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1. 发明授权

US3470240A 13,14-seco-steroids and process for preparation thereof 失效
标题翻译： 13,14-SECO-STEROIDS及其制备方法
公开(公告)号：US3470240A
公开(公告)日：1969-09-30
申请号：US3470240D
申请日：1965-08-17
申请人： CIBA GEIGY CORP
发明人： ANNER GEORG , KALVODA JAROSLAV
IPC分类号： C07C49/423 , C07J1/00 , C07J75/00 , C09B1/34 , C07C69/12 , C07C171/07
CPC分类号： C07J75/00 , C07C49/423 , C07J1/00 , C09B1/34 , Y10S8/924

2. 发明授权

US3865883A 1,2,3,4,9,12-Hexahydrophenanthrenes 失效
标题翻译： 1,2,3,4,9,12-六氢卟吩
公开(公告)号：US3865883A
公开(公告)日：1975-02-11
申请号：US23580872
申请日：1972-03-17
申请人： SYNTEX CORP
发明人： EDWARDS JOHN A , FRIED JOHN H
IPC分类号： C07C49/755 , C07C51/09 , C07C51/235 , C07C51/29 , C07C51/36 , C07C51/377 , C07C51/41 , C07C57/44 , C07C59/68 , C07C59/90 , C07C171/07
CPC分类号： C07C59/90 , C07C49/755 , C07C51/09 , C07C51/235 , C07C51/29 , C07C51/36 , C07C51/377 , C07C51/41 , C07C57/44 , C07C59/68 , C07C2603/26 , C07C62/34 , C07C62/32 , C07C62/38
摘要： New compounds of the 1,2,3,4,9,12-hexahydrophenanthrene class, useful as estrogenic and anti-fertility agents, and methods for their preparation. 1 Alpha -Ethyl-2 Alpha -carboxy-2 Beta methyl-7-methoxy-1,2,3,4,9,12-hexahydrophenanthrene is exemplified as illustrative of the class.
摘要翻译：可用作雌激素和抗生育剂的1,2,3,4,9,12-六氢菲类的新化合物及其制备方法。 1个α-乙基-2α-羧基-2β-甲基-7-甲氧基-1,2,3,4,9,12-六氢菲作为该类的说明。

3. 发明授权

US3471550A 20beta-alkanoyloxy-5-oxo-3,5-seco-a-nor-pregnan-3-oic acids 失效
标题翻译： 20BETA-ALKANOYLOXY-5-OXO-3,5-SECO-A-NOR-PREGNAN-3-OIC ACIDS
公开(公告)号：US3471550A
公开(公告)日：1969-10-07
申请号：US3471550D
申请日：1968-06-17
申请人： HOFFMANN LA ROCHE
发明人： USKOKOVIC MILAN RADOJE
IPC分类号： C07C59/215 , C07C59/80 , C07C309/65 , C07C309/66 , C07C309/73 , C07C171/07 , C07C167/02 , C07C169/06
CPC分类号： C07C59/215 , C07C59/80 , C07C309/65 , C07C309/66 , C07C309/73 , C07C2603/14 , C07C2603/16 , Y10S435/939

4. 发明授权

US3591607A Retrosteroid a-ring formation 失效
标题翻译：回波环形成
公开(公告)号：US3591607A
公开(公告)日：1971-07-06
申请号：US3591607D
申请日：1966-04-19
申请人： HOFFMANN LA ROCHE
发明人： BASEL ANDOR FURST , KOCH WOLFGANG , USKOKOVIC MILAN RADOJE
IPC分类号： C07C59/205 , C07C59/215 , C07C171/07 , C07D3/00
CPC分类号： C07C59/205 , C07C59/215 , C07C2603/16
摘要： IS A MEMBER SELECTED FROM THE GROUP CONSISTING OF HYDROGEN, ALKYL, HYDROXY, LOWER ALKANOYLOXY; AND HALO; Q, WHEN TAKEN ALONE, IS OXO; T1, WHEN TAKEN ALONE, IS A MEMBER SELECTED FROM THE GROUP CONSISTING OF ALKALI METAL OXY AND LOWER ALKOXY; AND T1 AND Q, WHEN TAKEN TOGETHER, ARE NITRILE. THESE COMPOUNDS ARE INTERMEDIATES WHICH CAN BE CONVERTED TO A KNOWN CLASS OF ENDOCRINOLOGICALLY ACTIVE 9,10-STEROIDS.

Y-CH2-CO-

Y IS A MEMBER SELECTED FORM THE GROUP CONSISTING OF HYDROGEN, HALO, AND HYDROXY; R17A, WHEN R17B IS HYDROXY AND LOWER ALKANOYLOXY, IS A MEMBER SELECTED FROM THE GROUP CONSISTING OF HYDROGEN AND LOWER ALIPHATIC HYDRCARBYL, AND, WHEN R17B IS

Y-CH2-CO-

R17B IS A MEMBER SELECTED FROM THE GROUP CONSISTING OF HYDROXY, LOWER ALKANOYLOZY, AND

>C(-R17B)-R17A

R1 IS A MEMBER SELECTED FROM THE GROUP CONSISTING OF HYDROGEN, LOWER ALKYL, LOWER ALKOXY, AND LOWER ALKYLTHIO: R2 IS A MEMBER SELECTED FROM THE GROUP CONSISTING OF HYDROGEN, LOWER ALKYL, LOWER ALKOXY, AND LOWER ALKYLTHIO; R6 IS A MEMBER SELECTED FROM THE GROUP CONSISTING OF HYDROGEN, LOWER ALKYL, LOWER ALKYLTHIO, LOWER ALKANOYLTHIO, AND HALO; R7 IS A MEMBER SELECTED FROMTHE GROUP CONSISTING OF HYDROGEN, LOWER ALKYL, LOWER ALKYLTHIO, LOWER ALKANOYLTHIO, AND HALO; R11 IS A MEMBER SELECTED FROM THE GROUP CONSISTING OF HYDORGEN, HYDROXT, AND LOWER ALKANOYLOXY; R16 IS A MEMBER SELECTED FROM THE GROUP CONSISTING OF HYDROGEN, LOWER ALKYL, HYDORXY, LOWER ALKOZY, LOWER ALKANOYLOXY, AND, WHEN THE 17B-SUBSTITUENT IS ACETYL OR SUBSTITUTED ACETYL, FLUORINE; Z IS A MEMBER SELECTED FROM THE GROUP CONSISTING OF CARBONYL, (17B-HYDROXY-17A-LOWER ALKANOIC ACID LACTONE), AND

8-(Q=C(-T1-CH(-R2)-CH(-R1)-)DECALIN

1-R11,3-C,3,4-(-Z-CH(-R16)-CH2-),5-R7,6-R6,7-(O=),8-CH3,

3,5-SECO-9B,10A STEROIDS OF THE FORMULA:

WHEREIN:

5. 发明授权

US3478106A Preparation of 13-alkylgona-1,3,5(10),8,14-pentaenes 失效
标题翻译：制备13-AlKYLGONA-1,3,5（10），8,14-PENTAENES
公开(公告)号：US3478106A
公开(公告)日：1969-11-11
申请号：US3478106D
申请日：1968-11-18
申请人： SMITH HERCHEL
发明人： HUGHES GORDON ALAN , SMITH HERCHEL
IPC分类号： A61K31/565 , C07J1/00 , C07J13/00 , C07J75/00 , C07C171/07 , C07C167/02
CPC分类号： A61K31/565 , C07J1/00 , C07J13/00 , C07J75/00

6. 发明授权

US3839420A 16,17-seco-delta4 and delta5(10)steroids 失效
标题翻译： 16,17-SECO-DELTA4和DELTA5（10）STEROIDS
公开(公告)号：US3839420A
公开(公告)日：1974-10-01
申请号：US14276371
申请日：1971-05-12
申请人： SYNTEX INC
发明人： CRABBE P , EDWARDS J , FRIED J
IPC分类号： C07C62/32 , C07C62/38 , C07C171/07
CPC分类号： C07C62/38 , C07C62/32 , C07C2603/26
摘要： 1. A COMPOUND SELECTED FROM THE GROUP OF COMPOUNDS REPRESENTED BY THE FOMULAS:

2-(O=),3-R3,3-R4,7-R1,7-R2,8-(CH3-CH2-)-2,3,4,4A,4B,5,6,-

7,8,8A,9,10-DODECAHYDROPHENANTHRENE

AND

2-(O=),3-R3,3-R4,7-R1,7-R2,8-(CH3-CH2-)-1,2,3,4,4B,5,6,-

7,8,8A,9,10-DODECAHYDROPHENANTHRENE

WHEREIN R1 IS A HYDROXYLATED HYDROCARBON RADICAL REPRESENTED BY THE FORMULAS

-CH2-OH -CH(-OH)-LOWER ALKYL -C(-OH)(-LOWER ALKYL)2

ESTERS THEREOF WHEREIN THE CARBOXYLIC ACID MOIETY HAS FROM 1 TO 12 CARBON ATOMS: AND THE HYDROLYZABLE HYDROCARBON CARBOXYLIC ACID R2 IS LOWER ALKYL; R3 AND R4 ARE HYDROGEN OR METHYL, PROVIDED THAT R4 IS METHYL WHEN R3 IS METHYL.

7. 发明授权

US3489777A Process for the preparation of equilenin,its homologues and derivatives,and intermediate products obtained by this process 失效
标题翻译：制备伊曲宁，其原子和衍生物的方法以及本方法获得的中间产物
公开(公告)号：US3489777A
公开(公告)日：1970-01-13
申请号：US3489777D
申请日：1967-11-22
申请人： ROUSSEL UCLAF
发明人： HOREAU ALAIN , LORTHIOY FRANCOISE-ELISABETH
IPC分类号： C07C45/62 , C07C45/68 , C07C45/71 , C07C49/753 , C07C167/02 , C07C169/10 , C07C171/07
CPC分类号： C07C49/753

8. 发明授权

US3454605A Isomerization of the 17-side chain on 20-keto steroids 失效
标题翻译： 20-KETO STEROIDS上的17个侧链的异构体
公开(公告)号：US3454605A
公开(公告)日：1969-07-08
申请号：US3454605D
申请日：1967-12-20
申请人： UPJOHN CO
发明人： WALKER BRADFORD H
IPC分类号： C07J5/00 , C07J75/00 , C07C169/00 , C07C171/07
CPC分类号： C07J5/00 , C07J75/00

9. 发明授权

US3833644A B,d-seco-delta4 and delta5(10)-steroidal compounds 失效
标题翻译： B，D-SECO-DELTA4和DELTA5（10）-STEROIDAL化合物
公开(公告)号：US3833644A
公开(公告)日：1974-09-03
申请号：US16445971
申请日：1971-07-20
申请人： SYNTEX CORP
发明人： CRABBE P , FRIED J
IPC分类号： C07D307/20 , C07D309/10 , C07D309/12 , C07C171/07
CPC分类号： C07D309/10 , C07D307/20 , C07D309/12
摘要： NEW 5,6;16,17-DISECO- AND 5,6;15,17-DISECO - NOR STEROIDAL COMPOUNDS OF THE ESTRANE SERIES, UNSATURATED AT C-4,5 OR C-5(10) USEFUL AS ANTIANDROGENIC AGENTS, AND METHODS FOR THEIR PREPARATION.

10. 发明授权

US3674816A Annulene steroids,intermediates,and method of making 失效
标题翻译：神经刺激物，中间体和制备方法
公开(公告)号：US3674816A
公开(公告)日：1972-07-04
申请号：US3674816D
申请日：1970-01-28
申请人： SYNTEX CORP
发明人： EDWARDS JOHN A , FRIED JOHN H , MCCRAE WILLIAM
IPC分类号： C07J69/00 , C07J75/00 , C07C171/07 , C07C169/20
CPC分类号： C07J69/00 , C07J75/00
摘要： 3-Keto-5,19-cyclo-androsta-1,7-diene and -1,6-diene steroids; 3lower alkoxy-5,19-cyclo-5,10-secoandrosta-1(10),2,4,7-tetraene and -1(10),2,4,6-tetraene steroids; 3-carboxylic acyloxy-5,19cyclo-5,10-seco-androsta-1(10),2,4,7-tetraene and -1(10),2,4,6tetraene steroids; and 3-desoxy-5,19-cyclo-5,10-seco-androsta1(10),2,4,7-tetraene and -1(10),2,4,6-tetraene steroids and methods of preparing these steroids and converting them to useful 5,10-sec-5,19-cycloandrosta-(10),2,4,6-pentaene steroids. The above compounds have utility as intermediates in the production of 5,10-sec-5,19-cycloandrosta-1(10),2,4,6-pentaene steroids which have utility in the treatment of conditions related to estrogen deficiencies and in the control and regulation of fertility.

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