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    • 1. 发明申请
    • FOAMABLE FLUORIDE ORAL CARE COMPOSITION
    • 可燃氟化物口服护理组合物
    • US20090087391A1
    • 2009-04-02
    • US11865457
    • 2007-10-01
    • Marilou Theresa JoziakSteven Wade Fisher
    • Marilou Theresa JoziakSteven Wade Fisher
    • A61K8/21A61K8/00
    • A61Q11/00A61K8/046A61K8/19A61K8/20A61K8/21A61K8/365A61K8/44A61K8/90
    • A dental fluoride foam composition comprising an aqueous solution of a water soluble fluoride ion releasable salt, a surfactant selected from the group consisting of nonionic surfactants, zwitterionic surfactants, betaine surfactants and mixtures thereof; and an orally compatible acidifying agent in an amount sufficient to adjust the pH of the composition to about 3 to about 5. The composition is stable at low temperatures and is a clear solution substantially free of precipitates when held at 4.4° C. for 12 hours. When dispensed from a container into the trough of a dental tray, the composition forms a low density, rapidly collapsible foam which substantially liquefies in about 1 minute after being dispensed from the foam generating container and placed in contact with a patient's teeth.
    • 一种氟化氟发泡组合物,其包含水溶性氟离子可释放盐的水溶液,选自非离子表面活性剂,两性离子表面活性剂,甜菜碱表面活性剂及其混合物的表面活性剂; 和足以将组合物的pH调节至约3至约5的口服相容的酸化剂。该组合物在低温下是稳定的,并且当在4.4℃下保持12小时时,该清洁溶液基本上不含沉淀物 。 当从容器分配到牙盘的槽中时,组合物形成低密度,快速可折叠的泡沫,其在从泡沫发生容器分配并放置成与患者的牙齿接触之后约1分钟内基本液化。
    • 2. 发明授权
    • Foamable fluoride oral care composition
    • 可发泡氟化物口腔护理组合物
    • US08802060B2
    • 2014-08-12
    • US11865457
    • 2007-10-01
    • Marilou Theresa JoziakSteven Wade Fisher
    • Marilou Theresa JoziakSteven Wade Fisher
    • A61K8/00A61Q11/00A61K6/00
    • A61Q11/00A61K8/046A61K8/19A61K8/20A61K8/21A61K8/365A61K8/44A61K8/90
    • A dental fluoride foam composition comprising an aqueous solution of a water soluble fluoride ion releasable salt, a surfactant selected from the group consisting of nonionic surfactants, zwitterionic surfactants, betaine surfactants and mixtures thereof; and an orally compatible acidifying agent in an amount sufficient to adjust the pH of the composition to about 3 to about 5. The composition is stable at low temperatures and is a clear solution substantially free of precipitates when held at 4.4° C. for 12 hours. When dispensed from a container into the trough of a dental tray, the composition forms a low density, rapidly collapsible foam which substantially liquefies in about 1 minute after being dispensed from the foam generating container and placed in contact with a patient's teeth.
    • 一种氟化氟发泡组合物,其包含水溶性氟离子可释放盐的水溶液,选自非离子表面活性剂,两性离子表面活性剂,甜菜碱表面活性剂及其混合物的表面活性剂; 和足以将组合物的pH调节至约3至约5的口服相容的酸化剂。该组合物在低温下是稳定的,并且当在4.4℃下保持12小时时,该清洁溶液基本上不含沉淀物 。 当从容器分配到牙盘的槽中时,组合物形成低密度,快速可折叠的泡沫,其在从泡沫发生容器分配并放置成与患者的牙齿接触之后约1分钟内基本液化。