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    • 6. 发明授权
    • Delivery system for dental agents
    • 牙科药剂输送系统
    • US6139820A
    • 2000-10-31
    • US360998
    • 1999-07-26
    • Dan E. FischerSteven D. Jensen
    • Dan E. FischerSteven D. Jensen
    • A61K8/21A61Q11/00A61K7/16A61K7/18
    • A61Q11/00A61K8/21A61K2800/22
    • Toothpaste and other dentifrices formulated to include a volume increasing agent (density reducing agent) in order to significantly increase the volume of the toothpaste at the time it is dispensed onto a toothbrush. The inventive dental compositions preferably include a substantial quantity of entrained or trapped air or other gas in order to reduce the density, and hence the weight, of toothpaste actually placed within a person's mouth. The result is a reduction in the amount of active ingredients introduced into a person's mouth that might be ingested. The entrained air or other gas can also increase the availability of the active ingredient since the foamed composition increases the dispersibility of the active ingredients within saliva. The net effect is that a person decreases the actual amount of toothpaste without decreasing the volume, or visual amount, of toothpaste dispensed on the toothbrush. The density-reduction effect can alternatively be provided by means of a lower density filler in addition to, or instead of, the entrained gas. Such fillers typically include trapped air or voids.
    • 牙膏和其他洁牙剂配制成包括体积增加剂(密度降低剂),以便在分配到牙刷时显着增加牙膏的体积。 本发明的牙科用组合物优选地包括大量夹带或捕获的空气或其它气体,以便减少实际放置在人的嘴中的牙膏的密度,并因此减轻牙膏的重量。 结果是减少了可能被摄入的人口中的活性成分的量。 夹带的空气或其它气体也可以增加活性成分的可用性,因为发泡组合物增加活性成分在唾液中的分散性。 净效果是,一个人减少牙膏的实际量,而不会减少分配在牙刷上的牙膏的体积或视觉量。 除了或代替夹带的气体之外,还可以通过较低密度的填料来提供密度降低效果。 这种填料通常包括被捕获的空气或空隙。