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    • 7. 发明授权
    • Medical emulsion for lubrication and delivery of drugs
    • 用于润滑和输送药物的医用乳液
    • US06391832B2
    • 2002-05-21
    • US09887039
    • 2001-06-21
    • Robert T. LyonsDavid H. DillardBruce FieggenRobert M. RaukerScott T. Bluni
    • Robert T. LyonsDavid H. DillardBruce FieggenRobert M. RaukerScott T. Bluni
    • C10M17300
    • A61K9/0019A61B17/320758A61K9/1075B82Y5/00Y10S514/937Y10S514/938
    • A medical lubricant suitable for injection into the blood stream of a patient. The lubricant is suitable for use with rotating equipment such as atherectomy drive shafts moving within sheaths and over guide wires and other minimally invasive medical devices introduced into a patient through a catheter like instrument. The lubricant is an oil-in-water emulsion including a surfactant, a co-surfactant, and a pH buffer. The lubricant can further include a cryogenic agent and a pH adjusting agent. One lubricant includes olive oil as an emulsified oil, egg yolk phospholipid as a surfactant, sodium deoxycholate as a co-surfactant, glycerin as a cryogenic agent, L-histidine as a pH buffer, and is pH adjusted using sodium hydroxide. The lubricant also includes a therapeutic agent. The lubricant can withstand freeze/thaw cycles as well as saline dilution, heating, and shear stress without significant creaming, separation, or unacceptable increases in oil droplet size.
    • 适用于注射到患者血液中的医用润滑剂。 润滑剂适用于旋转设备,例如在护套内移动的动脉粥样化组织驱动轴,以及通过导管样仪器引导到患者体内的导丝和其他微创医疗装置。 润滑剂是包括表面活性剂,辅助表面活性剂和pH缓冲剂的水包油乳液。 润滑剂可进一步包括低温剂和pH调节剂。 一种润滑剂包括作为乳化油的橄榄油,作为表面活性剂的蛋黄磷脂,作为辅助表面活性剂的脱氧胆酸钠,作为低温剂的甘油,作为pH缓冲剂的L-组氨酸,并使用氢氧化钠进行pH调节。 润滑剂还包括治疗剂。 润滑剂可以承受冷冻/融化循环以及盐水稀释,加热和剪切应力,而没有显着的奶油,分离或油滴尺寸的不可接受的增加。