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1. 发明授权

US4064173A 9,10-Seco-steroids 失效
标题翻译： 9,10-类固醇
公开(公告)号：US4064173A
公开(公告)日：1977-12-20
申请号：US651763
申请日：1976-01-23
申请人： Jean-Marie Cassal , Andor Furst , Werner Meier
发明人： Jean-Marie Cassal , Andor Furst , Werner Meier
IPC分类号： C07C401/00 , C07C49/27
CPC分类号： C07C205/45 , C07C2102/24
摘要： A process for the preparation of 9,10-seco-steroids of the formula ##STR1## WHEREIN R.sup.1 and R.sup.2 independently are hydrogen, amino, OR.sup.5, OCOR.sup.6 or NHCOR.sup.5 wherein R.sup.5 is hydrogen or lower alkyl and R.sup.6 is lower alkyl or phenyl; R.sup.3 is lower alkyl; R.sup.4 is oxo, ##STR2## wherein R.sup.13 is lower alkyl, lower alkoxy -- lower alkylene, tetrahydropyranyl or tetrahydrofuryl, R.sup.14 is lower alkyl or aryl and R.sup.15 and R.sup.16 are lower alkyl or taken together form lower alkylene or arylene, and n is 1 or 2 is disclosed. The 9,10-seco-steroids of this invention are useful intermediates for the preparation of steroids.
摘要翻译：其中R 1和R 2独立地为氢，氨基，OR 5，OCOR 6或NHCOR 5，其中R 5为氢或低级烷基且R 6为低级烷基或苯基; R3是低级烷基; R4是氧代，其中R13是低级烷基，低级烷氧基 - 低级亚烷基，四氢吡喃基或四氢呋喃基，R14是低级烷基或芳基，R15和R16是低级烷基或一起形成低级亚烷基或亚芳基，n是1或 2。本发明的9,10-秒类固醇是制备类固醇的有用中间体。

2. 发明授权

US3786099A Process for the preparation of cyclodecanone 失效
标题翻译： CYCLODECANONE的制备方法
公开(公告)号：US3786099A
公开(公告)日：1974-01-15
申请号：US3786099D
申请日：1967-11-20
申请人： GEIGY AG J R
发明人： HOWELL F
IPC分类号： C07C29/17 , C07C45/67 , C07C51/31 , C07C49/27
CPC分类号： C10M3/00 , C07C29/175 , C07C45/673 , C07C51/316 , C07C2601/18 , C10M2207/282 , C10M2207/34 , C10N2230/08 , C10N2240/12 , C10N2240/121 , C07C35/205 , C07C49/413 , C07C55/20
摘要： CYCLODECANONE IS PRODUCED BY CATALYTIC HYDROGENATION OF 6-HYDROXY CYCLODECANONE, AND IS CONVERTED TO EBACIC ACID. THE LATTER CAN ALSO BE PRODUCED BY OXIDATION OF MIXTURES OF CYCLODECANONE AND CYCLODECANO,L, OR CYCLODECANOL ALONE. INDUCEMENT AND CONTROL OF EXOTHERMIC REACTION DURING THE CONVERTION TO EBACIC ACID ARE DESCRIBED.

3. 发明授权

US3560571A Novel photochemical reaction of 4-caranone and novel reaction products resulting therefrom 失效
标题翻译：四卡因和新型反应产物的新型光化学反应
公开(公告)号：US3560571A
公开(公告)日：1971-02-02
申请号：US3560571D
申请日：1967-05-29
申请人： PROCTER & GAMBLE
发明人： KROPP PAUL J
IPC分类号： C07C45/29 , C07C45/58 , C07C45/67 , C07C45/85 , C07C49/647 , C07D303/04 , C11B9/00 , C07C49/27 , C07C49/28
CPC分类号： C11B9/003 , C07C45/292 , C07C45/58 , C07C45/67 , C07C45/85 , C07C49/647 , C07D303/04 , C11B9/0026
摘要： PHOTOCHEMICAL REACTION OF 4-CARANONE TO OBTAIN THE NOVEL COMPOUNDS, 2-(2''METHYL-2''-BUT-3''-ENYL)-4-METHYLCYCLOBUTANONE AND 2,2,5-TRIMETHYL-3-VINYLCYCLOPENTANONE, AND THE PROCESS OF CONVERTING 3-CARENE TO 4-CARANONE BY EPOXIDIZING 3-CARENE AND, SUBSEQUENTLY, TREATING THAT PRODUCT WITH A LEWIS ACID CATALYST.

4. 发明授权

US4062878A Preparation of novel keto-esters 失效
标题翻译：新型酮酯的制备
公开(公告)号：US4062878A
公开(公告)日：1977-12-13
申请号：US723720
申请日：1976-09-16
申请人： Pierre Pesnelle , Paul Jose Teisseire
发明人： Pierre Pesnelle , Paul Jose Teisseire
IPC分类号： C07C43/196 , C07C43/215 , C07C43/23 , C07C49/27 , C07C49/76 , C09B11/06
CPC分类号： C07C43/215 , C07C43/196 , C07C43/23
摘要： Novel keto-esters which are represented by the general formula ##STR1## wherein R.sup.1 represents methyl or benzyl, and X represents hydroxy, trityloxy, tosyloxy or halogen, and process for the preparation of said keto-esters.
摘要翻译：由通式A表示的新型酮酯，其中R1表示甲基或苄基，X表示羟基，三苯甲基氧基，甲苯磺酰氧基或卤素，以及制备所述酮酯的方法。

5. 发明授权

US3927031A Stereospecific total steroidal synthesis via substituted C/D-trans indanones 失效
标题翻译：通过取代的C / D反式茚满酮进行立体特异性总体甾体合成
公开(公告)号：US3927031A
公开(公告)日：1975-12-16
申请号：US48271474
申请日：1974-06-24
申请人： HOFFMANN LA ROCHE
发明人： HAJOS ZOLTAN GEORGE
IPC分类号： C07C62/26 , C07C62/38 , C07C49/27 , C07D317/26
CPC分类号： C07C49/523 , C07C62/26 , C07C62/38 , C07C205/43 , C07C2603/16
摘要： Total synthesis of known progestationally active steroidal materials. The steroids can be synthesized depending on the particular starting reactants selected by employing as intermediates bicyclic compounds of the formula
and lower alkyl; R7 is lower alkyl; R15 is selected from the group consisting of oxo, lower alkylenedioxy or (hydrogen and lower alkoxy); B is selected from the group consisting of lower alkoxy-carbonyl-methylene, lower-aryloxy-carbonyl-methylene, cyanomethylene, lower alkyl sulfinyl-methylene, lower alkyl sulfonyl-methylene, and R25 and R26 are independently selected from the group consisting of hydrogen, hydroxyl and lower alkyl.

wherein R6 is selected from the group

WHEREIN M IS AN INTEGER HAVING A VALUE OF 1 OR 2; R4 is hydrogen or lower alkyl;; Z is lower alkylenedioxymethylene, CH(OR2) and carbonyl; R8 when taken alone is hydrogen; R9 when taken alone is lower alkoxycarbonyl, aryloxy-carbonyl, lower cycloalkyloxycarbonyl, carbonyl-halide, hydrogen, carboxy, formyl and methylene-X, where X is a leaving group and when taken together are methylene; with the proviso that when Z is carbonyl R8 when taken alone is hydrogen; R9 when taken alone is carbonyl halide, hydrogen, carboxy, formyl and methylene-X where X is a leaving group and when taken together are methylene and R2 is hydrogen, lower alkyl, lower alkoxy-lower alkyl, phenyllower alkyl, tetrahydropyranyl, lower alkanoyl, benzoyl, nitrobenzoyl, carboxy-lower alkanoyl, carboxybenzoyl, trifluoroacetyl and camphorsulfonyl AND REACTING THEM IN THE CASE WHERE R8 and R9 taken together are methylene or R8 is hydrogen and R9 is methylene-X with Beta keto esters and other analogs of the formula

D R A W I N G
摘要翻译：已知的促孕活性甾体材料的全合成。可以根据通过使用作为中间体选择的特定起始反应物来合成类固醇，其具有下式的双环化合物，其中M是具有1或2的值的整数; R4是氢或低级烷基; Z是低级亚烷基二氧基亚甲基，CH（OR 2）和羰基; 单独使用时为R8; 当单独使用时，R 9为低级烷氧基羰基，芳氧基羰基，低级环烷氧基羰基，羰基卤化物，氢，羧基，甲酰基和亚甲基-X，其中X为离去基团，并且一起为亚甲基时; 条件是当Z为羰基时，当单独使用时为氢; 当单独使用时，R 9是卤素，氢，羧基，甲酰基和亚甲基-X，其中X是离去基团，当它们一起是亚甲基且R 2是氢时，低级烷基，低级烷氧基 - 低级烷基，苯基 - 低级烷基，四氢吡喃基，低级烷酰基，苯甲酰基，硝基苯甲酰基，羧基 - 低级烷酰基，羧基苯甲酰基，三氟乙酰基和樟脑磺酰，并在其中反应。其中R8和R9一起为亚甲基或R8为氢，R9为亚甲基-X，带有β-酮酯和其他类似物式O-PARALLEL R6-CBV其中R6选自基团R26R25 || R7-C-CH-CH2-PAR-PARALLELR15和低级烷基; R7是低级烷基; R 15选自氧代，低级亚烷基二氧基或（氢和低级烷氧基）; B选自低级烷氧基 - 羰基 - 亚甲基，低级 - 芳氧基 - 羰基 - 亚甲基，氰基亚甲基，低级烷基亚磺酰基 - 亚甲基，低级烷基磺酰基 - 亚甲基，R 25和R 26独立地选自氢，羟基和低级烷基。

6. 发明授权

US3821307A Bicyclic ketones having biological activity 失效
标题翻译：具有生物活性的双系克隆
公开(公告)号：US3821307A
公开(公告)日：1974-06-28
申请号：US13925471
申请日：1971-04-30
申请人： HOOKER CHEMICAL CORP
发明人： HOCH P
IPC分类号： C07D307/93 , C07C49/27 , C07C49/80
CPC分类号： C07C49/477 , C07C49/513 , C07C49/517 , C07C49/693 , C07C49/697 , C07C49/753 , C07D307/93
摘要： Bicyclic ketones of the formula

WHEREIN R1, R2, R3, R4, X1, X2, X3, X4 and X5 are certain substituents selected from hydrogen, halogen, alkyl, alkenyl, halogenated alkyl, halogenated alkenyl, alkoxy, hydrocarbyl, halogen-substituted hydrocarbyl, carboxy, hydroxy-substituted alkyl, alkoxy-substituted alkyl, and hydroxy-substituted alkoxyalkyl, with at least two of X1, X2, X3 and X4 being halogen, and X6 is halogen. The bicyclic ketones are made by treating a corresponding tricyclic hemiketal with phosphorus halide and hydrolyzing. The bicyclic ketones are useful as chemical intermediates and as insecticides.

7. 发明授权

US3655766A Phosphoranylidene substituted cyclic compounds 失效
标题翻译：磷酸二苯酯取代的环状化合物
公开(公告)号：US3655766A
公开(公告)日：1972-04-11
申请号：US3655766D
申请日：1968-06-07
申请人： MONSANTO CO
发明人： BIRUM GAIL H , MATTHEWS CLIFFORD N
IPC分类号： A01N57/18 , C07F9/535 , C08K5/50 , D06M13/285 , C07C49/27
CPC分类号： A01N57/18 , C07F9/5352 , C08K5/50 , D06M13/285
摘要： STABLE, YLIDE-SUBSITUTED 1,3-CYCLOBUTANEDIONES ARE SYNTHESIZED FROM TRIORGANOPHOSPHORANYLIDENEKETONE AND ALDEHYDES OR ACTIVE KETONES. ANALOGOUS ADDUCTS ARE FORMED FROM TRIOGANOPHOSPHORANYLIDENEKETENE AND KETENS IN A ONE-STEP REACTION. IN CONTRAST TO THE ABOVE REACTIONS YIELDING SUBSTITUED 1,3-CYCLOBUTANDIONES, REACTION OF ARYL ISOCYANATES WITH TRIOGANOPHOSPHORANYLIDENEKETENE RESULTS IN 2:1 ADDUCTS HAVING SIX-MEMBERED RING STRUCTURES. THE NEW COMPOUNDS ARE USEFUL AS FIRE RETARDANTS, BIOLOGICAL TOXICANTS, PLASTICIZER, TEXTILE TREATING AGENTS AND LUBRICANT ADDITIVES.

8. 发明授权

US4291176A Production of insecticidally active vinyl-cyclopropane carboxylic acid esters 失效
标题翻译：杀虫活性乙烯基 - 环丙烷羧酸酯的生产
公开(公告)号：US4291176A
公开(公告)日：1981-09-22
申请号：US827514
申请日：1977-08-24
申请人： Hans-Georg Heine , Willy Hartmann
发明人： Hans-Georg Heine , Willy Hartmann
IPC分类号： C07C69/743 , A01N53/00 , A01N53/10 , C07C45/00 , C07C45/51 , C07C45/63 , C07C45/68 , C07C45/76 , C07C49/457 , C07C49/647 , C07C49/687 , C07C49/693 , C07C49/697 , C07C51/00 , C07C61/35 , C07C61/40 , C07C62/08 , C07C67/00 , C07C69/74 , C07C233/10 , C07C233/38 , C07C255/45 , C07C313/00 , C07C317/44 , C07C49/27 , C07C49/45 , C07C49/533 , C07C49/54 , C07C49/80
CPC分类号： C07C255/31 , A01N53/00 , C07C45/00 , C07C45/516 , C07C45/63 , C07C45/68 , C07C45/76 , C07C49/687 , C07C49/693 , C07C49/697 , C07C51/00 , C07C61/40 , C07C62/08 , C07C67/42 , C07C2101/02 , C07C2101/04 , C07C2101/14 , C07C2102/50
摘要： Insecticidally active vinyl-cyclopropane carboxylic acid esters of the formula ##STR1## are prepared by reacting ##STR2## in which R.sup.12 is a radical selected from the group consisting of ##STR3## with an alcoholate of the formulaM--O--R.sup.8.Various processes for making the intermediates are also described. Many of the intermediates and end products are new.
摘要翻译：式（I）的杀虫活性乙烯基 - 环丙烷羧酸酯通过使其中R12是选自下列基团的基团与式M-O-R8的醇化物反应的“IMAGE”制备。还描述了制备中间体的各种方法。许多中间体和最终产品都是新的。

9. 发明授权

US3681464A Saturated indane derivatives and processes for producing same 失效
标题翻译：饱和吲哚衍生物及其生产方法
公开(公告)号：US3681464A
公开(公告)日：1972-08-01
申请号：US3681464D
申请日：1969-08-18
申请人： INT FLAVORS & FRAGRANCES INC
发明人： THEIMER ERNST T
IPC分类号： C07C1/24 , C07C5/11 , C07C13/465 , C07C29/00 , C07C29/09 , C07C29/132 , C07C29/19 , C07C35/32 , C07C37/04 , C07C45/28 , C07C45/51 , C07C49/443 , C07C49/633 , C07D303/04 , C07D303/32 , C09B9/00 , C11B9/00 , C11D3/50 , C11D9/44 , C07C49/27
CPC分类号： C11D3/0084 , C07C1/24 , C07C5/11 , C07C13/465 , C07C29/00 , C07C29/095 , C07C29/132 , C07C29/19 , C07C35/32 , C07C37/04 , C07C45/28 , C07C45/513 , C07C49/443 , C07C49/633 , C07C2602/08 , C07D303/04 , C07D303/32 , C09B9/00 , C11B9/0049 , C11B9/0076 , C11D3/50 , C11D9/442 , Y10S424/01 , Y10S424/02 , C07C13/48 , C07C39/17
摘要： Saturated indane derivatives having the formula WHEREIN R is a carbonyl oxygen, a hydroxy group, an acyloxy group, or an alkyloxy group; perfume compositions containing such indane derivatives; and process for producing same.

10. 发明授权

US3627833A Preparation of dihydroresorcinol 失效
标题翻译：二氢硬脂醇的制备
公开(公告)号：US3627833A
公开(公告)日：1971-12-14
申请号：US3627833D
申请日：1968-07-05
申请人： MOBIL OIL CORP
发明人： TOBIAS MICHAEL A
IPC分类号： C07C37/07 , C07C45/58 , C07C49/27 , C07C45/00
CPC分类号： C07C37/07 , C07C45/58 , C07C49/403 , C07C39/15
摘要： 2,3-Epoxycyclohexanone is rearranged thermally to dihydroresorcinol. Dehydrogenation of dihydroresorcinol produces resorcinol.

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