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1. 发明申请

US20040192618A1 Phenolic acid salts of gabapentin in liquid and/or semi-solid dosage forms and methods of use 失效
标题翻译：加巴喷丁在液体和/或半固体剂型中的酚酸盐和使用方法
公开(公告)号：US20040192618A1
公开(公告)日：2004-09-30
申请号：US10806260
申请日：2004-03-22
发明人： Jeffrey S. Kiel , H. Greg Thomas , Narasimhan Mani
IPC分类号： C07H005/04 , A61K031/7024
CPC分类号： C07H5/04 , A61K31/7024
摘要： The present invention relates to pharmaceutical compositions of gabapentin tannate, processes for production of those compositions and methods of use of those compositions. The present invention provides a novel process for preparation of the tannate salt of gabapentin in liquid or semi-solid dosage form for human and veterinary pharmaceutical use. Tannate salts of active pharmaceutical ingredients are used in sustained release applications and to improve certain organoleptic properties such as taste. The process may utilize either natural or synthetic tannic acid.
摘要翻译：本发明涉及鞣酸加巴喷丁的药物组合物，这些组合物的制备方法和这些组合物的使用方法。本发明提供了用于人和兽用药物用途的液体或半固体剂型中加巴喷丁的鞣酸盐的新方法。活性药物成分的鞣酸盐用于持续释放应用，并改善某些感官特性如味道。该方法可以使用天然或合成的单宁酸。

2. 发明申请

US20040131590A1 Methods and reagents for the enhancement of virus transduction in the bladder epithelium 有权
标题翻译：用于增强膀胱上皮细胞中病毒转导的方法和试剂
公开(公告)号：US20040131590A1
公开(公告)日：2004-07-08
申请号：US10327869
申请日：2002-12-26
发明人： Nagarajan Ramesh , David Frey , Bahram Memarzadeh , DeChao Yu
IPC分类号： A61K048/00 , A61K031/7024
CPC分类号： A61K48/0083 , A61K9/0019 , A61K31/337 , A61K31/7024 , A61K35/761 , A61K45/06 , A61K47/10 , A61K47/26 , C12N7/00 , C12N2710/10332 , C12N2710/10343 , Y02A50/393 , Y02A50/465 , A61K2300/00 , A61K35/76
摘要： Agents and methods for enhancing recombinant virus transduction in the bladder epithelium are described. A first method involves contacting the luminal surface of the bladder with a composition comprising a transduction enhancing agent and an oncolytic virus. Alternatively, the luminal surface of the bladder can be contacted first with a pretreatment composition comprising a transduction enhancing agent and, subsequently, with a composition comprising an oncolytic virus. Bladder treatment compositions comprising a transduction enhancing agent and an oncolytic virus are also described.
摘要翻译：描述了用于增强膀胱上皮中的重组病毒转导的药剂和方法。第一种方法包括使膀胱的腔表面与包含转导增强剂和溶瘤病毒的组合物接触。或者，膀胱的腔表面可以首先与包含转导增强剂的预处理组合物接触，随后与含有溶瘤病毒的组合物接触。还描述了包含转导增强剂和溶瘤病毒的膀胱治疗组合物。

3. 发明申请

US20040091465A1 Therapeutic antiangiogenic compositions and methods 审中-公开
标题翻译：治疗性抗血管生成组合物和方法
公开(公告)号：US20040091465A1
公开(公告)日：2004-05-13
申请号：US10607501
申请日：2003-06-26
发明人： Zachary Yim
IPC分类号： A61K038/43 , A61K031/7024
CPC分类号： A61K31/7024 , A61K38/39
摘要： An inhibitor of endothelial cell proliferation, capable of inhibiting angiogenesis and causing tumor regression, that is approximately 20 kDa and corresponds to a C-terminal fragment of collagen type XVIII, and methods of treating angiogenesis-related disease are provided. The inhibitor is known as endostatin. In a preferred embodiment, endostatin is administered to a patient in a pharmaceutical formulation. The pharmaceutical formulation preferably comprises endostatin combined with sucrose octasulfate.
摘要翻译：提供能够抑制血管生成并引起肿瘤消退的内皮细胞增殖抑制剂，其约为20kDa，并且对应于XVIII型胶原的C-末端片段，以及治疗血管生成相关疾病的方法。抑制剂被称为内皮抑素。在优选的实施方案中，将内贴抑制素以药物制剂施用于患者。药物制剂优选包含与蔗糖八硫酸盐结合的内皮抑制素。

4. 发明申请

US20040077718A1 Use of isovaleryl l-carnitine for the preparation of a medicament for the prevention and cure of osteoporosis 失效
标题翻译：异戊酰基l-肉碱用于制备用于预防和治愈骨质疏松症的药物
公开(公告)号：US20040077718A1
公开(公告)日：2004-04-22
申请号：US10470158
申请日：2003-07-24
发明人： Aleardo Koverech , Alberta Zallone
IPC分类号： A61K031/7024 , A61K031/22 , A61K031/513
CPC分类号： A61K31/221
摘要： The use of isovaleryl L-camitine for the preparation of a medicament for the prevention and cure of osteoporosis and for the prevention and cure of fractures occurring during osteoporosis post-menopause or during the ageing, is described.
摘要翻译：描述了使用异戊酰基L-camitine制备用于预防和治愈骨质疏松症的药物以及用于预防和治愈在绝经后或老化期间发生的骨质疏松症的骨折。

5. 发明申请

US20040037881A1 Method for the management of incontinence 审中-公开
公开(公告)号：US20040037881A1
公开(公告)日：2004-02-26
申请号：US10645467
申请日：2003-08-20
发明人： George V. Guittard , Francisco Ja , Susan M. Marks , David J. Kidney , Fernando E. Gumucio
IPC分类号： A61K031/7024 , A61K031/205 , A61K009/22
CPC分类号： A61K9/0004 , A61K9/2031 , A61K9/2054 , A61K31/216 , A61K31/221
摘要： A composition and a dosage form are disclosed comprising oxybutynin alone/or accompanied by another drug indicated for therapy. A method is disclosed for administering oxybutynin alone/or accompanied by a different drug or for administering oxybutynin and a different drug according to a therapeutic program for the management of incontinence alone, and for other therapy.

6. 发明申请

US20040018995A1 Derivatives of monosaccharides as cell adhesion inhibitors 审中-公开
公开(公告)号：US20040018995A1
公开(公告)日：2004-01-29
申请号：US10611091
申请日：2003-07-01
发明人： Sudershan K. Arora , Jang Bahadur Gupta , Vishwas D. Joshi
IPC分类号： A61K031/7052 , A61K031/7024 , C07H005/06
CPC分类号： C07H9/04
摘要： This invention relates generally to compounds and processes for synthesizing derivatives of 2-3-O-isopropylidene-null-L-xylo-2-hexulofuranosonic acid. The compounds of this invention are useful, inter-alia, for the inhibition and prevention of cell adhesion and cell adhesion-mediated pathologies, including inflammatory and autoimmune diseases, such as bronchial asthma, rheumatoid arthritis, type I diabetes, multiple sclerosis, allograft rejection and psoriasis. This invention also relates to pharmacological compositions containing derivatives of 2-3-O-isopropylidene-null-L-xylo-2-hexulofuranosonic acid and the methods of treating such pathologies as listed above.

7. 发明申请

US20030215513A1 Method for releasing nanosized particles of an active substance from a diffusion-controlled pharmaceutical composition for oral use 审中-公开
标题翻译：从用于口服使用的扩散控制药物组合物释放活性物质的纳米尺寸颗粒的方法
公开(公告)号：US20030215513A1
公开(公告)日：2003-11-20
申请号：US10372045
申请日：2003-02-20
发明人： Peter Fyhr , John Kendrup , Johan Borgstrom , Maria Nilsson
IPC分类号： A61K031/7024 , A61K031/56 , A61K031/55 , A61K031/455 , A61K031/426 , A61K031/337 , A61K031/522
CPC分类号： A61K9/14 , A61K9/0004 , A61K9/51
摘要： The present invention relates to a method for releasing an active substance from a composition. The active substance is either substantially water-insoluble and/or immobilised on or in nanosized particles. A diffusion gradient is established between the inside and the outside of the composition, which allows the transport of a nanosuspension of the active substance through the pores of the membrane.
摘要翻译：本发明涉及从组合物中释放活性物质的方法。活性物质基本上不溶于和/或固定在纳米尺寸的颗粒上或纳米尺寸的颗粒中。在组合物的内部和外部之间建立扩散梯度，这允许活性物质的纳米悬浮液通过膜的孔传输。

8. 发明申请

US20030203854A1 Composition for effecting serum cholesterol levels 审中-公开
标题翻译：用于影响血清胆固醇水平的组合物
公开(公告)号：US20030203854A1
公开(公告)日：2003-10-30
申请号：US10131620
申请日：2002-04-23
发明人： Ivo Pischel , Herbert Clinton Fairow , Ralf Jager
IPC分类号： A61K031/7024 , A61K031/202 , A61K031/16 , A61K031/225
CPC分类号： A61K31/16 , A23D7/0053 , A23D7/0056 , A23D7/011 , A23D7/013 , A23D9/007 , A23D9/013 , A23L27/60 , A23L33/11 , A23V2002/00 , A61K9/0056 , A61K9/1075 , A61K9/127 , A61K9/2009 , A61K9/2013 , A61K31/20 , A61K31/202 , A61K31/225 , A61K31/575 , A61K31/7024 , A61K45/06 , C07J9/00 , A23V2250/2136 , A23V2250/61 , A23V2250/642 , A23V2250/1628 , A23V2250/161
摘要： A new composition for effecting serum cholesterol levels is claimed, said composition comprising a) at least a waxy acid with 23 to 50 carbon atoms or derivatives thereof and with serum cholesterol level reducing properties, and b) 0 to 99.99% by weight of at least a component with serum cholesterol level effecting properties, and c) 0 to 20% by weight of at least a pharmaceutically acceptable formulation aid. The efficacy of this composition can be enhanced by further incorporation of other cholesterol reducing agents, like lecithin, tocotrienol, saponins, fibers, long-chain waxy alcohols and niacin. The claimed composition combines the benefits of the single physiolocology active constituence together with the technology to increase the biovailability.
摘要翻译：所要求的用于实现血清胆固醇水平的新组合物，所述组合物包含a）至少一种具有23-50个碳原子的蜡酸或其衍生物，并具有降低血清胆固醇水平的性质，以及b）至少0至99.99重量％具有影响血清胆固醇水平的组分，以及c）0至20重量％的至少一种药学上可接受的制剂助剂。通过进一步掺入其它胆固醇降低剂如卵磷脂，生育三烯酚，皂角苷，纤维，长链蜡质醇和烟酸，可以提高该组合物的功效。所声称的组合结合了单一生理活动选区的优点以及提高生物利用度的技术。

9. 发明申请

US20030198611A1 Method of treating onychomycosis with urea and an antioxidant 有权
标题翻译：用尿素和抗氧化剂治疗甲真菌病的方法
公开(公告)号：US20030198611A1
公开(公告)日：2003-10-23
申请号：US10127963
申请日：2002-04-22
申请人： Bradley Pharmaceuticals, Inc.
发明人： Bradley P. Glassman , Dileep Bhagwat , Daniel Glassman
IPC分类号： A61K038/05 , A61K031/7024 , A61K031/375 , A61K031/385 , A61K007/04
CPC分类号： A61Q3/00 , A61K8/42 , A61K8/676 , A61K8/678 , A61K8/97 , A61K31/375 , A61K31/385 , A61K31/7024 , A61K36/87 , A61K38/063 , A61K2300/00
摘要： A method of treating onychomycosis is described which includes administration of a topical formulation containing an effective amount of urea and an antioxidant to an infected area around a nail of a patient.
摘要翻译：描述了治疗甲真菌病的方法，其包括向患者的指甲周围的感染区域施用含有有效量的尿素和抗氧化剂的局部制剂。

10. 发明申请

US20030176364A1 Antimicrobial therapeutic compositions and methods of use 失效
标题翻译：抗微生物治疗组合物和使用方法
公开(公告)号：US20030176364A1
公开(公告)日：2003-09-18
申请号：US10370411
申请日：2003-02-18
发明人： Dusan Ninkov
IPC分类号： A61K031/7024 , A61K031/24 , A61K031/05
CPC分类号： A61K31/05 , A61K31/16 , A61K45/06 , A61K2300/00
摘要： The invention provides therapeutic antimicrobial compositions and methods for their use based on natural organic phenolic compounds combined with pharmacological agents. The antimicrobial activities of each carvacrol and thymol are believed to be enhanced, while the pharmacological properties of procaine and related compounds are added to provide their unique properties to facilitate usefulness and effectiveness in humans. The therapeutic compositions are active against bacterial, fungal, and protozoan infections. The forms of the invention are intended to treat various internal infections through parenteral, subcutaneous, intradermal, intravenous, and intramuscular injections. They are also intended as useful agents to treat microbial infections that have become resistant to conventional anitibiotics as well as secondary opportunistic infections.
摘要翻译：本发明提供治疗性抗微生物组合物及其基于天然有机酚类化合物与药物代谢物组合使用的方法。据信，每种香芹酚和百里酚的抗微生物活性得到增强，而普鲁卡因和相关化合物的药理学性质被加入以提供其独特的性质来促进人类的有用性和有效性。治疗组合物对细菌，真菌和原生动物感染具有活性。本发明的形式旨在通过肠胃外，皮下，皮内，静脉内和肌内注射治疗各种内部感染。它们也被用作治疗已经变得对常规的抗生素以及次级机会性感染具有抗性的微生物感染的有用试剂。

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