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1. 发明申请

US20040235792A1 Serine protease inhibitors compromising a hydrogen-bond acceptor 审中-公开
标题翻译：丝氨酸蛋白酶抑制剂损害氢键受体
公开(公告)号：US20040235792A1
公开(公告)日：2004-11-25
申请号：US10466736
申请日：2003-12-18
发明人： John J Deadman , John Spencer , Paulette A Greenidge , Christopher A Goodwin , Vijay Vir Kakkar , Michael F Scully , Richard Jones Holland
IPC分类号： A61K031/69 , C07F005/04
CPC分类号： A61K31/69 , A61K31/00 , C07C335/32 , C07F5/02 , C07F5/025 , C07F5/04
摘要： Compounds, useful as protease inhibitors, of the formula (I): where: Ar is a ring or ring system, for example a benzene ring, and may be substituted by one or more moieties in addition to X and LJ; X is a functional group which is a hydrogen-bond acceptor, e.g. a nitro or boronate group BY1Y2; L is a linker, most preferably (CR5R6)nullSnull; J is a moiety containing a basic nitrogen atom but not containing an amino acid residue, preferably amidino, guanidine, amino carboxamido, hydroxylamino, or imidazolyl, or an N-substituted analogue thereof.
摘要翻译：用作蛋白酶抑制剂的式（I）化合物：其中：Ar是环或环系，例如苯环，除X和LJ之外，还可被一个或多个部分取代; X是一个官能团，它是一个氢键受体。硝基或硼酸酯基团BY 1 Y 2; L是接头，最优选（CR 5 R 6）-S-; J是含有碱性氮原子但不含有氨基酸残基，优选脒基，胍，氨基甲酰氨基，羟氨基或咪唑基或其N-取代的类似物的部分。

2. 发明申请

US20030153779A1 Process for separating reaction mixtures and recycling quaternary salts and bases 失效
标题翻译：分离反应混合物和回收季盐和碱的方法
公开(公告)号：US20030153779A1
公开(公告)日：2003-08-14
申请号：US10320061
申请日：2002-12-16
发明人： Peter Fischer , Sven Michael Hansen , Claus-Peter Reisinger
IPC分类号： C07F009/02 , C07F005/04 , C07C277/06
CPC分类号： B01J31/0268 , B01J31/0214 , B01J31/0215 , B01J31/0235 , B01J31/0239 , B01J31/26 , B01J31/28 , B01J31/4015 , B01J31/4053 , B01J38/48 , B01J2231/34 , C07C37/72 , C07C37/74 , C07C68/08 , Y02P20/127 , Y02P20/52 , Y02P20/584 , C07C69/96 , C07C39/04
摘要： A process for the removal and recovery of quaternary salt (A) and base (D) from a reaction mixture is disclosed. The reaction mixture resulting from oxidative direct carbonylation contains in addition to (A) and (D), at least one hydroxyaromatic compound (B) and at least one reaction product (C) and optionally a solvent, and the process entails a) adding acid to the reaction mixture to cause conversion of (D) into a hydroxyaromatic compound (B2) b) separating the reaction mixture into b1.) that contains (C) and optionally (B) and/or (B2) and b2.) that contains (A) and optionally (B) and/or (B2), and c) reacting b1.) with a base (E) to re-form (D).
摘要翻译：公开了从反应混合物中除去和回收季盐（A）和碱（D）的方法。由氧化性直接羰基化产生的反应混合物除（A）和（D）外还含有至少一种羟基芳族化合物（B）和至少一种反应产物（C）和任选的溶剂，该方法需要a）加入酸将反应混合物转化为羟基芳族化合物（B2）b）将含有（C）和任选（B）和/或（B2）和b2）的反应混合物分离成b1。（A）和任选的（B）和/或（B2），和c）使b1。）与碱（E）反应以重新形成（D）。

3. 发明申请

US20030236427A1 Cross-metathesis of olefins directly substituted with an electron-withdrawing group using transition metal carbene catalysts 有权
公开(公告)号：US20030236427A1
公开(公告)日：2003-12-25
申请号：US10409017
申请日：2003-04-07
发明人： Robert H. Grubbs , John P. Morgan , Jennifer A. Love , Tina M. Trnka
IPC分类号： C07F015/00 , C07F005/04 , C07C253/30
CPC分类号： C07C253/30 , C07C255/15 , C07C255/34
摘要： The invention pertains to the use of Group 8 transition metal alkylidene complexes as catalysts for olefin cross-metathesis reactions. In particular, ruthenium and osmium alkylidene complexes substituted with an N-heterocyclic carbene ligand and at least one electron donor ligand in the form of a heterocyclic group are used to catalyze cross-metathesis reactions to provide a olefin products that are directly substituted with an electron-withdrawing group.

4. 发明申请

US20020094586A1 Detection of analytes 审中-公开
标题翻译：检测分析物
公开(公告)号：US20020094586A1
公开(公告)日：2002-07-18
申请号：US09754219
申请日：2001-01-05
申请人： Sensors for Medicine and Science, Inc.
发明人： George Y. Daniloff , Aristotle G. Kalivretenos , Alexandre V. Nikolaitchik , Edwin F. Ullman
IPC分类号： C07C069/76 , C07F005/04
CPC分类号： G01N33/66
摘要： Disclosed are methods for detecting analytes with indicator systems which may undergo a molecular configurational change upon exposure to the analyte. The configurational change affects a detectable quality associated with the indicator system, thereby allowing detection of the presence or concentration of the analyte.
摘要翻译：公开了用于用指示剂系统检测分析物的方法，所述指示剂体系在暴露于分析物时可能经历分子结构变化。配置变化影响与指示剂系统相关的可检测质量，从而允许检测分析物的存在或浓度。

5. 发明申请

US20020038053A1 4-Cyclohexy1-1,3,2-oxazaborolidine chiral accessories 失效
标题翻译： 4-环己基-1,1,3,2-恶唑硼烷手性配件
公开(公告)号：US20020038053A1
公开(公告)日：2002-03-28
申请号：US09943127
申请日：2001-08-30
发明人： Richard W. Draper
IPC分类号： C07F005/04
CPC分类号： C07F5/025 , B01J31/0252 , B01J31/146 , B01J2231/64 , C07B2200/07 , C07C29/143 , C07C215/38 , C07C217/74 , C07C231/18 , C07C303/40 , C07C2601/14 , C07F5/02 , C07F5/04 , C07C235/60 , C07C311/08 , C07C33/46 , C07C35/23
摘要： Prochiral ketones are enantioselectively reduced to chiral secondary alcohols with a compound having the formula I: 1 where, the two R2 groups are identical and are each a substituted or unsubstituted, aryl, alkyl, cycloalkyl or aralkyl group; and R3 is a hydrogen atom or a substituted or unsubstituted, alkyl, aryl, aralkyl or alkoxy group; wherein the substituents on the R2 and R3 groups are substantially non-reactive.
摘要翻译：将前手性酮与具有式I的化合物对映选择性地还原成手性仲醇：其中两个R 2基团相同并且各自为取代或未取代的芳基，烷基，环烷基或芳烷基; 且R 3为氢原子或取代或未取代的烷基，芳基，芳烷基或烷氧基; 其中R2和R3基团上的取代基基本上是非反应性的。

6. 发明申请

US20040147697A1 Boron-containing compound, ion-conductive polymer and polyelectrolyte for electrochemical devices 有权
标题翻译：含硼化合物，离子导电聚合物和用于电化学装置的聚电解质
公开(公告)号：US20040147697A1
公开(公告)日：2004-07-29
申请号：US10717645
申请日：2003-11-21
发明人： Takefumi Okumura , Shin Nishimura , Norio Iwayasu , Shoichi Yokoyama , Takeshi Yabe
IPC分类号： C08F130/06 , C07F005/04
CPC分类号： H01M10/0565 , C07F5/04 , C08F30/06 , C08G65/328 , C08G79/08 , H01B1/122 , H01M6/181 , H01M10/0525
摘要： An object of the present invention is to provide a boron-containing compound capable of forming an ion-conductive polyelectrolyte having high ion-conductive properties, and a polymer of said compound. According to the present invention, there are provided a polymerizable boron-containing compound of (formula 1), a polymer thereof, a polymer of a compound of (formula 2) and a compound of (formula 3), and a polyelectrolyte for electrochemical device comprising either of these polymers and at least one electrolyte salt: 1
摘要翻译：本发明的目的是提供一种能够形成具有高离子传导性的离子传导性聚电解质的含硼化合物和所述化合物的聚合物。根据本发明，提供了（式1）的聚合性含硼化合物，其聚合物，（式2）化合物和（式3）化合物的聚合物和电化学装置用聚电解质包括这些聚合物中的任一种和至少一种电解质盐：

7. 发明申请

US20040063986A1 Boron chelate complexes 审中-公开
标题翻译：硼螯合物
公开(公告)号：US20040063986A1
公开(公告)日：2004-04-01
申请号：US10467220
申请日：2003-09-23
发明人： Ulrich Wietelmann , Uwe Lischka , Klaus Schade , Jan-Christoph Panitz
IPC分类号： C07F005/04
CPC分类号： H01M10/0525 , C07F5/022 , C07F5/04 , H01G11/06 , H01G11/58 , H01M10/0568 , Y02E60/13
摘要： Boron chelate complexes of the general formula 1 are described, where X is either nullC(R1R2)null or nullC(R1R2)nullC(nullO)null, in which R1, R2 independently of one another denote H, alkyl (with 1 to 5 C atoms), aryl, silyl or a polymer, and one of the alkyl radicals R1 or R2 may be bonded to a further chelatoborate radical, or X denotes 1,2-aryl with up to two substituents S in the positions 3 to 6 2 in which S1, S2 independently of one another denote alkyl (with 1 to 5 C atoms), fluorine or a polymer, as well as Mnull denotes Linull, Nanull, Knull, Rbnull, Csnull or null(R3R4R5R6)Nnullnull or Hnull, where R3, R4, R5, R6 independently of one another denote H or alkyl with preferably 1 to 4 C atoms.
摘要翻译：描述了通式的硼螯合物，其中X是-C（R 1 R 2） - 或-C（R 1 R 2）-C（= O） - ，其中 R 1，R 2彼此独立地表示H，烷基（具有1至5个C原子），芳基，甲硅烷基或聚合物，并且烷基R 1或R 2之一可以是键合到另一个螯合硼酸根基团，或X表示在3至6位上具有至多两个取代基S的1,2-芳基，其中S 1，S 2彼此独立地表示烷基（具有1至5个碳原子原子），氟或聚合物，以及M +表示Li +，Na +，K +，Rb +，Cs +或[（R 3 R 4）其中R 3，R 4，R 5，R 6彼此独立地表示H或烷基，其中R 3，R 5，R 5，优选1至4个C原子。

8. 发明申请

US20040048992A1 Process for preparation of salt-like chemical compound, and its use in catalyst systems for preparing polyolefins 失效
标题翻译：盐类化合物的制备方法及其在制备聚烯烃的催化剂体系中的应用
公开(公告)号：US20040048992A1
公开(公告)日：2004-03-11
申请号：US10659163
申请日：2003-09-10
发明人： Jorg Schottek , Gerhard Erker , Gerald Kehr
IPC分类号： C08F004/44 , C07F005/02 , C07F005/04
CPC分类号： C08F10/00 , C07F5/027 , C08F4/65912 , C08F4/65916 , C08F4/65922 , C08F110/02 , C08F110/06 , Y10S526/943 , C08F4/61908 , C08F4/65908 , C08F4/603 , C08F2500/15
摘要： A salt-like chemical compound of the formula (I), (C6R15)3MR2nullnull(I) where R1 are identical or different and are each a hydrogen atom, a halogen atom, C1-C20-alkyl, C6-C14-aryl, C1-C10-alkoxy, C2-C10-alkenyl, C7-C20-arylalkyl, C7-C20-alkylaryl, C6-C10-aryloxy, C1-C10-haloalkyl, C6-C10-haloaryl, C2-C10-alkynyl or C3-C20-alkylsilyl, M is an element of main group III of the Periodic Table of the Elements, and R2 is a substituted or unsubstituted heterocycle, can be used in catalyst systems for preparing polyolefins.
摘要翻译：式（I）的盐状化合物，（C 6 R 15）3 R 2（I）其中R 1相同或不同，各自为氢原子，卤素原子，C 1 -C 20 - 烷基，C 6 -C 10 - 芳基，C 1 -C 10 - 烷氧基，C 2 -C 10 - 烯基，C 7 -C 20 - 芳基烷基，C 7 -C 20 - 烷基芳基，C 6 -C 10 - 芳氧基，C 1 -C 10 - ，C 2 -C 10炔基或C 3 -C 20烷基甲硅烷基，M是元素周期表的主要III族元素，R 2是取代或未取代的杂环，可用于制备聚烯烃的催化剂体系。

9. 发明申请

US20020072620A1 Processes for the purification of tocopherol and/or sterol compounds and compositions containing orthoborate ester mixtures 有权
标题翻译：纯化生育酚和/或固醇化合物和含有原硼酸酯混合物的组合物的方法
公开(公告)号：US20020072620A1
公开(公告)日：2002-06-13
申请号：US09922208
申请日：2001-08-03
发明人： Patrick M. McCurry JR. , Stephen W. Turner , Carl Pickens , Jan R. Varvil
IPC分类号： C07J009/00 , C07D311/76 , C07F005/04
CPC分类号： C07D311/72
摘要： Processes for purifying compounds are disclosed which include reacting (i) a mixture of at least one tocopherol compound or sterol compound, and an alcohol having from about 10 to 30 carbons with (ii) one or more boron-containing compounds to form a second mixture of orthoborate esters, wherein the mole ratio of tocopherol, sterol and alcohol to boron is at least about 2.5:1; heating the second mixture to form a residue containing the orthoborate esters; contacting the residue with a compound capable of solvolyzing the orthoborate esters to form a third mixture including the boron-containing compound(s), the alcohol and the tocopherol and/or sterol compound(s); and recovering the tocopherol and/or sterol compound(s). Another process for purifying such compounds includes an activated carbon treatment, which may alternatively follow the other process steps; formation of borate esters; heating to remove low boiling point components; formation of a residue comprising the borate esters; contacting the residue with a compound capable of solvolyzing the borate esters; and separation of the remaining components. Compositions including mixtures of alkyl/tocopherol/sterol orthoborate esters are also disclosed.
摘要翻译：公开了用于纯化化合物的方法，其包括使（i）至少一种生育酚化合物或固醇化合物的混合物和具有约10至30个碳的醇与（ii）一种或多种含硼化合物反应以形成第二混合物的正硼酸酯，其中生育酚，固醇和醇与硼的摩尔比为至少约2.5:1; 加热第二混合物以形成含有原硼酸酯的残余物; 使残余物与能够使原硼酸酯溶剂化的化合物接触以形成包含含硼化合物，醇和生育酚和/或固醇化合物的第三混合物; 并回收生育酚和/或固醇化合物。净化这些化合物的另一种方法包括活性炭处理，其可以替代地遵循其它工艺步骤; 形成硼酸酯; 加热去除低沸点组分; 形成含有硼酸酯的残渣; 使残余物与能够溶解硼酸酯的化合物接触; 并分离其余组分。还公开了包括烷基/生育酚/正硼酸甾醇酯的混合物的组合物。

10. 发明申请

US20040235793A1 Benzoylcyclohexenone derivatives 失效
标题翻译：苯甲酰环己烯酮衍生物
公开(公告)号：US20040235793A1
公开(公告)日：2004-11-25
申请号：US10485922
申请日：2004-02-05
发明人： Wolfgang Von Deyn , Ernst Baumann , Michael Hofmann , Markus Kordes , Ulf Misslitz , Liliana Parra Rapado , Cyrill Zagar , Matthias Witschel , Andreas Landes
IPC分类号： A61K031/69 , C07F005/04
CPC分类号： C07D231/12 , A01N41/10 , C07C317/24 , C07C323/32 , C07C323/65 , C07C2601/16 , C07D233/56 , C07D249/08
摘要： Benzoylcyclohexenone derivatives of the formula I 1 in which the variables R1 to R10 and n are as defined in claim 1, and their salts, and their use for controlling harmful plants are described.
摘要翻译：描述了其中变量R 1至R 10和n如权利要求1中所定义的式I的苯甲酰基环己烯酮衍生物及其盐及其用于防治有害植物的用途。

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