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1. 发明申请

US20040220262A1 Transdermal and topical administration of drugs using basic permeation enhancers 审中-公开
标题翻译：使用碱性渗透促进剂透皮和局部给药药物
公开(公告)号：US20040220262A1
公开(公告)日：2004-11-04
申请号：US10860887
申请日：2004-06-03
发明人： Tsung-Min Hsu , Nicole T. Gricenko , Alan T. J. Hickey , Eric C. Jacobson , Rose C. LoBello , Jane Obara , Eric C. Luo
IPC分类号： A61K031/24
CPC分类号： A61K8/0208 , A61K8/19 , A61K8/347 , A61K8/41 , A61K8/92 , A61K9/0014 , A61K9/06 , A61K9/7038 , A61K9/7053 , A61K31/04 , A61K31/137 , A61K31/19 , A61K31/20 , A61K31/343 , A61K31/365 , A61K31/4745 , A61K31/513 , A61K31/60 , A61K31/662 , A61K31/7004 , A61K31/7056 , A61K31/737 , A61K31/795 , A61K38/212 , A61K47/02 , A61K47/18 , A61K47/22 , A61Q19/02
摘要： Methods are provided for enhancing the permeability of skin or mucosal tissue to topical or transdermal application of pharmacologically or cosmeceutically active agents. The methods entail the use of a base in order to increase the flux of the active agent through a body surface while minimizing the likelihood of skin damage, irritation or sensitization. The permeation enhancer can be an inorganic or organic base. Compositions and transdermal systems are also described.
摘要翻译：提供了用于增强皮肤或粘膜组织对局部或透皮施用药理学或药妆活性剂的渗透性的方法。该方法需要使用碱以增加活性剂通过身体表面的通量，同时最小化皮肤损伤，刺激或致敏的可能性。渗透促进剂可以是无机或有机碱。还描述了组合物和透皮系统。

2. 发明申请

US20040058994A1 Local prevention or amelioration of pain from surgically closed wounds 审中-公开
标题翻译：局部预防或改善手术闭合性伤口疼痛
公开(公告)号：US20040058994A1
公开(公告)日：2004-03-25
申请号：US10669365
申请日：2003-09-25
申请人： EpiCept Corporation
发明人： R. Douglas Cassel
IPC分类号： A61K031/24
CPC分类号： A61L15/44 , A61K9/7084 , A61K31/167 , A61K31/245 , A61K31/445 , A61K31/47 , A61K45/06 , A61L2300/402
摘要： A non-invasive and non-systemic method for intradermal prevention OR amelioration of pain from a surgically closed wound is disclosed. The method comprises topical delivery of a local anesthetic to an exterior surface of a surgically closed wound.
摘要翻译：公开了一种用于皮内预防的非侵入性和非全身性方法或改善手术闭合性伤口疼痛的方法。该方法包括将局部麻醉剂局部输送到手术闭合伤口的外表面。

3. 发明申请

US20040039053A1 Use of(-) (3-halomethylphenoxy) (4-halophenyl) acetic acid derivatives for treatment of insulin resistance, type 2 diabetes, hyperlipidemia and hyperuricemia 审中-公开
标题翻译：（ - ）（3-卤甲基苯氧基）（4-卤苯基）乙酸衍生物用于治疗胰岛素抵抗，2型糖尿病，高脂血症和高尿酸血症
公开(公告)号：US20040039053A1
公开(公告)日：2004-02-26
申请号：US10432742
申请日：2003-05-27
发明人： Kenneth L. Luskey , Jian Luo , Zuchun Zhao
IPC分类号： A61K031/24 , A61K031/195
CPC分类号： C07D207/08 , A61K31/20 , A61K31/215 , A61K31/216 , A61K31/235 , A61K31/24 , A61K31/265 , A61K31/335 , A61K31/40 , A61K31/425 , A61K31/445 , A61K31/455 , A61K31/495 , A61K31/50 , A61K31/535 , A61K31/64 , A61K38/28 , A61K45/06 , C07D205/04 , C07D207/34 , C07D213/65 , C07D213/81 , C07D213/82 , C07D295/185 , C07D317/40 , C07D333/40 , Y10S514/866 , A61K2300/00
摘要： The present invention provides the use of (null) (3-halomethylphenoxy) (4-halophenyl) acetic acid derivatives and compositions in the treatment of insulin resistance, Type 2 diabetes, hyperlipidemia and hyperuricemia. It further provides (null) (3-halomethylphenoxy) (4-halophenyl) acetic acid derivatives that are useful for the treatment of insulin resistance, Type 2 diabetes, hyperlipidemia and hyperuricemia.
摘要翻译：本发明提供（ - ）（3-卤代甲基苯氧基）（4-卤代苯基）乙酸衍生物和组合物在治疗胰岛素抵抗，2型糖尿病，高脂血症和高尿酸血症中的用途。它还提供可用于治疗胰岛素抵抗，2型糖尿病，高脂血症和高尿酸血症的（ - ）（3-卤代甲基苯氧基）（4-卤代苯基）乙酸衍生物。

4. 发明申请

US20030235613A1 Popping oral administration form 审中-公开
标题翻译：流行口头表达
公开(公告)号：US20030235613A1
公开(公告)日：2003-12-25
申请号：US10173814
申请日：2002-06-19
申请人： CTS Chemical Industries Ltd.
发明人： Sigal First , Rina Yamin
IPC分类号： A61K009/46 , A61K009/14 , A61K033/10 , A61K031/473 , A61K031/24 , A61K031/192 , A61K031/137
CPC分类号： A61K9/0095 , A61K9/0056
摘要： Disclosed are popping pharmaceutical oral administration forms, which comprise an active ingredient, and pressurized gas trapped within cavities in a pharmaceutically acceptable material in a manner that allows the gas to escape from the administration form upon dissolution or shattering of said form. Such an oral administration form may be popular with children that will prefer it on other ones, which do not pop. Methods for preparation of such oral administration forms are also disclosed.
摘要翻译：本发明公开了一种药物口服给药形式，其包含活性成分，以及在药学上可接受的材料中被捕获在空腔内的加压气体，其允许气体在所述形式的溶解或破碎时从给药形式逸出。这样一种口头表达式可能会受到不喜欢流行的其他儿童喜欢的儿童的欢迎。还公开了这种口服给药形式的制备方法。

5. 发明申请

US20030176483A1 Topical synergistic microbicide 审中-公开
标题翻译：局部协同杀微生物剂
公开(公告)号：US20030176483A1
公开(公告)日：2003-09-18
申请号：US10096672
申请日：2002-03-13
发明人： Gerald N. Kern
IPC分类号： A61K031/4178 , A61K031/275 , A61K031/24 , A61K031/195 , A61K031/10
CPC分类号： A61K47/20 , A61K9/0014 , A61K45/06
摘要： Application of topical synergistic microbicide composition(s) of high practical utility both as a treatment and/or prevention against HSV Type 1 and/or Type 2 and related diseases and secondary opportunist disease causing agents, while reducing the inflammation, prolonged healing times and reduce scaring.
摘要翻译：应用具有高实用效用的局部协同杀微生物剂组合物作为治疗和/或预防HSV 1型和/或2型及相关疾病和次级机会性疾病引发剂，同时减少炎症，延长愈合时间和减少害怕

6. 发明申请

US20030171402A1 Method of treating neutrophil-related diseases with topical anesthetics 有权
公开(公告)号：US20030171402A1
公开(公告)日：2003-09-11
申请号：US10326224
申请日：2002-12-20
发明人： Gerald J. Gleich , Loren W. Hunt JR.
IPC分类号： A61K031/445 , A61K031/24
CPC分类号： A61K31/4453 , A61K31/167 , A61K31/24 , A61K31/245 , A61K31/445 , A61K31/47 , Y10S514/826 , Y10S514/851 , Y10S514/87
摘要： A therapeutic method is provided to treat neutrophil-associated pulmonary diseases, such as chronic obstructive pulmonary disease, by locally administering to a mammal in need of such treatment, an effective amount of a topical anesthetic, such as lidocaine, or a pharmaceutically acceptable salt thereof.

7. 发明申请

US20030166718A1 Formulation 有权
标题翻译：公式
公开(公告)号：US20030166718A1
公开(公告)日：2003-09-04
申请号：US10347332
申请日：2003-01-13
发明人： Jeanne-Marie Lecomte , Jean-Charles Schwartz
IPC分类号： A61K009/14 , A61K031/24
CPC分类号： A61K9/0095 , A61K9/1635 , A61K31/223
摘要： A dry powder granulated formulation of the compound racedotril and its use in therapy in the treatment of diarrhoea.
摘要翻译：化合物马草酮的干粉状颗粒制剂及其在治疗腹泻中的应用。

8. 发明申请

US20030161849A1 Cosmetic and dermatological preparations in the form of O/W emulsions, comprising an amino-substituted hydroxybenzophenone 审中-公开
标题翻译：包含氨基取代的羟基二苯甲酮的O / W乳液形式的化妆品和皮肤病学制剂
公开(公告)号：US20030161849A1
公开(公告)日：2003-08-28
申请号：US10234158
申请日：2002-09-05
发明人： Thomas Heidenfelder , Thomas Wunsch , Valerie Andre
IPC分类号： A61K031/24 , A61K007/00
CPC分类号： A61Q19/00 , A61K8/06 , A61K8/062 , A61K8/33 , A61K8/342 , A61K8/375 , A61K8/41 , A61K8/445 , A61K8/585 , A61K8/891 , A61Q17/04
摘要： Cosmetic or dermatological preparations in the form of an O/W emulsion, comprising an amino-substituted hydroxybenzophenone of the formula I. 1
摘要翻译：以O / W乳液形式的化妆品或皮肤病学制剂，其包含式I的氨基取代的羟基二苯甲酮。

9. 发明申请

US20030138505A1 Intradermal-penetration agents for topical local anesthetic administration 有权
公开(公告)号：US20030138505A1
公开(公告)日：2003-07-24
申请号：US10201901
申请日：2002-07-25
申请人： EpiCept Corp.
发明人： Wilfried Fischer , Petra Huber , Paul Mason
IPC分类号： A61K035/78 , A61K031/24 , A61K009/70
CPC分类号： A61K9/7061 , A61K9/0014 , A61K47/44 , A61K47/46
摘要： A non-invasive and non-systemic method for administering a local anesthetic. The method comprises topical application of a local anesthetic in combination with an intradermal-penetration agent selected from the group consisting an aloe composition, a triglyceride, and a mixture thereof.

10. 发明申请

US20030130211A1 Injectable compositions for the controlled delivery of pharmacologically active compound 有权
标题翻译：用于控制递送药理学活性化合物的可注射组合物
公开(公告)号：US20030130211A1
公开(公告)日：2003-07-10
申请号：US10274445
申请日：2002-10-18
发明人： Yerramilli V.S.N. Murthy , Robert H. Suva
IPC分类号： A61K031/704 , A61K031/496 , A61K031/202 , A61K031/65 , A61K031/63 , A61K031/24 , A61K031/205
CPC分类号： A61K31/00 , A61K9/0019 , A61K9/0024 , A61K31/24 , A61K31/496 , A61K31/65 , A61K31/7034 , A61K31/7048 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/20 , A61K47/22 , A61K47/26 , A61K2300/00
摘要： The present invention provides compositions and methods for extending the release times and lowering the toxicity of pharmacologically active compounds. The compounds comprise a salt of the pharmacologically active compound with a lipophilic counterion and a pharmaceutically acceptable water soluble solvent combined together to form an injectable composition. The lipophilic counterion may be a saturated or unsaturated C8-C22 fatty acid, and preferably may be a saturated or unsaturated C10-C18 fatty acid. When injected into a mammal, at least a portion of the composition precipitates and releases the active compound over time. Thus, the composition forms a slowly releasing drug depot of the active compound in the mammal. Therefore, the present invention enables one to provide a controlled dose administration of the active compound for a periods of up to 15 days or even longer. Many compounds can be administered according to the present invention including, but not limited to, tilmicosin, oxytetracycline, metoprolol, fluoxetine, roxithromycin, and turbinafine.
摘要翻译：本发明提供用于延长释放时间并降低药理活性化合物的毒性的组合物和方法。化合物包含药理活性化合物的盐与亲脂性抗衡离子和药学上可接受的水溶性溶剂组合在一起形成可注射组合物。亲油抗衡离子可以是饱和或不饱和的C 8 -C 22脂肪酸，优选可以是饱和或不饱和的C 10 -C 18脂肪酸。当注射到哺乳动物中时，组合物的至少一部分随时间沉淀并释放活性化合物。因此，组合物在哺乳动物中形成缓慢释放活性化合物的药物贮库。因此，本发明使得能够提供活性化合物的受控剂量给药长达15天甚至更长时间。根据本发明可以施用许多化合物，包括但不限于替米考星，土霉素，美托洛尔，氟西汀，罗红霉素和头孢噻吩。

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