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    • 3. 发明申请
    • Compositions for raising uric acid levels and methods of using the same
    • 用于提高尿酸水平的组合物及其使用方法
    • US20040176306A1
    • 2004-09-09
    • US10804760
    • 2004-03-19
    • Meir S. SacksKnox Van Dyke
    • A61K038/05A61K031/7076A61K031/375A61K031/355
    • A61K45/06A61K31/70A61K31/78A61K2300/00
    • Compositions for the treatment of uric acid deficiency are disclosed. The compositions generally comprise either a precursor or derivative of uric acid, which, when administered to a patient, will result in a raising of the uric acid levels in that patient. The compositions can optionally comprise one or more additional active ingredients such as antioxidants, glutathione precursors, or inhibitors of NO synthase or homocysteine. Methods for raising uric acid levels in a patient are also disclosed. These methods are useful for in the treatment of various illnesses, such as cancer, infectious disease, Alzheimer disease and neurodegenerative diseases. Use of improved solutions comprising the present compositions in organ preservation is also disclosed.
    • 公开了治疗尿酸缺乏症的组合物。 组合物通常包含尿酸的前体或衍生物,其在给予患者时将导致该患者中的尿酸水平的升高。 组合物可任选地包含一种或多种另外的活性成分,例如抗氧化剂,谷胱甘肽前体,或NO合成酶或高半胱氨酸的抑制剂。 还公开了提高患者尿酸水平的方法。 这些方法可用于治疗各种疾病,如癌症,感染性疾病,阿尔茨海默病和神经变性疾病。 还公开了在器官保存中使用包含本发明组合物的改良溶液。