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1. 发明授权

US07894663B2 Method and system for multiple view volume rendering 有权
标题翻译：多视图体绘制的方法和系统
公开(公告)号：US07894663B2
公开(公告)日：2011-02-22
申请号：US11772147
申请日：2007-06-30
申请人： Sevald Berg , Stein Inge Rabben , Sigmund Frigstad
发明人： Sevald Berg , Stein Inge Rabben , Sigmund Frigstad
IPC分类号： G06K9/00 , G06T15/00
CPC分类号： A61B8/00 , A61B8/465 , A61B8/483 , G06T19/00 , G06T2210/41 , G06T2219/008
摘要： A method and system for multiple view volume rendering are provided. The method includes identifying a plurality of view directions relative to an image of an object and automatically volume rendering a volumetric data set based on the plurality of view directions. The method further includes generating an image for each view direction using the rendered data.
摘要翻译：提供了一种用于多视图体绘制的方法和系统。该方法包括识别相对于对象的图像的多个视图方向，并且基于多个视图方向自动地体积地绘制体数据集。该方法还包括使用渲染数据为每个视图方向生成图像。

2. 发明申请

US20050010098A1 Method and apparatus for knowledge based diagnostic imaging 审中-公开
标题翻译：用于基于知识的诊断成像的方法和装置
公开(公告)号：US20050010098A1
公开(公告)日：2005-01-13
申请号：US10810132
申请日：2004-03-26
申请人： Sigmund Frigstad , Bjorn Olstad
发明人： Sigmund Frigstad , Bjorn Olstad
IPC分类号： A61B5/00 , A61B5/055 , A61B6/00 , A61B8/00 , A61B8/08 , G06F19/00 , A61B5/05 , G06F17/00
CPC分类号： A61B8/00 , A61B5/0002 , A61B5/055 , A61B6/00 , A61B6/541 , A61B6/56 , A61B6/563 , A61B8/08 , A61B8/483 , A61B8/543 , A61B8/56 , A61B8/565 , G06F19/321 , G06F19/3418
摘要： A knowledge based diagnostic imaging system, comprising diagnostic equipment for analyzing a patient to obtain a new patient data set containing at least one of MR data, CT data, ultrasound data, x-ray data, SPECT data and PET data. The diagnostic equipment automatically analyzes the new patient data set with respect to a physiologic parameter of the patient to obtain a patient value for said physiologic parameter. A database containing past patient data sets for previously analyzed patients. The past patient data sets contain data indicative of the physiologic parameter with respect to previously analyzed patients. A network interconnects the diagnostic equipment and the database to support access to the past patient data sets.
摘要翻译：一种基于知识的诊断成像系统，包括用于分析患者以获得包含MR数据，CT数据，超声数据，x射线数据，SPECT数据和PET数据中的至少一个的新患者数据集的诊断设备。诊断设备相对于患者的生理参数自动分析新的患者数据集，以获得所述生理参数的患者价值。包含先前分析患者的过去患者数据集的数据库。过去的患者数据集包含与先前分析的患者相关的指示生理参数的数据。网络将诊断设备和数据库互连，以支持对过去患者数据集的访问。

3. 发明授权

US06409671B1 Ultrasonography 失效
标题翻译：超声检查
公开(公告)号：US06409671B1
公开(公告)日：2002-06-25
申请号：US09597726
申请日：2000-06-19
申请人： Morten Eriksen , Sigmund Frigstad
发明人： Morten Eriksen , Sigmund Frigstad
IPC分类号： A61B800
CPC分类号： A61B8/481 , A61B5/0456 , A61B8/06 , A61B8/13 , A61K49/223 , G01S7/52036 , G01S15/8979
摘要： Local aberrations in the perfusion and/or compliance of vasculated tissue may be detected by contrast agent-enhanced ultrasound imaging procedures wherein a sequence of ultrasound image data is generated in respect of a region of interest in vasculated tissue, the image data is processed to generate waveforms representative of arterial pulsatility, and these waveforms are analyzed for variations such as phase distortions which are characteristic of local aberrations in tissue perfusion and/or compliance.
摘要翻译：脉冲组织的灌注和/或依从性的局部像差可以通过造影剂增强的超声成像程序来检测，其中针对血管组织中的感兴趣区域生成超声图像数据序列，处理图像数据以产生波形代表动脉搏动，并且对这些波形进行分析，例如相位失真，其是组织灌注和/或依从性中的局部像差的特征。

4. 发明授权

US06375931B2 Contrast agents 失效
标题翻译：对比剂
公开(公告)号：US06375931B2
公开(公告)日：2002-04-23
申请号：US09291277
申请日：1999-04-14
申请人： Jonny Østensen , Morten Eriksen , Sigmund Frigstad , Pål Rongved
发明人： Jonny Østensen , Morten Eriksen , Sigmund Frigstad , Pål Rongved
IPC分类号： A61B800
CPC分类号： A61K49/223 , Y10S977/928 , Y10S977/929
摘要： Ultrasonic visualization of a subject, particularly of perfusion in the myocardium and other tissues, is performed using novel gas-containing contrast agent preparations which promote controllable and temporary growth of the gas phase in vivo following administration and can therefore act as deposited perfusion tracers. The preparations include a coadministerable composition comprising a diffusible component capable of inward diffusion into the dispersed gas phase to promote temporary growth thereof. In cardiac perfusion imaging the preparations may advantageously be coadministered with vasodilator drugs such as adenosine in order to enhance the differences in return signal intensity from normal and hypoperfused myocardial tissue respectively.
摘要翻译：使用新型含气体的造影剂制剂，使用受试者的超声波可视化，特别是心肌和其他组织中的灌注进行，其在给药后在体内促进气相的可控和临时生长，因此可用作沉积的灌注示踪剂。制剂包括可共混组合物，其包含能够向内扩散到分散气相中以促进其暂时生长的可扩散组分。在心脏灌注成像中，制剂可以有利地与血管扩张剂药物如腺苷共同施用，以分别增强来自正常和低灌注心肌组织的返回信号强度的差异。

5. 发明授权

US06783752B2 Contrast agents 失效
标题翻译：对比剂
公开(公告)号：US06783752B2
公开(公告)日：2004-08-31
申请号：US10007325
申请日：2001-12-05
申请人： Jonny Østensen , Morten Eriksen , Sigmund Frigstad , Pål Rongved
发明人： Jonny Østensen , Morten Eriksen , Sigmund Frigstad , Pål Rongved
IPC分类号： A61B800
CPC分类号： A61K49/223 , Y10S977/928 , Y10S977/929
摘要： Ultrasonic visualisation of a suject, particularly of perfusion in the myocardium and other tissues, is performed using novel gas-containing contrast agent preparations which promote controllable and temporary growth of the gas phase in vivo following administration and can therefore act as deposited perfusion tracers. The preparations include a coadministerable composition comprising a diffusible component capable of inward diffusion into the dispersed gas phase to promote temporary growth thereof. In cardiac perfusion imaging the preparations may advantageously be coadministered with vasodilator drugs such as adenosine in order to enhance the differences in return signal intensity from normal and hypoperfused myocardial tissue respectively.
摘要翻译：使用新型含气体的造影剂制剂进行超声波可视化，特别是心肌和其他组织中的灌注，其可在给药后在体内促进气相的可控和临时生长，因此可用作沉积灌注示踪剂。制剂包括可共混组合物，其包含能够向内扩散到分散气相中以促进其暂时生长的可扩散组分。在心脏灌注成像中，制剂可以有利地与血管扩张剂药物如腺苷共同施用，以分别增强来自正常和低灌注心肌组织的返回信号强度的差异。

6. 发明授权

US06315730B1 Ultrasound imaging of tissue perfusion by pulse energy disruption of contrast agent 有权
标题翻译：超声成像通过脉冲能量破坏造影剂组织灌注
公开(公告)号：US06315730B1
公开(公告)日：2001-11-13
申请号：US09425290
申请日：1999-10-25
申请人： Lars Hoff , Jonny Østensen , Sigmund Frigstad , Morten Eriksen
发明人： Lars Hoff , Jonny Østensen , Sigmund Frigstad , Morten Eriksen
IPC分类号： A61B814
CPC分类号： A61B8/481 , A61B8/06 , A61B8/13 , A61K41/0028 , A61K49/223
摘要： A method of measuring tissue perfusion in a human or non-human animal subject which comprises administering an effective amount of an ultrasound contrast agent to said subject, irradiating tissue in a target region with at least one pulse of ultrasound having energy sufficient to destroy or discernibly modify the echogenic properties of substantially all contrast agent in said target region, and ultrasonically detecting and quantifying the rate of flow of either further contrast agent into said target region or modified contrast agent out of said target region.
摘要翻译：一种测量人或非人类动物受试者中的组织灌注的方法，其包括向所述受试者施用有效量的超声造影剂，用至少一个具有足以破坏或可辨别的能量的超声波照射目标区域中的组织修改所述目标区域中基本上所有造影剂的回声特性，并且超声检测和定量任何另外的造影剂进入所述目标区域或修改的造影剂在所述目标区域之外的流速。

7. 发明授权

US5601085A Ultrasound imaging 失效
标题翻译：超声成像
公开(公告)号：US5601085A
公开(公告)日：1997-02-11
申请号：US538286
申请日：1995-10-02
申请人： Jonny Ostensen , Morton Eriksen , Lars Hoff , Sigmund Frigstad , Nils Sponheim , Knut Dyrstad
发明人： Jonny Ostensen , Morton Eriksen , Lars Hoff , Sigmund Frigstad , Nils Sponheim , Knut Dyrstad
IPC分类号： A61B8/06 , A61B8/00 , A61K49/22 , G01S7/52 , G01S15/52 , G06T1/00
CPC分类号： A61B8/481 , A61K49/223 , G01S15/52 , G01S7/52036
摘要： Temporal variations in backscatter from an ultrasound contrast agent located in the vascular system and induced by movement of the scatterers are used to visualise the presence of contrast agent by determining areas where correlation between successive ultrasound images is poor. This low level of correlation arising from intravascular contrast agent movement permits distinction between stationary bulk tissue and moving bulk tissue since movement of the latter solid tissue scatterers is correlated.
摘要翻译：使用位于血管系统中并由散射体移动引起的超声造影剂的后向散射的时间变化，通过确定连续超声图像之间的相关性较差的区域来显现造影剂的存在。由于血管内造影剂运动引起的这种低水平的相关性允许区分固定块体组织和运动体块组织，因为后者的固体组织散射体的运动是相关的。

8. 发明授权

US08764660B2 Methods and apparatus for combined audible and ultrasound inspection of objects, including patients 有权
标题翻译：包括患者在内的物体的声音和超声检查的组合方法和装置
公开(公告)号：US08764660B2
公开(公告)日：2014-07-01
申请号：US11872884
申请日：2007-10-16
申请人： Sigmund Frigstad , Jean-Francois Gelly , Hans Garmann Torp
发明人： Sigmund Frigstad , Jean-Francois Gelly , Hans Garmann Torp
IPC分类号： A61B8/00
CPC分类号： A61B8/14 , A61B8/4472
摘要： An acquisition component is provided that includes an audible sound sensor configured to receive audible sounds within a sensing area and a multi-element ultrasound transducer configured to emit ultrasound signals and to receive reflections of the ultrasound signals in the same sensing area. The audible sound sensor and the multi-element ultrasound transducer may be configured to be simultaneously operable.
摘要翻译：提供了一种采集部件，其包括构造成在感测区域内接收可听见的声音的声音传感器，以及配置成发射超声信号并且在相同感测区域中接收超声信号的反射的多元件超声换能器。可听见的声音传感器和多元素超声换能器可被配置成同时可操作。

9. 发明授权

US07892522B2 Contrast agents 有权
标题翻译：对比剂
公开(公告)号：US07892522B2
公开(公告)日：2011-02-22
申请号：US09950985
申请日：2001-09-13
申请人： David Johnson , Jonny Østensen , Morten Eriksen , Audun Tornes , Sigmund Frigstad , Harald Dugstad , Jo Klaveness , Pål Rongved , Roald Skurtveit , Jorunn Brænden
发明人： David Johnson , Jonny Østensen , Morten Eriksen , Audun Tornes , Sigmund Frigstad , Harald Dugstad , Jo Klaveness , Pål Rongved , Roald Skurtveit , Jorunn Brænden
IPC分类号： A61B8/00 , A61K9/127 , A61B8/14
CPC分类号： A61K49/223
摘要： Ultrasound contrast agents comprising microbubbles of biocompatible gas, e.g. a sulphur halide or a perfluorocarbon, stabilized by opsonisable amphiphilic material, e.g. a membrane-forming lipid such as a phospholipid, especially a negatively charged phospholipid such as a phosphatidylserine, may exhibit prolonged contrast-generating residence time in the liver following intravenous administration.
摘要翻译：超声造影剂包括生物相容性气体的微泡，例如卤化物或全氟化碳，通过可调节的两亲性材料稳定，例如。成膜脂质如磷脂，特别是带负电荷的磷脂如磷脂酰丝氨酸，可以在静脉内给药后在肝脏中产生延长的对比度产生停留时间。

10. 发明授权

US07678050B2 Method and apparatus for detecting cardiac events 有权
标题翻译：检测心脏事件的方法和装置
公开(公告)号：US07678050B2
公开(公告)日：2010-03-16
申请号：US11064645
申请日：2005-02-24
申请人： Svein Arne Aase , Sigmund Frigstad , Hans Garmann Torp
发明人： Svein Arne Aase , Sigmund Frigstad , Hans Garmann Torp
IPC分类号： A61B8/00
CPC分类号： A61B8/08 , A61B8/0883 , A61B8/488
摘要： A method and apparatus for detecting cardiac events. Ultrasonic data comprising a heart cycle is acquired by a probe. Tissue velocities associated with the ultrasonic data are detected. One of a maximum and a minimum value is detected based on the tissue velocities. A time within the heart cycle associated with the maximum or minimum value is determined, and a cardiac event is detected with respect to the time within the heart cycle and the maximum or minimum value.
摘要翻译：一种用于检测心脏事件的方法和装置。包括心脏周期的超声数据由探针获得。检测与超声波数据相关的组织速度。基于组织速度检测最大值和最小值之一。确定与最大或最小值相关联的心脏周期内的时间，并且相对于心脏周期内的时间和最大值或最小值检测心脏事件。

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