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1. 发明授权

US06632614B2 Method for detecting anti-Streptococcus pyogenes DNase B antibody in a test sample 失效
标题翻译：在测试样品中检测抗化脓性链球菌DNA酶B抗体的方法
公开(公告)号：US06632614B2
公开(公告)日：2003-10-14
申请号：US09119900
申请日：1998-07-21
申请人： Craig W. Adams , Patty P. Y. Pang , C. Marina Belei
发明人： Craig W. Adams , Patty P. Y. Pang , C. Marina Belei
IPC分类号： G01N3353
CPC分类号： C12Q1/44 , C07K16/40 , C12N9/22 , G01N2333/922
摘要： The gene for Streptococcus pyogenes DNase B has been cloned and vectors incorporating the cloned DNA have been used to transform Escherichia coli, allowing efficient and rapid production of the DNase in E. coli without the necessity of growing large quantities of S. pyogenes. The enzyme can be produced with a leader peptide at its amino terminus. An improved method for the purification of naturally occurring S. pyogenes DNase B enzyme is also provided. The DNase B enzyme produced, either by purification of naturally occurring enzyme or by recombinant DNA techniques, can be used to generate antibodies and can also be used in immunochemical assays to detect the presence of anti-DNase B antibodies in serum as a marker of infection by S. pyogenes.
摘要翻译：已经克隆了化脓性链球菌的基因，并且使用掺入克隆的DNA的载体转化大肠杆菌，允许在 E中有效快速地生产DNase。大肠杆菌，而不需要生长大量的 S。化脓性。该酶可以在其氨基末端用前导肽产生。用于纯化天然存在的 S的改进方法。脓疱病还提供了DNA酶B酶。通过纯化天然存在的酶或通过重组DNA技术产生的DNA酶B酶可用于产生抗体，也可用于免疫化学测定以检测血清中抗DNase B抗体作为感染标志物的存在由 S。化脓性

2. 发明授权

US06420152B1 Recombinant DNase B derived from Streptococcus pyogenes 失效
标题翻译：衍生自化脓性链球菌的重组DNA酶B
公开(公告)号：US06420152B1
公开(公告)日：2002-07-16
申请号：US08393889
申请日：1995-02-24
申请人： Craig W Adams , Patty P. Y. Pang , C. Marina Belei
发明人： Craig W Adams , Patty P. Y. Pang , C. Marina Belei
IPC分类号： C12N916
CPC分类号： C07K16/40 , C12N9/22 , C12Q1/44 , G01N2333/922
摘要： The gene for Streptococcus pyogenes DNase B has been cloned and vectors incorporating the cloned DNA have been used to transform Escherichia coli, allowing efficient and rapid production of the DNase in E. coli without the necessity of growing large quantities of S. pyogenes. The enzyme can be produced with a leader peptide at its amino terminus. An improved method for the purification of naturally occurring S. pyogenes DNase B enzyme is also provided. The DNase B enzyme produced, either by purification of naturally occurring enzyme or by recombinant DNA techniques, can be used to generate antibodies and can also be used in immunochemical assays to detect the presence of anti-DNase B antibodies in serum as a marker of infection by S. pyogenes.
摘要翻译：已经克隆了化脓性链球菌DNase B的基因，并且已经使用掺入克隆DNA的载体来转化大肠杆菌，从而能够在大肠杆菌中高效快速地生产DNA酶，而不需要生长大量的化脓性链球菌。该酶可以在其氨基末端用前导肽产生。还提供了用于纯化天然存在的化脓性链球菌DNA酶B酶的改进方法。通过纯化天然存在的酶或通过重组DNA技术产生的DNA酶B酶可用于产生抗体，也可用于免疫化学测定以检测血清中抗DNase B抗体作为感染标志物的存在化脓性链球菌。

3. 发明授权

US07005510B1 Recombinant DNase B derived from Streptococcus pyogenes 失效
标题翻译：衍生自化脓性链球菌的重组DNA酶B
公开(公告)号：US07005510B1
公开(公告)日：2006-02-28
申请号：US08482785
申请日：1995-06-07
申请人： Craig W Adams , Patty P. Y. Pang , C. Marina Belei
发明人： Craig W Adams , Patty P. Y. Pang , C. Marina Belei
IPC分类号： C07H21/02 , C07H21/04 , C12N15/09 , C12N1/20 , C12N15/00
CPC分类号： C12Q1/44 , C07K16/40 , C12N9/22 , G01N2333/922
摘要： The gene for Streptococcus pyogenes DNase B has been cloned and vectors incorporating the cloned DNA have been used to transform Escherichia coli, allowing efficient and rapid production of the DNase in E. coli without the necessity of growing large quantities of S. pyogenes. The enzyme can be produced with a leader peptide at its amino-terminus. An improved method for the purification of naturally occurring S. pyogenes DNase B enzyme is also provided. The DNase B enzyme produced, either by purification of naturally occurring enzyme or by recombinant DNA techniques, can be used to generate antibodies and can also be used in immunochemical assays to detect the presence of anti-DNase B antibodies in serum as a marker of infection by S. pyogenes.
摘要翻译：已经克隆了化脓性链球菌DNase B的基因，并且已经使用掺入克隆DNA的载体来转化大肠杆菌，从而能够在大肠杆菌中高效快速地生产DNA酶，而不需要生长大量的化脓性链球菌。该酶可以在其氨基末端用前导肽产生。还提供了用于纯化天然存在的化脓性链球菌DNA酶B酶的改进方法。通过纯化天然存在的酶或通过重组DNA技术产生的DNA酶B酶可用于产生抗体，也可用于免疫化学测定以检测血清中抗DNase B抗体作为感染标志物的存在化脓性链球菌。

4. 发明授权

US06770277B1 Recombinant DNase B derived from streptococcus pyogenes 失效
标题翻译：衍生自化脓性链球菌的重组DNA酶B
公开(公告)号：US06770277B1
公开(公告)日：2004-08-03
申请号：US08472630
申请日：1995-06-07
申请人： Craig W Adams , Patty P. Y. Pang , C. Marina Belei
发明人： Craig W Adams , Patty P. Y. Pang , C. Marina Belei
IPC分类号： A61K39395
CPC分类号： C12Q1/44 , C07K16/40 , C12N9/22 , G01N2333/922
摘要： The gene for Streptococcus pyogenes DNase B has been cloned and vectors incorporating the cloned DNA have been used to transform Escherichia coli, allowing efficient and rapid production of the DNase in E. coli without the necessity of growing large quantities of S. pyogenes. The enzyme can be produced with a leader peptide at its aminoterminus. An improved method for the purification of naturally occurring S. pyogenes DNase B enzyme is also provided. The DNase B enzyme produced, either by purification of naturally occurring enzyme or by recombinant DNA techniques, can be used to generate antibodies and can also be used in immunochemical assays to detect the presence of anti-DNase B antibodies in serum as a marker of infection by S. pyogenes.
摘要翻译：已经克隆了化脓性链球菌DNase B的基因，并且已经使用掺入克隆DNA的载体来转化大肠杆菌，从而能够在大肠杆菌中高效快速地生产DNA酶，而不需要生长大量的化脓性链球菌。该酶可以在其氨基末端用前导肽产生。还提供了用于纯化天然存在的化脓性链球菌DNA酶B酶的改进方法。通过纯化天然存在的酶或通过重组DNA技术产生的DNA酶B酶可用于产生抗体，也可用于免疫化学测定以检测血清中抗DNase B抗体作为感染标志物的存在化脓性链球菌。

5. 发明授权

US07247455B2 Streptococcus pyogenes DNase B leader peptide and methods for its use 失效
标题翻译：化脓性链球菌DNA酶B前导肽及其使用方法
公开(公告)号：US07247455B2
公开(公告)日：2007-07-24
申请号：US10453032
申请日：2003-06-03
申请人： Craig W Adams , Patty P. Y. Pang , C. Marina Belei
发明人： Craig W Adams , Patty P. Y. Pang , C. Marina Belei
IPC分类号： C12N15/09
CPC分类号： C12Q1/44 , C07K16/40 , C12N9/22 , G01N2333/922
摘要： The gene for Streptococcus pyogenes DNase B has been cloned and vectors incorporating the cloned DNA have been used to transform Escherichia coli, allowing efficient and rapid production of the DNase in E. coli without the necessity of growing large quantities of S. pyogenes. The enzyme can be produced with a leader peptide at its amino terminus. An improved method for the purification of naturally occurring S. pyogenes DNase B enzyme is also provided. The DNase B enzyme produced, either by purification of naturally occurring enzyme or by recombinant DNA techniques, can be used to generate antibodies and can also be used in immunochemical assays to detect the presence of anti-DNase B antibodies in serum as a marker of infection by S. pyogenes.
摘要翻译：已经克隆了化脓性链球菌DNase B的基因，并且已经使用掺入克隆DNA的载体来转化大肠杆菌，从而能够在大肠杆菌中高效快速地生产DNA酶，而不需要生长大量的化脓性链球菌。该酶可以在其氨基末端用前导肽产生。还提供了用于纯化天然存在的化脓性链球菌DNA酶B酶的改进方法。通过纯化天然存在的酶或通过重组DNA技术产生的DNA酶B酶可用于产生抗体，也可用于免疫化学测定以检测血清中抗DNase B抗体作为感染标志物的存在化脓性链球菌。

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