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1. 发明申请

US20220281804A1 CYCLIC DIONES AS HERBICIDAL COMPOUNDS 有权
公开(公告)号：US20220281804A1
公开(公告)日：2022-09-08
申请号：US17631052
申请日：2020-07-27
申请人： SYNGENTA CROP PROTECTION AG
发明人： Alan Joseph HENNESSY , Elizabeth Pearl JONES , Suzanna Jane DALE , Alexander William GREGORY , Ian Thomas Tinmouth HOULSBY , Yunas BHONOAH , Julia COMAS-BARCELO , Philip Michael ELVES
IPC分类号： C07C233/32 , C07C233/56 , C07C233/61 , C07C233/76 , C07C235/14 , C07C237/24 , C07C255/19 , C07C255/29 , C07C259/08 , C07C275/26 , C07C275/50 , C07C311/07 , C07C311/14 , C07D213/61 , C07D213/75 , C07D213/81 , C07D213/85 , C07D237/24 , C07D239/30 , C07D241/24 , C07D263/34 , C07D265/30 , C07D279/12 , C07D305/08 , C07D319/12 , A01N37/18 , A01N37/36 , A01N37/42 , A01N37/44 , A01N41/06 , A01N43/20 , A01N43/40 , A01N43/54 , A01N43/58 , A01N43/60 , A01N43/76 , A01N43/84 , A01N47/06
摘要： The present invention relates to compounds of Formula (I), wherein R1, R2, R3, R4x, R4y, m, n and G are as defined herein. The invention further relates to herbicidal compositions which comprise a compound of Formula (I), to their use for controlling weeds, in particular in crops of useful plants.

2. 发明申请

US20210332005A1 CH-ACIDIC METHACRYLIC ESTERS FOR THE PREPARATION OF AQUEOUS POLYMER DISPERSIONS 有权
公开(公告)号：US20210332005A1
公开(公告)日：2021-10-28
申请号：US17260223
申请日：2019-07-08
申请人： EVONIK OPERATIONS GMBH
发明人： Marcel TRESKOW , Maik CASPARI , Thorben SCHÜTZ , Steffen KRILL
IPC分类号： C07C255/19 , C08F220/60 , C09D133/26
摘要： The present invention relates to CH-acidic methacrylic esters and also copolymers obtainable from CH-acidic methacrylic esters. Furthermore, the present invention relates to coating compositions comprising these copolymers.

3. 发明授权

US10601069B2 Non-aqueous electrolyte additive, and non-aqueous electrolyte for lithium secondary battery comprising the same and lithium secondary battery 有权
公开(公告)号：US10601069B2
公开(公告)日：2020-03-24
申请号：US15737503
申请日：2017-03-21
申请人： LG Chem, Ltd.
发明人： Sung Hoon Yu , Kyung Mi Lee
IPC分类号： H01M10/052 , H01M10/0525 , H01M10/0567 , C07D213/84 , C07D213/85 , C07C255/25 , C07C255/19 , C07C255/09 , C07D241/24 , C07C255/54 , C07C255/15 , C07C255/13 , C07C255/24 , C07C255/07 , C07C255/51 , H01M2/16 , H01M4/131 , H01M4/66 , H01M10/0585 , H01M10/0569 , H01M10/0568 , H01M4/02
摘要： The present invention relates to a non-aqueous electrolyte additive, and a non-aqueous electrolyte for a lithium secondary battery including the same and a lithium secondary battery, and particularly, to a non-aqueous electrolyte additive having a nitrile group and a propargyl group, and a non-aqueous electrolyte for a lithium secondary battery and a lithium secondary battery, which include the non-aqueous electrolyte additive so that capacity and cycle lifespan characteristics at high temperature can be improved.

4. 发明授权

US09732029B2 Nitroso compounds as nitroxyl donors and methods of use thereof 有权
公开(公告)号：US09732029B2
公开(公告)日：2017-08-15
申请号：US14444750
申请日：2014-07-28
申请人： Cardioxyl Pharmaceuticals, Inc.
发明人： Lisa Marie Frost , Stephen Martin Courtney , Frederick Arthur Brookfield , Vincent Jacob Kalish
IPC分类号： C07C207/04 , C07C207/00 , C07D309/14 , C07D407/12 , C07D211/44 , C07D211/58 , C07D333/42 , C07D405/12 , C07D405/14 , C07D451/10 , C07F9/117 , C07F9/58 , C07C255/19 , C07D309/10 , C07F9/59
CPC分类号： C07C207/00 , C07C207/04 , C07C255/19 , C07D211/44 , C07D211/58 , C07D309/10 , C07D309/14 , C07D333/42 , C07D405/12 , C07D405/14 , C07D407/12 , C07D451/10 , C07F9/117 , C07F9/58 , C07F9/59
摘要： The invention relates to nitroso derivatives including carboxylic acid and phosphoric acid esters of hydroxy nitroso compounds that donate nitroxyl (HNO) under physiological conditions. The compounds and compositions of the invention are useful in treating and/or preventing the onset and/or development of diseases or conditions that are responsive to nitroxyl therapy, including heart failure, ischemia/reperfusion injury and cancer.

5. 发明授权

US09725402B2 Nitroso compounds as nitroxyl donors and methods of use thereof 有权
公开(公告)号：US09725402B2
公开(公告)日：2017-08-08
申请号：US14927994
申请日：2015-10-30
申请人： Cardioxyl Pharmaceuticals, Inc.
发明人： Lisa Marie Frost , Stephen Martin Courtney , Frederick Arthur Brookfield , Vincent Jacob Kalish
IPC分类号： C07C207/04 , C07C207/00 , C07D309/14 , C07D407/12 , C07D211/44 , C07D211/58 , C07D333/42 , C07D405/12 , C07D405/14 , C07D451/10 , C07F9/117 , C07F9/58 , C07C255/19 , C07D309/10 , C07F9/59
CPC分类号： C07C207/00 , C07C207/04 , C07C255/19 , C07D211/44 , C07D211/58 , C07D309/10 , C07D309/14 , C07D333/42 , C07D405/12 , C07D405/14 , C07D407/12 , C07D451/10 , C07F9/117 , C07F9/58 , C07F9/59
摘要： The invention relates to nitroso derivatives including carboxylic acid and phosphoric acid esters of hydroxy nitroso compounds that donate nitroxyl (HNO) under physiological conditions. The compounds and compositions of the invention are useful in treating and/or preventing the onset and/or development of diseases or conditions that are responsive to nitroxyl therapy, including heart failure, ischemia/reperfusion injury and cancer.

7. 发明授权

US06878829B2 Method for producing β-alaninamides 失效
标题翻译： β-丙氨酰胺生产方法
公开(公告)号：US06878829B2
公开(公告)日：2005-04-12
申请号：US10220608
申请日：2001-03-02
申请人： Stefan Hildbrand , Thomas Ruppen , Dario Veghini
发明人： Stefan Hildbrand , Thomas Ruppen , Dario Veghini
IPC分类号： C07C231/14 , C07C237/12 , C07C255/19 , C07D207/337 , C07D233/54 , C07D233/60 , C07D233/64
CPC分类号： C07D233/64 , C07C231/14 , C07C255/19 , Y02P20/55 , C07C237/12
摘要： β-alaninamides of the general formula Wherein R1 is hydrogen or C1-6 alkyl which is unsubstituted or substituted with hyroxy, amino, carboxy, carbamoyl, methylmercapto, guanidino, unsubstituted or substituted aryl or heteroaryl, and R2 is hydrogen, or R1 and R2 together form a group of the formula —(CH2)n— where n is 3 or 4, and R3 is hydrogen, a negative charge compensated by an equivalent of an inorganic or organic cation or is C1-6 alkyl, are prepared, without using an amino-protective group, by reacting the corresponding α-amino acid or the corresponding α-amino acid ester with a cyanoacetic ester to give a cyanoacetamide and by subsequent catalytic hydrogenation. The method is particularly suitable for preparing carnosine (β-alanyl-L-histidine, R1=imidazol-4-yl-methyl, R2=R3=H), a naturally occurring dipeptide which used as a dietary supplement with antioxidative action.
摘要翻译：通式为β-丙烯酰胺，其中R 1为氢或未被取代或被羟基，氨基，羧基，氨基甲酰基，甲基巯基，胍基，未取代或取代的芳基或杂芳基取代的C 1-6烷基，R 2为氢，或R 1和R 2一起形成式 - （CH 2）n - 的基团，其中n为3或4，R 3为氢，负电荷由当量的无机或通过使相应的α-氨基酸或相应的α-氨基酸酯与氰基乙酸酯反应得到氰基乙酰胺，然后通过随后的催化氢化制备无需氨基保护基团的有机阳离子或C 1-6烷基。该方法特别适用于制备肌肽（β-丙氨酰-L-组氨酸，R 1 =咪唑-4-基 - 甲基，R 2 = R 3 = H），天然存在的二肽，其用作一种具有抗氧化作用的膳食补充剂。

8. 发明申请

US20050004164A1 2-Cyanopropanoic acid amide and ester derivatives and methods of their use 审中-公开
标题翻译： 2-氰基丙酸酰胺和酯衍生物及其使用方法
公开(公告)号：US20050004164A1
公开(公告)日：2005-01-06
申请号：US10833678
申请日：2004-04-28
申请人： Thomas Caggiano , Antony Brazzale , William Moore , Callain Kim
发明人： Thomas Caggiano , Antony Brazzale , William Moore , Callain Kim
IPC分类号： A61K20060101 , A61K31/277 , A61K31/44 , A61K31/47 , A61K31/495 , A61K31/496 , A61P29/00 , C07C255/19 , C07C255/41 , C07C323/62 , C07D205/04 , C07D209/08 , C07D211/18 , C07D211/34 , C07D211/82 , C07D213/74 , C07D215/00 , C07D215/14 , C07D217/06 , C07D217/16 , C07D295/185 , C07D295/192 , C07D401/04
CPC分类号： C07C323/62 , C07C255/41 , C07C2601/14 , C07D211/34 , C07D215/14 , C07D295/192 , C07D401/04
摘要： This invention provides compounds of formula I or a pharmaceutically acceptable salt thereof that are useful for the treatment of the inflammatory component of diseases and are particularly useful in treating atherosclerosis, myocardial infarction, congestive heart failure, inflammatory bowel disease, arthritis, type II diabetes, and autoimmune diseases such as multiple sclerosis and rheumatiod arthritis.
摘要翻译：本发明提供式I化合物或其药学上可接受的盐，其可用于治疗疾病的炎性成分，并且特别可用于治疗动脉粥样硬化，心肌梗塞，充血性心力衰竭，炎性肠病，关节炎，II型糖尿病，和自身免疫性疾病如多发性硬化和风湿性关节炎。

9. 发明授权

US06130347A Preparation of cyanoacetic esters 失效
标题翻译：制备氰基乙酸酯
公开(公告)号：US06130347A
公开(公告)日：2000-10-10
申请号：US432204
申请日：1999-11-02
申请人： Manfred Julius , Rolf Schneider , Klaus Mundinger , Jakob Fischer
发明人： Manfred Julius , Rolf Schneider , Klaus Mundinger , Jakob Fischer
IPC分类号： B01J31/02 , C07B61/00 , C07C253/14 , C07C255/17 , C07C255/19
CPC分类号： C07C253/14
摘要： Cyanoacetic esters are prepared by reacting a corresponding monochloroacetic ester with hydrogen cyanide in the presence of a base, where the base is a compound selected from the group consisting of tertiary amines, salts of carbonic acid, salts of carbonic acid monoesters, salts of carboxylic acids, amidines, guanidines and aromatic N-heterocyclic compounds.
摘要翻译：氰基乙酸酯通过在碱存在下使相应的一氯乙酸酯与氰化氢反应来制备，其中碱是选自叔胺，碳酸的盐，碳酸单酯的盐，羧酸的盐脒，胍和芳族N-杂环化合物。

10. 发明授权

US6087367A Potent inducers of terminal differentiation and methods of use thereof 失效
标题翻译：终末分化的潜在诱导剂及其使用方法
公开(公告)号：US6087367A
公开(公告)日：2000-07-11
申请号：US314195
申请日：1999-05-18
申请人： Ronald Breslow , Paul A. Marks , Richard A. Rifkind , Branko Jursic
发明人： Ronald Breslow , Paul A. Marks , Richard A. Rifkind , Branko Jursic
IPC分类号： C07D295/18 , A61K31/16 , A61K31/164 , A61K31/165 , A61K31/167 , A61K31/192 , A61K31/197 , A61K31/20 , A61K31/216 , A61K31/221 , A61K31/275 , A61K31/277 , A61K31/425 , A61K31/426 , A61K31/427 , A61K31/44 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/445 , A61K31/4453 , A61K31/52 , A61P35/00 , A61P35/02 , A61P43/00 , C07C229/24 , C07C229/30 , C07C233/05 , C07C233/06 , C07C233/07 , C07C233/15 , C07C233/25 , C07C233/34 , C07C233/36 , C07C233/43 , C07C233/54 , C07C233/64 , C07C233/92 , C07C237/04 , C07C237/42 , C07C255/19 , C07C255/42 , C07C255/44 , C07C255/60 , C07C259/06 , C07C259/08 , C07C259/10 , C07C271/10 , C07C271/28 , C07C275/28 , C07D211/16 , C07D211/26 , C07D211/32 , C07D213/56 , C07D213/75 , C07D277/02 , C07D277/20 , C07D277/44 , C07D277/46 , C07D295/185 , C07D487/04 , C07D519/00 , A01N43/90 , A01N37/18 , A01N43/40
CPC分类号： C07D213/75 , A61K31/16 , A61K31/164 , A61K31/167 , A61K31/197 , A61K31/221 , A61K31/277 , A61K31/427 , A61K31/4453 , C07C233/05 , C07C233/06 , C07C233/07 , C07C233/15 , C07C233/25 , C07C233/36 , C07C233/43 , C07C233/54 , C07C233/92 , C07C237/42 , C07C255/42 , C07C255/44 , C07C255/60 , C07C259/06 , C07C259/08 , C07C259/10 , C07C275/28 , C07D211/32 , C07D277/46 , C07D295/185 , C07C2101/14
摘要： The present invention provides the compound having the structure: ##STR1## wherein each of R.sub.1 and R.sub.2 are independently the same as or different from each other; when R.sub.1 and R.sub.2 are the same, each is a substituted or unsubstituted arylamino, cycloalkylamino, pyridineamino, piperidino, 9-purine-6-amine, or thiozoleamino group; when R.sub.1 and R.sub.2 are different, R.sub.1 =R.sub.3 --N--R.sub.4, wherein each of R.sub.3 and R.sub.4 are independently the same as or different from each other and are a hydrogen atom, a hydroxyl group, a substituted or unsubstituted, branched or unbranched alkyl, alkenyl, cycloalkyl, aryl, alkyloxy, aryloxy, arylalkyloxy, or pyridine group, or R.sub.3 and R.sub.4 bond together to form a piperidine group and R.sub.2 is a hydroxylamino, hydroxyl, amino, alkylamino, dialkylamino or alkyloxy group; and n is an integer from about 4 to about 8.The present invention also provides a method of selectively inducing terminal differentiation of neoplastic cells and thereby inhibiting proliferation of such cells. Moreover, the present invention provides a method of treating a patient having a tumor characterized by proliferation of neoplastic cells. Lastly, the present invention provides a pharmaceutical composition comprising a pharmaceutically acceptable carrier and a therapeutically acceptable amount of the compound above.
摘要翻译：本发明提供具有以下结构的化合物：其中R1和R2各自独立地相同或不同; 当R 1和R 2相同时，各自为取代或未取代的芳基氨基，环烷基氨基，吡啶氨基，哌啶子基，9-嘌呤-6-胺或硫代唑氨基; 当R1和R2不同时，R1 = R3-N-R4，其中R3和R4各自独立地相同或不同，为氢原子，羟基，取代或未取代的支链或非支链烷基，烯基，环烷基，芳基，烷氧基，芳氧基，芳基烷氧基或吡啶基，或R3和R4键合在一起形成哌啶基，R2是羟基氨基，羟基，氨基，烷基氨基，二烷基氨基或烷氧基; 并且n为约4至约8的整数。本发明还提供了选择性诱导肿瘤细胞的终末分化并由此抑制这些细胞增殖的方法。此外，本发明提供了治疗具有以肿瘤细胞增殖为特征的肿瘤的患者的方法。最后，本发明提供包含药学上可接受的载体和治疗上可接受量的上述化合物的药物组合物。

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