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1. 发明申请

US20030032672A1 Method for preparing a conjugated linoleic acid-containing structured lipid and use of the same 审中-公开
标题翻译：制备含共轭亚油酸的结构化脂质的方法及其用途
公开(公告)号：US20030032672A1
公开(公告)日：2003-02-13
申请号：US10126093
申请日：2002-04-18
发明人： In Hwan Kim , Soo Hyun Chung , Jae Hong Jeong , Chil Surk Yoon
IPC分类号： A61K031/231 , C07C059/147 , C07C059/185
CPC分类号： A61K31/231 , A23K20/158 , A23L33/115 , A23V2002/00 , C07C69/587 , C11C3/08 , C11C3/10 , A23V2250/1866
摘要： Disclosed is a method for preparing a CLA-enriched structured lipid by a transesterification of medium chain triglyceride (MCT) with ester or free fatty acid form of CLA using lipases, and use of the same. It has been known that CLA mainly exists in an acid form, and has various beneficial biological activities, but rapid oxidation property during storage. And also, animal fat or plant oil, widely ingested by animals or humans, is naturally produced as an acylglycerol form containing various fatty acids. The CLA-containing structured lipid is manufactured by mixing free or ester form of CLA with acylglyceride at a molar ratio of 1:1null1:5, adding immobilized lipase of 2.2null20% by weight of CLA and acylglyceride to the mixture with a solvent, and incubating at 35null75null C. for 1-36 hours. The CLA-containing structured lipid is a natural TG form and contains a high content of CLA, characterized by at least 15% content of CLA in total fatty acid composition, and at least 5% of CLA at sn-2 position. Accordingly, with the CLA-enriched MCT being administrated, it can efficiently provide biological activities of CLA, such as inhibition of carcinogenesis and reduction of fat accumulation in a body, as well as rapidly supply calories, an innate nutritional property of MCT.
摘要翻译：公开了一种通过中链甘油三酯（MCT）与脂肪酶的酯或游离脂肪酸形式的酯交换制备富含CLA的结构化脂质的方法，并使用该方法。已知CLA主要以酸的形式存在，并且具有各种有益的生物活性，但在储存期间具有快速的氧化性能。而且，动物或人类广泛摄取的动物脂肪或植物油天然产生为含有各种脂肪酸的酰基甘油形式。通过将游离或酯形式的CLA与酰基甘油酯以1:1〜1:5的摩尔比混合制造，通过将具有2.2〜20重量％的CLA和酰基甘油酯的固定化脂肪酶加入到混合物中来制备含CLA的结构化脂质溶剂，并在35〜75℃下孵育1-36小时。含CLA的结构化脂质是天然的TG形式，并且含有高含量的CLA，其特征在于总脂肪酸组成中至少15％的CLA含量，以及sn-2位置的至少5％的CLA。因此，通过施用富CLA的MCT，可以有效地提供CLA的生物活性，例如抑制癌发生和减少体内脂肪的积累，以及快速提供卡路里，MCT的先天营养特性。

2. 发明申请

US20040132818A1 Carboxylic acids and derivatives thereof and pharmaceutical compositions containing them 审中-公开
标题翻译：羧酸及其衍生物和含有它们的药物组合物
公开(公告)号：US20040132818A1
公开(公告)日：2004-07-08
申请号：US10680429
申请日：2003-10-08
发明人： Jacob Bar-Tana
IPC分类号： C07C059/185 , A61K031/20
CPC分类号： C07C69/602 , C07C55/02
摘要： The invention relates to carboxylic acids and derivatives thereof and pharmaceutical compound containing them. The active compounds are represented by the formula compound represented by formula I, wherin R1-R4 each independently represents an unsubstituted or substituted hydrocarbyl or heterocyclyl radical, Q represents a diradical consisting of a linear chain of 11 to 18 carbon atoms, one or more of which may be replaced by heteroatoms, said chain being optionally substituted by inert substituents and one or more of said carbon or heteroatom chain members optionally forming part of a ring structure, and where one or both of the carboxyl groups can be substituted by an in vitro hydrolyzable physiologically acceptable substituent; with the proviso that: compounds wherein R1-R4 each represents CH3 and Q represents a linear chain of 14 carbons, are excluded; and compounds wherein Q represents a linear chain of carbon atoms one of which is replaced by oxygen or sulfur, are excluded. 1
摘要翻译：本发明涉及羧酸及其衍生物和含有它们的药物化合物。活性化合物由式I表示的式化合物表示，R 1 -R 4各自独立地表示未取代或取代的烃基或杂环基，Q表示由11至18个碳原子的直链键组成的双基，其中一个或多个其可以被杂原子替代，所述链任选被惰性取代基取代，并且一个或多个所述碳或杂原子链构件任选地形成环结构的一部分，并且其中一个或两个羧基可被体外取代可水解的生理学上可接受的取代基; 条件是：其中R 1 -R 4各自表示CH 3且Q表示14个碳的直链的化合物; 和其中Q表示碳原子的直链链，其中一个被氧或硫取代的化合物被排除。

3. 发明申请

US20030055275A1 Prevention of neutrophil recruitment 失效
公开(公告)号：US20030055275A1
公开(公告)日：2003-03-20
申请号：US10176892
申请日：2002-06-20
发明人： Charles N. Serhan
IPC分类号： C11D001/28 , C07C059/147 , C07C059/185
CPC分类号： A61K31/22 , C07C59/68 , C07C69/736
摘要： Aspirin (ASA) triggers a switch in the biosynthesis of lipid mediators, inhibiting prostanoid production and initiating 15-epi-lipoxin generation, through the acetylation of cyclooxygenase II.

4. 发明申请

US20030186823A1 Novel compositions of material, especially lubricants and pressure transmitting means, the production and use thereof 有权
标题翻译：材料的新型组合物，特别是润滑剂和压力传递装置，其生产和使用
公开(公告)号：US20030186823A1
公开(公告)日：2003-10-02
申请号：US10181710
申请日：2002-09-12
发明人： Wolfgang Hoelderich , Ulrich Keller , Jutta Fischer , Patrick Weckes , Theo Mang , Rolf Luther , Helena Wagner
IPC分类号： C10M101/00 , C07C059/147 , C07C059/185
CPC分类号： C07C69/67 , C07C59/305 , C07C59/66 , C10M101/04 , C10M105/34 , C10M105/38 , C10M129/68 , C10M129/70 , C10M129/74 , C10M2207/2815 , C10M2207/2835 , C10M2207/401 , C10N2220/026 , C10N2220/10 , C10N2230/06 , C10N2230/10 , C10N2230/64 , C10N2240/04 , C10N2240/08 , C10N2260/00
摘要： The invention relates to novel compositions of matter which may advantageously be used as lubricants or pressure transfer media or else for functional liquids and lubricant additives. The lubricants according to the invention are the reaction products of an electro-philic addition of linear or branched, aliphatic or aromatic carboxylic acids, carboxylic anhydrides, carbonyl halides or novel neoacids to the double bonds of fatty acids, esters thereof and/or of other fatty acid derivatives and also of synthetic esters. Owing to their increased oxidation resistance compared to the starting materials and also their low toxicity, the novel class of synthetic esters based on oleochemicals may find use in novel environmentally compatible lubricants, pressure transfer systems, functional liquids and lubricant additives.
摘要翻译：本发明涉及可有利地用作润滑剂或压力转移介质或功能性液体和润滑剂添加剂的新型物质组合物。根据本发明的润滑剂是直链或支链的脂族或芳族羧酸，羧酸酐，羰基卤化物或新型新酸的亲电加成到脂肪酸，其酯和/或其它物质的双键的反应产物脂肪酸衍生物以及合成酯。由于它们与起始原料相比具有增加的抗氧化性，而且它们的低毒性，基于油脂化学品的新一类合成酯可用于新型环境相容的润滑剂，压力传递系统，功能性液体和润滑剂添加剂。

5. 发明申请

US20030032825A1 METHOD FOR PURIFYING AZELAIC ACID 无效
标题翻译：氨基酸消毒方法
公开(公告)号：US20030032825A1
公开(公告)日：2003-02-13
申请号：US09106592
申请日：1998-06-29
发明人： DENNIS G GAIGE , KENNETH R MCVAY , EDWARD L EWBANK
IPC分类号： C07C059/185
CPC分类号： C07C51/48 , C07C55/18
摘要： The invention is a method for recovering azelaic acid from a mixed oxidation product by prepurifying the azelaic acid and introducing the prepurified azelaic acid into the central portion of a dual countercurrent extraction column operated at an elevated temperature and introducing an aqueous phase into the top of the extraction column and a water immiscible solvent for the monocarboxylic acids in the prepurified azelaic acid into the bottom portion of the extraction column and recovering the purified azelaic acid from the aqueous phase. The azelaic acid can be recovered from the aqueous phase by drying the aqueous phase and separating a low boiling fraction and a high boiling fraction from the azelaic acid product by distillation.
摘要翻译：本发明是一种从混合氧化产物中回收壬二酸的方法，通过预处理壬二酸并将预纯化的壬二酸引入到在高温下操作的双逆流萃取塔的中心部分，并将水相引入到萃取柱和用于预纯化的壬二酸中的单羧酸的水不混溶溶剂进入萃取柱的底部，并从水相中回收纯化的壬二酸。通过干燥水相并通过蒸馏从壬二酸产物中分离低沸点馏分和高沸点馏分，可以从水相中回收壬二酸。

6. 发明申请

US20020156304A1 Synthetic method of ketol unsaturated fatty acids 失效
标题翻译：酮醇不饱和脂肪酸的合成方法
公开(公告)号：US20020156304A1
公开(公告)日：2002-10-24
申请号：US10110239
申请日：2002-04-10
发明人： Yoshihiro Yokokawa , Koji Kobayashi , Shosuke Yamamura
IPC分类号： C07C059/185 , C07C059/147
CPC分类号： C07C51/373 , Y02P20/55 , C07C59/90
摘要： The present invention provides an efficient synthetic method of null-ketol unsaturated fatty acid having a double bond at a null-position to the ketone group thereof. It comprises the steps of: preparing compound (4) by reacting monosubstituted acetylene (2) with epoxide (3); and preparing null-ketol unsaturated fatty acid (1) from said compound (4) as shown in Reaction Formula 1: 1 wherein R1 represents an alkyl group of 1-18 carbon atoms or an aliphatic hydrocarbon group of 2-18 carbon atoms having 1-5 double or triple bonds at given positions; R2 represents a protecting group for a hydroxyl group; R3 represents a protecting group for a carboxyl group; R is identical to R1 or, when R1 has one or more triple bonds, represents an aliphatic hydrocarbon group in which each triple bond of R1 is converted to a double bond; and A represents an alkylene group of 1-18 carbon atoms.
摘要翻译：本发明提供了在与酮基的β-位具有双键的α-酮醇不饱和脂肪酸的有效合成方法。它包括以下步骤：通过使单取代乙炔（2）与环氧化物（3）反应制备化合物（4）; 和由反应式1所示的所述化合物（4）制备α-酮醇不饱和脂肪酸（1）：其中R1表示1-18个碳原子的烷基或具有1- 在给定位置5个双重或三重键; R2表示羟基的保护基; R3表示羧基的保护基; R与R1相同，或者当R1具有一个或多个三键时，表示R1的每个三键转化为双键的脂族烃基; A表示1-18个碳原子的亚烷基。

7. 发明申请

US20040204597A1 Method for preparing ruthenium-carrying alumina and method for oxidizing alcohol 失效
标题翻译：制备载有钌的氧化铝的方法和氧化醇的方法
公开(公告)号：US20040204597A1
公开(公告)日：2004-10-14
申请号：US10481755
申请日：2003-12-23
发明人： Noritaka Mizuno , Kazuya Yamaguchi , Hajime Ishida
IPC分类号： C07C059/185 , C07C059/147 , C07C25/44
CPC分类号： C07D333/22 , B01J21/04 , B01J23/462 , B01J37/031 , C07C45/38 , C07C45/39 , C07C51/235 , C07C53/126
摘要： A ruthenium-carrying alumina, which is prepared by suspending alumina in a solution containing trivalent ruthenium and adding a base to the suspension, is provided. This ruthenium-carrying alumina is useful as a catalyst for oxidizing alcohols by contacting the alcohols with molecular oxygen, and can be used for oxidizing the alcohols at a high conversion to produce ketones, aldehydes, carboxylic acids, etc. with good productivity.
摘要翻译：提供了一种载有钌的氧化铝，其通过将氧化铝悬浮在含有三价钌的溶液中并将悬浮液加入到碱中来制备。该载带钌的氧化铝可用作通过使醇与分子氧接触而使醇氧化的催化剂，并且可以以高转化率用于氧化醇，以生产良好的酮，醛，羧酸等。

8. 发明申请

US20040198814A1 Ketone compounds and compositions for cholesterol management and related uses 有权
标题翻译：酮类化合物和胆固醇管理及相关用途的组合物
公开(公告)号：US20040198814A1
公开(公告)日：2004-10-07
申请号：US10743952
申请日：2003-12-24
发明人： Jean-Louis Henri Dasseux , Daniela Carmen Oniciu
IPC分类号： A61K031/275 , A61K031/20 , C07C059/147 , C07C059/185
CPC分类号： C07C49/17 , C07C49/185 , C07C49/215 , C07C49/245 , C07C49/258 , C07C49/507 , C07C49/723 , C07C49/743 , C07C49/747 , C07C49/782 , C07C49/82 , C07C49/86 , C07C50/30 , C07C59/347 , C07C59/353 , C07C59/84 , C07C69/716 , C07C69/738 , C07C261/04 , C07C309/07 , C07C309/24 , C07D233/72 , C07D233/84 , C07D233/86 , C07D257/04 , C07D261/12 , C07D305/12 , C07D307/33 , C07D309/12 , C07D309/30 , C07D309/40 , C07D495/04 , C07F9/093 , C07F9/2425 , C07F9/4423
摘要： The present invention relates to novel ketone compounds, compositions comprising ketone compounds, and methods useful for treating and preventing cardiovascular diseases, dyslipidemias, dysproteinemias, and glucose metabolism disorders comprising administering a composition comprising a ketone compound. The compounds, compositions, and methods of the invention are also useful for treating and preventing Alzheimer's Disease, Syndrome X, peroxisome proliferator activated receptor-related disorders, septicemia, thrombotic disorders, obesity, pancreatitis, hypertension, renal disease, cancer, inflammation, and impotence. In certain embodiments, the compounds, compositions, and methods of the invention are useful in combination therapy with other therapeutics, such as hypocholesterolemic and hypoglycemic agents.
摘要翻译：本发明涉及新颖的酮化合物，包含酮化合物的组合物，以及可用于治疗和预防心血管疾病，血脂异常，dysproteinemias和葡萄糖代谢紊乱的方法，包括施用包含酮化合物的组合物。本发明的化合物，组合物和方法还可用于治疗和预防阿尔茨海默病，综合征X，过氧化物酶体增殖物激活受体相关病症，败血症，血栓形成障碍，肥胖症，胰腺炎，高血压，肾脏疾病，癌症，炎症和阳。在某些实施方案中，本发明的化合物，组合物和方法可用于与其它治疗剂如降胆固醇和降血糖药物组合治疗。

9. 发明申请

US20030149288A1 Conjugated linoleic acid powder 审中-公开
公开(公告)号：US20030149288A1
公开(公告)日：2003-08-07
申请号：US10200889
申请日：2002-07-23
申请人： Natural ASA
发明人： Duane Fimreite
IPC分类号： C07C059/185 , A61K031/202 , C07C059/147
CPC分类号： C11C3/14 , A23D9/05 , A23K20/158 , A23K50/00 , A23K50/30 , A23K50/42 , A23K50/45 , A23K50/75 , A23L33/12 , A23V2002/00 , A61K31/20 , A61K31/201 , A61K31/23 , A61K31/231 , C11B3/10 , C11B3/12 , C11C3/02 , A23V2250/1866
摘要： A powder containing a high amount of conjugated linoleic acid or other oil is provided. The powder contains either triglycerides containing CLA, free fatty acids of CLA, or alkylesters of CLA, or another desired oil. The powder is free flowing and has good organoleptic properties. The powder may be used as a dietary supplement or combined with foodstuffs to form a food product suitable for consumption by animals or humans.

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