 METHOD AND APPARATUS FOR MULTI-SPECTRAL ANALYSIS IN NONINVASIVE NIR SPECTROSCOPY 审中-公开
标题翻译：非线性近红外光谱中多光谱分析的方法与装置
公开(公告)号：WO1997028438A1
公开(公告)日：1997-08-07
申请号：PCT/US1997001370
申请日：1997-01-31
申请人： INSTRUMENTATION METRICS, INC.
发明人： INSTRUMENTATION METRICS, INC. , KHALIL, Gamal , MALIN, Stephen, F.
IPC分类号： G01N21/35
CPC分类号： A61B5/1455 , A61B5/14532 , G01N21/314 , G01N21/3577 , G01N21/359
摘要： A method and apparatus are described for determining the concentration of an analyte present in a sample using multi-spectral analysis in the near infrared range. Incident radiation containing a plurality of distinct, nonoverlapping regions of wavelengths in the range of approximately 1100 to 3500 nm is used to scan a sample. Diffusively reflected radiation emerging from the sample is detected, and a value indicative of the concentration of the analyte is obtained using an application of chemometrics techniques. Information obtained from each nonoverlapping region of wavelengths can be cross-correlated in order to remove background interferences.
摘要翻译：描述了一种方法和装置，用于在近红外范围内使用多光谱分析来确定存在于样品中的分析物的浓度。使用包含大约1100至3500nm范围内的多个不同的，不重叠的波长区域的入射辐射来扫描样品。检测出从样品中出现的扩散反射辐射，并且使用化学计量学技术获得指示分析物浓度的值。从波长的每个非重叠区域获得的信息可以是交叉相关的，以便去除背景干扰。

9. 发明申请

WO2022040056A1 ON-DEVICE FUNCTIONALITY USING REMOTE SYSTEM UPDATES 审中-公开
公开(公告)号：WO2022040056A1
公开(公告)日：2022-02-24
申请号：PCT/US2021/046056
申请日：2021-08-15
申请人： BRANCH METRICS, INC.
发明人： GILLIAM, Charles , GLOVER, Eric J , BAUER, Jonas , GASKIN, Dmitri , CHEN, Nicholas , KHAITAN, Rishi , JAIN, Suvir , AGHAMIRZAEI, Behdad , SIMON, Robert , GARCIA-MARTINEZ, Antonio , YOON, You , LEUNG, Christopher , STROMINGER, Lila , KUMAR, Deepika , MAHAJAN, Akshay , DU, Jing , KLASTAITIS, Benas , PRABHAKAR, Fabiana
IPC分类号： G06F8/65 , G06F8/61 , G06F16/23 , G06F16/903 , G06F16/955 , G06Q30/02 , G06Q30/06
摘要： A user device stores a local application including initial search records and an initial search function. Each initial search record includes an application link that opens an application page and search data that describes the application page. The initial search function is configured to select from the initial search records. The user device executes the local application to request and receive search update data from a remote system. The search update data includes updated search records and an updated search function. The user device updates the initial search records and the initial search function with the updated search records and the updated search function. The user device receives a search query from a requesting application, selects a set of updated search records based on the search query and the updated search function, and provides a response to the requesting application including application links from the set of updated search records.

10. 发明申请

WO2021154772A1 SPECTROFEROMETER 审中-公开
公开(公告)号：WO2021154772A1
公开(公告)日：2021-08-05
申请号：PCT/US2021/015163
申请日：2021-01-27
申请人： LAYER METRICS INC.
发明人： MURPHY, Domicnic
IPC分类号： H01J49/00 , H01J49/06 , H01J49/42
摘要： Spectroferometers and methods of use are provided. The spectroferometers includes an enclosure, one or more interferometer beam- splitting elements, and one or more spectrometer beam-dispersing elements. The one or more interferometer beam- splitting elements and the one or more spectrometer beam-dispersing elements are housed in the enclosure, share one or more radiation sensitive elements, which are arranged to generate a signal in response to incident electromagnetic radiation, and each generate one or more optical outputs. The one or more optical outputs are arranged such that respective optical axes intersect substantially in a plane of the one or more radiation sensitive elements.

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