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1. 发明公开

US20240219392A1 METHOD FOR MANUFACTURING A PATIENT SPECIFIC CELL POPULATION USING A MULTIFUNCTIONAL SELF-CONTAINED APPARATUS AND TUBING SET 审中-公开
公开(公告)号：US20240219392A1
公开(公告)日：2024-07-04
申请号：US18596432
申请日：2024-03-05
申请人： Miltenyi Biotec B.V. & Co. KG
发明人： Stefan Miltenyi , Winfried Schimmelpfennig , Holger Lantow , Niklas Elmar Neuschaefer , Martin Biehl , Eiad Kabaha , Juergen Schulz
IPC分类号： G01N33/58 , A61M1/02 , A61M1/36 , B01D15/38 , B01D21/26 , B01L3/00 , B03C1/00 , B03C1/027 , B03C1/032 , B03C1/033 , B03C1/034 , B03C1/28 , B04B1/12 , B04B5/00 , B04B5/04 , B04B5/10 , B04B7/08 , B04B13/00 , C12M1/00 , C12M1/26 , C12M1/36 , C12N5/00 , C12N5/077 , C12N5/0783 , C12N5/0789 , G01N35/00
CPC分类号： G01N33/58 , A61M1/0209 , A61M1/3618 , A61M1/3633 , A61M1/3679 , A61M1/3692 , A61M1/3693 , A61M1/3696 , B01D15/3809 , B01D15/3885 , B01D21/26 , B03C1/002 , B03C1/027 , B03C1/032 , B03C1/0332 , B03C1/0335 , B03C1/034 , B03C1/288 , B04B1/12 , B04B5/00 , B04B5/04 , B04B5/0442 , B04B5/10 , B04B7/08 , B04B13/00 , C12M23/28 , C12M33/10 , C12M41/48 , C12M47/04 , C12N5/0018 , C12N5/0636 , C12N5/0646 , C12N5/0647 , C12N5/0669 , G01N35/0098 , A61M1/3623 , A61M2202/0071 , A61M2202/0413 , A61M2202/0427 , A61M2202/10 , B01D21/262 , B01L3/5021 , B03C2201/18 , B03C2201/26 , B04B2005/0464 , B04B2013/006 , C12N2500/34 , C12N2501/998 , G01N2333/70596
摘要： The invention relates to a system, comprising: a) a sample processing unit, comprising an input port and an output port coupled to a rotating container having at least one sample chamber, the sample processing unit configured provide a first processing step to a sample or to rotate the container so as to apply a centrifugal force to a sample deposited in the chamber and separate at least a first component and a second component of the deposited sample; and b) a sample separation unit coupled to the output port of the sample processing unit, the cell separation unit comprising separation column holder, a pump and a plurality of valves configured to at least partially control fluid flow through a fluid circuitry and a separation column positioned in the holder, the separation column configured to separate labeled and unlabeled components of sample flowed through the column.

2. 发明授权

US11499977B2 Equipment and procedure for culturing, separating, and genetically modifying donor cells for reinfusion into a patient 有权
公开(公告)号：US11499977B2
公开(公告)日：2022-11-15
申请号：US17725388
申请日：2022-04-20
申请人： MILTENYI BIOTEC B.V. & CO. KG
发明人： Stefan Miltenyi , Winfried Schimmelpfennig , Holger Lantow , Niklas Elmar Neuschaefer , Martin Biehl , Eiad Kabaha , Juergen Schulz
IPC分类号： C12M3/00 , B01L3/00 , G01N33/58 , A61M1/36 , B03C1/28 , B04B5/04 , B04B13/00 , B03C1/032 , B03C1/00 , B03C1/027 , B03C1/033 , B03C1/034 , A61M1/02 , G01N35/00 , C12N5/00 , C12M1/26 , C12M1/00 , B01D21/26 , B04B5/00 , B04B5/10 , B04B1/12 , B04B7/08 , B01D15/38 , C12N5/0789 , C12N5/077 , C12N5/0783 , C12M1/36
摘要： The invention relates to a system, comprising: a) a sample processing unit, comprising an input port and an output port coupled to a rotating container having at least one sample chamber, the sample processing unit configured provide a first processing step to a sample or to rotate the container so as to apply a centrifugal force to a sample deposited in the chamber and separate at least a first component and a second component of the deposited sample; and b) a sample separation unit coupled to the output port of the sample processing unit, the cell separation unit comprising separation column holder (42), a pump (64) and a plurality of valves (1-11) configured to at least partially control fluid flow through a fluid circuitry and a separation column (40) positioned in the holder, the separation column configured to separate labeled and unlabeled components of sample flowed through the column.

3. 发明授权

US5932096A Magnetic purifying apparatus for purifying a fluid 失效
公开(公告)号：US5932096A
公开(公告)日：1999-08-03
申请号：US933090
申请日：1997-09-18
申请人： Norihide Saho , Hisashi Isogami , Minoru Morita , Fumitaka Handa , Katsuhiko Asano
发明人： Norihide Saho , Hisashi Isogami , Minoru Morita , Fumitaka Handa , Katsuhiko Asano
IPC分类号： B03C1/027 , B01D35/06 , B03C1/00
CPC分类号： B03C1/027 , Y10S505/892
摘要： An improved apparatus for removing magnetic material from a flowing fluid such as water by magnetic separation has a single set of electromagnets which are used with a plurality of magnetic filters for continuous magnetic separation operation alternately without obstructing the flow of the fluid being processed. A high-gradient magnetic filter arrangement which passes through a magnetic field generated by the magnets is made up of at least two magnetic filters separated by a watertight partition. When the fluid being processed is flowing through one of the magnetic filters, the other filter is removed from the flow of the fluid into a magnetic filter housing which is separated from the fluid flow through the magnetic filter by means of partitions. Backwashing of this other magnetic filter is carried out while purification of the fluid being processed by the former magnetic filter continues uninterrupted. Dummy magnetic filters are provided at the outer ends of the magnetic filter arrangement so that whichever of the magnetic filters is removed from the flow of the fluid being processed, the filter matrices do not leave the magnetic field formed by the plurality of magnets, and consequently the magnetic filters can be moved in and out of the magnetic field with a minimal driving force.

4. 发明授权

US4204948A Self-purging seal 失效
标题翻译：自动清洗密封
公开(公告)号：US4204948A
公开(公告)日：1980-05-27
申请号：US970245
申请日：1978-12-18
申请人： Ionel Wechsler , John A. Oberteuffer , John J. Nolan , Henry H. Kolm , Eric Georgelis , Bo R. Arvidson
发明人： Ionel Wechsler , John A. Oberteuffer , John J. Nolan , Henry H. Kolm , Eric Georgelis , Bo R. Arvidson
IPC分类号： B03C1/02 , B01D35/06 , B03C1/027 , B03C1/029 , B03C1/03
CPC分类号： B03C1/03
摘要： In a moving matrix magnetic separator in which a matrix device moves relative to a processing device and a seal assembly seals a longitudinal section of the matrix device to an associated processing device, the seal assembly including a sealing surface on one of the devices and a seal on the other, the improvement comprising said seal including a base portion extending generally longitudinally in the direction of motion of the matrix device; first and second salient, resilient lip portions extending from the base portion toward an associated sealing surface in the gap between the matrix device and the processing device, and extending generally longitudinally to the direction of motion of the matrix device and spaced from each other transversely to the direction of motion of the matrix device and forming a channel therebetween; a pressurized purge fluid chamber formed by the channel and the associated sealing surface; and means for supplying purging fluid to the purge fluid chamber formed by the channel and lip portions with the associated sealing surface.
摘要翻译：在其中矩阵装置相对于处理装置移动并且密封组件将矩阵装置的纵向部分密封到相关处理装置的移动矩阵磁选机中，密封组件包括在装置之一上的密封表面和密封件另一方面，包括所述密封件的改进包括基本上在基体装置的运动方向上纵向延伸的基部; 第一和第二突出的弹性唇部从基部向基体装置和处理装置之间的间隙中的相关联的密封表面延伸，并且大致纵向延伸到矩阵装置的运动方向，并且彼此横向间隔开矩阵装置的运动方向并在其间形成通道; 由通道和相关联的密封表面形成的加压清洗流体室; 以及用于将清洗流体供应到由通道和由相关联的密封表面的唇部形成的清洗流体室的装置。

5. 发明授权

US4054513A Magnetic separation, method and apparatus 失效
标题翻译：磁分离，方法和装置
公开(公告)号：US4054513A
公开(公告)日：1977-10-18
申请号：US632654
申请日：1975-11-17
申请人： William Windle
发明人： William Windle
IPC分类号： B03C1/027 , B03C1/00
CPC分类号： B03C1/027 , Y10S505/933
摘要： In the method and apparatus described a high intensity magnetic field is established in a first zone. A quantity of fluid having magnetizable particles suspended therein is passed through a first separating chamber containing magnetizable packing material and disposed within the first zone, so that the magnetizable particles are magnetized by the magnetic field and attracted to the packing material. The first separating chamber is then moved out of the first zone and into a second zone and a second separating chamber containing magnetizable packing material is moved into the first zone. The magnetizable particles attracted to the packing material of the first separating chamber are removed within the second zone; and, concurrently with this process, a further quantity of fluid having magnetizable particles suspended therein is passed through the second separating chamber disposed within the first zone, so that the magnetizable particles are magnetized by the magnetic field and attracted to the packing material. The high intensity magnetic field is at this time continuously maintained in the first zone.
摘要翻译：在所描述的方法和装置中，在第一区域中建立高强度磁场。使可悬浮于其中的可磁化颗粒的流体通过包含可磁化包装材料的第一分离室并且设置在第一区域内，使得可磁化颗粒被磁场磁化并吸引到包装材料上。然后将第一分离室移出第一区域并进入第二区域，并且包含可磁化包装材料的第二分离室移动到第一区域中。吸引到第一分离室的包装材料的可磁化颗粒在第二区域内被去除; 并且与该方法同时，具有悬浮在其中的可磁化颗粒的另外量的流体通过设置在第一区域内的第二分离室，使得可磁化颗粒被磁场磁化并吸引到包装材料。此时，高强度磁场在第一区域连续保持。

6. 发明公开

US20230176062A1 DEVICES AND DISPOSABLES FOR PATIENT-SPECIFIC CELL THERAPY MANUFACTURING 审中-公开
公开(公告)号：US20230176062A1
公开(公告)日：2023-06-08
申请号：US18083279
申请日：2022-12-16
申请人： Miltenyi Biotec B.V. & Co. KG
发明人： Stefan Miltenyi , Winfried Schimmelpfennig , Holger Lantow , Niklas Elmar Neuschaefer , Martin Biehl , Eiad Kabaha , Juergen Schulz
IPC分类号： G01N33/58 , A61M1/36 , B03C1/28 , B04B5/04 , B04B13/00 , B03C1/032 , B03C1/00 , B03C1/027 , B03C1/033 , B03C1/034 , A61M1/02 , G01N35/00 , C12N5/00 , C12M1/26 , C12M1/00 , B01D21/26 , B04B5/00 , B04B5/10 , B04B1/12 , B04B7/08 , B01D15/38 , C12N5/0789 , C12N5/077 , C12N5/0783 , C12M1/36
CPC分类号： G01N33/58 , A61M1/0209 , A61M1/3618 , A61M1/3633 , A61M1/3679 , A61M1/3692 , A61M1/3693 , A61M1/3696 , B01D15/3809 , B01D15/3885 , B01D21/26 , B03C1/002 , B03C1/027 , B03C1/032 , B03C1/034 , B03C1/288 , B03C1/0332 , B03C1/0335 , B04B1/12 , B04B5/00 , B04B5/04 , B04B5/10 , B04B5/0442 , B04B7/08 , B04B13/00 , C12M23/28 , C12M33/10 , C12M41/48 , C12M47/04 , C12N5/0018 , C12N5/0636 , C12N5/0646 , C12N5/0647 , C12N5/0669 , G01N35/0098 , B01L3/5021 , B03C2201/18 , B03C2201/26
摘要： The invention relates to a system, comprising: a) a sample processing unit, comprising an input port and an output port coupled to a rotating container having at least one sample chamber, the sample processing unit configured provide a first processing step to a sample or to rotate the container so as to apply a centrifugal force to a sample deposited in the chamber and separate at least a first component and a second component of the deposited sample; and b) a sample separation unit coupled to the output port of the sample processing unit, the cell separation unit comprising separation column holder (42), a pump (64) and a plurality of valves (1-11) configured to at least partially control fluid flow through a fluid circuitry and a separation column (40) positioned in the holder, the separation column configured to separate labeled and unlabeled components of sample flowed through the column.

7. 发明授权

US11531031B2 Single use tubing set for making genetically modified donor cells for reinfusion into a patient 有权
公开(公告)号：US11531031B2
公开(公告)日：2022-12-20
申请号：US17725509
申请日：2022-04-20
申请人： MILTENYI BIOTEC B.V. & CO. KG
发明人： Stefan Miltenyi , Winfried Schimmelpfennig , Holger Lantow , Niklas Elmar Neuschaefer , Martin Biehl , Eiad Kabaha , Juergen Schulz
IPC分类号： C12M3/00 , B01L3/00 , G01N33/58 , A61M1/36 , B03C1/28 , B04B5/04 , B04B13/00 , B03C1/032 , B03C1/00 , B03C1/027 , B03C1/033 , B03C1/034 , A61M1/02 , G01N35/00 , C12N5/00 , C12M1/26 , C12M1/00 , B01D21/26 , B04B5/00 , B04B5/10 , B04B1/12 , B04B7/08 , B01D15/38 , C12N5/0789 , C12N5/077 , C12N5/0783 , C12M1/36
摘要： The invention relates to a system, comprising: a) a sample processing unit, comprising an input port and an output port coupled to a rotating container having at least one sample chamber, the sample processing unit configured provide a first processing step to a sample or to rotate the container so as to apply a centrifugal force to a sample deposited in the chamber and separate at least a first component and a second component of the deposited sample; and b) a sample separation unit coupled to the output port of the sample processing unit, the cell separation unit comprising separation column holder (42), a pump (64) and a plurality of valves (1-11) configured to at least partially control fluid flow through a fluid circuitry and a separation column (40) positioned in the holder, the separation column configured to separate labeled and unlabeled components of sample flowed through the column.

8. 发明授权

US5868257A Magnetic separation systems 失效
标题翻译：磁选系统
公开(公告)号：US5868257A
公开(公告)日：1999-02-09
申请号：US535021
申请日：1996-04-01
申请人： Adam Antoni Stadtmuller
发明人： Adam Antoni Stadtmuller
IPC分类号： B03C1/027 , B03C1/00
CPC分类号： B03C1/027
摘要： A magnetic separator for separating magnetisable particles from a slurry is described. The separator includes means for establishing a magnetic field (10) in a separation zone. At least one separation chamber (12) with an inlet and outlet containing a fluid permeable magnetizable separating packing material, and, at least one compensating chamber (4) containing a magnetizable compensating packing, are linked and are movable such that movement of the separation chamber or chambers into the separation zone results in movement of the compensating chamber or chambers out of the separation zone and vice-versa. The magnetization characteristics and/or the demagnetization factors of the separating and compensating packings are substantially the same.
摘要翻译： PCT No.PCT / GB94 / 00989 Sec。 371日期：1996年4月1日 102（e）日期1996年4月1日PCT提交1993年5月7日PCT公布。公开号WO94 / 26417 日期1994年11月24日描述了一种用于从浆料中分离可磁化颗粒的磁选机。分离器包括用于在分离区域中建立磁场（10）的装置。具有入口和出口的至少一个具有流体可渗透的可磁化分离包装材料的分离室（12）以及包含可磁化补偿填料的至少一个补偿室（4）被连接并可移动，使得分离室或室进入分离区导致补偿室或室离开分离区，反之亦然。分离和补偿填料的磁化特性和/或去磁因素基本相同。

9. 发明授权

US4602997A Apparatus for separating ferromagnetic materials from fluid media 失效
标题翻译：用于将铁磁材料与流体介质分离的装置
公开(公告)号：US4602997A
公开(公告)日：1986-07-29
申请号：US758571
申请日：1985-07-23
申请人： Alexandr V. Sandulyak , Vyacheslav I. Garaschenko , Vladimir V. Sandulyak , Oleg J. Korkhov
发明人： Alexandr V. Sandulyak , Vyacheslav I. Garaschenko , Vladimir V. Sandulyak , Oleg J. Korkhov
IPC分类号： B03C1/027 , B03C1/033 , B03C1/10 , B01D35/06
CPC分类号： B03C1/033 , B03C1/027
摘要： Disclosed is an apparatus for separating ferromagnetic materials from fluid media which has stationary chambers containing a ferromagnetic filtering packing capable of being magnetized. The chambers, arranged pairwise, are provided with a self-contained means of magnetization, the magnetic circuit whereof comprises two opposite sections which are located on either side of a line through the centers of the chambers. Each of the sections is made up of a magnet and pole pieces arranged next to the chambers at the diametrically opposite ends of a line at right angles to the center line referred to above so that the two sections form a closed magnetic circuit in conjuction with the ferromagnetic packings.
摘要翻译：公开了一种用于将铁磁材料与流体介质分离的装置，其具有包含能够被磁化的铁磁过滤填料的固定室。成对设置的腔室设置有独立的磁化装置，磁路包括位于通过腔室中心的线的任一侧上的两个相对部分。每个部分由与上述中心线成直角的线的直径相对的端部处设置在腔室旁边的磁体和极片组成，使得两个部分形成闭合的磁路，其结合于铁磁填料

10. 发明授权

US3920543A Moving matrix magnetic separator 失效
标题翻译：移动矩阵磁选机
公开(公告)号：US3920543A
公开(公告)日：1975-11-18
申请号：US33817673
申请日：1973-03-05
申请人： MAGNETIC ENG ASS INC
发明人： MARSTON PETER G , NOLAN JOHN J
IPC分类号： B01D35/06 , B03C1/02 , B03C1/027 , B03C1/029 , B03C1/03 , B03C1/10 , B03C1/26
CPC分类号： B03C1/029 , B03C1/032 , B03C1/0335 , B03C1/034 , B03C2201/18
摘要： A moving matrix magnetic separator including a magnetic pole unit having a first ferromagnetic pole member; a second ferromagnetic pole member aligned with and spaced from the first pole member; and a working magnetic field volume formed by the space between the first and second pole members; electromagnetic coil means encircling the magnetic pole unit proximate the working magnetic field volume for producing a magnetic field in a first direction through the working magnetic field volume between the pole members; a moveable matrix member moveable through the working magnetic field volume between the first and second pole members in a second direction transverse to the first direction; and inlet means proximate one of the pole members for directing fluid through the matrix member and the working magnetic field volume in the first direction, and outlet means proximate the other of the pole members for removing fluid from the matrix member and the working magnetic field volume.
摘要翻译：一种移动矩阵磁选机，包括具有第一铁磁极构件的磁极单元; 与第一极构件对准并与第一极构件间隔开的第二铁磁极构件; 以及由第一和第二极构件之间的空间形成的工作磁场体积; 电磁线圈装置围绕工作磁场体积环绕磁极单元，用于通过磁极构件之间的工作磁场体积在第一方向上产生磁场; 可移动矩阵构件在横向于第一方向的第二方向上可移动穿过第一和第二极构件之间的工作磁场体积; 以及靠近一个极构件的入口装置，用于引导流体通过矩阵构件和在第一方向上的工作磁场体积，以及靠近另一个极构件的出口装置，用于从矩阵构件移除流体和工作磁场体积。

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