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1. 发明授权

US06391832B2 Medical emulsion for lubrication and delivery of drugs 有权
标题翻译：用于润滑和输送药物的医用乳液
公开(公告)号：US06391832B2
公开(公告)日：2002-05-21
申请号：US09887039
申请日：2001-06-21
申请人： Robert T. Lyons , David H. Dillard , Bruce Fieggen , Robert M. Rauker , Scott T. Bluni
发明人： Robert T. Lyons , David H. Dillard , Bruce Fieggen , Robert M. Rauker , Scott T. Bluni
IPC分类号： C10M17300
CPC分类号： A61K9/0019 , A61B17/320758 , A61K9/1075 , B82Y5/00 , Y10S514/937 , Y10S514/938
摘要： A medical lubricant suitable for injection into the blood stream of a patient. The lubricant is suitable for use with rotating equipment such as atherectomy drive shafts moving within sheaths and over guide wires and other minimally invasive medical devices introduced into a patient through a catheter like instrument. The lubricant is an oil-in-water emulsion including a surfactant, a co-surfactant, and a pH buffer. The lubricant can further include a cryogenic agent and a pH adjusting agent. One lubricant includes olive oil as an emulsified oil, egg yolk phospholipid as a surfactant, sodium deoxycholate as a co-surfactant, glycerin as a cryogenic agent, L-histidine as a pH buffer, and is pH adjusted using sodium hydroxide. The lubricant also includes a therapeutic agent. The lubricant can withstand freeze/thaw cycles as well as saline dilution, heating, and shear stress without significant creaming, separation, or unacceptable increases in oil droplet size.
摘要翻译：适用于注射到患者血液中的医用润滑剂。润滑剂适用于旋转设备，例如在护套内移动的动脉粥样化组织驱动轴，以及通过导管样仪器引导到患者体内的导丝和其他微创医疗装置。润滑剂是包括表面活性剂，辅助表面活性剂和pH缓冲剂的水包油乳液。润滑剂可进一步包括低温剂和pH调节剂。一种润滑剂包括作为乳化油的橄榄油，作为表面活性剂的蛋黄磷脂，作为辅助表面活性剂的脱氧胆酸钠，作为低温剂的甘油，作为pH缓冲剂的L-组氨酸，并使用氢氧化钠进行pH调节。润滑剂还包括治疗剂。润滑剂可以承受冷冻/融化循环以及盐水稀释，加热和剪切应力，而没有显着的奶油，分离或油滴尺寸的不可接受的增加。

2. 发明授权

US06281175B1 Medical emulsion for lubrication and delivery of drugs 有权
标题翻译：用于润滑和输送药物的医用乳液
公开(公告)号：US06281175B1
公开(公告)日：2001-08-28
申请号：US09534056
申请日：2000-03-24
申请人： Robert T. Lyons , David H. Dillard , Bruce Fieggen
发明人： Robert T. Lyons , David H. Dillard , Bruce Fieggen
IPC分类号： C10M17300
CPC分类号： A61K9/0019 , A61B17/320758 , A61K9/1075 , B82Y5/00 , Y10S514/937 , Y10S514/938
摘要： A medical lubricant suitable for injection into the blood stream of a patient. The lubricant is suitable for use with rotating equipment such as atherectomy drive shafts moving within sheaths and over guide wires and other minimally invasive medical devices introduced into a patient through a catheter like instrument. The lubricant is an oil-in-water emulsion including a surfactant, a co-surfactant, and a pH buffer. The lubricant can further include a cryogenic agent and a pH adjusting agent. One lubricant includes olive oil as an emulsified oil, egg yolk phospholipid as a surfactant, sodium deoxycholate as a co-surfactant, glycerin as a cryogenic agent, L-histidine as a pH buffer, and is pH adjusted using sodium hydroxide. The lubricant can also include a therapeutic agent. The lubricant can withstand freeze/thaw cycles as well as saline dilution, heating, and shear stress without significant creaming, separation, or unacceptable increases in oil droplet size. Compared to saline, the lubricant provides significantly increased lubrication efficiency for rapidly moving parts.
摘要翻译：适用于注射到患者血液中的医用润滑剂。润滑剂适用于旋转设备，例如在护套内移动的动脉粥样化组织驱动轴，以及通过导管样仪器引导到患者体内的导丝和其他微创医疗装置。润滑剂是包括表面活性剂，辅助表面活性剂和pH缓冲剂的水包油乳液。润滑剂可进一步包括低温剂和pH调节剂。一种润滑剂包括作为乳化油的橄榄油，作为表面活性剂的蛋黄磷脂，作为辅助表面活性剂的脱氧胆酸钠，作为低温剂的甘油，作为pH缓冲剂的L-组氨酸，并使用氢氧化钠进行pH调节。润滑剂还可以包括治疗剂。润滑剂可以承受冷冻/融化循环以及盐水稀释，加热和剪切应力，而没有显着的奶油，分离或油滴尺寸的不可接受的增加。与盐水相比，润滑剂为快速移动的部件提供了显着提高的润滑效率。

3. 发明授权

US06054421A Medical emulsion lubricant 失效
标题翻译：医用乳液润滑剂
公开(公告)号：US06054421A
公开(公告)日：2000-04-25
申请号：US935698
申请日：1997-09-23
申请人： Robert T. Lyons , David H. Dillard , Bruce Fieggen
发明人： Robert T. Lyons , David H. Dillard , Bruce Fieggen
IPC分类号： C10M171/00 , A61B17/22 , A61K9/107 , C10N40/06 , C10M173/00
CPC分类号： A61K9/1075 , A61B17/320758 , Y10S514/937 , Y10S514/938
摘要： A medical lubricant suitable for injection into the blood stream of a patient. The lubricant is suitable for use with rotating equipment such as atherectomy drive shafts moving within sheaths and over guide wires. The lubricant is an oil-in-water emulsion including a surfactant and a co-surfactant. The lubricant can include a cryogenic agent and a pH buffer and be pH adjusted. One lubricant includes olive oil as an emulsified oil, egg yolk phospholipid as a surfactant, sodium deoxycholate as a co-surfactant, glycerin as a cryogenic agent, L-histidine as a pH buffer, and is pH adjusted using sodium hydroxide. The lubricant can withstand freeze/thaw cycles as well as saline dilution, heating, and shear stress without significant creaming, separation, or unacceptable increases in oil droplet size. Compared to saline, the lubricant provides significantly increased lubrication efficiency for rapidly moving parts.
摘要翻译：适用于注射到患者血液中的医用润滑剂。润滑剂适用于旋转设备，例如在鞘内和导丝上移动的动脉粥样化组织切割驱动轴。润滑剂是包含表面活性剂和辅助表面活性剂的水包油乳液。润滑剂可以包括低温剂和pH缓冲液并进行pH调节。一种润滑剂包括作为乳化油的橄榄油，作为表面活性剂的蛋黄磷脂，作为辅助表面活性剂的脱氧胆酸钠，作为低温剂的甘油，作为pH缓冲剂的L-组氨酸，并使用氢氧化钠进行pH调节。润滑剂可以承受冷冻/融化循环以及盐水稀释，加热和剪切应力，而没有显着的奶油，分离或油滴尺寸的不可接受的增加。与盐水相比，润滑剂为快速移动的部件提供了显着提高的润滑效率。

4. 发明申请

US20120289772A1 DEPLOYMENT CATHETER 有权
标题翻译：部署导管
公开(公告)号：US20120289772A1
公开(公告)日：2012-11-15
申请号：US13107564
申请日：2011-05-13
申请人： Desmond O'Connell , Erik Liljegren , David H. Dillard , Hugo X. Gonzalez
发明人： Desmond O'Connell , Erik Liljegren , David H. Dillard , Hugo X. Gonzalez
IPC分类号： A61B1/267 , A61M16/00
CPC分类号： A61B17/00234 , A61B1/00087 , A61B1/018 , A61B1/2676 , A61B17/3468 , A61B34/20 , A61B2017/00296 , A61B2017/00309 , A61B2017/0034 , A61B2017/00367 , A61B2017/00809 , A61B2034/2051
摘要： A deployment catheter is described herein that preferably is configured to deliver a medical device such as a valve to a location in a patient such as a patient's airway. Preferably, such a deployment catheter is configured to be used in conjunction with a bronchoscope. In some embodiments, a locking lever is provided to reduce the likelihood of accidental deployment of the device, and which resets conveniently after use to as to permit multiple device deployments.
摘要翻译：本文描述了展开导管，其优选地被配置为将诸如阀门的医疗装置递送到患者例如患者气道中的位置。优选地，这种展开导管配置成与支气管镜结合使用。在一些实施例中，提供锁定杆以减少设备的意外部署的可能性，并且在使用之后方便地复位以允许多个设备部署。

5. 发明授权

US07476203B2 Device and method for measuring the diameter of an air passageway 有权
标题翻译：用于测量空气通道直径的装置和方法
公开(公告)号：US07476203B2
公开(公告)日：2009-01-13
申请号：US11260012
申请日：2005-10-26
申请人： Lauri J. DeVore , William A. Sirokman , James M. Kutsko , David H. Dillard , Peter R. Westman
发明人： Lauri J. DeVore , William A. Sirokman , James M. Kutsko , David H. Dillard , Peter R. Westman
IPC分类号： A61B5/117 , A61B5/103
CPC分类号： A61B5/1076
摘要： The invention provides a device for measuring an inside diameter of a body lumen, such as an air passageway. The device includes a flexible catheter having an inflation lumen, a fluid dispenser in fluid communication with the inflation lumen and operable to communicate a measurable fluid volume change with the inflation lumen, and an expandable member in fluid communication with the inflation lumen and having a known relationship between volume and a changeable transverse dimension, the transverse dimension being changeable in response to fluid volume changes of the fluid dispenser and arranged for placement adjacent to opposing portions of an interior wall of the air passageway. The expandable member may be dimensioned for transoral placement into the air passageway, and may comprise a balloon that includes a complaint material.
摘要翻译：本发明提供一种用于测量诸如空气通道的体腔的内径的装置。该装置包括具有充气腔的柔性导管，与充气腔流体连通并可操作以将可测量的流体体积变化与充气腔连通的流体分配器，以及与充气腔流体连通并具有已知体积与可变的横向尺寸之间的关系，横向尺寸可以响应于流体分配器的流体体积变化而变化，并且布置成邻近空气通道的内壁的相对部分放置。可膨胀构件的尺寸可以用于横向放置到空气通道中，并且可以包括包括投诉材料的气囊。

6. 发明授权

US07842061B2 Methods of achieving lung volume reduction with removable anchored devices 有权
标题翻译：用可拆卸锚固装置实现肺容积减小的方法
公开(公告)号：US07842061B2
公开(公告)日：2010-11-30
申请号：US10746981
申请日：2003-12-23
申请人： David H. Dillard , Hugo X. Gonzalez , Seung Yi , Lauri J. DeVore , Mia Park , Dean T. Corcoran , Jenni Rimbaugh
发明人： David H. Dillard , Hugo X. Gonzalez , Seung Yi , Lauri J. DeVore , Mia Park , Dean T. Corcoran , Jenni Rimbaugh
IPC分类号： A61M29/00
CPC分类号： A61B17/12104 , A61B17/12172 , A61B2017/00809 , A61F2/24 , A61F2002/043
摘要： An intra-bronchial device placed and anchored in an air passageway of a patient to collapse a lung portion associated with the air passageway. The device includes a support structure, an obstructing member carried by the support structure that reduces ventilation to the lung portion by preventing air from being inhaled into the lung portion, and at least one anchor carried by the support structure that anchors the obstruction device within the air passageway. The anchor may engage the air passageway wall by piercing or friction, include a stop dimensioned for limiting the piercing of the air passageway wall, and may be releasable from the air passageway for removal of the intra-bronchial device. The anchors may be carried by a peripheral portion of the support structure, or by a central portion of the support structure. The obstructing member may be a one-way valve.
摘要翻译：将支气管内装置放置并锚定在患者的空气通道中以折叠与空气通道相关联的肺部分。该装置包括支撑结构，由支撑结构承载的阻塞构件，其通过防止空气被吸入肺部而减少对肺部的通气，以及由支撑结构承载的至少一个锚固件，其将阻塞装置固定在内部空气通道。锚固件可以通过穿孔或摩擦接合空气通道壁，包括尺寸适于限制空气通道壁的刺穿的止挡件，并且可以从空气通道释放以去除支气管内装置。锚固件可以由支撑结构的周边部分或支撑结构的中心部分承载。阻塞构件可以是单向阀。

7. 发明授权

US06569177B1 Ablation atherectomy burr 有权
标题翻译：消融粥样斑块切除术
公开(公告)号：US06569177B1
公开(公告)日：2003-05-27
申请号：US09769191
申请日：2001-01-19
申请人： David H. Dillard , Garrett R. Beget , Vittorino Monni
发明人： David H. Dillard , Garrett R. Beget , Vittorino Monni
IPC分类号： A61B1732
CPC分类号： A61B17/320758 , A61B2017/320004
摘要： An ablation burr for a rotational atherectomy device that may reduce the risk of damage to a vessel wall while providing ablative cutting surfaces out to the maximum diameter of the burr. Two different abrasive surfaces are provided on the leading surface of the ablation burr. A less aggressive or finer abrasiveness is provided near the ablation burr maximum diameter, which is the portion of the burr nearest the vessel wall. This portion of the burr also presents a relatively shallow angle of attach to the vessel wall. A more aggressive or coarser abrasive is applied to portions of the burr disposed further from the vessel wall. In one embodiment, the more aggressive abrasive portion of the burr has a concave profile, thereby further reducing the possibility that the more aggressive abrasive will contact the vessel wall, even when the burr is rotated significantly away from the vessel axis. The ablation burr body may be profiled with an offset or stepped sections on the leading surface that are dimensioned such that the abrasive particles do not extend radially beyond the maximum diameter of the smooth back surface of the ablation burr.
摘要翻译：用于旋转粥样斑块切除装置的消融毛刺，其可以减少损伤血管壁的风险，同时将烧蚀切割表面提供到毛刺的最大直径。两个不同的研磨表面设置在消融毛刺的前表面上。在消融毛刺最大直径附近提供较少的侵蚀性或更细的磨蚀性，其是最靠近血管壁的毛刺部分。毛刺的这一部分也呈现出相对较浅的附着于血管壁的角度。将较为侵蚀性或较粗糙的研磨剂施加到设置在血管壁之外的毛刺部分。在一个实施例中，毛刺的更具侵蚀性的研磨部分具有凹形轮廓，从而进一步降低了更具侵蚀性的磨料将与血管壁接触的可能性，即使当毛刺被显着地远离血管轴线旋转时。消融毛刺体可以在引导表面上具有偏移或阶梯部分的形状，其尺寸被设计成使得磨料颗粒不会径向延伸超出消融毛刺的平滑后表面的最大直径。

8. 发明授权

US06569146B1 Method and apparatus for treating saphenous vein graft lesions 失效
标题翻译：治疗隐静脉移植物病变的方法和装置
公开(公告)号：US06569146B1
公开(公告)日：2003-05-27
申请号：US09642627
申请日：2000-08-18
申请人： Dennis Werner , David H. Dillard , Ray Fei , Gary Swinford , Verivada Chandru Chandrasekaran , Tim J. Johnson
发明人： Dennis Werner , David H. Dillard , Ray Fei , Gary Swinford , Verivada Chandru Chandrasekaran , Tim J. Johnson
IPC分类号： A61M3100
CPC分类号： A61B17/22 , A61B17/00491 , A61B2017/22038 , A61B2017/22054 , A61B2017/22067 , A61B2017/22082 , A61B2017/320004
摘要： A method for treating loosely formed, friable or fragile lesions in a patient's blood vessel. A catheter having a pair of sealing mechanisms is advanced such that the sealing mechanisms are positioned distal to and proximal to the lesion. The sealing mechanisms are activated to seal the vessel on either side of the lesion. A medication is then delivered through the catheter to the sealed area of the vessel. The medication interacts with the lesion in order to partially or completely solidify it. Once the lesion is solidified, the catheter is removed and the lesion can be treated with a conventional intravascular device.
摘要翻译：一种用于治疗患者血管中松散形成的，易碎的或易碎的病变的方法。具有一对密封机构的导管被推进，使得密封机构位于病变的远侧和近侧。激活密封机构以密封病变两侧的血管。然后将药物通过导管输送到容器的密封区域。药物与病变相互作用以部分或完全固化。一旦病变固化，导管被移除，病变可用常规的血管内装置治疗。

9. 发明授权

US08414655B2 Removable lung reduction devices, systems, and methods 有权
公开(公告)号：US08414655B2
公开(公告)日：2013-04-09
申请号：US12828629
申请日：2010-07-01
申请人： Clifton A. Alferness , Hugo X. Gonzalez , David H. Dillard
发明人： Clifton A. Alferness , Hugo X. Gonzalez , David H. Dillard
IPC分类号： A61F2/04
CPC分类号： A61B17/12104 , A61B17/12022 , A61B17/12036 , A61B17/12172 , A61B2017/1205 , A61B2017/12054 , A61F2002/043 , A61M16/0404
摘要： An air passageway obstruction device includes a frame structure and a flexible membrane overlying the frame structure. The frame structure is collapsible upon advancement of the device into the air passageway, expandable into a rigid structure upon deploying in the air passageway and recollapsible upon removal from the air passageway. The flexible membrane obstructs inhaled air flow into a lung portion communicating with the air passageway. The device may be removed after deployment in an air passageway by recollapsing the device and pulling the device proximally through a catheter.

10. 发明申请

US20110079221A1 ONE-WAY VALVE DEVICES FOR ANCHORED IMPLANTATION IN A LUNG 有权
标题翻译：用于在肺中锚固植入的单向阀装置
公开(公告)号：US20110079221A1
公开(公告)日：2011-04-07
申请号：US12968771
申请日：2010-12-15
申请人： David H. Dillard , Hugo X. Gonzalez , Seung Yi , Lauri J. DeVore , Mia Park , Dean T. Corcoran , Jenni Rimbaugh , Clifton A. Alferness
发明人： David H. Dillard , Hugo X. Gonzalez , Seung Yi , Lauri J. DeVore , Mia Park , Dean T. Corcoran , Jenni Rimbaugh , Clifton A. Alferness
IPC分类号： A61M16/00
CPC分类号： A61B17/12104 , A61B17/12172 , A61B2017/00809 , A61F2/24 , A61F2002/043
摘要： An intra-bronchial device placed and anchored in an air passageway of a patient to collapse a lung portion associated with the air passageway. The device includes a support structure, an obstructing member carried by the support structure that reduces ventilation to the lung portion by preventing air from being inhaled into the lung portion, and at least one anchor carried by the support structure that anchors the obstruction device within the air passageway. The anchor may engage the air passageway wall by piercing or friction, include a stop dimensioned for limiting the piercing of the air passageway wall, and may be releasable from the air passageway for removal of the intra-bronchial device. The anchors may be carried by a peripheral portion of the support structure, or by a central portion of the support structure. The obstructing member may be a one-way valve.
摘要翻译：将支气管内装置放置并锚定在患者的空气通道中以折叠与空气通道相关联的肺部分。该装置包括支撑结构，由支撑结构承载的阻塞构件，其通过防止空气被吸入肺部而减少对肺部的通气，以及由支撑结构承载的至少一个锚固件，其将阻塞装置锚定在内部空气通道。锚固件可以通过穿孔或摩擦接合空气通道壁，包括尺寸适于限制空气通道壁的刺穿的止挡件，并且可以从空气通道释放以去除支气管内装置。锚固件可以由支撑结构的周边部分或支撑结构的中心部分承载。阻塞构件可以是单向阀。

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