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1. 发明授权

US07060256B2 Increased peroxide content tooth bleaching gel 有权
公开(公告)号：US07060256B2
公开(公告)日：2006-06-13
申请号：US10758915
申请日：2004-01-16
申请人： Michael A. Pellico
发明人： Michael A. Pellico
IPC分类号： A61K8/20 , A61K8/22 , A61K8/30 , A61K8/38 , A61B19/02
CPC分类号： A61K8/22 , A61K8/19 , A61K8/42 , A61K8/731 , A61K2800/88 , A61Q11/00
摘要： A two-component tooth whitening system which incorporates an increased peroxide content, wherein the components are adapted to be mixed and applied to the teeth from a dental bleaching tray is provided. A first component includes both carbamide peroxide and hydrogen peroxide and a second component comprises an orally compatible activator gel.

2. 发明授权

US4576817A Enzymatic bandages and pads 失效
标题翻译：酶绷带和垫
公开(公告)号：US4576817A
公开(公告)日：1986-03-18
申请号：US618071
申请日：1984-06-07
申请人： Robert E. Montgomery , Michael A. Pellico
发明人： Robert E. Montgomery , Michael A. Pellico
IPC分类号： A61L15/38 , A61K37/48
CPC分类号： A61L15/38 , Y10S604/904
摘要： Enzymatic absorbent materials such as bandages and pads, for body contact applications, contain serum-activated oxidoreductase enzyme for producing hydrogen peroxide upon contact of the enzymatic materials with serum. An illustrative serum-activated oxidoreductase enzyme is glucose oxidase with the corresponding substrate in serum being glucose.
摘要翻译：用于身体接触应用的诸如绷带和垫的酶学吸收材料含有血清活化的氧化还原酶，用于在酶材料与血清接触时产生过氧化氢。示例性的血清活化氧化还原酶是葡萄糖氧化酶，血清中相应的底物是葡萄糖。

3. 发明授权

US09333260B2 Compositions and methods for enzymatic treatment of lung disorders 有权
标题翻译：用于酶治疗肺部疾病的组合物和方法
公开(公告)号：US09333260B2
公开(公告)日：2016-05-10
申请号：US12299897
申请日：2007-05-10
申请人： Michael A. Pellico , Pamela Bosco
发明人： Michael A. Pellico , Pamela Bosco
IPC分类号： A61K31/573 , A61K38/40 , A61K38/44 , A61K38/47 , A61K45/06
CPC分类号： A61K38/44 , A61K9/007 , A61K31/375 , A61K31/573 , A61K38/40 , A61K38/443 , A61K38/47 , A61K45/06 , A61K47/02 , A61K47/10 , A61K47/12 , A61K47/26 , C12Y101/03004 , C12Y101/03009 , C12Y101/03017 , C12Y111/01007 , C12Y111/02002 , C12Y302/01017 , A61K2300/00
摘要： A therapeutic composition for the treatment of lung diseases or disorders and diseases or disorders of the airway passages including pneumonia, acute respiratory failure, and acute respiratory distress syndrome is based on the generation of a biocidal anion by an enzymatic reaction catalyzed by a peroxidase. The peroxide utilized by the peroxidase enzyme can be endogenous or can be generated by the action of an oxidase enzyme on a suitable substrate.
摘要翻译：用于治疗肺部疾病或疾病的疾病或疾病或疾病或病症的治疗组合物，包括肺炎，急性呼吸衰竭和急性呼吸窘迫综合征，基于通过由过氧化物酶催化的酶反应产生杀生物阴离子。过氧化物酶使用的过氧化物可以是内源的，或者可以通过氧化酶在合适的底物上的作用而产生。

4. 发明授权

US5453284A Stabilized enzymatic dentifrice 失效
标题翻译：稳定的酶洁牙剂
公开(公告)号：US5453284A
公开(公告)日：1995-09-26
申请号：US283816
申请日：1994-08-01
申请人： Michael A. Pellico
发明人： Michael A. Pellico
IPC分类号： A23K1/165 , A23K1/18 , A61K8/66 , A61K9/00 , A61K38/43 , A61K38/44 , A61K38/54 , A61Q11/00 , A61K7/28
CPC分类号： A61K8/66 , A61K38/40 , A61K38/44 , A61K38/443 , A61K38/47 , A61K9/0056 , A61Q11/00 , C12Y101/03004 , C12Y101/03005 , C12Y111/01007 , C12Y302/01017
摘要： Hydro-activated and/or oxygen activated aqueous, enzymatic, antimicrobial dentifrices are stabilized against enzymatic activation prior to oral application of the dentifrice by incorporating a thickener into the dentifrice formulation so as to provide the formulation with an enzyme immobilizing viscosity which inhibits enzymatic action during processing and in the dentifrice package. An illustrative, thickened, enzymatic dentifrice with this enhancement contains glucose oxidase, glucose, lactoperoxidase and potassium thiocyanate together with carboxymethylcellulose in an amount to provide the dentifrice with a viscosity of at least about 800 centipoises.
摘要翻译：在通过将增稠剂掺入洁齿剂制剂中口服应用洁齿剂之前，将水激活和/或氧活化的水性，酶促抗微生物洁牙剂稳定化以防止酶活化，从而为制剂提供固定粘度的酶，其抑制酶活性加工和洁齿剂包装。具有这种增强作用的说明性，增稠的酶促洁牙剂含有葡萄糖氧化酶，葡萄糖，乳过氧化物酶和硫氰酸钾以及羧甲基纤维素，其用量为洁齿剂提供至少约800厘泊的粘度。

5. 发明授权

US4578265A Di-enzymatic dentifrice 失效
标题翻译：二酶洁齿剂
公开(公告)号：US4578265A
公开(公告)日：1986-03-25
申请号：US292633
申请日：1981-08-13
申请人： Michael A. Pellico , Robert E. Montgomery
发明人： Michael A. Pellico , Robert E. Montgomery
IPC分类号： A61L15/44 , A61F13/00 , A61F13/15 , A61F13/20 , A61F13/472 , A61K8/66 , A61Q11/00 , A61K7/28 , A61K37/48
CPC分类号： A61Q11/00 , A61K8/66
摘要： A di-enzymatic dentifrice is provided which contains an oxidizable substrate and an oxidoreductase enzyme specific to such substrate for producing hydrogen peroxide upon oral application of the dentifrice and further contains a thiocyanate salt and lactoperoxidase for interacting with hydrogen peroxide to produce a hypothiocyanate bacterial inhibitor. An illustrative enzymatic system for this purpose contains glucose, glucose oxidase, potassium thiocyanate and lactoperoxidase.
摘要翻译：提供了一种二酶法洁齿剂，其含有可氧化底物和对这种底物特异性的氧化还原酶，用于在口服应用洁齿剂时产生过氧化氢，并且还含有硫氰酸盐和乳过氧化物酶以与过氧化氢相互作用以产生硫氰酸盐细菌抑制剂。用于此目的的说明性酶系统包含葡萄糖，葡萄糖氧化酶，硫氰酸钾和乳过氧化物酶。

6. 发明授权

US06214339B1 Di-enzymatic treatment of outer ear infection in dogs and cats 有权
标题翻译：狗和猫的外耳感染的二酶处理
公开(公告)号：US06214339B1
公开(公告)日：2001-04-10
申请号：US09481861
申请日：2000-01-12
申请人： Michael A. Pellico
发明人： Michael A. Pellico
IPC分类号： A61K3844
CPC分类号： A61K38/443 , A61K38/40 , A61K38/44 , A61K38/47 , A61K2300/00
摘要： Otitis externa is treated in dogs and cats by administering to the outer ear of the infected animal a dosage, effective to alleviate the symptoms of the infection, of a substantially non-aqueous, di-enzymatic therapeutic composition, in a liquid or gel fluid carrier. The composition contains an oxidizable substrate and an oxidoreductase enzyme specific to such substrate for producing hydrogen peroxide upon encountering the environment of the outer ear and further contains an iodide salt and and a peroxidatic peroxidase for interacting with the hydrogen peroxide to produce a hypoiodite biocidal agent. Any unbound water present in the composition is limited to an amount not more than about 1.0 wt. % to stabilize the composition against the production of hydrogen peroxide prior to aural application of the composition to enhance efficacy of treatment. An illustrative di-enzymatic composition composition contains glucose, glucose oxidase, potassium iodide and lactoperoxidase in a fluid mixture of glycerol and propylene glycol.
摘要翻译：通过向受感染动物的外耳施用在液体或凝胶流体载体中施用有效缓解感染症状的基本上非水性的二酶治疗组合物的剂量，在狗和猫中治疗外耳炎。。组合物含有可氧化底物和对这种底物特异性的氧化还原酶，用于在遇到外耳的环境时产生过氧化氢，并且还含有碘化物盐和过氧化物过氧化物酶，用于与过氧化氢相互作用以产生次碘酸盐杀生物剂。存在于组合物中的任何未结合的水都限制在不超过约1.0wt。％以在组合物的耳道施用之前稳定组合物抵抗过氧化氢的产生，以增强治疗的功效。示例性的二酶组合物组合物在甘油和丙二醇的流体混合物中含有葡萄糖，葡萄糖氧化酶，碘化钾和乳过氧化物酶。

7. 发明授权

US5928628A Two-component dental bleaching system and method 失效
标题翻译：双组分牙齿漂白系统及方法
公开(公告)号：US5928628A
公开(公告)日：1999-07-27
申请号：US957008
申请日：1997-10-23
申请人： Michael A. Pellico
发明人： Michael A. Pellico
IPC分类号： A61K6/00 , A61K8/22 , A61Q11/00 , A61K7/16 , A61K7/20
CPC分类号： A61K8/22 , A61K6/0023 , A61Q11/00 , A61K2800/88
摘要： A two-component dental bleaching system is provided wherein the components are adapted to be admixed and applied to the teeth from a dental bleaching tray. One component comprises a dental peroxide gel having a pH from about 4 to about 7 and the other component comprises an orally compatible alkaline gel having a pH from about 9 to about 13. The admixing of the components provides a dental bleaching gel having a pH from about 8.5 to about 11 to thereby increase the rate of release of active oxygen and accelerate the bleaching action.
摘要翻译：提供了一种双组分牙齿漂白系统，其中组分适于混合并从牙齿漂白托盘施加到牙齿上。一种组分包含pH为约4至约7的牙科过氧化物凝胶，另一种组分包含pH为约9至约13的经口相容的碱性凝胶。组分的混合物提供牙齿漂白凝胶，其pH值为约8.5至约11，从而增加活性氧的释放速率并加速漂白作用。

8. 发明授权

US5336494A Pet chewable products with enzymatic coating 失效
标题翻译：宠物咀嚼产品与酶涂
公开(公告)号：US5336494A
公开(公告)日：1994-08-09
申请号：US10841
申请日：1993-01-29
申请人： Michael A. Pellico
发明人： Michael A. Pellico
IPC分类号： A23K1/165 , A23K1/18 , A61K8/66 , A61K9/00 , A61K38/43 , A61K38/44 , A61K38/54 , A61Q11/00 , A61K37/50
CPC分类号： A61Q11/00 , A61K31/7004 , A61K38/40 , A61K38/44 , A61K38/443 , A61K38/47 , A61K8/66 , A61K9/0056 , C12Y101/03004 , C12Y101/03005 , C12Y111/01007
摘要： An orally chewable, enzymatically coated product is provided which, upon chewing, produces an anti-bacterial and bacteriostatic effect in the oral cavity by activation of an enzymatic system contained within the coating. The enzymatic surface coating is developed, in substantially dry form, from a thickened, aqueous coating solution having a viscosity from about 1,000 to about 50,000 centipoises and containing oxidizable substrate and oxidoreductase enzymes specific to such substrate for producing hydrogen peroxide upon oral chewing of the coated product and optionally, but advantageously, further containing peroxidatic peroxidase and an alkali metal salt of an oxygen accepting anion for interacting with hydrogen peroxide to produce oxidized anionic bacterial inhibitor. An illustrative enzymatic system for this purpose contains glucose, glucose oxidase, potassium thiocyanate and lactoperoxidase. The thickened enzymatic solution suppresses the enzymatic reaction during the preparation and application of the solution to the surface of the chewable product.
摘要翻译：提供口服咀嚼的酶促涂覆的产品，其在咀嚼时通过激活包含在涂层内的酶系统在口腔中产生抗细菌和抑菌作用。酶表面涂层以基本上干燥的形式从具有约1,000至约50,000厘泊的粘度的增稠的水性涂料溶液展开，并且包含可氧化底物和氧化还原酶特异性的这种底物，用于在涂覆的口腔咀嚼时产生过氧化氢产物和任选地但有利地还含有过氧化物过氧化物酶和氧接受阴离子的碱金属盐，用于与过氧化氢相互作用以产生氧化的阴离子细菌抑制剂。用于此目的的说明性酶系统包含葡萄糖，葡萄糖氧化酶，硫氰酸钾和乳过氧化物酶。增稠的酶溶液在将溶液制备和施加到咀嚼产品的表面期间抑制酶反应。

9. 发明授权

US5073363A Foamable fluoride gels and method 失效
标题翻译：可发泡氟化物凝胶和方法
公开(公告)号：US5073363A
公开(公告)日：1991-12-17
申请号：US465374
申请日：1990-01-16
申请人： Michael A. Pellico
发明人： Michael A. Pellico
IPC分类号： A61K6/00 , A61K8/21 , A61K8/39 , A61K8/40 , A61K8/44 , A61K8/46 , A61K8/60 , A61K8/73 , A61K8/90 , A61Q11/00
CPC分类号： A61Q11/00 , A61K8/042 , A61K8/046 , A61K8/21 , A61K8/39 , A61K8/40 , A61K8/442 , A61K8/466 , A61K8/60 , A61K8/73 , A61K8/90
摘要： An acidified and foamable fluoride gel composition, for use in dental therapy, is provided that contains water, dental fluoride, foaming agent, gelling agent and acidifying agent. An illustrative composition comprises water, sodium fluoride, Pluronic F108 nonionic surfactant and phosphoric acid. The foamable fluoride gel composition, which is packaged in a suitable container, is dispensed onto a toothbrush, or the like, for application to the teeth to be treated to thereby effect fluoride uptake by the dental enamel. The foamable fluoride gel provides substantially the same fluoride uptake as a tray fluoride gel but this result is achieved by a foamable fluoride gel with substantially less fluoride than that which is present in a tray fluoride.
摘要翻译：提供用于牙科治疗的酸化和发泡的氟化物凝胶组合物，其含有水，氟化氟，发泡剂，胶凝剂和酸化剂。示例性组合物包含水，氟化钠，Pluronic F108非离子表面活性剂和磷酸。将包装在合适的容器中的可发泡氟化物凝胶组合物分配到牙刷等上，以施加到待处理的牙齿上，从而实现牙釉质的氟化物摄取。可发泡氟化物凝胶提供与托盘氟化物凝胶基本上相同的氟化物吸收，但是该结果通过具有比托盘氟化物中存在的氟化物显着更少的氟化物的可发泡氟化物凝胶来实现。

10. 发明授权

US4626558A Dental impression composition containing finely sized polyacrylamide 失效
标题翻译：含有精细尺寸的聚丙烯酰胺的牙印模组合物
公开(公告)号：US4626558A
公开(公告)日：1986-12-02
申请号：US785985
申请日：1985-10-10
申请人： Michael A. Pellico
发明人： Michael A. Pellico
IPC分类号： A61K6/10
CPC分类号： A61K6/10
摘要： Powdered alginate compositions containing polyacrylamide in an amount from about 0.01 to about 0.25 wt. % and having a particle size less than about 300 mesh have enhanced smoothness characteristics, without visible signs of undissolved polymer, upon admixing with water to obtain orally settable, dental impression material.
摘要翻译：含有约0.01至约0.25重量％的聚丙烯酰胺的粉状藻酸盐组合物％并且具有小于约300目的粒度的颗粒具有增强的平滑性特征，没有未溶解的聚合物的可见迹象，与水混合以获得口腔可固化的牙印模材料。

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