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1. 发明申请

WO2022040350A1 HIGHLY SENSITIVE PLATFORM TO CHARACTERIZE EXTRACELLULAR VESICULAR BIOMARKERS FOR CANCER IMMUNOTHERAPY 审中-公开
公开(公告)号：WO2022040350A1
公开(公告)日：2022-02-24
申请号：PCT/US2021/046561
申请日：2021-08-18
申请人： OHIO STATE INNOVATION FOUNDATION , SPOT BIOSYSTEMS LTD.
发明人： REATEGUI, Eduardo , NGUYEN, Thi Hien Luong , KWAK, Kwang Joo , LEE, L. James
IPC分类号： C12Q1/6886 , G01N33/543 , G01N33/574 , C07K14/70596 , G01N33/54346 , G01N33/54373 , G01N33/57488
摘要： Methods and systems for characterizing extracellular vesicular biomarkers using a biochip with gold nanoparticles. The biochip includes a glass surface, a gold film layer on the glass surface, a plurality of gold nanoparticles coupled to the gold film layer, and a plurality of biotinylated antibodies coupled to the gold nanoparticles. In some implementations, the gold film layer of the biochip is coated with polyethylene glycol (PEG). The biotinylated antibodies are selected to capture specific types of extracellular vesicles. PD-L1/PD-1 proteins and RNAs in extracellular vesicles were characterized for cancer immunotherapy.

2. 发明申请

WO2016137499A1 VARIATIONS MANAGEMENT 审中-公开
标题翻译：变化管理
公开(公告)号：WO2016137499A1
公开(公告)日：2016-09-01
申请号：PCT/US2015/018039
申请日：2015-02-27
申请人： TEXTURA CORPORATION
发明人： ERBE, Paul, F. , FREEMAN, David, M. , SMITH, John, W. , VERNON, Christopher, R. , BOHNERT, James, Stanley
IPC分类号： G06Q10/00
CPC分类号： G06Q50/08 , G06Q30/04 , G06Q40/12 , G06Q50/18
摘要： Systems and methods are presented by which a contractor can initiate a proposed variation to a project contract and request payments against the proposed variation even before the variation is approved by the other party to the project contract. A data structure representative of proposed variation is generated and maintained as the proposed variation is reviewed, approved, and elevated to become part of the actual budget for the project. Because the same data structure is maintained throughout the process and after the proposed variation is approved, payment requests, payments, and any other actions taken against the data structure before the proposed variation is approved are automatically linked to the actual budget after approval and, thereby, are recognized and processed by external accounting systems as though the variations were created by the other party to the contract.
摘要翻译：提出系统和方法，承包商可以在项目合同的另一方批准变更之前，对项目合同提出建议的变更，并对建议的变更要求付款。建议变更的数据结构是由提出的变更进行审查，批准和提升为项目实际预算的一部分，生成和维护。因为在整个过程中保持相同的数据结构，并且在批准了所提出的变更之后，批准之前的支付请求，支付和针对数据结构的任何其他动作被批准，所以在批准之后将自动与实际预算相关联，由此，由外部会计系统确认和处理，好像变更是由合同另一方创建的。

3. 发明申请

WO2016109635A1 ADAPTIVE USER INTERFACE FOR AN AUTONOMOUS VEHICLE 审中-公开
标题翻译：用于自动车辆的自适应用户界面
公开(公告)号：WO2016109635A1
公开(公告)日：2016-07-07
申请号：PCT/US2015/068012
申请日：2015-12-30
申请人： ROBERT BOSCH GMBH
发明人： NAGY, Akos , BECKER, Jan , DECHANT, Moritz Achim Florian
IPC分类号： B60W50/14 , B60W30/14 , B60W30/09
CPC分类号： B60W50/14 , B60K2350/1028 , B60K2350/96 , B60W30/09 , B60W30/14 , B60W50/08 , B60W2050/146 , B60W2540/00 , B60W2540/22
摘要： Systems and methods are described for an adaptive user interface system for a vehicle with an automatic vehicle system. The adaptive user interface system includes a display and an electronic controller. The controller is configured to generate a graphical user interface indicative of operation of the automatic vehicle system, output the graphical user interface on the display, monitor an indicia of a driver's comfort level, and determine, based on the monitored indicia, when the driver is not comfortable with the operation of the automatic vehicle system. In response to determining that the driver is not comfortable with the operation of the automatic vehicle system, the electronic controller modifies the graphical user interface to provide an increased level of detail.
摘要翻译：对于具有自动车辆系统的车辆的自适应用户接口系统描述了系统和方法。自适应用户界面系统包括显示器和电子控制器。控制器被配置为生成指示自动车辆系统的操作的图形用户界面，在显示器上输出图形用户界面，监视驾驶员的舒适度水平的标记，并且基于所监视的标记来确定驾驶员何时不适合自动车辆系统的运行。响应于确定驾驶员对自动车辆系统的操作不舒服，电子控制器修改图形用户界面以提供增加的细节水平。

4. 发明申请

WO2016109540A1 SYSTEMS AND METHODS FOR OPERATING AUTONOMOUS VEHICLES USING PERSONALIZED DRIVING PROFILES 审中-公开
标题翻译：使用个性化驾驶型号操作自动车辆的系统和方法
公开(公告)号：WO2016109540A1
公开(公告)日：2016-07-07
申请号：PCT/US2015/067868
申请日：2015-12-29
申请人： ROBERT BOSCH GMBH
发明人： NAGY, Akos , BECKER, Jan , RAJARAM, Shetty , VETTER, Joerg , KREMER, Christian , MAMAEVA, Tatiana , GULATI, Shilpa
IPC分类号： B60W50/14 , B60W50/08 , B60W30/14 , B60W30/09 , B60W40/09
CPC分类号： B60W30/09 , B60W30/14 , B60W40/09 , B60W50/08 , B60W50/10 , B60W50/14 , B60W2050/146 , B60W2540/04 , B60W2540/28 , B60W2540/30
摘要： Systems and methods for controlling an autonomous vehicle. One method includes receiving, with an electronic processor of the autonomous vehicle, a profile selection. The method further includes receiving, with the electronic processor, a driver profile including a plurality of settings based on the profile selection. The method further includes, when the autonomous vehicle is operating in an autonomous driving mode, controlling, with the electronic processor, at least one vehicle control system of the autonomous vehicle based on at least one of the plurality of settings. The method further includes operating, with the electronic processor, the autonomous vehicle in a manual driving mode. The method further includes receiving, with the electronic processor, data from at least one sensor while the autonomous vehicle operates in the manual driving mode. The method further includes determining, with the electronic processor, a driving style based on the data and adjusting at least one of the plurality of settings based on the driving style.
摘要翻译：用于控制自主车辆的系统和方法。一种方法包括用自动车辆的电子处理器接收轮廓选择。该方法还包括使用电子处理器接收包括基于简档选择的多个设置的驾驶员简档。该方法还包括：当自主车辆以自主驾驶模式操作时，基于所述多个设置中的至少一个，利用所述电子处理器控制所述自主车辆的至少一个车辆控制系统。该方法还包括用电子处理器以自动驾驶模式操作自主车辆。该方法还包括在自动车辆以手动驾驶模式操作时，利用电子处理器接收来自至少一个传感器的数据。该方法还包括使用电子处理器基于数据确定驾驶风格，并且基于驾驶风格来调整多个设置中的至少一个。

5. 发明申请

WO2016109482A1 DRIVE STATE INDICATOR FOR AN AUTONOMOUS VEHICLE 审中-公开
标题翻译：自动车辆的驾驶状态指示器
公开(公告)号：WO2016109482A1
公开(公告)日：2016-07-07
申请号：PCT/US2015/067788
申请日：2015-12-29
申请人： ROBERT BOSCH GMBH
发明人： NAGY, Akos , BECKER, Jan
IPC分类号： G05D1/00 , B60W50/14
CPC分类号： G05D1/0061 , B60W50/14 , B60W2050/143 , G05D2201/0213
摘要： A system and method for indicating the drive state of an autonomous vehicle. The system includes a human machine interface and an electronic controller electrically coupled to the human machine interface and which is configured to display a drive state indicator. The drive state indicator includes a mode indicator based on a current operating mode for the autonomous vehicle, a duration indicator based on a duration for the current operating mode and a descriptor based on the duration. The electronic controller is further configured to update the duration indicator and the descriptor based on a remainder of the duration. In an alternative embodiment, the electronic controller is further configured to determine whether a second operating mode is available and display a second mode indicator based on the second operating mode when a second operating mode is available.
摘要翻译：一种用于指示自主车辆的驾驶状态的系统和方法。该系统包括人机界面和电耦合到人机界面的电子控制器，并被配置为显示驱动状态指示器。驱动状态指示器包括基于自主车辆的当前操作模式的模式指示符，基于当前操作模式的持续时间的持续时间指示符和基于持续时间的描述符。电子控制器还被配置为基于持续时间的剩余部分来更新持续时间指示符和描述符。在替代实施例中，电子控制器还被配置为当第二操作模式可用时，确定第二操作模式是否可用并且基于第二操作模式显示第二模式指示器。

6. 发明申请

WO2014116685A1 INVITATION-TO-BID MANAGEMENT SYSTEM 审中-公开
标题翻译：招标管理系统
公开(公告)号：WO2014116685A1
公开(公告)日：2014-07-31
申请号：PCT/US2014/012522
申请日：2014-01-22
申请人： TEXTURA CORPORATION
发明人： ALLIN, Patrick, J. , KHADIR, Mateen , TURINELLI, Franco
IPC分类号： G06F17/30 , G06Q10/06 , G06Q50/08
CPC分类号： G06Q50/08 , G06Q30/0611
摘要： A system is described that provides a single dashboard that organizes and displays all invitations-to-bid that have been received by a user from all of their various bid opportunity sources. The system also provides analytics and report functionality to prioritize invitations-to-bid and identify optimal project opportunities. Based on user-defined criteria, the system can be enabled to automatically respond with an approval or a rejection of certain invitations. In some embodiments, the system provides automatic notifications of bid deadlines to ensure that bid submissions are received on time.
摘要翻译：描述了一种系统，其提供单个仪表板，其组织并显示用户从所有各种出价机会来源接收到的所有邀请。该系统还提供分析和报告功能，优先考虑出价邀请并确定最佳项目机会。根据用户定义的标准，系统可以通过批准或拒绝某些邀请来自动响应。在一些实施例中，系统提供投标截止日期的自动通知，以确保按时收到投标提交。

7. 发明申请

WO2022182876A1 TREATMENT PLANNING FOR ATRIAL FIBRILLATION USING PATIENT-SPECIFIC MODELS BASED ON QUANTIFICATION OF FIBRILLATORY AREA 审中-公开
公开(公告)号：WO2022182876A1
公开(公告)日：2022-09-01
申请号：PCT/US2022/017705
申请日：2022-02-24
申请人： RANJAN, Ravi , KAMALI, Roya , UNIVERSITY OF UTAH RESEARCH FOUNDATION
发明人： RANJAN, Ravi , KAMALI, Roya
IPC分类号： A61B34/10 , A61B5/00 , A61B18/14 , A61B34/00 , A61B34/20
摘要： Systems and methods for developing an implementing an ablation plan for treating atrial fibrillation. A 3D digital model of cardiac tissue of a patient is segmented into a plurality of different sections and a fibrillatory area of each section is quantified. The fibrillatory area is based on a surface area of the section and a weighted surface area of each adjacent section, wherein the weighting is based on a proportion of a boundary between the section and the adjacent section that is not occupied by ablative scar tissue. An ablation plan is then defined based on the determining fibrillatory area of each section by adding planned ablation areas on the boundaries between sections until the quantified fibrillatory area of each section is below a maximum fibrillatory area threshold. The ablation plan is then displayed on a display screen to guide an ablation procedure according to the ablation plan.

8. 发明申请

WO2020092889A1 LED ILLUMINATION SYSTEM 审中-公开
公开(公告)号：WO2020092889A1
公开(公告)日：2020-05-07
申请号：PCT/US2019/059373
申请日：2019-11-01
申请人： MEDICAL INSTRUMENT DEVELOPMENT LABORATORIES, INC.
发明人： PETERSON, Erik, W.
IPC分类号： G02B6/00 , G02B5/00 , G02B5/08 , G02B26/00 , G02B26/08 , A61B3/00 , A61B17/00
摘要： An optical system for adjusting a proportion of light of a particular spectral band that is emitted from the optical system. A dichroic mirror is configured to reflect light of a first spectral band from a light source towards a distal end of an optical fiber while allowing light of a second spectral band to pass through the dichroic mirror. The second mirror is positioned behind the dichroic mirror and is configured to reflect light of the second spectral band. A mirror actuator is coupled to the second mirror and is configured to adjust a proportion of the light of the second spectral band that is emitted by the optical system by adjusting a position of the second mirror relative to the dichroic mirror.

9. 发明申请

WO2020018769A1 BRAIN INJURY MONITORING WITH RECOVERY TRAJECTORY 审中-公开
公开(公告)号：WO2020018769A1
公开(公告)日：2020-01-23
申请号：PCT/US2019/042370
申请日：2019-07-18
申请人： DUKE UNIVERSITY
发明人： KOLLS, Bradley , COLLINS, Leslie , THROCKMORTON, Chandra
IPC分类号： A61B5/0476 , A61B5/04 , A61B5/0484
摘要： Systems and methods for continuously monitoring brain function of clinic patients. In some such implementations, a system uses continuously monitored EEG data signal and other information from multiple clinical sources to estimate the current severity of a brain injury and to predict recovery potential of a given patient with the brain injury. Healing progress can be monitored by displaying a predicted recovery trajectory indicative of the predicted recovery potential and, in some implementations, a series of estimations of the severity of the brain injury at each of a plurality of different times during the recovery process.

10. 发明申请

WO2016205283A1 SYSTEMS AND METHODS FOR MONITORING LONGWALL MINE ROOF STABILITY 审中-公开
标题翻译：用于监测长壁矿山稳定性的系统和方法
公开(公告)号：WO2016205283A1
公开(公告)日：2016-12-22
申请号：PCT/US2016/037509
申请日：2016-06-15
申请人： JOY MM DELAWARE, INC.
发明人： KNUTH, Jason
IPC分类号： E21D23/00 , E21C27/00
CPC分类号： E21D23/26 , E21C35/12 , E21F17/185
摘要： Systems and methods are described for monitoring a condition of a mine roof using a longwall mining system. A plurality of powered roof supports is controlled to apply an adjustable support pressure on a mine roof. A condition of the mine roof is monitored based on the adjustable support pressure applied to the roof by a respective actuator of each powered roof support. In some implementations, the condition of the mine roof is monitored by generating and analyzing a graphical pressure map based on the adjustable support pressure applied by each powered roof support and a relative position of a shearer moving across the mine face. In some implementations, roof collapse events are detected based on temporally similar changes in the adjustable support pressure applied by multiple adjacent powered roof supports as indicated by the graphical pressure map.
摘要翻译：描述了使用长壁采矿系统监测矿山屋顶状况的系统和方法。控制多个动力顶棚支撑件以在矿顶上施加可调节的支撑压力。基于通过每个动力屋顶支撑件的相应致动器施加到屋顶的可调支撑压力来监测矿顶的状况。在一些实施方式中，通过基于由每个动力屋顶支撑件施加的可调节的支撑压力和穿过矿井面的采煤机的相对位置生成和分析图形压力图来监测矿山屋顶的状况。在一些实施方式中，根据图形压力图所示的由多个相邻的动力屋顶支撑件施加的可调支撑压力的时间上相似的变化来检测屋顶塌陷事件。

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