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1. 发明申请

US20100080759A1 Method for Forming Nano-bubble 有权
标题翻译：形成纳米气泡的方法
公开(公告)号：US20100080759A1
公开(公告)日：2010-04-01
申请号：US12423956
申请日：2009-04-15
申请人： Walter H. Chang , Cheng-An Lin , Chih-Hsien Lee , Chih-Kuang Yeh
发明人： Walter H. Chang , Cheng-An Lin , Chih-Hsien Lee , Chih-Kuang Yeh
IPC分类号： A61K49/22 , A61K47/30 , A61K49/18
CPC分类号： A61K49/223 , B82Y5/00 , Y10S977/906 , Y10S977/929
摘要： The present invention discloses a method for forming a nano-bubble. The forming method is different from the oil-water emulsion reaction in the prior art. The method comprises: taking an inorganic particle as a nucleus and performing a polymer coating process to coat at least one first polymer on the surface of the nucleus to form an organic/inorganic composite particle; then removing the nucleus of the organic/inorganic composite particle by way of the dissolution of a first solvent to form an impregnated nano-particle; performing a freeze-drying process to remove the first solvent to have the impregnated nano-particle form a hollow nano-particle; and finally dissolving the hollow nano-particle in a second solvent to form the nano-bubble.
摘要翻译：本发明公开了一种形成纳米气泡的方法。成型方法与现有技术中的油水乳液反应不同。该方法包括：以无机颗粒为核，并进行聚合物涂覆工艺以在核表面上涂覆至少一种第一聚合物以形成有机/无机复合颗粒; 然后通过溶解第一溶剂去除有机/无机复合颗粒的核以形成浸渍的纳米颗粒; 进行冷冻干燥处理以除去第一溶剂以使浸渍的纳米颗粒形成中空纳米颗粒; 最终将中空纳米颗粒溶解在第二溶剂中以形成纳米气泡。

2. 发明授权

US07367934B2 Methods of enhancing radiation effects with metal nanoparticles 有权
标题翻译：用金属纳米粒子增强辐射效应的方法
公开(公告)号：US07367934B2
公开(公告)日：2008-05-06
申请号：US11186675
申请日：2005-07-21
申请人： James F. Hainfeld , Daniel N. Slatkin
发明人： James F. Hainfeld , Daniel N. Slatkin
IPC分类号： A61N5/00
CPC分类号： A61N5/00 , A61K41/0038 , A61K41/0052 , A61K47/6849 , A61K47/6923 , A61K47/6929 , A61K49/222 , A61K49/226 , A61N1/406 , A61N5/062 , A61N5/10 , A61N2005/1098 , B82Y5/00 , Y10S977/728 , Y10S977/777 , Y10S977/91 , Y10S977/911 , Y10S977/923 , Y10S977/927 , Y10S977/928 , Y10S977/929 , Y10S977/93
摘要： The present invention provides methods of using metal nanoparticles 0.5 to 400 nm in diameter to enhance the dose and effectiveness of x-rays or of other kinds of radiation in therapeutic regimes of ablating a target tissue such as tumor. The metal nanoparticles can be administered intravenously, intra-arterially, or locally to achieve specific loading in and around the target tissue. The metal nanoparticles can also be linked to chemical and/or biochemical moieties which bind specifically to the target tissue. The enhanced radiation methods can also be applied to ablate unwanted tissues or cells ex vivo.
摘要翻译：本发明提供使用直径为0.5-400nm的金属纳米粒子的方法，以提高X射线或其它种类的辐射在烧蚀靶组织如肿瘤的治疗方案中的剂量和效力。金属纳米颗粒可以静脉内，动脉内或局部施用，以实现靶组织内和周围的特异性负载。金属纳米颗粒也可以连接到特异性结合靶组织的化学和/或生物化学部分。增强的辐射方法也可用于离体消融不需要的组织或细胞。

3. 发明申请

US20050118104A1 Contrast agents 审中-公开
标题翻译：对比剂
公开(公告)号：US20050118104A1
公开(公告)日：2005-06-02
申请号：US10889361
申请日：2004-07-12
申请人： Jonny Ostensen , Morten Eriksen , Sigmund Frigstad , Pal Rongved
发明人： Jonny Ostensen , Morten Eriksen , Sigmund Frigstad , Pal Rongved
IPC分类号： A61K49/00 , A61K9/107 , A61K9/127 , A61K49/22
CPC分类号： A61K49/223 , Y10S977/928 , Y10S977/929
摘要： Ultrasonic visualisation of a suject, particularly of perfusion in the myocardium and other tissues, is performed using novel gas-containing contrast agent preparations which promote controllable and temporary growth of the gas phase in vivo following administration and can therefore act as deposited perfusion tracers. The preparations include a coadministerable composition comprising a diffusible component capable of inward diffusion into the dispersed gas phase to promote temporary growth thereof. In cardiac perfusion imaging the preparations may advantageously be coadministered with vasodilator drugs such as adenosine in order to enhance the differences in return signal intensity from normal and hypoperfused myocardial tissue respectively.
摘要翻译：使用新型含气体的造影剂制剂进行超声波可视化，特别是心肌和其他组织中的灌注，其可在给药后在体内促进气相的可控和临时生长，因此可用作沉积灌注示踪剂。制剂包括可共混组合物，其包含能够向内扩散到分散气相中以促进其暂时生长的可扩散组分。在心脏灌注成像中，制剂可以有利地与血管扩张剂药物如腺苷共同施用，以分别增强来自正常和低灌注心肌组织的返回信号强度的差异。

4. 发明授权

US06680047B2 Diagnostic/therapeutic agents 失效
标题翻译：诊断/治疗剂
公开(公告)号：US06680047B2
公开(公告)日：2004-01-20
申请号：US09925715
申请日：2001-08-10
申请人： Jo Klaveness , Pål Rongved , Anders Høgset , Helge Tolleshaug , Alan Cuthbertson , Aslak Godal , Lars Hoff , Geir Gogstad , Klaus Bryn , Anne Nævestad , Dagfinn Løvhaug , Halldis Hellebust , Magne Solbakken
发明人： Jo Klaveness , Pål Rongved , Anders Høgset , Helge Tolleshaug , Alan Cuthbertson , Aslak Godal , Lars Hoff , Geir Gogstad , Klaus Bryn , Anne Nævestad , Dagfinn Løvhaug , Halldis Hellebust , Magne Solbakken
IPC分类号： A61B800
CPC分类号： A61K51/1255 , A61K47/542 , A61K47/62 , A61K47/6925 , A61K49/0002 , A61K49/0043 , A61K49/0047 , A61K49/0054 , A61K49/0056 , A61K49/0058 , A61K49/0091 , A61K49/223 , A61K51/065 , A61K51/1227 , Y10S977/928 , Y10S977/929 , Y10S977/93
摘要： Targetable diagnostic and/or therapeutically active agents, e.g. ultrasound contrast agents, comprising a suspension in an aqueous carrier liquid of a reporter comprising gas-containing or gas-generating material, said agent being capable of forming at least two types of binding pairs with a target.
摘要翻译：靶向诊断和/或治疗活性剂，例如超声造影剂，其包含在包含含气体或气体产生材料的报道分子的含水载体液体中的悬浮液，所述试剂能够与靶形成至少两种结合对。

5. 发明申请

US20030012735A1 Methods for diagnostic imaging by regulating the administration rate of contrast agent 审中-公开
标题翻译：通过调节造影剂的施用率进行诊断成像的方法
公开(公告)号：US20030012735A1
公开(公告)日：2003-01-16
申请号：US10213533
申请日：2002-08-06
发明人： Evan C. Unger , Terry Matsunaga , Thomas A. Fritz , Varadarajan Ramaswami
IPC分类号： A61K049/00 , G06K009/00
CPC分类号： A61K49/223 , Y10S977/801 , Y10S977/927 , Y10S977/928 , Y10S977/929 , Y10S977/93
摘要： Methods for providing an image of an internal region of a patient. Embodiments of the methods involve administering to the patient a contrast agent which comprises a vesicle composition comprising, in an aqueous carrier, a gas or gaseous precursor and vesicles comprising lipids, proteins or polymers. The patient is scanned using diagnostic imaging, such as ultrasound, to obtain a visible image of the region. The contrast agent is administered to the patient at a rate to substantially eliminate diagnostic artifacts in the image. The methods are particularly useful for diagnosing the presence of any diseased tissue in the patient.
摘要翻译：提供患者内部区域的图像的方法。该方法的实施方案涉及向患者施用造影剂，其包含囊泡组合物，所述囊泡组合物在水性载体中包含气体或气体前体和包含脂质，蛋白质或聚合物的囊泡。使用诸如超声波之类的诊断成像扫描患者，以获得该区域的可见图像。将造影剂以基本上消除图像中的诊断伪像的速率施用于患者。该方法对于诊断患者中任何患病组织的存在特别有用。

6. 发明授权

US06479034B1 Method of preparing gas and gaseous precursor-filled microspheres 失效
标题翻译：制备气体和气态前体填充微球的方法
公开(公告)号：US06479034B1
公开(公告)日：2002-11-12
申请号：US09118329
申请日：1998-07-17
申请人： Evan C. Unger , Thomas A. Fritz , Terry Matsunaga , VaradaRajan Ramaswami , David Yellowhair , Guanli Wu
发明人： Evan C. Unger , Thomas A. Fritz , Terry Matsunaga , VaradaRajan Ramaswami , David Yellowhair , Guanli Wu
IPC分类号： A61B800
CPC分类号： A61K49/227 , A61K9/127 , A61K9/1277 , A61K9/1278 , A61K41/0028 , A61K41/0052 , A61K49/1815 , A61K49/22 , A61K49/223 , A61M5/3145 , Y10S424/812 , Y10S436/829 , Y10S977/907 , Y10S977/915 , Y10S977/927 , Y10S977/929
摘要： Methods of and apparatus for preparing temperature activated gaseous precursor-filled liposomes are described. Gaseous precursor-filled liposomes prepared by these methods are particularly useful, for example, in ultrasonic imaging applications and in therapeutic drug delivery systems.
摘要翻译：描述了制备温度活化气态前体填充脂质体的方法和装置。通过这些方法制备的气态前体填充脂质体在例如超声成像应用和治疗药物递送系统中是特别有用的。

7. 发明授权

US06461588B1 Use of bile acid conjugates, derivatives thereof with metal complexes as blood pool agents for nuclear magnetic resonance diagnostics 有权
标题翻译：使用胆汁酸共轭物，其衍生物与金属络合物作为核磁共振诊断的血液池剂
公开(公告)号：US06461588B1
公开(公告)日：2002-10-08
申请号：US09318618
申请日：1999-05-26
申请人： Pier Lucio Anelli , Marino Brocchetta , Christoph De Haen , Ornella Gazzotti , Luciano Lattuada , Giovanna Lux , Giuseppe Manfredi , Pierfrancesco Morosini , Daniela Palano , Michele Serleti , Fulvio Uggeri , Massimo Visigalli
发明人： Pier Lucio Anelli , Marino Brocchetta , Christoph De Haen , Ornella Gazzotti , Luciano Lattuada , Giovanna Lux , Giuseppe Manfredi , Pierfrancesco Morosini , Daniela Palano , Michele Serleti , Fulvio Uggeri , Massimo Visigalli
IPC分类号： A61B5055
CPC分类号： A61K49/10 , A61K49/085 , Y10S977/928 , Y10S977/929 , Y10S977/93
摘要： Blood pool imaging contrast agents containing paramagnetic bi- and tri-valent metal ion chelates of bile acid conjugates with molecules having chelating activity are used in magnetic resonance imaging of the vascular system and particularly the coronaries.
摘要翻译：血液成像造影剂含有胆酸偶联物与具有螯合活性的分子的顺磁性二价和三价金属离子螯合物用于血管系统特别是冠状动脉的磁共振成像。

8. 发明申请

US20010002993A1 CONTRAST AGENTS 失效
标题翻译：对比剂
公开(公告)号：US20010002993A1
公开(公告)日：2001-06-07
申请号：US09291277
申请日：1999-04-14
发明人： JONNY OSTENSEN , MORTEN ERIKSEN , SIGMUND FRIGSTAD , PAL RONGVED
IPC分类号： A61B008/00
CPC分类号： A61K49/223 , Y10S977/928 , Y10S977/929
摘要： Ultrasonic visualisation of a subject, particularly of perfusion in the myocardium and other tissues, is performed using novel gas-containing contrast agent preparations which promote controllable and temporary growth of the gas phase in vivo following administration and can therefore act as deposited perfusion tracers. The preparations include a coadministerable composition comprising a diffusible component capable of inward diffusion into the dispersed gas phase to promote temporary growth thereof. In cardiac perfusion imaging the preparations may advantageously be coadministered with vasodilator drugs such as adenosine in order to enhance the differences in return signal intensity from normal and hypoperfused myocardial tissue respectively.
摘要翻译：使用新型含气体的造影剂制剂，使用受试者的超声波可视化，特别是心肌和其他组织中的灌注进行，其在给药后在体内促进气相的可控和临时生长，因此可用作沉积的灌注示踪剂。制剂包括可共混组合物，其包含能够向内扩散到分散气相中以促进其暂时生长的可扩散组分。在心脏灌注成像中，制剂可以有利地与血管扩张剂药物如腺苷共同施用，以分别增强来自正常和低灌注心肌组织的返回信号强度的差异。

9. 发明授权

US06217908B1 Bioadhesive microspheres and their use as drug delivery and imaging systems 失效
标题翻译：生物粘附微球及其作为药物递送和成像系统的用途
公开(公告)号：US06217908B1
公开(公告)日：2001-04-17
申请号：US08052473
申请日：1993-04-23
申请人： Edith Mathiowitz , Donald Chickering , Jules Serge Jacob
发明人： Edith Mathiowitz , Donald Chickering , Jules Serge Jacob
IPC分类号： A61K916
CPC分类号： A61K9/1641 , A61K9/167 , Y10S977/795 , Y10S977/906 , Y10S977/929
摘要： Bioadhesive polymers in the form of, or as a coating on, microcapsules containing drugs or bioactive substances which may serve for therapeutic, or diagnostic purposes in diseases of the gastrointestinal tract, are described. The polymeric microspheres all have a bioadhesive force of at least 11 mN/cm2 (110 N/m2). Techniques for the fabrication of bioadhesive microspheres, as well as a method for measuring bioadhesive forces between microspheres and selected segments of the gastrointestinal tract in vitro are also described. This quantitative method provides a means to establish a correlation between the chemical nature, the surface morphology and the dimensions of drug-loaded microspheres on one hand and bioadhesive forces on the other, allowing the screening of the most promising materials from a relatively large group of natural and synthetic polymers which, from theoretical consideration, should be used for making bioadhesive microspheres.
摘要翻译：描述了可以用作胃肠道疾病中的治疗或诊断目的的药物或生物活性物质的形式或作为包衣形式的生物粘附聚合物。聚合物微球全部具有至少11mN / cm 2（110N / m 2）的生物附着力。还描述了用于制造生物粘附微球的技术，以及用于测量体外微球和胃肠道的选定区段之间的生物粘附力的方法。这种定量方法提供了一种手段来建立化学性质，表面形态和药物负载微球的尺寸与生物粘附力之间的相关性，另一方面可以从相对较大的组中筛选出最有希望的材料天然和合成的聚合物，从理论上考虑，应用于制造生物粘附微球。

10. 发明授权

US6068857A Microparticles containing active ingredients, agents containing these microparticles, their use for ultrasound-controlled release of active ingredients, as well as a process for their production 失效
标题翻译：含有活性成分的微粒，含有这些微粒的试剂，其用于超声控制释放活性成分的用途，以及其生产方法
公开(公告)号：US6068857A
公开(公告)日：2000-05-30
申请号：US605174
申请日：1996-08-05
申请人： Werner Weitschies , Dieter Heldmann , Peter Hauff , Thomas Fritzsch , Harald Stahl
发明人： Werner Weitschies , Dieter Heldmann , Peter Hauff , Thomas Fritzsch , Harald Stahl
IPC分类号： A61K9/00 , A61K9/16 , A61K9/19 , A61K9/50 , A61K41/00 , A61K49/00 , A61K49/22 , A61K9/52 , B01J3/04 , B01J13/04
CPC分类号： A61K41/0028 , A61K49/223 , A61K9/0009 , A61K9/1635 , A61K9/1647 , Y10S977/773 , Y10S977/915 , Y10S977/927 , Y10S977/929
摘要： The invention relates to new microparticles containing active ingredients, which contain at least one gas or a gaseous phase in addition to the active ingredient(s), agents containing these particles (microparticulate systems), their use for ultrasound-controlled in vivo release of active ingredients, as well as a process for the production of particles and agents.
摘要翻译： PCT No.PCT / EP94 / 02806 Sec。 371日期：1996年8月5日 102（e）日期1996年8月5日PCT 1994年8月25日PCT公布。公开号WO95 / 07072 日期：1995年3月16日本发明涉及含有活性成分的新型微粒，除了活性成分以外含有至少一种气体或气相，含有这些颗粒的试剂（微粒体系），它们用于超声控制活性成分的体内释放，以及生产颗粒和试剂的方法。

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