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1. 发明授权

US09738595B2 Carboxamide compounds 有权
公开(公告)号：US09738595B2
公开(公告)日：2017-08-22
申请号：US14770557
申请日：2014-01-31
申请人： SYNGENTA PARTICIPATIONS AG
发明人： Andre Jeanguenat , Olivier Loiseleur , Jerome Yves Cassayre , Anthony Cornelius O'Sullivan
IPC分类号： C07C233/76 , C07D213/61 , A01N37/18 , A01N43/40 , C07D263/38 , C07C255/48 , C07C271/24 , C07C323/62 , C07C233/87 , C07C235/46 , A01C1/06 , A01N25/00 , A01N43/54 , C07D213/50 , C07D239/28
CPC分类号： C07C233/76 , A01C1/06 , A01N25/00 , A01N37/18 , A01N43/40 , A01N43/54 , C07C233/87 , C07C235/46 , C07C255/48 , C07C271/24 , C07C323/62 , C07C2601/02 , C07D213/50 , C07D213/61 , C07D239/28 , C07D263/38
摘要： Compounds of the formula (I), in which the substituents are as defined in claim 1, are suitable for use as nematicides.

2. 发明授权

US4263319A 4-Substituted-2-indanol insecticidal ester derivatives 失效
标题翻译： 4-取代的2-茚满醇杀虫酯衍生物
公开(公告)号：US4263319A
公开(公告)日：1981-04-21
申请号：US42372
申请日：1979-05-24
申请人： John F. Engel
发明人： John F. Engel
IPC分类号： C07C323/19 , A01N37/10 , A01N53/00 , A01N53/02 , A01N53/04 , A01N53/10 , A01P7/04 , C07C17/26 , C07C29/52 , C07C35/32 , C07C57/38 , C07C61/40 , C07C67/00 , C07C67/303 , C07C69/743 , C07C201/00 , C07C255/19 , C07C255/39 , C07C255/48 , C07C255/55 , C07C317/22 , C07D307/45 , C07D333/04 , C07F9/54 , C07C61/04 , C07C61/13
CPC分类号： C07C61/40 , A01N37/10 , A01N53/00 , C07C17/2635 , C07C29/143 , C07C29/52 , C07C35/32 , C07C57/38 , C07F9/5442 , C07C2102/08
摘要： Novel compounds of the formula ##STR1## are disclosed in which R.sup.1 is a phenyl, phenoxy, phenylthio, benzyl or heterocyclic radical which may be substituted, and R.sup.2 is hydrogen, a substituted-vinylcyclopropanecarbonyl group, a tetramethylcyclopropanecarbonyl group, or a 1-(substituted-phenyl)-2-methylpropylcarbonyl group. The compounds wherein R.sup.2 is other than hydrogen are insecticides.
摘要翻译：公开了新的式“IMAGE”化合物，其中R 1是可被取代的苯基，苯氧基，苯硫基，苄基或杂环基，R2是氢，取代的乙烯基环丙烷羰基，四甲基环丙烷羰基或1-（取代的苯基）-2-甲基丙基羰基。其中R2不是氢的化合物是杀虫剂。

3. 发明授权

US11180461B2 Triazoles as Kv3 inhibitors 有权
公开(公告)号：US11180461B2
公开(公告)日：2021-11-23
申请号：US16785083
申请日：2020-02-07
申请人： AUTIFONY THERAPEUTICS LIMITED
发明人： Agostino Marasco , Giuseppe Alvaro , Anne Dècor , Dieter Hamprecht , Paolo Dambruoso , Simona Tommasi
IPC分类号： C07D405/14 , C07D249/12 , C07D307/94 , C07D311/04 , C07D311/76 , C07D311/96 , C07D401/04 , C07D307/87 , C07C43/313 , C07C255/46 , C07C43/29 , C07C255/37 , C07C43/225 , C07C255/48 , C07D405/04
摘要： Compounds of formula (I) are of use in the modulation of Kv3.1, Kv.3.2 and Kv3.3 channels and have utility in the treatment or prevention of related disorders.

4. 发明授权

US4424166A Preparation of 1,1-dihalogeno-alkenes 失效
标题翻译：制备1,1-二卤代烯烃
公开(公告)号：US4424166A
公开(公告)日：1984-01-03
申请号：US237005
申请日：1981-02-23
申请人： Fritz Maurer , Uwe Priesnitz , Hans-Jochem Riebel
发明人： Fritz Maurer , Uwe Priesnitz , Hans-Jochem Riebel
IPC分类号： C07C69/743 , C07C17/00 , C07C17/26 , C07C17/263 , C07C21/02 , C07C21/17 , C07C22/00 , C07C22/02 , C07C22/04 , C07C22/08 , C07C45/00 , C07C49/567 , C07C51/00 , C07C61/40 , C07C67/00 , C07C231/00 , C07C231/12 , C07C233/38 , C07C253/00 , C07C255/48 , C07C121/48 , C07C61/35 , C07C121/66
CPC分类号： C07C17/263
摘要： In the preparation of a 1,1-dihalogenoalkene of the formula ##STR1## in which R.sup.1 is a hydrogen atom or an optionally substituted alkyl, alkenyl, alkynyl, cycloalkyl, aralkyl, aralkenyl or aryl radical, and R.sup.2 is an optionally substituted alkyl, alkenyl, alkynyl, cycloalkyl, aralkyl, aralkenyl or aryl radical, or R.sup.1 and R.sup.2 together form an optionally branched and/or optionally benzo-fused hydrocarbon chain, and X.sup.1 and X.sup.2 each independently is a halogen atom, wherein a carbonyl compound of the formula ##STR2## is reacted with a trihalogenoacetate of the formula ##STR3## in which X.sup.3 is a halogen atom, and M.sup..sym. is an alkali metal ion or one equivalent of an alkaline earth metal ion, in the presence of an approximately equimolar amount of a phosphorus-containing compound, the improvement which comprises employing as said phosphorus-containing compound a phosphorous acid trialkyl ester or a phosphorous acid triamide and effecting the reaction at a temperature between about 0.degree. and 200.degree. C. A preferred end product is ##STR4## and the preferred phosphorus-containing compound is trimethyl phosphite, triethyl phosphite, tripropyl phosphite or phosphorous acid tris-dimethyl-amide.
摘要翻译：在制备其中R 1为氢原子或任选取代的烷基，烯基，炔基，环烷基，芳烷基，芳烯基或芳基的式“IMAGE”的1,1-二卤代烯烃中，R 2为任选取代的烷基，烯基，炔基，环烷基，芳烷基，芳烯基或芳基，或R 1和R 2一起形成任选支链和/或任选的苯并稠合烃链，并且X 1和X 2各自独立地为卤素原子，其中式与式（X3）中的X为卤素原子的式（III）的三卤代乙酸酯反应，M（+）为碱金属离子或1当量碱土金属离子，在大约等摩尔量存在下的含磷化合物，其改进包括使用磷酸三烷基酯或亚磷酸三酰胺作为所述含磷化合物，并在约0℃至200℃的温度下进行反应。优选的最终产物是“IMAGE”，优选的含磷化合物是亚磷酸三甲酯，亚磷酸三乙酯，亚磷酸三丙酯或亚磷酸三 - 二甲基 - 酰胺。

5. 发明授权

US4342704A Process for the preparation of 1,1-dichloroalkenes 失效
标题翻译：制备1,1-二氯烯烃的方法
公开(公告)号：US4342704A
公开(公告)日：1982-08-03
申请号：US165872
申请日：1980-07-02
申请人： Hellmut Hoffmann , Fritz Maurer , Uwe Priesnitz , Hans-Jochem Riebel
发明人： Hellmut Hoffmann , Fritz Maurer , Uwe Priesnitz , Hans-Jochem Riebel
IPC分类号： C07C17/263 , C07B31/00 , C07B37/04 , C07C17/00 , C07C17/26 , C07C21/19 , C07C22/00 , C07C22/04 , C07C25/28 , C07C45/00 , C07C45/41 , C07C45/54 , C07C45/68 , C07C49/355 , C07C49/557 , C07C62/18 , C07C67/00 , C07C253/00 , C07C255/48 , C07F9/40 , C07F9/42 , C07C120/00 , C07C45/61 , C07C102/00 , C07C121/48
CPC分类号： C07C17/2635 , C07C21/19 , C07C22/00 , C07C22/04 , C07C25/28 , C07C45/41 , C07C45/54 , C07C45/68 , C07C49/355 , C07C62/18 , C07F9/4006 , C07F9/4018 , C07F9/4065 , C07F9/42
摘要： A process for the preparation of a 1,1-dichloroalkene of the formula ##STR1## in which R.sup.1 is hydrogen or an optionally substituted alkyl, alkenyl, alkynyl, aralkyl or aryl radical, andR.sup.2 is an optionally substituted alkyl, alkenyl, alkynyl, aralkyl, aralkenyl or aryl radical, or cycloalkyl which is optionally substituted by halogen, alkyl, alkanoyl, carbamoyl, cyano or phenyl, orR.sup.1 and R.sup.2 together form a hydrocarbon chain which is optionally branched and/or optionally contains a fused benzene ring,comprising reacting an aldehyde or ketone of the formula ##STR2## with a dichloromethane-phosphonic acid ester of the formula ##STR3## in which R.sup.3 each independently is alkyl or phenyl or the two radicals R.sup.3 together are alkanediyl,in the presence of a base at a temperature between about -50.degree. and +50.degree. C. Preferably either the base is metered into a mixture of the aldehyde or ketone and phosphonic acid ester or the ester is added to a mixture of the base and aldehyde or ketone.
摘要翻译：制备式“IMAGE”的1,1-二氯烯烃的方法，其中R 1为氢或任选取代的烷基，烯基，炔基，芳烷基或芳基，R 2为任选取代的烷基，烯基，炔基，芳烷基，芳烯基或芳基，或任选被卤素，烷基，烷酰基，氨基甲酰基，氰基或苯基取代的环烷基，或R 1和R 2一起形成任选支链和/或任选地含有稠合苯环的烃链，包括使式“IMAGE”的醛或酮与式“IMAGE”的二氯甲烷 - 膦酸酯反应，其中R 3各自独立地为烷基或苯基，或两个基团R 3一起为烷二基，在碱的存在下，温度在约-50℃和+ 50℃之间。优选地将碱定量为醛或酮和膦酸酯的混合物，或将酯加入到碱和醛或酮的混合物中。

6. 发明授权

US4330482A Process for the preparation of halogenoalkenes 失效
标题翻译：卤代烯烃的制备方法
公开(公告)号：US4330482A
公开(公告)日：1982-05-18
申请号：US218394
申请日：1980-12-18
申请人： Hellmut Hoffmann
发明人： Hellmut Hoffmann
IPC分类号： C07C69/743 , C07B31/00 , C07B37/04 , C07C17/00 , C07C17/263 , C07C45/00 , C07C45/68 , C07C49/567 , C07C67/00 , C07C253/00 , C07C255/06 , C07C255/48 , C07F9/38 , C07F9/40 , C07C21/19 , C07C121/48
CPC分类号： C07F9/4065 , C07C45/68 , C07C49/567 , C07F9/4018 , C07F9/4056
摘要： In the process for the production of a halogenoalkene of the formula ##STR1## in which R.sup.1 is an optionally substituted alkyl, alkenyl, alkinyl, cycloalkyl, cycloalkenyl, aralkyl, aralkenyl or aryl radical or an optionally substituted heterocyclic radical,R.sup.2 represents a halogen atom, a cyano group, an optionally substituted alkyl, alkenyl, alkinyl, cycloalkyl, aralkenyl, aryl, alkylcarbonyl, arylcarbonyl, alkoxycarbonyl or aminocarbonyl radical or an optionally substituted heterocyclic radical, andX is a halogen atom,in which an .alpha.-hydroxy-phosphonic acid ester of the formula ##STR2## in which R.sup.3 each independently is an alkyl or phenyl radical, or the two radicals R.sup.3 together are an alkanediyl (alkylene) radical,is reacted with a phosphorus-containing olefinating agent of the formula ##STR3## in which Z.sup.1 is the phosphorus-containing radical ##STR4## R.sup.4 and R.sup.5 each independently is an alkyl, phenyl, alkoxy or phenoxy radical or together are an alkanedioxy radical, andR.sup.6 is an alkyl or phenyl radical,in the presence of a base at a temperature between about -70.degree. and +150.degree. C., the improvement which comprises effecting the reaction in the presence of a halogen carrier. The end products are useful as intermediates such as in synthesizing pyrethroid-like insecticides.
摘要翻译：在制备其中R 1为任选取代的烷基，烯基，炔基，环烷基，环烯基，芳烷基，芳烯基或芳基或任选取代的杂环基团的式IMAMA的卤代烯烃的方法中，R 2表示卤素原子，氰基，任选取代的烷基，烯基，炔基，环烷基，芳烯基，芳基，烷基羰基，芳基羰基，烷氧基羰基或氨基羰基或任选取代的杂环基，X是卤素原子，其中α-羟基膦酸其中R 3各自独立地是烷基或苯基，或者两个基团R 3一起是烷二基（亚烷基）基团的式“IMAGE”的酸酯与式“IMAGE”的含磷烯烃化合物在其中Z 1是含磷基团R 4和R 5各自独立地是烷基，苯基，烷氧基或苯氧基，或者一起是烷二氧基，R 6是烷基 1或苯基，在碱存在下，温度在约-70℃至+ 150℃之间，其改进包括在卤素载体存在下进行反应。最终产物可用作合成拟除虫菊酯类杀虫剂的中间体。

7. 发明授权

US4328169A Process for the preparation of vinylcyclopropane derivatives 失效
标题翻译：乙烯基环丙烷衍生物的制备方法
公开(公告)号：US4328169A
公开(公告)日：1982-05-04
申请号：US200750
申请日：1980-10-27
申请人： Allen L. Hall
发明人： Allen L. Hall
IPC分类号： C07C69/743 , B01J31/00 , B01J31/02 , B01J31/06 , C07B61/00 , C07C41/00 , C07C43/257 , C07C45/00 , C07C49/533 , C07C49/798 , C07C67/00 , C07C67/30 , C07C67/343 , C07C69/757 , C07C201/00 , C07C207/00 , C07C231/00 , C07C231/12 , C07C233/58 , C07C235/82 , C07C253/00 , C07C253/30 , C07C255/46 , C07C255/48 , C07C301/00 , C07C309/63 , C07C313/00 , C07C315/04 , C07C319/20 , C07C325/00 , C07C331/02 , C07C331/16 , C07F9/38 , C07F9/40 , C07F9/53 , C07C121/48 , C07C103/19
CPC分类号： C07C67/343
摘要： This invention provides a convenient and commercially adaptable process for the preparation of vinylcyclopropane derivatives in high yield. For the process an alkylating agent and activated methylene compound are reacted in the presence of an alkylene oxide derivative and alkali metal compound. Water can also be present and/or the reaction may be carried out in an inert organic diluent.
摘要翻译：本发明提供了以高产率制备乙烯基环丙烷衍生物的方便和商业上适应性的方法。对于该方法，烷基化剂和活化的亚甲基化合物在烯化氧衍生物和碱金属化合物的存在下反应。水也可以存在和/或反应可以在惰性有机稀释剂中进行。

8. 发明授权

US4284582A Process for the preparation of cyclopropane derivatives, intermediates in the synthesis of pyrethroid insecticides 失效
标题翻译：制备环丙烷衍生物的方法，中间体合成拟除虫菊酯类杀虫剂
公开(公告)号：US4284582A
公开(公告)日：1981-08-18
申请号：US177453
申请日：1980-08-12
申请人： Albert E. Kaye , Alan C. Tucker
发明人： Albert E. Kaye , Alan C. Tucker
IPC分类号： B01J23/00 , B01J27/00 , B01J31/00 , C07C67/00 , C07C253/00 , C07C255/45 , C07C255/48 , C07C120/00 , C07C121/48
CPC分类号： C07C255/45
摘要： Compounds of formula: ##STR1## wherein both groups X are chlorine, bromine or trifluoromethyl, or one X is chlorine or bromine and the other is trifluoromethyl, and Y is --CN or --COOR in which R is an alkyl group, are obtained by (A) reacting a compound of the formula: ##STR2## wherein X.sup.1 is chlorine or bromine, with a compound of the formula:X.sub.2 C.dbd.CH--CH.dbd.C(CH.sub.3).sub.2in the presence of metallic copper or at least one copper salt and a base, or (B) reacting a compound of the formula:Y--CH.sub.2 --CNwith a compound of the formula:X.sub.2 C.dbd.CH--CH.dbd.C(CH.sub.3).sub.2and chlorine or bromine, in the presence of at least one reducible copper salt and a base, or (C) reacting a compound of formula:X--CH.sub.2 --CNwith a compound of the formula: ##STR3## wherein X.sup.1 is chlorine or bromine, in the presence of at least one copper salt.The compounds are intermediates in the synthesis of pyrethroid insecticides.
摘要翻译：其中两个基团X为氯，溴或三氟甲基，或一个X为氯或溴，另一个为三氟甲基，Y为-CN或其中R为烷基的-COOR，分别为（A）在金属铜或至少一种铜盐的存在下使下式的化合物：其中X 1是氯或溴与下式的化合物：X2C = CH-CH = C（CH3）和（B）使下式化合物与下式化合物的反应：式中：X 2 C = CH-CH = C（CH 3）2和氯或溴的化合物在至少一种或者（C）在至少一种铜盐存在下使式：X-CH 2 -CN的化合物与下式的化合物：其中X 1是氯或溴反应。这些化合物是合成拟除虫菊酯杀虫剂的中间体。

9. 发明授权

US4252820A Arthropodicidal 2,2-dimethyl-3-(2-perfluoroalkyl-2-perhaloalkyl-vinyl)-cyclopropanecarbo xylic acid esters 失效
标题翻译：节肢动物节段性2,2-二甲基-3-（2-全氟烷基-2-全卤代烷基 - 乙烯基） - 环丙烷羧酸酯
公开(公告)号：US4252820A
公开(公告)日：1981-02-24
申请号：US53676
申请日：1979-07-02
申请人： Reinhard Lantzsch , Hermann Hagemann , Ingeborg Hammann , Wolfgang Behrenz , Bernhard Homeyer
发明人： Reinhard Lantzsch , Hermann Hagemann , Ingeborg Hammann , Wolfgang Behrenz , Bernhard Homeyer
IPC分类号： C07C69/747 , A01N53/00 , A01N53/02 , A01N53/04 , A01N53/06 , B01J31/00 , C07B61/00 , C07C45/69 , C07C49/16 , C07C51/09 , C07C51/60 , C07C67/00 , C07C253/00 , C07C255/10 , C07C255/39 , C07C255/48 , C07C313/00 , C07C319/20 , C07C323/19 , C07D209/49 , C07D307/45 , C07D333/32 , C07D333/34 , A01N37/08 , A01N37/34 , C07C69/743 , C07C121/48
CPC分类号： C07C51/09 , A01N53/00 , C07C45/69 , C07C49/16 , C07C51/60
摘要： 2,2-Dimethyl-3-(2'-perfluoroalkyl-2'-perhaloalkyl-vinyl)-cyclopropane of the formula ##STR1## in which R is --COOR.sup.2, --COOH, --CO--Halogen, --CN or --CO--CH.sub.3,R.sup.1 is fluorine or CF.sub.3,R.sup.3 is fluorine, chlorine, bromine or R.sup.1 CF.sub.2 --, andR.sup.2 is the radical of an alcoholwhich possess arthropodicidal properties. These compounds can be produced by adding a compound of the formula ##STR2## to an olefin of the formula ##STR3## to produce a compound of the formula ##STR4## and dehydrohalogenating said compound. This compound may be hydrolyzed, saponified or esterified, depending upon the particular derivative desired.
摘要翻译：其中R是-COOR 2，-COOH，-CO-卤素，-CN或-CO-的式“IMAGE”的2,2-二甲基-3-（2'-全氟烷基-2'-全卤代烷基 - 乙烯基） - 环丙烷， CH3，R1是氟或CF3，R3是氟，氯，溴或R1CF2-，R2是具有节肢动物特性的醇的基团。这些化合物可以通过将式“IMAGE”的化合物加入到下式的烯烃中以制备式“化合物”并将所述化合物脱卤化氢来制备。该化合物可以被水解，皂化或酯化，这取决于所需的具体衍生物。

10. 发明申请

US20200172496A1 TRIAZOLES AS KV3 INHIBITORS 审中-公开
公开(公告)号：US20200172496A1
公开(公告)日：2020-06-04
申请号：US16785083
申请日：2020-02-07
申请人： AUTIFONY THERAPEUTICS LIMITED
发明人： Agostino Marasco , Giuseppe Alvaro , Anne Dècor , Dieter Hamprecht , Paolo Dambruoso , Simona Tommasi
IPC分类号： C07D249/12 , C07D405/14 , C07D307/94 , C07D311/04 , C07D311/76 , C07D311/96 , C07D401/04 , C07D307/87 , C07C43/313 , C07C255/46 , C07C43/29 , C07C255/37 , C07C43/225 , C07C255/48
摘要： Compounds of formula (I) are of use in the modulation of Kv3.1, Kv.3.2 and Kv3.3 channels and have utility in the treatment or prevention of related disorders.

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